JP2018537112A5 - - Google Patents
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- JP2018537112A5 JP2018537112A5 JP2018531258A JP2018531258A JP2018537112A5 JP 2018537112 A5 JP2018537112 A5 JP 2018537112A5 JP 2018531258 A JP2018531258 A JP 2018531258A JP 2018531258 A JP2018531258 A JP 2018531258A JP 2018537112 A5 JP2018537112 A5 JP 2018537112A5
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- Prior art keywords
- cell
- composition
- gene
- fusion molecule
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 20
- 230000004927 fusion Effects 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 230000004568 DNA-binding Effects 0.000 claims description 6
- 108700019146 Transgenes Proteins 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 101150076800 B2M gene Proteins 0.000 claims description 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 101710185494 Zinc finger protein Proteins 0.000 claims description 4
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims description 4
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 4
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 4
- 210000003738 lymphoid progenitor cell Anatomy 0.000 claims description 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 108020005004 Guide RNA Proteins 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 108700042075 T-Cell Receptor Genes Proteins 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000002103 transcriptional effect Effects 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 101150091887 Ctla4 gene Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269410P | 2015-12-18 | 2015-12-18 | |
| US62/269,410 | 2015-12-18 | ||
| US201662305097P | 2016-03-08 | 2016-03-08 | |
| US62/305,097 | 2016-03-08 | ||
| US201662329439P | 2016-04-29 | 2016-04-29 | |
| US62/329,439 | 2016-04-29 | ||
| PCT/US2016/066988 WO2017106537A2 (en) | 2015-12-18 | 2016-12-15 | Targeted disruption of the mhc cell receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202691A Division JP7262434B2 (ja) | 2015-12-18 | 2020-12-07 | Ｍｈｃ細胞受容体の標的化破壊 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018537112A JP2018537112A (ja) | 2018-12-20 |
| JP2018537112A5 true JP2018537112A5 (enExample) | 2019-11-14 |
Family
ID=59057846
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531258A Withdrawn JP2018537112A (ja) | 2015-12-18 | 2016-12-15 | Ｍｈｃ細胞受容体の標的化破壊 |
| JP2020202691A Active JP7262434B2 (ja) | 2015-12-18 | 2020-12-07 | Ｍｈｃ細胞受容体の標的化破壊 |
| JP2022101756A Active JP7541550B2 (ja) | 2015-12-18 | 2022-06-24 | Ｍｈｃ細胞受容体の標的化破壊 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202691A Active JP7262434B2 (ja) | 2015-12-18 | 2020-12-07 | Ｍｈｃ細胞受容体の標的化破壊 |
| JP2022101756A Active JP7541550B2 (ja) | 2015-12-18 | 2022-06-24 | Ｍｈｃ細胞受容体の標的化破壊 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10500229B2 (enExample) |
| EP (1) | EP3390437B1 (enExample) |
| JP (3) | JP2018537112A (enExample) |
| KR (1) | KR20180088911A (enExample) |
| CN (2) | CN108699132B (enExample) |
| AU (2) | AU2016374253B2 (enExample) |
| BR (1) | BR112018012235A2 (enExample) |
| CA (1) | CA3008382A1 (enExample) |
| EA (1) | EA201891212A1 (enExample) |
| IL (2) | IL259935B2 (enExample) |
| MX (2) | MX2018007519A (enExample) |
| NZ (1) | NZ743429A (enExample) |
| SG (2) | SG11201805157TA (enExample) |
| WO (1) | WO2017106537A2 (enExample) |
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