NO20081425L - 8-substituerte benzoazepiner som Toll-lignende reseptormodulatorer - Google Patents

8-substituerte benzoazepiner som Toll-lignende reseptormodulatorer

Info

Publication number
NO20081425L
NO20081425L NO20081425A NO20081425A NO20081425L NO 20081425 L NO20081425 L NO 20081425L NO 20081425 A NO20081425 A NO 20081425A NO 20081425 A NO20081425 A NO 20081425A NO 20081425 L NO20081425 L NO 20081425L
Authority
NO
Norway
Prior art keywords
toll
receptor modulators
methods
substituted benzoazepines
benzoazepines
Prior art date
Application number
NO20081425A
Other languages
English (en)
Other versions
NO342587B1 (no
Inventor
Robert D Groneberg
George Andrew Doherty
Todd C Eary
Zachary JONES
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of NO20081425L publication Critical patent/NO20081425L/no
Publication of NO342587B1 publication Critical patent/NO342587B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Det er tilveiebragt preparater og fremgangsmåter som kan anvendes til modulering av signalisering gjennom de Toll-lignende reseptorer TLR7 og/eller TLR8. Preparatene og fremgangsmåtene har anvendelse ved behandlingen av autoimmun-itet, betennelse, allergi, astma, transplantatawis-ning, transplantat-versus-verts-sykdom, infeksjon, sepsis, kreft og immunsvikt.
NO20081425A 2005-08-19 2008-03-18 8-substituerte benzoazepiner som Toll-lignende reseptormodulatorer NO342587B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71000405P 2005-08-19 2005-08-19
PCT/US2006/032098 WO2007024612A2 (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators

Publications (2)

Publication Number Publication Date
NO20081425L true NO20081425L (no) 2008-05-19
NO342587B1 NO342587B1 (no) 2018-06-18

Family

ID=37623842

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081425A NO342587B1 (no) 2005-08-19 2008-03-18 8-substituerte benzoazepiner som Toll-lignende reseptormodulatorer

Country Status (31)

Country Link
US (2) US8153622B2 (no)
EP (3) EP2322510A3 (no)
JP (1) JP5138592B2 (no)
KR (2) KR101442846B1 (no)
CN (6) CN101309906A (no)
AP (1) AP2008004386A0 (no)
AU (1) AU2006283620B2 (no)
BR (1) BRPI0614941B8 (no)
CA (3) CA2865331C (no)
CR (2) CR9809A (no)
DK (1) DK1940797T3 (no)
EA (1) EA018543B1 (no)
EC (1) ECSP088292A (no)
ES (1) ES2391031T3 (no)
HK (1) HK1122017A1 (no)
HR (1) HRP20120695T1 (no)
IL (2) IL189467A (no)
MA (1) MA29838B1 (no)
MX (1) MX2008002141A (no)
MY (1) MY146567A (no)
NO (1) NO342587B1 (no)
NZ (1) NZ565907A (no)
PL (1) PL1940797T3 (no)
PT (1) PT1940797E (no)
RS (1) RS52447B (no)
SI (1) SI1940797T1 (no)
TN (1) TNSN08076A1 (no)
TW (2) TWI404537B (no)
UA (1) UA92754C2 (no)
WO (1) WO2007024612A2 (no)
ZA (1) ZA200802496B (no)

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