DE69638023D1 - Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden - Google Patents
Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methodenInfo
- Publication number
- DE69638023D1 DE69638023D1 DE69638023T DE69638023T DE69638023D1 DE 69638023 D1 DE69638023 D1 DE 69638023D1 DE 69638023 T DE69638023 T DE 69638023T DE 69638023 T DE69638023 T DE 69638023T DE 69638023 D1 DE69638023 D1 DE 69638023D1
- Authority
- DE
- Germany
- Prior art keywords
- delta
- analogs
- derivatives
- domain
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title 1
- 101000914947 Bungarus multicinctus Long neurotoxin homolog TA-bm16 Proteins 0.000 abstract 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 abstract 1
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000269370 Xenopus <genus> Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58995P | 1995-06-28 | 1995-06-28 | |
PCT/US1996/011178 WO1997001571A1 (en) | 1995-06-28 | 1996-06-28 | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69638023D1 true DE69638023D1 (de) | 2009-10-22 |
Family
ID=21692156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69638023T Expired - Lifetime DE69638023D1 (de) | 1995-06-28 | 1996-06-28 | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
Country Status (11)
Country | Link |
---|---|
US (5) | US6262025B1 (de) |
EP (1) | EP0861261B9 (de) |
JP (3) | JPH11508771A (de) |
AT (1) | ATE442373T1 (de) |
AU (1) | AU723939B2 (de) |
CA (1) | CA2226087C (de) |
DE (1) | DE69638023D1 (de) |
DK (1) | DK0861261T3 (de) |
ES (1) | ES2334953T3 (de) |
PT (1) | PT861261E (de) |
WO (1) | WO1997001571A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
ES2334953T3 (es) | 1995-06-28 | 2010-03-17 | Imperial Cancer Research Technology Limited | Secuencias de nucleotidos y proteinas de genes delta de vertebrados y metodos basados en los mismos. |
US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
JP4283891B2 (ja) | 1995-11-17 | 2009-06-24 | 旭化成株式会社 | 分化抑制ポリペプチド |
US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
EP0972041B2 (de) * | 1997-04-04 | 2017-01-18 | Millennium Pharmaceuticals, Inc. | Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen |
US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
JP4171528B2 (ja) | 1997-05-14 | 2008-10-22 | 旭化成株式会社 | 新規な分化抑制剤 |
CA2295439A1 (en) * | 1997-06-18 | 1998-12-23 | Zymogenetics, Inc. | Mammalian neuro-growth factor like protein |
US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
CA2333893A1 (en) * | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
JP2002523018A (ja) * | 1998-07-27 | 2002-07-30 | アムジエン・インコーポレーテツド | デルタ関連ポリペプチド |
CA2343353A1 (en) * | 1998-09-18 | 2000-03-30 | Hyseq, Inc. | Methods and compositions relating to egf-repeat-containing polypeptides |
EP1518930B1 (de) * | 1998-10-13 | 2007-05-30 | Genentech, Inc. | Verfahren und Zusammenstzung zur Hemmung des Wachtums von neoplastischen Zellen |
US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
US20080194022A1 (en) * | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
WO2002018544A2 (en) * | 2000-08-31 | 2002-03-07 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
JP2004536877A (ja) * | 2001-07-25 | 2004-12-09 | ロランティス リミテッド | 免疫療法に用いるノッチシグナル伝達モジュレーター |
GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
EP1448599A2 (de) * | 2001-11-14 | 2004-08-25 | Lorantis Limited | Inhibitoren des notch signalwegs zur verwendung in der behandlung von krebs |
JP2006515177A (ja) * | 2002-09-10 | 2006-05-25 | ロランティス リミテッド | Notchリガンドタンパク質を含む医薬組成物及び医学的処置 |
GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
EP1639090A4 (de) * | 2003-06-09 | 2008-04-16 | Univ Michigan | Zusammensetzungen und verfahren zur behandlung und diagnose von krebs |
EP1654383A1 (de) * | 2003-08-08 | 2006-05-10 | Licentia, Ltd. | Materialien und verfahren zum screening, zur diagnose und zur therapie von colorectalem krebs |
US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
CA2621226A1 (en) * | 2005-09-01 | 2007-03-08 | Vasgene Therapeutics, Inc. | Methods for using and identifying modulators of delta-like 4 |
US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
JP5129149B2 (ja) | 2005-10-31 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を処置および診断するための組成物および方法 |
JP2009513708A (ja) | 2005-10-31 | 2009-04-02 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
PL2066694T3 (pl) * | 2006-09-29 | 2016-04-29 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworu |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
AU2009296246B2 (en) | 2008-09-26 | 2015-07-30 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
PL3072526T3 (pl) | 2009-10-16 | 2019-04-30 | Oncomed Pharm Inc | Kombinacja terapeutyczna i zastosowanie przeciwciał antagonistycznych względem DLL4 i środków antyhipertensyjnych |
CA2782299A1 (en) * | 2009-12-01 | 2011-06-09 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancers comprising k-ras mutations |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
WO2011127470A1 (en) | 2010-04-09 | 2011-10-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
CA3090548A1 (en) | 2010-04-09 | 2011-10-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
WO2013147793A1 (en) * | 2012-03-29 | 2013-10-03 | Fleming Robert J | Methods and compositions for modulating notch activity |
CA2887711A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
CA2897499A1 (en) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
BR112016009898A2 (pt) | 2013-10-31 | 2017-12-05 | Hutchinson Fred Cancer Res | células-tronco/progenitoras hematopoiéticas e efetoras não-t modificadas e usos das mesmas |
AU2015338974B2 (en) | 2014-10-31 | 2021-08-26 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
EP3247808B1 (de) | 2015-01-21 | 2021-05-05 | Fred Hutchinson Cancer Research Center | Poc- und/oder tragbare plattform für gentherapie |
US20180355318A1 (en) | 2015-04-29 | 2018-12-13 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
EP3353204B1 (de) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-spezifischer anti-vegf/dll4-antikörper zur verwendung bei der behandlung von platin-resistentem eierstockkrebs |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
US6004924A (en) | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
WO1994007522A1 (en) | 1992-09-30 | 1994-04-14 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
US5750652A (en) | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
ES2334953T3 (es) * | 1995-06-28 | 2010-03-17 | Imperial Cancer Research Technology Limited | Secuencias de nucleotidos y proteinas de genes delta de vertebrados y metodos basados en los mismos. |
US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
JP4283891B2 (ja) * | 1995-11-17 | 2009-06-24 | 旭化成株式会社 | 分化抑制ポリペプチド |
CA2238404A1 (en) | 1995-11-22 | 1997-05-29 | Yale University | Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions |
AU720890B2 (en) | 1996-05-31 | 2000-06-15 | National American Red Cross, The | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
WO1998017793A1 (en) | 1996-10-21 | 1998-04-30 | Hsc Research And Development Limited Partnership | Fringe proteins and notch signalling |
CN1160371C (zh) | 1996-11-07 | 2004-08-04 | 洛伦蒂斯有限公司 | Notch蛋白及其配体 |
US20020010137A1 (en) * | 1997-09-18 | 2002-01-24 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
EP0972041B2 (de) | 1997-04-04 | 2017-01-18 | Millennium Pharmaceuticals, Inc. | Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen |
US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
JP4171528B2 (ja) | 1997-05-14 | 2008-10-22 | 旭化成株式会社 | 新規な分化抑制剤 |
US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
TW406393B (en) * | 1997-12-01 | 2000-09-21 | United Microelectronics Corp | Method of manufacturing dielectrics and the inner-lining |
CA2333893A1 (en) | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
US7399633B2 (en) * | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
US20070003893A1 (en) * | 2005-06-30 | 2007-01-04 | Radek Bures | Combination lighter and breath freshener dispenser |
-
1996
- 1996-06-28 ES ES96924334T patent/ES2334953T3/es not_active Expired - Lifetime
- 1996-06-28 CA CA2226087A patent/CA2226087C/en not_active Expired - Lifetime
- 1996-06-28 PT PT96924334T patent/PT861261E/pt unknown
- 1996-06-28 DK DK96924334T patent/DK0861261T3/da active
- 1996-06-28 AU AU64817/96A patent/AU723939B2/en not_active Expired
- 1996-06-28 EP EP96924334A patent/EP0861261B9/de not_active Expired - Lifetime
- 1996-06-28 JP JP9504614A patent/JPH11508771A/ja not_active Withdrawn
- 1996-06-28 US US08/981,392 patent/US6262025B1/en not_active Expired - Lifetime
- 1996-06-28 AT AT96924334T patent/ATE442373T1/de active
- 1996-06-28 DE DE69638023T patent/DE69638023D1/de not_active Expired - Lifetime
- 1996-06-28 WO PCT/US1996/011178 patent/WO1997001571A1/en active Application Filing
-
2001
- 2001-02-15 US US09/783,931 patent/US7118890B2/en not_active Expired - Fee Related
- 2001-07-17 US US09/908,322 patent/US6783956B2/en not_active Expired - Fee Related
-
2006
- 2006-07-24 US US11/492,497 patent/US7928071B2/en not_active Expired - Fee Related
- 2006-10-10 US US11/546,583 patent/US8415303B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 JP JP2008179448A patent/JP2009039101A/ja not_active Withdrawn
-
2011
- 2011-10-04 JP JP2011220536A patent/JP2012070735A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU6481796A (en) | 1997-01-30 |
US20030073620A1 (en) | 2003-04-17 |
ES2334953T3 (es) | 2010-03-17 |
CA2226087A1 (en) | 1997-01-16 |
JP2012070735A (ja) | 2012-04-12 |
WO1997001571A1 (en) | 1997-01-16 |
US7118890B2 (en) | 2006-10-10 |
EP0861261A4 (de) | 2001-08-29 |
AU723939B2 (en) | 2000-09-07 |
US6262025B1 (en) | 2001-07-17 |
ATE442373T1 (de) | 2009-09-15 |
EP0861261B1 (de) | 2009-09-09 |
US7928071B2 (en) | 2011-04-19 |
DK0861261T3 (da) | 2009-12-14 |
US20020107194A1 (en) | 2002-08-08 |
US20070082846A1 (en) | 2007-04-12 |
PT861261E (pt) | 2009-12-16 |
JPH11508771A (ja) | 1999-08-03 |
US8415303B2 (en) | 2013-04-09 |
US20070134239A1 (en) | 2007-06-14 |
EP0861261B9 (de) | 2010-02-24 |
JP2009039101A (ja) | 2009-02-26 |
US6783956B2 (en) | 2004-08-31 |
EP0861261A1 (de) | 1998-09-02 |
CA2226087C (en) | 2012-01-31 |
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