MX2017007138A - Metodos y composiciones para terapia celular adoptiva. - Google Patents

Metodos y composiciones para terapia celular adoptiva.

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Publication number
MX2017007138A
MX2017007138A MX2017007138A MX2017007138A MX2017007138A MX 2017007138 A MX2017007138 A MX 2017007138A MX 2017007138 A MX2017007138 A MX 2017007138A MX 2017007138 A MX2017007138 A MX 2017007138A MX 2017007138 A MX2017007138 A MX 2017007138A
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MX
Mexico
Prior art keywords
receptor
methods
cells
prior
compositions
Prior art date
Application number
MX2017007138A
Other languages
English (en)
Inventor
j gilbert Mark
Original Assignee
Juno Therapeutics Inc
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Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2017007138A publication Critical patent/MX2017007138A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Abstract

Se proporcionan métodos para múltiples administraciones de células para terapia celular adoptiva, y para administrar células a sujetos que han recibido administraciones previas, y composiciones y artículos de fabricación para el use en los métodos. Las células generalmente expresan moléculas recombinantes tales como receptores recombinantes, par ejemplo receptores de antígeno quimérico (CARS) y/u otros receptores transgénicos. Los métodos pueden involucrar la administración de células que expresan un primer o previo receptor(es) y células que expresan un segundo o subsecuente receptor(es), el segundo o subsecuente receptor(es) que es distinto del primero, y que generalmente no expresa el primer receptor y/o la administración de las células que expresan el segundo receptor a un sujeto que ha recibido la primera administración. Los métodos pueden proporcionar varias ventajas, tales como eficacia mejorada en el contexto de una respuesta inmune en el sujeto contra el primero o previo receptor y/o en el contexto de perdida de antígeno, regulación hacia abajo o modificación, después de una primera o previa administración.
MX2017007138A 2014-12-03 2015-12-03 Metodos y composiciones para terapia celular adoptiva. MX2017007138A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462087224P 2014-12-03 2014-12-03
PCT/US2015/063839 WO2016090190A1 (en) 2014-12-03 2015-12-03 Methods and compositions for adoptive cell therapy

Publications (1)

Publication Number Publication Date
MX2017007138A true MX2017007138A (es) 2017-08-28

Family

ID=55022703

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017007138A MX2017007138A (es) 2014-12-03 2015-12-03 Metodos y composiciones para terapia celular adoptiva.
MX2022005955A MX2022005955A (es) 2014-12-03 2017-06-05 Metodos y composiciones para terapia celular adoptiva.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022005955A MX2022005955A (es) 2014-12-03 2017-06-05 Metodos y composiciones para terapia celular adoptiva.

Country Status (11)

Country Link
US (3) US11266739B2 (es)
EP (2) EP3227323B1 (es)
JP (2) JP7068820B2 (es)
KR (1) KR20170087514A (es)
CN (1) CN107206025A (es)
AU (2) AU2015358400B2 (es)
CA (1) CA2969456A1 (es)
ES (1) ES2819553T3 (es)
HK (1) HK1244826A1 (es)
MX (2) MX2017007138A (es)
WO (1) WO2016090190A1 (es)

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