ATE326478T1 - Peptidderivat - Google Patents
PeptidderivatInfo
- Publication number
- ATE326478T1 ATE326478T1 AT01915695T AT01915695T ATE326478T1 AT E326478 T1 ATE326478 T1 AT E326478T1 AT 01915695 T AT01915695 T AT 01915695T AT 01915695 T AT01915695 T AT 01915695T AT E326478 T1 ATE326478 T1 AT E326478T1
- Authority
- AT
- Austria
- Prior art keywords
- function regulator
- regulator
- development
- present
- peptide derivative
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000006870 function Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004217 heart function Effects 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000007102 metabolic function Effects 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000001525 receptor binding assay Methods 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000087114 | 2000-03-23 | ||
| JP2000288891 | 2000-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326478T1 true ATE326478T1 (de) | 2006-06-15 |
Family
ID=26588465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01915695T ATE326478T1 (de) | 2000-03-23 | 2001-03-22 | Peptidderivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7635751B2 (de) |
| EP (1) | EP1270585B1 (de) |
| JP (1) | JP4786047B2 (de) |
| KR (1) | KR20020081466A (de) |
| CN (1) | CN1419563A (de) |
| AT (1) | ATE326478T1 (de) |
| AU (1) | AU2001242749A1 (de) |
| CA (1) | CA2403447A1 (de) |
| DE (1) | DE60119714T2 (de) |
| WO (1) | WO2001070769A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063892A1 (en) * | 2002-01-29 | 2003-08-07 | Takeda Chemical Industries, Ltd. | Use of apelin |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| EP1967210A4 (de) * | 2005-12-20 | 2009-11-11 | Takeda Pharmaceutical | Neue anwendung von apelin |
| RU2303454C1 (ru) * | 2006-06-22 | 2007-07-27 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Средство, нормализующее репродуктивную функцию у женщин, и способ его получения |
| EP1903052A3 (de) * | 2006-07-28 | 2008-04-02 | Faust Pharmaceuticals SA | APJ Rezeptor-Liganden und deren Verwendung |
| WO2013050441A1 (en) | 2011-10-05 | 2013-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation |
| EP2785365B1 (de) | 2011-11-28 | 2017-07-19 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Pharmazeutische zusammensetzung zur verwendung bei der behandlung von dysfunktion in zusammenhang mit der alterung |
| CN104254540A (zh) * | 2012-01-09 | 2014-12-31 | 安科治疗公司 | Apj受体化合物 |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| US8921307B2 (en) | 2012-11-20 | 2014-12-30 | Novartis Ag | Synthetic linear apelin mimetics for the treatment of heart failure |
| ES2875957T3 (es) | 2012-12-20 | 2021-11-11 | Amgen Inc | Agonistas del receptor APJ y usos de los mismos |
| CN105705167A (zh) | 2013-07-25 | 2016-06-22 | 诺华股份有限公司 | 合成的apelin多肽的生物缀合物 |
| MX2016001020A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca. |
| CN104436158A (zh) * | 2013-09-22 | 2015-03-25 | 华中科技大学 | Apelin-13在治疗糖尿病肾病中的应用 |
| GB201407532D0 (en) * | 2014-04-29 | 2014-06-11 | Univ Ulster | Apelin analogues |
| CR20170338A (es) | 2015-01-23 | 2017-09-12 | Novartis Ag | Conjugados de ácidos grasos y apelina sintética con mayor vida media |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| DK3300500T3 (da) | 2015-05-20 | 2020-05-18 | Amgen Inc | Triazolagonister af apj-receptoren |
| ES2930077T3 (es) | 2016-02-15 | 2022-12-07 | Inst Nat Sante Rech Med | Apelina para su uso en el tratamiento de la disfunción cognitiva posoperatoria |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| EP3541803B1 (de) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazolpyridylverbindungen als agonisten des apj-rezeptors |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| EP3541792B1 (de) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazol-furan-verbindungen als agonisten des apj-rezeptors |
| US11149040B2 (en) | 2017-11-03 | 2021-10-19 | Amgen Inc. | Fused triazole agonists of the APJ receptor |
| WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| WO2026007693A1 (zh) * | 2024-07-05 | 2026-01-08 | 浙江大学 | Apelin-13多肽突变体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2128208C (en) * | 1992-11-17 | 2004-01-06 | Ronald Godiska | Novel seven transmembrane receptors |
| AU1685499A (en) * | 1997-12-24 | 1999-07-19 | Takeda Chemical Industries Ltd. | Polypeptide, their production and use |
| US6475718B2 (en) * | 1998-09-08 | 2002-11-05 | Schering Aktiengesellschaft | Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus |
| AU5759399A (en) * | 1998-09-25 | 2000-04-17 | Takeda Chemical Industries Ltd. | Peptide derivative |
-
2001
- 2001-03-22 DE DE60119714T patent/DE60119714T2/de not_active Expired - Lifetime
- 2001-03-22 CN CN01807077A patent/CN1419563A/zh active Pending
- 2001-03-22 AT AT01915695T patent/ATE326478T1/de not_active IP Right Cessation
- 2001-03-22 EP EP01915695A patent/EP1270585B1/de not_active Expired - Lifetime
- 2001-03-22 KR KR1020027012331A patent/KR20020081466A/ko not_active Withdrawn
- 2001-03-22 AU AU2001242749A patent/AU2001242749A1/en not_active Abandoned
- 2001-03-22 CA CA002403447A patent/CA2403447A1/en not_active Abandoned
- 2001-03-22 WO PCT/JP2001/002278 patent/WO2001070769A1/ja not_active Ceased
- 2001-03-22 US US10/239,321 patent/US7635751B2/en not_active Expired - Fee Related
- 2001-03-23 JP JP2001084010A patent/JP4786047B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60119714T2 (de) | 2006-09-07 |
| EP1270585A1 (de) | 2003-01-02 |
| CA2403447A1 (en) | 2001-09-27 |
| US7635751B2 (en) | 2009-12-22 |
| EP1270585B1 (de) | 2006-05-17 |
| US20040116336A1 (en) | 2004-06-17 |
| AU2001242749A1 (en) | 2001-10-03 |
| EP1270585A4 (de) | 2004-12-15 |
| CN1419563A (zh) | 2003-05-21 |
| WO2001070769A1 (fr) | 2001-09-27 |
| KR20020081466A (ko) | 2002-10-26 |
| JP2002167397A (ja) | 2002-06-11 |
| JP4786047B2 (ja) | 2011-10-05 |
| DE60119714D1 (de) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |