JP2018522072A5 - - Google Patents
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- JP2018522072A5 JP2018522072A5 JP2018525531A JP2018525531A JP2018522072A5 JP 2018522072 A5 JP2018522072 A5 JP 2018522072A5 JP 2018525531 A JP2018525531 A JP 2018525531A JP 2018525531 A JP2018525531 A JP 2018525531A JP 2018522072 A5 JP2018522072 A5 JP 2018522072A5
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- 239000000203 mixture Substances 0.000 claims 26
- 210000004986 primary T-cell Anatomy 0.000 claims 14
- 108020005004 Guide RNA Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 6
- 230000037442 genomic alteration Effects 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 108091008874 T cell receptors Proteins 0.000 claims 5
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- ALNDFFUAQIVVPG-NGJCXOISSA-N (2r,3r,4r)-3,4,5-trihydroxy-2-methoxypentanal Chemical compound CO[C@@H](C=O)[C@H](O)[C@H](O)CO ALNDFFUAQIVVPG-NGJCXOISSA-N 0.000 claims 3
- 150000004713 phosphodiesters Chemical class 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091008875 B cell receptors Proteins 0.000 claims 2
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 claims 2
- 101000634853 Homo sapiens T cell receptor alpha chain constant Proteins 0.000 claims 2
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100026964 M1-specific T cell receptor beta chain Human genes 0.000 claims 2
- 102100029452 T cell receptor alpha chain constant Human genes 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101150043532 CISH gene Proteins 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101001000998 Homo sapiens Protein phosphatase 1 regulatory subunit 12C Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021149724A JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199905P | 2015-07-31 | 2015-07-31 | |
| US62/199,905 | 2015-07-31 | ||
| US201562232983P | 2015-09-25 | 2015-09-25 | |
| US62/232,983 | 2015-09-25 | ||
| US201662286206P | 2016-01-22 | 2016-01-22 | |
| US62/286,206 | 2016-01-22 | ||
| US201662295670P | 2016-02-16 | 2016-02-16 | |
| US62/295,670 | 2016-02-16 | ||
| US201662330464P | 2016-05-02 | 2016-05-02 | |
| US62/330,464 | 2016-05-02 | ||
| US201662360245P | 2016-07-08 | 2016-07-08 | |
| US62/360,245 | 2016-07-08 | ||
| PCT/US2016/044858 WO2017023803A1 (en) | 2015-07-31 | 2016-07-29 | Modified cells and methods of therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021149724A Division JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522072A JP2018522072A (ja) | 2018-08-09 |
| JP2018522072A5 true JP2018522072A5 (enExample) | 2019-09-05 |
| JP7409773B2 JP7409773B2 (ja) | 2024-01-09 |
Family
ID=57943822
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525531A Active JP7409773B2 (ja) | 2015-07-31 | 2016-07-29 | 改変された細胞および治療の方法 |
| JP2021149724A Pending JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A Pending JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021149724A Pending JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A Pending JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (13) | US20170119820A1 (enExample) |
| EP (2) | EP4339287A3 (enExample) |
| JP (3) | JP7409773B2 (enExample) |
| CN (1) | CN108472314A (enExample) |
| CA (1) | CA2993431A1 (enExample) |
| GB (3) | GB2595063B (enExample) |
| IL (2) | IL295616A (enExample) |
| WO (2) | WO2017023801A1 (enExample) |
Families Citing this family (197)
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2016
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