BR112018000632A2 - moléculas de anticorpo que ligam a cd79 - Google Patents
moléculas de anticorpo que ligam a cd79Info
- Publication number
- BR112018000632A2 BR112018000632A2 BR112018000632A BR112018000632A BR112018000632A2 BR 112018000632 A2 BR112018000632 A2 BR 112018000632A2 BR 112018000632 A BR112018000632 A BR 112018000632A BR 112018000632 A BR112018000632 A BR 112018000632A BR 112018000632 A2 BR112018000632 A2 BR 112018000632A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody molecules
- binding antibody
- sequence
- binding domain
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
a presente divulgação se refere às moléculas de anticorpo compreendendo um domínio de ligação específico para cd79, o dito domínio de ligação compreendendo a seq id no: 1, 2, 3 ou 4, e/ou seq id no: 5, 6 e 7. a divulgação também se estende às composições farmacêuticas compreendendo as ditas moléculas de anticorpo e ao uso das moléculas/composições de anticorpo no tratamento.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2015/066368 WO2016009029A1 (en) | 2014-07-16 | 2015-07-16 | Molecules with specificity for cd45 and cd79 |
PCT/EP2015/066369 WO2016009030A2 (en) | 2014-07-16 | 2015-07-16 | Molecules with specificity for cd79 and cd22 |
GBGB1601075.3A GB201601075D0 (en) | 2016-01-20 | 2016-01-20 | Antibodies molecules |
PCT/EP2016/066989 WO2017009474A1 (en) | 2015-07-16 | 2016-07-15 | Antibody molecules which bind cd79 |
Publications (2)
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BR112018000632A2 true BR112018000632A2 (pt) | 2018-09-18 |
BR112018000632A8 BR112018000632A8 (pt) | 2023-03-21 |
Family
ID=55488253
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Application Number | Title | Priority Date | Filing Date |
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BR112018000632A BR112018000632A8 (pt) | 2015-07-16 | 2016-07-15 | Moléculas de anticorpo que ligam a cd79 |
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US (1) | US10618957B2 (pt) |
EP (1) | EP3322728A1 (pt) |
JP (1) | JP6998857B2 (pt) |
KR (1) | KR20180030662A (pt) |
CN (1) | CN107922492B (pt) |
AU (1) | AU2016293119A1 (pt) |
BR (1) | BR112018000632A8 (pt) |
CA (1) | CA2992371A1 (pt) |
CL (1) | CL2018000107A1 (pt) |
CO (1) | CO2018000410A2 (pt) |
EA (1) | EA201890320A1 (pt) |
GB (1) | GB201601075D0 (pt) |
HK (1) | HK1250737A1 (pt) |
IL (1) | IL256853A (pt) |
MX (1) | MX2018000590A (pt) |
WO (1) | WO2017009474A1 (pt) |
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UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
KR102339240B1 (ko) | 2013-10-15 | 2021-12-15 | 더 스크립스 리서치 인스티튜트 | 펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도 |
CN106029098A (zh) | 2014-02-25 | 2016-10-12 | 免疫医疗公司 | 人源化rfb4抗cd22抗体 |
GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
GB201411420D0 (en) | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
MX2017001642A (es) | 2014-08-06 | 2017-04-27 | Astellas Pharma Inc | ANTICUERPO IGß ANTIHUMANO NOVEDOSO. |
US9975949B2 (en) | 2014-12-05 | 2018-05-22 | Genentech, Inc. | Anti-CD79b antibodies and methods of use |
US11091546B2 (en) | 2015-04-15 | 2021-08-17 | The Scripps Research Institute | Optimized PNE-based chimeric receptor T cell switches and uses thereof |
US20160304611A1 (en) | 2015-04-17 | 2016-10-20 | Immunomedics, Inc. | Combination therapy for treating adult patients with relapsed/refractory cd22+ b-cell acute lymphoblastic leukemia |
GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
CN110248668B (zh) | 2016-12-15 | 2023-05-30 | 杜克大学 | 用于消耗调节性b10细胞的抗体和方法以及与免疫检查点抑制剂的联用 |
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- 2016-07-15 AU AU2016293119A patent/AU2016293119A1/en not_active Abandoned
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HK1250737A1 (zh) | 2019-01-11 |
CA2992371A1 (en) | 2017-01-19 |
BR112018000632A8 (pt) | 2023-03-21 |
MX2018000590A (es) | 2018-08-01 |
US20180201678A1 (en) | 2018-07-19 |
JP2018529313A (ja) | 2018-10-11 |
US10618957B2 (en) | 2020-04-14 |
CL2018000107A1 (es) | 2018-07-27 |
AU2016293119A1 (en) | 2018-01-25 |
GB201601075D0 (en) | 2016-03-02 |
CN107922492A (zh) | 2018-04-17 |
CN107922492B (zh) | 2022-03-18 |
JP6998857B2 (ja) | 2022-02-10 |
WO2017009474A1 (en) | 2017-01-19 |
EP3322728A1 (en) | 2018-05-23 |
EA201890320A1 (ru) | 2018-06-29 |
CO2018000410A2 (es) | 2018-04-10 |
KR20180030662A (ko) | 2018-03-23 |
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