BR112016009898A2 - células-tronco/progenitoras hematopoiéticas e efetoras não-t modificadas e usos das mesmas - Google Patents

células-tronco/progenitoras hematopoiéticas e efetoras não-t modificadas e usos das mesmas

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Publication number
BR112016009898A2
BR112016009898A2 BR112016009898A BR112016009898A BR112016009898A2 BR 112016009898 A2 BR112016009898 A2 BR 112016009898A2 BR 112016009898 A BR112016009898 A BR 112016009898A BR 112016009898 A BR112016009898 A BR 112016009898A BR 112016009898 A2 BR112016009898 A2 BR 112016009898A2
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BR
Brazil
Prior art keywords
progenitors
stem cells
cells
effector
effector stem
Prior art date
Application number
BR112016009898A
Other languages
English (en)
Inventor
Delaney Colleen
Jensen Michael
Gardner Rebecca
Original Assignee
Hutchinson Fred Cancer Res
Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res, Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute filed Critical Hutchinson Fred Cancer Res
Publication of BR112016009898A2 publication Critical patent/BR112016009898A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

células-tronco/progenitoras hematopoiéticas (hspc) e/ou células efetoras não-t são geneticamente modificadas para expressar (i) um componente extracelu-lar, incluindo um domínio de ligação ao ligante que liga um marcador celular prefe-rencialmente expresso em uma célula indesejada; e (ii) um componente intracelular que compreende um domínio efetor. dentre outros usos, as células modificadas po-dem ser administradas aos pacientes para se direcionar às células cancerosas in-desejadas sem a necessidade de correspondência imunológica antes da adminis-tração.
BR112016009898A 2013-10-31 2014-10-31 células-tronco/progenitoras hematopoiéticas e efetoras não-t modificadas e usos das mesmas BR112016009898A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361898387P 2013-10-31 2013-10-31
PCT/US2014/063576 WO2015066551A2 (en) 2013-10-31 2014-10-31 Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof

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BR112016009898A2 true BR112016009898A2 (pt) 2017-12-05

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US (3) US20160250258A1 (pt)
EP (2) EP3063175A4 (pt)
JP (2) JP6685900B2 (pt)
KR (1) KR20160079854A (pt)
CN (1) CN105873952A (pt)
AU (2) AU2014342020C1 (pt)
BR (1) BR112016009898A2 (pt)
CA (1) CA2929087A1 (pt)
IL (2) IL245360B (pt)
MX (1) MX2016005689A (pt)
NZ (2) NZ758715A (pt)
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