ATE442373T1 - Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden - Google Patents

Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden

Info

Publication number
ATE442373T1
ATE442373T1 AT96924334T AT96924334T ATE442373T1 AT E442373 T1 ATE442373 T1 AT E442373T1 AT 96924334 T AT96924334 T AT 96924334T AT 96924334 T AT96924334 T AT 96924334T AT E442373 T1 ATE442373 T1 AT E442373T1
Authority
AT
Austria
Prior art keywords
delta
analogs
derivatives
domain
protein
Prior art date
Application number
AT96924334T
Other languages
English (en)
Inventor
David Ish-Horowicz
Domingo Henrique
Julian Lewis
Spyridon Artavanis-Tsakonas
Grace Gray
Original Assignee
Imp Cancer Res Tech
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp Cancer Res Tech, Univ Yale filed Critical Imp Cancer Res Tech
Application granted granted Critical
Publication of ATE442373T1 publication Critical patent/ATE442373T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96924334T 1995-06-28 1996-06-28 Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden ATE442373T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58995P 1995-06-28 1995-06-28
PCT/US1996/011178 WO1997001571A1 (en) 1995-06-28 1996-06-28 Nucleotide and protein sequences of vertebrate delta genes and methods based thereon

Publications (1)

Publication Number Publication Date
ATE442373T1 true ATE442373T1 (de) 2009-09-15

Family

ID=21692156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96924334T ATE442373T1 (de) 1995-06-28 1996-06-28 Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden

Country Status (11)

Country Link
US (5) US6262025B1 (de)
EP (1) EP0861261B9 (de)
JP (3) JPH11508771A (de)
AT (1) ATE442373T1 (de)
AU (1) AU723939B2 (de)
CA (1) CA2226087C (de)
DE (1) DE69638023D1 (de)
DK (1) DK0861261T3 (de)
ES (1) ES2334953T3 (de)
PT (1) PT861261E (de)
WO (1) WO1997001571A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
ATE442373T1 (de) 1995-06-28 2009-09-15 Imp Cancer Res Tech Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
AU6952498A (en) 1997-04-04 1998-10-30 Millenium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
EP1004669B1 (de) 1997-05-14 2007-04-18 Asahi Kasei Kabushiki Kaisha Neuer hemmer der differentierung
AU737132B2 (en) * 1997-06-18 2001-08-09 Zymogenetics Inc. Mammalian neuro-growth factor like protein
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
JP2002520007A (ja) * 1998-07-13 2002-07-09 イエール ユニバーシティー Delta切断産物およびそれに基づく方法
WO2000006726A2 (en) * 1998-07-27 2000-02-10 Amgen Inc. Delta-related polypeptides
JP2002526077A (ja) * 1998-09-18 2002-08-20 ハイセック,インコーポレーテッド Egf反復を含むポリペプチドに関する方法と組成物
EP1518930B1 (de) * 1998-10-13 2007-05-30 Genentech, Inc. Verfahren und Zusammenstzung zur Hemmung des Wachtums von neoplastischen Zellen
US8084258B2 (en) * 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20080194022A1 (en) * 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001288628A1 (en) * 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
EP1410018A1 (de) * 2001-07-25 2004-04-21 Lorantis Limited Methode zur detektion von modulatoren von notch signaltransduktion
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
AU2002339157A1 (en) * 2001-11-14 2003-05-26 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
WO2004024764A1 (en) * 2002-09-10 2004-03-25 Lorantis Limited Pharmaceutical composition and medical treatments comprising notch ligand proteins
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
EP2003196A3 (de) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs
EP1654383A1 (de) * 2003-08-08 2006-05-10 Licentia, Ltd. Materialien und verfahren zum screening, zur diagnose und zur therapie von colorectalem krebs
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7906116B2 (en) * 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
AU2006287228B2 (en) * 2005-09-01 2012-12-13 Alora Biopharma, Inc. Methods for using and identifying modulators of Delta-like 4
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
PT2500360E (pt) 2005-10-31 2015-10-15 Oncomed Pharm Inc Composições e métodos para diagnóstico e tratamento do cancro
US7723112B2 (en) * 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2664738C (en) * 2006-09-29 2017-03-07 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
WO2008092002A2 (en) * 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
ES2663536T3 (es) 2008-09-26 2018-04-13 Oncomed Pharmaceuticals, Inc. Agentes que se unen a receptores frizzled y usos de los mismos
US8883145B2 (en) 2009-10-16 2014-11-11 Oncomed Pharmaceuticals, Inc. Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
CA2782299A1 (en) * 2009-12-01 2011-06-09 Oncomed Pharmaceuticals, Inc. Methods for treating cancers comprising k-ras mutations
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
WO2011127472A1 (en) 2010-04-09 2011-10-13 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function
JP6165627B2 (ja) 2010-04-09 2017-07-19 フレッド ハッチンソン キャンサー リサーチ センター Hlaの適合なしに造血機能を提供するための組成物および方法
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
JP6170496B2 (ja) 2011-09-23 2017-07-26 オンコメッド ファーマシューティカルズ インコーポレイテッド Vegf/dll4結合剤およびその使用
US9834755B2 (en) 2011-12-08 2017-12-05 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2013147793A1 (en) * 2012-03-29 2013-10-03 Fleming Robert J Methods and compositions for modulating notch activity
HK1212216A1 (en) 2012-10-23 2016-06-10 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP6371294B2 (ja) 2012-10-31 2018-08-08 オンコメッド ファーマシューティカルズ インコーポレイテッド Dll4アンタゴニストによる処置の方法およびモニタリング
EP2943566A1 (de) 2013-01-08 2015-11-18 Fred Hutchinson Cancer Research Center Zusammensetzungen und verfahren zur expansion von embryonalen hämatopoetischen stammzellen
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Wnt経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
NZ758715A (en) 2013-10-31 2023-01-27 Seattle Children’S Hospital Dba Seattle Children’S Res Institute Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
WO2016070051A2 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
JP6734283B2 (ja) 2015-01-21 2020-08-05 フレッド ハッチンソン キャンサー リサーチ センター 遺伝子治療用ポイントオブケア及び/又はポータブルプラットフォーム
US20180355318A1 (en) 2015-04-29 2018-12-13 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
EP3353204B1 (de) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-spezifischer anti-vegf/dll4-antikörper zur verwendung bei der behandlung von platin-resistentem eierstockkrebs

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4795699A (en) 1987-01-14 1989-01-03 President And Fellows Of Harvard College T7 DNA polymerase
US5856441A (en) 1991-05-03 1999-01-05 Yale University Serrate fragments and derivatives
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
IE20030749A1 (en) * 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
WO1993012141A1 (en) 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
AU5168393A (en) 1992-09-30 1994-04-26 Yale University Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids
US5750652A (en) 1994-01-21 1998-05-12 Yale University Deltex proteins
ATE442373T1 (de) 1995-06-28 2009-09-15 Imp Cancer Res Tech Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) * 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
CA2238404A1 (en) 1995-11-22 1997-05-29 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
JP2000512134A (ja) 1996-05-31 2000-09-19 ザ ナショナル アメリカン レッド クロス Jagged/Notchタンパク質および核酸に基づく治療および診断の方法および組成物
CA2268751A1 (en) 1996-10-21 1998-04-30 Hsc Research And Development Limited Partnership Fringe proteins and notch signalling
WO1998020142A1 (en) 1996-11-07 1998-05-14 Lorantis Limited Notch
US20020010137A1 (en) * 1997-09-18 2002-01-24 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
AU6952498A (en) 1997-04-04 1998-10-30 Millenium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
EP1004669B1 (de) 1997-05-14 2007-04-18 Asahi Kasei Kabushiki Kaisha Neuer hemmer der differentierung
US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6692919B1 (en) * 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
TW406393B (en) * 1997-12-01 2000-09-21 United Microelectronics Corp Method of manufacturing dielectrics and the inner-lining
JP2002520007A (ja) 1998-07-13 2002-07-09 イエール ユニバーシティー Delta切断産物およびそれに基づく方法
US8084258B2 (en) * 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
WO2002059285A1 (en) * 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
US20070003893A1 (en) * 2005-06-30 2007-01-04 Radek Bures Combination lighter and breath freshener dispenser

Also Published As

Publication number Publication date
US7118890B2 (en) 2006-10-10
ES2334953T3 (es) 2010-03-17
US7928071B2 (en) 2011-04-19
CA2226087A1 (en) 1997-01-16
US6783956B2 (en) 2004-08-31
US6262025B1 (en) 2001-07-17
PT861261E (pt) 2009-12-16
EP0861261A4 (de) 2001-08-29
EP0861261A1 (de) 1998-09-02
US20070134239A1 (en) 2007-06-14
CA2226087C (en) 2012-01-31
US8415303B2 (en) 2013-04-09
US20020107194A1 (en) 2002-08-08
EP0861261B1 (de) 2009-09-09
US20030073620A1 (en) 2003-04-17
JP2009039101A (ja) 2009-02-26
WO1997001571A1 (en) 1997-01-16
DK0861261T3 (da) 2009-12-14
US20070082846A1 (en) 2007-04-12
JPH11508771A (ja) 1999-08-03
AU723939B2 (en) 2000-09-07
JP2012070735A (ja) 2012-04-12
DE69638023D1 (de) 2009-10-22
EP0861261B9 (de) 2010-02-24
AU6481796A (en) 1997-01-30

Similar Documents

Publication Publication Date Title
ATE442373T1 (de) Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
PT813545E (pt) Sequências nucleotídicas e proteicas de genes serrate de vertebrado e métodos nelas baseados
US5198423A (en) Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
EP1124846A4 (de) Nukleotid- und proteinsequenzen von nogo-genen und darauf beruhende methoden
PT93910A (pt) Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula
BR0109494A (pt) Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas
BR0107613A (pt) Bloqueio do crescimento de axÈnios mediado por receptor nogo
RU95115239A (ru) Аналог эритропоэтина
ATE105842T1 (de) Von thrombin abstammende polypeptid- zusammensetzungen und methoden für ihre benutzung.
EA012071B1 (ru) Селективные агонисты рецептора y4 для терапевтического воздействия
BR9714160A (pt) Antìgenos uspa1 e uspa2 de moraxella catarrhalis
JPH06507639A (ja) セレクチンとb百日咳毒素の間のアミノ酸シーケンスの相同性−それから誘導されるペプチド、それに対する抗体、薬剤組成物
BR9508467A (pt) Composição de matéria peptídeo de ligação de receptor de somatostatina composição farmacéutica e processo para realizar uma cirurgia guiada por radiosótopos ou um procedimento de radiodiagnóstico ou radioterapéutico e para aliviar uma doença relacionada com somatostetina em um animal
CA2126212A1 (en) A novel molecule which inhibits neuropeptide tyrosine biological function
US7119168B2 (en) Paralytic peptide for use in neuromuscular therapy
ATE69727T1 (de) Zusammensetzung zur behandlung von an haemophilia- a-inhibitor leidenden kranken.
CA2003886A1 (en) Cloning and expression of simian transforming growth factor-beta 1
WO1999063094A3 (en) Nucleotide and protein sequences of gpr1 and methods based thereon
NO20060675L (no) Forbedrede, rekombinante, humane interferon-beta-lb-polypeptider
DE69634994D1 (de) Bindegewebe-wachstumsfaktor 3.
KR880701073A (ko) 제조합 dna 기법에 의해 생성된 민악티빈
ATE329027T1 (de) Menschliches leucinereiche wiederholungen enthaltendes protein, vorwiegend im dünndarm exprimiert, hlrrsi1
ATE219513T1 (de) Molekulares klonieren von genomischen und cdna- sequenzen, die für zelluläre rezeptoren für poliovirus kodieren
Frazier et al. Structure of human thrombospondin: complete amino acid sequence derived from cDNA
FI954889A7 (fi) Proteiini, jolla on TPO-aktiviteetti

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0861261

Country of ref document: EP