PT813545E - Sequências nucleotídicas e proteicas de genes serrate de vertebrado e métodos nelas baseados - Google Patents
Sequências nucleotídicas e proteicas de genes serrate de vertebrado e métodos nelas baseados Download PDFInfo
- Publication number
- PT813545E PT813545E PT96911262T PT96911262T PT813545E PT 813545 E PT813545 E PT 813545E PT 96911262 T PT96911262 T PT 96911262T PT 96911262 T PT96911262 T PT 96911262T PT 813545 E PT813545 E PT 813545E
- Authority
- PT
- Portugal
- Prior art keywords
- serrate
- analogs
- derivatives
- protein
- genes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Insects & Arthropods (AREA)
- Addiction (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/400,159 US5869282A (en) | 1991-12-11 | 1995-03-07 | Nucleotide and protein sequences of the serrate gene and methods based thereon |
Publications (1)
Publication Number | Publication Date |
---|---|
PT813545E true PT813545E (pt) | 2009-12-16 |
Family
ID=23582455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96911262T PT813545E (pt) | 1995-03-07 | 1996-03-07 | Sequências nucleotídicas e proteicas de genes serrate de vertebrado e métodos nelas baseados |
Country Status (11)
Country | Link |
---|---|
US (1) | US5869282A (pt) |
EP (1) | EP0813545B1 (pt) |
JP (4) | JPH11507203A (pt) |
AT (1) | ATE442381T1 (pt) |
AU (1) | AU718955B2 (pt) |
CA (1) | CA2214830C (pt) |
DE (1) | DE69638022D1 (pt) |
DK (1) | DK0813545T3 (pt) |
ES (1) | ES2333384T3 (pt) |
PT (1) | PT813545E (pt) |
WO (1) | WO1996027610A1 (pt) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004924A (en) | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
ES2334953T3 (es) * | 1995-06-28 | 2010-03-17 | Imperial Cancer Research Technology Limited | Secuencias de nucleotidos y proteinas de genes delta de vertebrados y metodos basados en los mismos. |
US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
CA2260365C (en) | 1996-07-16 | 2004-08-10 | Asahi Kasei Kogyo Kabushiki Kaisha | Differentiation-suppressive polypeptide |
AU773479B2 (en) * | 1996-11-07 | 2004-05-27 | Lorantis Limited | Notch |
US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
GB2335194B (en) * | 1996-11-07 | 2001-04-25 | Lorantis Ltd | Notch |
US6664098B1 (en) | 1997-05-14 | 2003-12-16 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitory agent |
US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
WO2000025809A1 (en) * | 1998-10-30 | 2000-05-11 | Smith & Nephew Plc | Compositions comprising notch receptor manipulating agents |
US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2003050502A2 (en) * | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
WO2002018544A2 (en) * | 2000-08-31 | 2002-03-07 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
EP1350262B8 (en) * | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Cpg-like nucleic acids and methods of use thereof |
GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
EP1409005A1 (en) * | 2001-07-25 | 2004-04-21 | Lorantis Limited | Modulators of notch signalling for use in immunotherapy |
US20030185829A1 (en) * | 2002-03-12 | 2003-10-02 | Erich Koller | Jagged 2 inhibitors for inducing apoptosis |
US20040102401A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of jagged 1 expression |
GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
WO2005074633A2 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
CA2612021A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
PT1978993T (pt) | 2005-10-31 | 2017-03-17 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro com base em recetores fzd humanos |
US7723112B2 (en) | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
US8802103B2 (en) * | 2007-05-15 | 2014-08-12 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2010037041A2 (en) | 2008-09-26 | 2010-04-01 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
WO2011063237A2 (en) | 2009-11-19 | 2011-05-26 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
JP2013530929A (ja) | 2010-04-01 | 2013-08-01 | オンコメッド ファーマシューティカルズ インコーポレイテッド | frizzled結合剤およびその使用 |
WO2011127472A1 (en) | 2010-04-09 | 2011-10-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
CA2795627C (en) | 2010-04-09 | 2023-03-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
RU2015101803A (ru) | 2012-06-22 | 2016-08-20 | Сайтомкс Терапьютикс, Инк. | Перекрестно реактивные антитела к jagged 1/k jagged 2, активируемые антитела к jagged и способы их применения |
CA2887711A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
US9956249B2 (en) | 2013-01-08 | 2018-05-01 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
EP2950885B1 (en) | 2013-02-04 | 2018-11-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
NZ719840A (en) | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
EP3247808B1 (en) | 2015-01-21 | 2021-05-05 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
EP3995142A3 (en) | 2015-04-29 | 2022-08-24 | Fred Hutchinson Cancer Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
JP2018537472A (ja) | 2015-12-04 | 2018-12-20 | フレッド ハッチンソン キャンサー リサーチ センター | 増殖造血幹細胞/前駆細胞集団の利用 |
US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
JP2021533788A (ja) | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Jag−1を上方制御することにより有毛細胞を生成するための組成物及び方法 |
CN112680471B (zh) * | 2019-10-17 | 2023-08-01 | 华南农业大学 | ZmSPL基因在调控玉米柱头乳突细胞发育中的应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
WO1993012141A1 (en) * | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
AU720890B2 (en) * | 1996-05-31 | 2000-06-15 | National American Red Cross, The | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
AU8003400A (en) * | 1999-10-06 | 2001-05-10 | Ansgar H. Santel | Mitofusins, fzo homologs and functional derivatives thereof |
JP5890756B2 (ja) | 2012-06-28 | 2016-03-22 | 昭和電工株式会社 | 磁気記録媒体及び磁気記憶装置 |
-
1995
- 1995-03-07 US US08/400,159 patent/US5869282A/en not_active Expired - Lifetime
-
1996
- 1996-03-07 DE DE69638022T patent/DE69638022D1/de not_active Expired - Lifetime
- 1996-03-07 PT PT96911262T patent/PT813545E/pt unknown
- 1996-03-07 WO PCT/US1996/003172 patent/WO1996027610A1/en active Application Filing
- 1996-03-07 DK DK96911262T patent/DK0813545T3/da active
- 1996-03-07 CA CA2214830A patent/CA2214830C/en not_active Expired - Lifetime
- 1996-03-07 AT AT96911262T patent/ATE442381T1/de active
- 1996-03-07 EP EP96911262A patent/EP0813545B1/en not_active Expired - Lifetime
- 1996-03-07 JP JP8527061A patent/JPH11507203A/ja not_active Withdrawn
- 1996-03-07 ES ES96911262T patent/ES2333384T3/es not_active Expired - Lifetime
- 1996-03-07 AU AU54202/96A patent/AU718955B2/en not_active Expired
-
2007
- 2007-10-03 JP JP2007260391A patent/JP2008099687A/ja not_active Withdrawn
-
2010
- 2010-07-23 JP JP2010166570A patent/JP2010273685A/ja not_active Withdrawn
-
2013
- 2013-02-08 JP JP2013023179A patent/JP2013150605A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE69638022D1 (de) | 2009-10-22 |
EP0813545A1 (en) | 1997-12-29 |
JP2010273685A (ja) | 2010-12-09 |
CA2214830A1 (en) | 1996-09-12 |
EP0813545B1 (en) | 2009-09-09 |
JPH11507203A (ja) | 1999-06-29 |
AU5420296A (en) | 1996-09-23 |
JP2008099687A (ja) | 2008-05-01 |
ATE442381T1 (de) | 2009-09-15 |
WO1996027610A1 (en) | 1996-09-12 |
AU718955B2 (en) | 2000-05-04 |
JP2013150605A (ja) | 2013-08-08 |
EP0813545A4 (en) | 2002-04-24 |
ES2333384T3 (es) | 2010-02-19 |
US5869282A (en) | 1999-02-09 |
DK0813545T3 (da) | 2009-12-14 |
CA2214830C (en) | 2012-06-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0813545A4 (en) | NUCLEOTID AND PROTEIN SEQUENCES OF A SERRATE GENE FROM VERBELTIEREN AND METHODS THEREFORE | |
EP0861261A4 (en) | NUCLEOTID AND PROTEIN SEQUENCES OF DELTA GENES FROM VERTEBRATEN AND METHODS BASED ON THEM | |
AU2005224028B2 (en) | Y4 selective receptor agonists for therapeutic interventions | |
US8962817B2 (en) | Vectors encoding a paralytic peptide | |
AU2005224027B2 (en) | Y2/Y4 selective receptor agonists for therapeutic interventions | |
DK0481000T3 (da) | Receptorer for fibroblastvækstfaktorer | |
EA011860B1 (ru) | Селективные агонисты рецептора y2 для терапевтического воздействия | |
BRPI0410164A (pt) | composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano | |
EP1806364A3 (fr) | Nouveaux anticorps anti-igf-ir et leurs applications | |
WO2001070769A1 (fr) | Derive peptidique | |
KR980002066A (ko) | 변이형 인간 성장호르몬 및 그의 용도 | |
KR20010085847A (ko) | 펩티드 유도체 | |
ATE321856T1 (de) | Humane rezeptortyrosinkinase | |
Cullen et al. | Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. | |
WO1997011091A1 (fr) | Nouveaux composes peptidiques et leurs compositions medicinales | |
WO1999063094A3 (en) | Nucleotide and protein sequences of gpr1 and methods based thereon | |
JPWO2004101610A1 (ja) | オリゴペプチド | |
Gagnon et al. | D-LysAsnProTyr tetrapeptide: a novel B-cell stimulant and stabilized bursin mimetic | |
AU2017200239A1 (en) | Designer osteogenic proteins | |
AR036104A1 (es) | Un receptor acoplado a la proteina g, gave3 |