MX2016013160A - Marcas geneticas de transgenes y metodos de uso. - Google Patents

Marcas geneticas de transgenes y metodos de uso.

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Publication number
MX2016013160A
MX2016013160A MX2016013160A MX2016013160A MX2016013160A MX 2016013160 A MX2016013160 A MX 2016013160A MX 2016013160 A MX2016013160 A MX 2016013160A MX 2016013160 A MX2016013160 A MX 2016013160A MX 2016013160 A MX2016013160 A MX 2016013160A
Authority
MX
Mexico
Prior art keywords
polynucleotide
transgene
domain
genetic tag
genetic
Prior art date
Application number
MX2016013160A
Other languages
English (en)
Inventor
C Jensen Michael
Johnson Adam
Original Assignee
Seattle Children's Hospital (Dba Seattle Children's Res Institute)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54288361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016013160(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Children's Hospital (Dba Seattle Children's Res Institute) filed Critical Seattle Children's Hospital (Dba Seattle Children's Res Institute)
Publication of MX2016013160A publication Critical patent/MX2016013160A/es

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Abstract

La presente invención proporciona marcas genéticas operablemente enlazadas a transgenes. La expresión de la marca genética permite la identificación, detección, selección y ablación de células que expresan el transgen y la marca genética. En algunas alternativas, la célula hospedadora genéticamente modificada comprende un transgen que comprende un polinucleótido que codifica para un receptor de antígeno quimérico que comprende un dominio de unión a ligando, un polinucleótido que comprende una región separadora, un polinucleótido que comprende un dominio transmembrana y un polinucleótido que comprende un dominio de señalización intracelular y un polinucleótido que codifica para una marca génica. En algunas alternativas, la célula hospedadora genéticamente modificada comprende un transgen que comprende un polinucleótido que codifica para un receptor de antígeno quimérico que comprende un dominio de unión a ligando, un polinucleótido que comprende una región separadora, un polinucleótido que comprende un dominio transmembrana y un polinucleótido que comprende un dominio de señalización intracelular y un poliriucleótido que codifica para una marca génica, y en donde el polinucleótido comprende además un ligador flexible que comprende los aminoácidos GGGSGGGS (SEQ ID NO: 45). También se describen formulaciones farmacéuticas producidas por el método, y métodos de uso de las mismas.
MX2016013160A 2014-04-10 2015-04-08 Marcas geneticas de transgenes y metodos de uso. MX2016013160A (es)

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US201461977751P 2014-04-10 2014-04-10
US201461986479P 2014-04-30 2014-04-30
US201462058973P 2014-10-02 2014-10-02
US201462088363P 2014-12-05 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US201462090845P 2014-12-11 2014-12-11
PCT/US2015/024895 WO2015157399A1 (en) 2014-04-10 2015-04-08 Transgene genetic tags and methods of use

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MX2016013159A MX2016013159A (es) 2014-04-10 2015-04-08 Expresion transgenica regulada por farmaco.
MX2016013158A MX2016013158A (es) 2014-04-10 2015-04-08 Productos de celulas t modificadas de genes de composicion definida.
MX2016013160A MX2016013160A (es) 2014-04-10 2015-04-08 Marcas geneticas de transgenes y metodos de uso.
MX2016013144A MX2016013144A (es) 2014-04-10 2015-04-08 Metodo y composiciones para inmunoterapia celular.
MX2016013149A MX2016013149A (es) 2014-04-10 2015-04-08 Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato.
MX2022010807A MX2022010807A (es) 2014-04-10 2016-10-06 Productos de celulas t modificadas de genes de composicion definida.

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MX2022010807A MX2022010807A (es) 2014-04-10 2016-10-06 Productos de celulas t modificadas de genes de composicion definida.

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