MX389797B - Expresión transgénica regulada por fármaco. - Google Patents

Expresión transgénica regulada por fármaco.

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Publication number
MX389797B
MX389797B MX2016013159A MX2016013159A MX389797B MX 389797 B MX389797 B MX 389797B MX 2016013159 A MX2016013159 A MX 2016013159A MX 2016013159 A MX2016013159 A MX 2016013159A MX 389797 B MX389797 B MX 389797B
Authority
MX
Mexico
Prior art keywords
polynucleotide
cells
genetically modified
expression
methods
Prior art date
Application number
MX2016013159A
Other languages
English (en)
Other versions
MX2016013159A (es
Inventor
Michael C Jensen
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54288361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX389797(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of MX2016013159A publication Critical patent/MX2016013159A/es
Publication of MX389797B publication Critical patent/MX389797B/es

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Abstract

La presente invención se refiere a ácidos nucleicos, vectores, células hospedadoras, métodos y composiciones para conferir y/o aumentar respuestas inmunitarias mediante inmunoterapia celular, tal como al transferir de manera adoptiva células T CD8+ de memoria central o combinaciones de células T de memoria central con células T CD4+ que se modifican genéticamente para expresar un receptor quimérico bajo el control de un promotor inducible. En algunas alternativas, la célula hospedadora genéticamente modificada comprende un ácido nucleico que comprende un polinucleótido que codifica para un receptor de antígeno quimérico que comprende un dominio de unión a ligando, un polinucleótido que comprende una región separadora, un polinucleótido que comprende un dominio transmembrana, y un polinucleótido que comprende un dominio de señalización intracelular bajo el control de un promotor inducible por fármaco. El control de la expresión del receptor quimérico proporciona la capacidad de activar y desactivar la expresión dependiendo del estado del paciente. También se describen formulaciones farmacéuticas producidas por el método y métodos de uso de las mismas.
MX2016013159A 2014-04-10 2015-04-08 Expresión transgénica regulada por fármaco. MX389797B (es)

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US201461977751P 2014-04-10 2014-04-10
US201461986479P 2014-04-30 2014-04-30
US201462058973P 2014-10-02 2014-10-02
US201462088363P 2014-12-05 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US201462090845P 2014-12-11 2014-12-11
PCT/US2015/024947 WO2015157432A1 (en) 2014-04-10 2015-04-08 Drug related transgene expression

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MX2016013144A MX395574B (es) 2014-04-10 2015-04-08 Metodo y composiciones para inmunoterapia celular.
MX2016013159A MX389797B (es) 2014-04-10 2015-04-08 Expresión transgénica regulada por fármaco.
MX2016013149A MX2016013149A (es) 2014-04-10 2015-04-08 Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato.
MX2016013158A MX2016013158A (es) 2014-04-10 2015-04-08 Productos de celulas t modificadas de genes de composicion definida.
MX2016013160A MX387465B (es) 2014-04-10 2015-04-08 Marcas genéticas de transgenes y métodos de uso.
MX2022010807A MX2022010807A (es) 2014-04-10 2016-10-06 Productos de celulas t modificadas de genes de composicion definida.

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MX2016013158A MX2016013158A (es) 2014-04-10 2015-04-08 Productos de celulas t modificadas de genes de composicion definida.
MX2016013160A MX387465B (es) 2014-04-10 2015-04-08 Marcas genéticas de transgenes y métodos de uso.
MX2022010807A MX2022010807A (es) 2014-04-10 2016-10-06 Productos de celulas t modificadas de genes de composicion definida.

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SG11201608393TA (en) 2016-11-29
CA2945303A1 (en) 2015-10-15
KR20160138298A (ko) 2016-12-02
AU2015243927B2 (en) 2021-09-02
BR112016023523A2 (pt) 2017-10-17
ZA201607060B (en) 2024-05-30

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