MX2019000586A - Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd). - Google Patents
Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd).Info
- Publication number
- MX2019000586A MX2019000586A MX2019000586A MX2019000586A MX2019000586A MX 2019000586 A MX2019000586 A MX 2019000586A MX 2019000586 A MX2019000586 A MX 2019000586A MX 2019000586 A MX2019000586 A MX 2019000586A MX 2019000586 A MX2019000586 A MX 2019000586A
- Authority
- MX
- Mexico
- Prior art keywords
- amd
- treatment
- sflt
- human subject
- aav
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
- A61B3/028—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing visual acuity; for determination of refraction, e.g. phoropters
- A61B3/032—Devices for presenting test symbols or characters, e.g. test chart projectors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00011—Details
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- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14171—Demonstrated in vivo effect
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Abstract
La descripción actual proporciona composiciones y métodos para la prevención o tratamiento de neovascularización ocular, tal como AMD, en un sujeto humano, al administrar subretinalmente una composición farmacéutica que comprende una cantidad farmacéuticamente efectiva de un vector que comprende un ácido nucleico que codifica proteína tirosina cinasa-1 relacionada con Fms (sFlt-1) soluble a un sujeto humano.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261647461P | 2012-05-15 | 2012-05-15 | |
US201261670535P | 2012-07-11 | 2012-07-11 | |
US201261678555P | 2012-08-01 | 2012-08-01 | |
US201261691660P | 2012-08-21 | 2012-08-21 | |
US201361775440P | 2013-03-08 | 2013-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019000586A true MX2019000586A (es) | 2021-06-15 |
Family
ID=49584435
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014013933A MX362452B (es) | 2012-05-15 | 2013-05-07 | Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1. |
MX2019000586A MX2019000586A (es) | 2012-05-15 | 2014-11-14 | Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014013933A MX362452B (es) | 2012-05-15 | 2013-05-07 | Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1. |
Country Status (27)
Country | Link |
---|---|
US (7) | US20130323302A1 (es) |
EP (2) | EP2849802B1 (es) |
JP (5) | JP6466322B2 (es) |
KR (3) | KR102218067B1 (es) |
CN (2) | CN115337407A (es) |
AU (3) | AU2013263159B2 (es) |
BR (1) | BR112014028633A8 (es) |
CA (1) | CA2873628C (es) |
CY (1) | CY1124495T1 (es) |
DK (1) | DK3501549T3 (es) |
ES (1) | ES2890813T3 (es) |
HK (1) | HK1207568A1 (es) |
HR (1) | HRP20211453T1 (es) |
HU (1) | HUE056327T2 (es) |
IL (2) | IL235679B (es) |
LT (1) | LT3501549T (es) |
MX (2) | MX362452B (es) |
NZ (2) | NZ702637A (es) |
PL (1) | PL3501549T3 (es) |
PT (1) | PT3501549T (es) |
RS (1) | RS62359B1 (es) |
RU (1) | RU2014150340A (es) |
SG (2) | SG10201609412QA (es) |
SI (1) | SI3501549T1 (es) |
TW (3) | TWI702955B (es) |
WO (1) | WO2013173129A2 (es) |
ZA (1) | ZA201409025B (es) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
RU2611202C2 (ru) | 2011-04-22 | 2017-02-21 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Вирионы аденоассоциированного вируса с вариантным капсидом и способы их использования |
TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
JP6600624B2 (ja) | 2013-05-31 | 2019-10-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アデノ随伴ウイルス変異体及びその使用方法 |
KR101591823B1 (ko) | 2013-12-27 | 2016-02-04 | 재단법인 목암생명공학연구소 | 증가된 유전자 발현능을 갖는 발현벡터 |
AU2015213770A1 (en) * | 2014-02-06 | 2016-09-01 | Genzyme Corporation | Compositions and methods for treating and preventing macular degeneration |
GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
US10000741B2 (en) | 2014-03-17 | 2018-06-19 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
LT3122878T (lt) * | 2014-03-24 | 2019-02-11 | Translate Bio, Inc. | Terapija mrnr, skirta akių ligų gydymui |
US10507232B2 (en) | 2014-04-02 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
RS62078B1 (sr) * | 2014-05-02 | 2021-07-30 | Genzyme Corp | Aav vektori za gensku terapiju mrežnjače i cns |
US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CA2966620A1 (en) | 2014-11-05 | 2016-05-12 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
US10570395B2 (en) | 2014-11-14 | 2020-02-25 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
EP3218484A4 (en) | 2014-11-14 | 2018-05-30 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
GB201502137D0 (en) * | 2015-02-09 | 2015-03-25 | Ucl Business Plc | Treatment |
BR112017018846A2 (pt) | 2015-03-02 | 2018-07-31 | Adverum Biotechnologies, Inc. | composições e métodos para entrega intravítrea de polinucleotídeos a cones retinianos. |
HUE051491T2 (hu) * | 2015-03-06 | 2021-03-01 | Massachusetts Eye & Ear Infirmary | Gén-augmentációs terápiák a PRPF31 gén mutációi által okozott öröklött retina degenerációra |
CN107532177A (zh) | 2015-03-24 | 2018-01-02 | 加利福尼亚大学董事会 | 腺相关病毒变体及其使用方法 |
US11104917B2 (en) * | 2015-05-08 | 2021-08-31 | Children's Medical Research Institute | Promoters for expression of heterologous genes |
CA2983593A1 (en) | 2015-05-14 | 2016-11-17 | St. Jude Children's Research Hospital, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
US10016514B2 (en) * | 2015-05-15 | 2018-07-10 | New Hope Research Foundation | Polynucleotides, vectors and methods for insertion and expression of transgenes |
WO2017066579A1 (en) | 2015-10-14 | 2017-04-20 | Audentes Therapeutics, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
GB201519086D0 (en) * | 2015-10-28 | 2015-12-09 | Syncona Partners Llp | Gene Therapy |
WO2017075335A1 (en) | 2015-10-28 | 2017-05-04 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
US10898586B2 (en) * | 2015-12-03 | 2021-01-26 | Friedrich Miescher Institute For Biomedical Research | SynP161, a promoter for the specific expression of genes in rod photoreceptors |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
BR112018013407A2 (pt) * | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc | anticorpos e conjugados dos mesmos |
CA3019426A1 (en) * | 2016-04-15 | 2017-10-19 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
KR20240005973A (ko) * | 2016-04-15 | 2024-01-12 | 리젠엑스바이오 인크. | 완전히-인간형의 번역후 변형된 항-VEGF Fab를 이용한 눈 질환의 치료 |
WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017192764A1 (en) * | 2016-05-03 | 2017-11-09 | Wayne State University | Method of enhancing viral-mediated gene delivery in the eye using proteosome inhibitors |
KR102427379B1 (ko) | 2016-05-18 | 2022-08-02 | 보이저 테라퓨틱스, 인크. | 헌팅톤 질환을 치료하기 위한 조성물 및 방법 |
SG11201809699XA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
PL3472317T3 (pl) | 2016-06-16 | 2022-08-08 | Adverum Biotechnologies, Inc. | Kompozycje i sposoby zmniejszania neowaskularyzacji oka |
EP3471780B1 (en) | 2016-06-16 | 2020-10-28 | Adverum Biotechnologies, Inc. | Treatment of amd using aav2 variant with aflibercept |
WO2018022905A2 (en) | 2016-07-29 | 2018-02-01 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
CA3035522A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
EP3528785A4 (en) | 2016-10-19 | 2020-12-02 | Adverum Biotechnologies, Inc. | MODIFIED AAV CASPIDS AND USES THEREOF |
CN107058315B (zh) * | 2016-12-08 | 2019-11-08 | 上海优卡迪生物医药科技有限公司 | 敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用 |
JP2020511539A (ja) * | 2017-03-16 | 2020-04-16 | リネージ セル セラピューティクス インコーポレイテッド | 網膜疾患治療法の治療効果を測定する方法 |
JP7343903B2 (ja) | 2017-03-17 | 2023-09-13 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | 遺伝子発現増強のための組成物および方法 |
CN111108198A (zh) | 2017-05-05 | 2020-05-05 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
JP2020518258A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | 筋萎縮性側索硬化症(als)治療組成物および方法 |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
WO2019018342A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | NETWORK EQUIPMENT TRACK GUIDE SYSTEM |
US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
CA3059995A1 (en) | 2017-08-28 | 2019-03-07 | The Regents Of The University Of California | Adeno-associated virus capsid variants and methods of use thereof |
EP3687464A4 (en) * | 2017-09-27 | 2021-09-29 | REGENXBIO Inc. | TREATMENT OF EYE DISEASES WITH A TOTALLY HUMAN POST-TRANSLATION MODIFIED ANTI-VEGF FAB |
EP3697905A1 (en) | 2017-10-16 | 2020-08-26 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
KR102205830B1 (ko) * | 2017-10-26 | 2021-01-21 | 주식회사 큐로진생명과학 | 솔루블 VEGFR-1 변이체 cDNA를 함유하는 rAAV를 포함하는 황반변성 치료용 조성물 |
EP3727468A4 (en) * | 2017-12-19 | 2021-09-22 | Akouos, Inc. | AAV-MEDIATED DELIVERY OF THERAPEUTIC ANTIBODIES TO THE INNER EAR |
US10610606B2 (en) * | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
WO2019173434A1 (en) | 2018-03-06 | 2019-09-12 | Voyager Therapeutics, Inc. | Insect cell manufactured partial self-complementary aav genomes |
JP7253274B2 (ja) * | 2018-05-08 | 2023-04-06 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | Aav適合性ラミニン-リンカー重合タンパク質 |
US20210207167A1 (en) | 2018-05-16 | 2021-07-08 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
US20210214749A1 (en) | 2018-05-16 | 2021-07-15 | Voyager Therapeutics, Inc. | Directed evolution |
CN112567035A (zh) | 2018-07-02 | 2021-03-26 | 沃雅戈治疗公司 | 肌萎缩侧索硬化症及脊髓相关病症的治疗 |
CA3107462A1 (en) | 2018-07-24 | 2020-01-30 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
EP3861113A1 (en) | 2018-10-04 | 2021-08-11 | Voyager Therapeutics, Inc. | Methods for measuring the titer and potency of viral vector particles |
EP3886809A4 (en) | 2018-11-28 | 2022-03-30 | Genascence Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF OSTEOARTHRITIS |
WO2020136384A1 (en) * | 2018-12-28 | 2020-07-02 | Constable Ian Jeffery | Methods of retinal administration |
CA3125770A1 (en) | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
US20200297869A1 (en) | 2019-03-04 | 2020-09-24 | Adverum Biotechnologies, Inc. | Sequential intravitreal administration of aav gene therapy to contralateral eyes |
TW202106699A (zh) | 2019-04-26 | 2021-02-16 | 美商愛德維仁生物科技公司 | 用於玻璃體內遞送之變異體aav蛋白殼 |
EP3962536A1 (en) | 2019-04-29 | 2022-03-09 | Voyager Therapeutics, Inc. | Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors |
US20220290182A1 (en) | 2019-08-09 | 2022-09-15 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
US20220364114A1 (en) | 2019-08-26 | 2022-11-17 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
CN114728132A (zh) * | 2019-09-20 | 2022-07-08 | 梅拉格特克斯治疗学股份有限公司 | 注射系统及其使用方法 |
CN112552410A (zh) * | 2019-09-26 | 2021-03-26 | 三生国健药业(上海)股份有限公司 | 一种抗体融合蛋白及其制法和在抗肿瘤中的应用 |
EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
KR102505262B1 (ko) * | 2019-12-04 | 2023-03-03 | (주) 씨드모젠 | 솔루블 VEGFR-1 변이체 cDNA를 함유하는 rAAV를 포함하는 당뇨망막병증 치료용 조성물 |
WO2022032153A1 (en) | 2020-08-06 | 2022-02-10 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
US20220267795A1 (en) * | 2021-02-24 | 2022-08-25 | Kinase Pharma Inc. | Compositions and methods for regulating production of an angiogensis inhibitor |
WO2022187473A2 (en) | 2021-03-03 | 2022-09-09 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
WO2022187548A1 (en) | 2021-03-03 | 2022-09-09 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
WO2022247917A1 (zh) | 2021-05-28 | 2022-12-01 | 上海瑞宏迪医药有限公司 | 衣壳变异的重组腺相关病毒及其应用 |
WO2023206134A1 (en) * | 2022-04-27 | 2023-11-02 | Beijing Sightnovo Medical Technology Co., Ltd | Compositions and methods for eye diseases |
WO2024054983A1 (en) | 2022-09-08 | 2024-03-14 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4874237A (en) | 1987-05-07 | 1989-10-17 | Lions Eye Inst. Of Western Australia | Electroretinogram apparatus |
JP2755817B2 (ja) | 1988-11-14 | 1998-05-25 | アメリカ合衆国 | パルボウイルスキャプシド |
FR2643252B1 (fr) | 1989-02-21 | 1991-06-07 | Technomed Int Sa | Appareil de destruction selective de cellules incluant les tissus mous et les os a l'interieur du corps d'un etre vivant par implosion de bulles de gaz |
US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
US6287815B1 (en) | 1989-09-14 | 2001-09-11 | Rijksuniversiteit Te Leiden | Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines |
JP3150340B2 (ja) | 1990-11-13 | 2001-03-26 | イムネクス コーポレイション | 二機能選択可能融合遺伝子 |
US5383917A (en) | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
CA2158745C (en) | 1993-03-25 | 2007-06-19 | Richard L. Kendall | Inhibitor of vascular endothelial cell growth factor |
EP0804590A1 (en) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
AU1925195A (en) | 1994-02-22 | 1995-09-04 | Dana-Farber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
FR2718150B1 (fr) | 1994-03-29 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US5527533A (en) * | 1994-10-27 | 1996-06-18 | Board Of Trustees Of The University Of Illinois | Method of retarding and ameliorating central nervous system and eye damage |
US20020168342A1 (en) | 1994-11-03 | 2002-11-14 | Cell Genesys, Inc. | Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods |
US6040183A (en) | 1995-06-07 | 2000-03-21 | University Of North Carloina At Chapel Hill | Helper virus-free AAV production |
US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US5641749A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
JP3345428B2 (ja) * | 1996-08-20 | 2002-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 合成甲状腺ホルマン組成物を使用した眼の処置 |
DE69736860T2 (de) | 1996-09-24 | 2007-05-16 | Merck & Co., Inc. | Verbindungen zur hemmung der angiogenese durch gentherapie |
FR2756297B1 (fr) | 1996-11-22 | 1999-01-08 | Centre Nat Rech Scient | Procede de production de virus recombinants |
US6153436A (en) | 1997-01-10 | 2000-11-28 | The Board Of Trustees Of The University Of Arkansas | Method of gene delivery using wildtype adeno associated viral (AAV) vectors with insertions |
JP4135120B2 (ja) | 1997-04-14 | 2008-08-20 | セル ジェネシス,インコーポレーテッド | 組換えaav生産の効率を上昇させる方法 |
AU7383298A (en) | 1997-05-13 | 1998-12-08 | Regents Of The University Of California, The | Novel antiangiogenic peptide agents and their therapeutic and diagnostic use |
US6458157B1 (en) * | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
AU9319198A (en) | 1997-09-19 | 1999-04-05 | Trustees Of The University Of Pennsylvania, The | Methods and vector constructs useful for production of recombinant aav |
JPH11100327A (ja) | 1997-09-26 | 1999-04-13 | Toray Ind Inc | 網膜変性症治療剤 |
AU9673998A (en) | 1997-10-01 | 1999-04-23 | G.D. Searle & Co. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
CA2318575A1 (en) | 1998-01-16 | 1999-07-22 | Chiron Corporation | Feline immunodeficiency virus gene therapy vectors |
AU754380B2 (en) | 1998-03-12 | 2002-11-14 | Genentech Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
AU764686B2 (en) * | 1998-08-28 | 2003-08-28 | Duke University | Adenoviruses deleted in the IVa2, 100K, polymerase and/or preterminal protein sequences |
EP1114171A1 (en) | 1998-09-17 | 2001-07-11 | University of Florida | Methods for treatment of degenerative retinal diseases |
US20040234505A1 (en) | 1998-09-23 | 2004-11-25 | Stuart Naylor | Polynucleotide constructs and uses thereof |
US6943153B1 (en) * | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
AU3755900A (en) * | 1999-03-15 | 2000-10-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
US7306799B2 (en) * | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
US7070959B1 (en) * | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
US6656136B1 (en) | 1999-10-25 | 2003-12-02 | Therus Corporation | Use of focused ultrasound for vascular sealing |
EP1274339B1 (en) | 2000-04-17 | 2011-06-08 | The University of Sydney | Method for objective electrophysiological assessment of visual function |
US6329181B1 (en) | 2000-08-07 | 2001-12-11 | Neurologix, Inc. | Helper functions for recombinant vector production |
WO2002062386A2 (en) * | 2001-02-06 | 2002-08-15 | Qlt Inc. | Photodynamic therapy of occult choroidal neovascularization linked to age-related macular degeneration |
US20040102765A1 (en) | 2001-03-27 | 2004-05-27 | Karsten Koenig | Method for the minimal-to non-invase optical treatment of tissues of the eye and for diagnosis thereof and device for carrying out said method |
CA2442670A1 (en) | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
JP2002363107A (ja) | 2001-06-04 | 2002-12-18 | Noriyuki Azuma | 色覚不全動物の色覚復元方法 |
WO2003012054A2 (en) | 2001-08-02 | 2003-02-13 | Institut Clayton De La Recherche | Methods and compositions relating to improved lentiviral vector production systems |
US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
US20060193830A1 (en) * | 2002-03-20 | 2006-08-31 | Hauswirth William W | Raav vector compositions and methods for the treatment of choroidal neovascularization |
WO2003092594A2 (en) | 2002-04-30 | 2003-11-13 | Duke University | Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use |
US8304233B2 (en) | 2002-06-04 | 2012-11-06 | Poetic Genetics, Llc | Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same |
WO2004020600A2 (en) | 2002-08-28 | 2004-03-11 | University Of Florida | Modified aav |
GB0220467D0 (en) | 2002-09-03 | 2002-10-09 | Oxford Biomedica Ltd | Composition |
US20100144038A1 (en) * | 2003-03-04 | 2010-06-10 | Masato Miyake | Composition And Method For Increasing Efficiency Of Introduction Of Target Substance Into Cell |
US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US20060166363A1 (en) | 2004-01-27 | 2006-07-27 | Sergei Zolotukhin | Modified baculovirus expression system for production of pseudotyped rAAV vector |
ES2390676T3 (es) * | 2004-10-21 | 2012-11-15 | Genentech, Inc. | Método para el tratamiento de enfermedades neovasculares intraoculares |
US20060172382A1 (en) | 2004-11-08 | 2006-08-03 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US7922670B2 (en) | 2005-02-24 | 2011-04-12 | Warren Jones | System and method for quantifying and mapping visual salience |
DK2359867T3 (en) | 2005-04-07 | 2015-01-05 | Univ Pennsylvania | A method for increasing an AAV vector function |
US20060234347A1 (en) * | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
WO2007046703A2 (en) | 2005-10-20 | 2007-04-26 | Amsterdam Molecular Therapeutics B.V. | Improved aav vectors produced in insect cells |
WO2007084773A2 (en) | 2006-01-20 | 2007-07-26 | University Of North Carolina At Chapel Hill | Enhanced production of infectious parvovirus vectors in insect cells |
US20070190028A1 (en) | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
US8118752B2 (en) | 2006-02-16 | 2012-02-21 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for mapping retinal function |
US7384145B2 (en) | 2006-02-16 | 2008-06-10 | The Board Of Trustees Of The University Of Illinois | Mapping retinal function using corneal electrode array |
US8216575B2 (en) * | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
CN101437543A (zh) * | 2006-05-04 | 2009-05-20 | 佛维雅制药股份有限公司 | 用于治疗新生血管病的包含vegf抑制剂和丝氨酸蛋白酶的组合 |
JP2009540011A (ja) * | 2006-06-12 | 2009-11-19 | エクセジェニックス、インク.ディー/ビー/エー オプコ ヘルス、インク. | 血管新生のsiRNA阻害のための組成物及び方法 |
GB0612096D0 (en) | 2006-06-19 | 2006-07-26 | Greater Glasgow Nhs Board | Functional imaging of the retina |
ES2785223T3 (es) | 2006-06-21 | 2020-10-06 | Uniqure Ip Bv | Células de insecto para la producción de vectores de AAV |
WO2008001543A1 (fr) | 2006-06-27 | 2008-01-03 | Advantest Corporation | Appareil de test de semi-conducteur et procédé de test de mémoire semi-conductrice |
ATE553206T1 (de) | 2006-08-24 | 2012-04-15 | Virovek Inc | Expression von genen mit überlappenden offenen leserastern in insektenzellen, verfahren und zusammensetzungen dafür |
AU2008215181A1 (en) | 2007-02-16 | 2008-08-21 | Objectivision Limited | Stimulus method for multifocal visual evoked potential |
EP1995309A1 (en) * | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
WO2008150459A1 (en) | 2007-05-30 | 2008-12-11 | The Trustees Of The University Of Pennsylvania | A method for transducing cells with primary cilia |
US8540369B2 (en) | 2007-08-16 | 2013-09-24 | The Research Foundation Of State University Of New York | Led variable light source |
US8518037B2 (en) | 2007-10-30 | 2013-08-27 | Boston Scientific Scimed, Inc. | Radiofrequency ablation device |
JP2011505147A (ja) * | 2007-11-30 | 2011-02-24 | スカラブ ゲノミクス, エルエルシー | lac発現システム |
JP2011512156A (ja) | 2008-02-19 | 2011-04-21 | アムステルダム モレキュラー セラピューティクス ビー.ブイ. | 昆虫細胞におけるパルボウイルスrep及びcapタンパク質の発現の最適化 |
CN101951925A (zh) | 2008-02-20 | 2011-01-19 | 建新公司 | 血管发生抑制 |
WO2009105690A2 (en) * | 2008-02-21 | 2009-08-27 | Targeted Genetics Corporation | Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea |
ITFI20080081A1 (it) | 2008-04-18 | 2009-10-19 | Strumenti Oftalmici C S O S R | Procedimento e sistema per la registrazione di risposte elettrofunzionali erg, perg e vep multifocali in tempo reale |
WO2009137006A2 (en) | 2008-04-30 | 2009-11-12 | The University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
EP2403867B1 (en) | 2009-03-04 | 2019-05-22 | Deutsches Krebsforschungszentrum | Assembly activating protein (aap) and its use for the manufacture of parvovirus particles essential consisting of vp3 |
WO2010114948A2 (en) | 2009-04-02 | 2010-10-07 | University Of Florida Research Foundation, Inc. | An inducible system for highly efficient production of recombinant adeno-associated virus (raav) vectors |
TWI466158B (zh) | 2009-07-03 | 2014-12-21 | Univ Lunghwa Sci & Technology | 電漿測量裝置、電漿系統及測量電漿特性之方法 |
EP2287323A1 (en) * | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
EP2292781A1 (en) | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
WO2011034947A2 (en) | 2009-09-15 | 2011-03-24 | University Of Washington | Reagents and methods for modulating cone photoreceptor activity |
WO2011088081A1 (en) | 2010-01-12 | 2011-07-21 | The University Of North Carolina At Chapel Hill | Restrictive inverted terminal repeats for viral vectors |
EP2545165B1 (en) | 2010-03-11 | 2020-07-29 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
SG10201908848RA (en) * | 2010-03-29 | 2019-10-30 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
CN201704771U (zh) | 2010-04-30 | 2011-01-12 | 陈福环 | 无水箱节水型抽水马桶 |
US9102718B2 (en) * | 2010-04-30 | 2015-08-11 | Lpath, Inc. | Anti-S1P antibody treatment of patients with ocular disease |
WO2011140450A1 (en) | 2010-05-07 | 2011-11-10 | Medicinelodge, Inc Dba Imds Co-Innovation | Surgical rasp with radiofrequency ablation |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
US20110052678A1 (en) * | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
JP6092782B2 (ja) | 2010-11-16 | 2017-03-08 | エクセリミューン, インコーポレイテッド | 組換えタンパク質の製造方法 |
CA2823890C (en) | 2011-01-07 | 2020-10-06 | Applied Genetic Technologies Corporation | Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases |
RU2611202C2 (ru) | 2011-04-22 | 2017-02-21 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Вирионы аденоассоциированного вируса с вариантным капсидом и способы их использования |
WO2013063601A1 (en) | 2011-10-28 | 2013-05-02 | University Of Florida Research Foundation, Inc. | Chimeric promoter for cone photoreceptor targeted gene therapy |
TWI702955B (zh) * | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
US20150111275A1 (en) | 2012-06-11 | 2015-04-23 | Daniel V. Palanker | Optical regulation of gene expression in the retina |
WO2014207190A1 (en) | 2013-06-28 | 2014-12-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for expressing a polynucleotide of interest in the retina of a subject |
US20150025939A1 (en) | 2013-07-18 | 2015-01-22 | Somnath Chatterjee | Company Centric Social Media Platfonn for Content Sharing aud Tracking |
ES2739288T3 (es) | 2013-09-13 | 2020-01-30 | California Inst Of Techn | Recuperación selectiva |
EP3633041A3 (en) | 2013-09-26 | 2020-07-29 | University of Florida Research Foundation, Inc. | Synthetic combinatorial aav capsid library for targeted gene therapy |
US10308957B2 (en) | 2014-03-04 | 2019-06-04 | University Of Florida Research Foundation, Inc. | rAAV vectors and methods for transduction of photoreceptors and RPE cells |
US10000741B2 (en) | 2014-03-17 | 2018-06-19 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
BR112017018846A2 (pt) | 2015-03-02 | 2018-07-31 | Adverum Biotechnologies, Inc. | composições e métodos para entrega intravítrea de polinucleotídeos a cones retinianos. |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
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