MX362452B - Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1. - Google Patents

Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1.

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Publication number
MX362452B
MX362452B MX2014013933A MX2014013933A MX362452B MX 362452 B MX362452 B MX 362452B MX 2014013933 A MX2014013933 A MX 2014013933A MX 2014013933 A MX2014013933 A MX 2014013933A MX 362452 B MX362452 B MX 362452B
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MX
Mexico
Prior art keywords
amd
treatment
sflt
human subject
aav
Prior art date
Application number
MX2014013933A
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English (en)
Other versions
MX2014013933A (es
Inventor
J Constable Ian
P Rakoczy Elizabeth
Lai Chooi-May
W Chalberg Thomas Jr
Original Assignee
Avalanche Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49584435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX362452(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avalanche Australia Pty Ltd filed Critical Avalanche Australia Pty Ltd
Publication of MX2014013933A publication Critical patent/MX2014013933A/es
Publication of MX362452B publication Critical patent/MX362452B/es

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Abstract

La presente invención se refiere a una composición farmacéutica en forma de dosis unitaria para usarse en el tratamiento de neovascularización de la retina en un sujeto humano que tiene degeneración macular relacionada con la edad (AMD) y que ha recibido una o más dosis de un inhibidor de Factor de Crecimiento Endotelial Vascular (VEGF), donde la composición farmacéutica comprende un virus asociado con adeno recombinante (rAAV), en donde el rAAV contiene un ácido nucleico comprende una secuencia que codifica una proteína anti-VEGF, en donde la composición farmacéutica comprende entre 1x 106 y 1x 1015 genomas del vector rAAV, en donde la composición farmacéutica está adaptada para ser administrable al ojo del sujeto humano y proporciona al sujeto humano elevada expresión de la proteína anti-VEGF cuando se mide alrededor de 365 días posteriores a la administración, y en donde dicho sujeto humano no recibe un tratamiento de rescate con un inhibidor VEGF durante el periodo entre alrededor de 180 días y alrededor De 365 días tras recibir la composición farmacéutica de dosis unitaria.
MX2014013933A 2012-05-15 2013-05-07 Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1. MX362452B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261647461P 2012-05-15 2012-05-15
US201261670535P 2012-07-11 2012-07-11
US201261678555P 2012-08-01 2012-08-01
US201261691660P 2012-08-21 2012-08-21
US201361775440P 2013-03-08 2013-03-08
PCT/US2013/040011 WO2013173129A2 (en) 2012-05-15 2013-05-07 Treatment of amd using aav sflt-1

Publications (2)

Publication Number Publication Date
MX2014013933A MX2014013933A (es) 2015-06-03
MX362452B true MX362452B (es) 2019-01-18

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ID=49584435

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014013933A MX362452B (es) 2012-05-15 2013-05-07 Tratamiento de degeneracion macular relacionada con la edad (amd) usando virus asociados con adeno (aav) sflt-1.
MX2019000586A MX2019000586A (es) 2012-05-15 2014-11-14 Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019000586A MX2019000586A (es) 2012-05-15 2014-11-14 Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd).

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US (7) US20130323302A1 (es)
EP (3) EP4371615A3 (es)
JP (5) JP6466322B2 (es)
KR (3) KR20210021111A (es)
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