MD20150035A2 - Inhibitori de tirozinkinaza Bruton - Google Patents

Inhibitori de tirozinkinaza Bruton Download PDF

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Publication number
MD20150035A2
MD20150035A2 MDA20150035A MD20150035A MD20150035A2 MD 20150035 A2 MD20150035 A2 MD 20150035A2 MD A20150035 A MDA20150035 A MD A20150035A MD 20150035 A MD20150035 A MD 20150035A MD 20150035 A2 MD20150035 A2 MD 20150035A2
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MD
Moldova
Prior art keywords
bruton
tyrosine kinase
compounds
disclosed
conditions
Prior art date
Application number
MDA20150035A
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English (en)
Russian (ru)
Inventor
Джон Роберт Спрингер
Балекудру Девадас
Дэни Джеймс ГАРЛАНД
Маргарет Ланахан Грэпперхаус
Сэунгил ХАНЬ
Сьюзен Ландис ХОКЕРМАН
Роберт Оуэн ХЬЮГС
Эддин САЙЯ
Марк Эдвард Шнуте
Шон Радж Селнесс
Дэниел Патрик Уолкер
Чжао-Кхуй ВАНЬ
Син
Кристоф Вольфганг ЦАПФ
Мишель Энн Шмидт
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596360&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20150035(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20150035A2 publication Critical patent/MD20150035A2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Invenţia se referă la compuşii cu formula (I):(I)care formează legături covalente cu tirozinkinaza Bruton (BTK). Sunt dezvăluite procedee de preparare a compuşilor menţionaţi. De asemenea, sunt dezvăluite compoziţii farmaceutice care includ compuşii menţionaţi. Sunt dezvăluite metode de utilizare a inhibitorilor BTK, singuri sau în combinaţie cu alţi agenţi terapeutici, pentru tratamentul bolilor sau afecţiunilor autoimune, bolilor sau afecţiunilor heteroimune, cancerului, inclusiv limfomului, şi bolilor sau afecţiunilor inflamatorii.
MDA20150035A 2012-11-02 2013-11-01 Inhibitori de tirozinkinaza Bruton MD20150035A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721920P 2012-11-02 2012-11-02
US201361772028P 2013-03-04 2013-03-04
PCT/IB2013/059846 WO2014068527A1 (en) 2012-11-02 2013-11-01 Bruton's tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
MD20150035A2 true MD20150035A2 (ro) 2015-10-31

Family

ID=49596360

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150035A MD20150035A2 (ro) 2012-11-02 2013-11-01 Inhibitori de tirozinkinaza Bruton

Country Status (27)

Country Link
US (4) US20150291554A1 (ro)
EP (1) EP2914586B1 (ro)
JP (1) JP6178861B2 (ro)
KR (1) KR101668574B1 (ro)
CN (1) CN105008344B (ro)
AP (1) AP2015008381A0 (ro)
AU (1) AU2013340345B2 (ro)
BR (1) BR112015009624A2 (ro)
CA (1) CA2888960C (ro)
CL (1) CL2015001168A1 (ro)
CO (1) CO7350624A2 (ro)
CR (1) CR20150228A (ro)
DO (1) DOP2015000100A (ro)
EA (1) EA201500393A1 (ro)
ES (1) ES2625944T3 (ro)
GE (1) GEP201606597B (ro)
HK (1) HK1211293A1 (ro)
IL (1) IL238571A0 (ro)
MD (1) MD20150035A2 (ro)
MX (1) MX2015005422A (ro)
NI (1) NI201500059A (ro)
PE (1) PE20151070A1 (ro)
PH (1) PH12015500940A1 (ro)
SG (1) SG11201502893WA (ro)
TN (1) TN2015000168A1 (ro)
TW (1) TWI518080B (ro)
WO (1) WO2014068527A1 (ro)

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US20150291554A1 (en) 2015-10-15
CR20150228A (es) 2015-09-14
AU2013340345B2 (en) 2016-10-27
ES2625944T3 (es) 2017-07-21
CL2015001168A1 (es) 2015-07-10
CA2888960C (en) 2017-08-15
MX2015005422A (es) 2015-08-05
SG11201502893WA (en) 2015-05-28
DOP2015000100A (es) 2015-12-31
US10266513B2 (en) 2019-04-23
AU2013340345A1 (en) 2015-04-30
US20190202798A1 (en) 2019-07-04
TN2015000168A1 (fr) 2016-10-03
WO2014068527A1 (en) 2014-05-08
CN105008344B (zh) 2017-07-25
US20170283393A1 (en) 2017-10-05
PE20151070A1 (es) 2015-08-01
KR101668574B1 (ko) 2016-10-24
EP2914586A1 (en) 2015-09-09
CA2888960A1 (en) 2014-05-08
JP2015535277A (ja) 2015-12-10
CN105008344A (zh) 2015-10-28
EP2914586B1 (en) 2017-04-05
JP6178861B2 (ja) 2017-08-09
TWI518080B (zh) 2016-01-21
CO7350624A2 (es) 2015-08-10
TW201431851A (zh) 2014-08-16
PH12015500940A1 (en) 2015-06-29
US10815213B2 (en) 2020-10-27
HK1211293A1 (en) 2016-05-20
GEP201606597B (en) 2017-01-10
AP2015008381A0 (en) 2015-04-30
EA201500393A1 (ru) 2016-05-31
IL238571A0 (en) 2015-06-30
US20210002251A1 (en) 2021-01-07
BR112015009624A2 (pt) 2017-11-14
KR20150075114A (ko) 2015-07-02
NI201500059A (es) 2015-06-05

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