SG11202110956RA - Compositions and methods for t-cell receptor gene assembly - Google Patents
Compositions and methods for t-cell receptor gene assemblyInfo
- Publication number
- SG11202110956RA SG11202110956RA SG11202110956RA SG11202110956RA SG11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- cell receptor
- receptor gene
- gene assembly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962829813P | 2019-04-05 | 2019-04-05 | |
| US201962838465P | 2019-04-25 | 2019-04-25 | |
| US201962898053P | 2019-09-10 | 2019-09-10 | |
| US202062972231P | 2020-02-10 | 2020-02-10 | |
| PCT/US2020/026558 WO2020206238A2 (en) | 2019-04-05 | 2020-04-03 | Compositions and methods for t-cell receptor gene assembly |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202110956RA true SG11202110956RA (en) | 2021-10-28 |
Family
ID=72667365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202110956RA SG11202110956RA (en) | 2019-04-05 | 2020-04-03 | Compositions and methods for t-cell receptor gene assembly |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20220089785A1 (en) |
| EP (1) | EP3947436A4 (en) |
| JP (1) | JP2022527364A (en) |
| KR (1) | KR20220004060A (en) |
| CN (1) | CN113906047A (en) |
| AU (1) | AU2020253491A1 (en) |
| CA (1) | CA3135850A1 (en) |
| IL (1) | IL286977A (en) |
| MX (1) | MX2021012207A (en) |
| SG (1) | SG11202110956RA (en) |
| WO (1) | WO2020206238A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230088518A (en) | 2018-08-13 | 2023-06-19 | 루트패스 제노믹스, 인크. | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof |
| EP3947436A4 (en) | 2019-04-05 | 2022-12-28 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| WO2023096890A1 (en) * | 2021-11-24 | 2023-06-01 | Rootpath Genomics, Inc. | Compositions and methods for polynucleotide assembly |
| CN116716327B (en) * | 2023-08-04 | 2023-10-20 | 科士华(南京)生物技术有限公司 | Method for constructing TCR vector |
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| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU4328801A (en) | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| US20030049712A1 (en) | 2001-07-31 | 2003-03-13 | Michael Haugwitz | Method of detecting protease activity in a cell |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| RU2478709C2 (en) | 2005-07-21 | 2013-04-10 | Эбботт Лэборетриз | GENE SET EXPRESSION INCLUDING sORF CONSTRUCTS AND METHODS FOR IMMUNOGLOBULIN EXPRESSION |
| WO2008109176A2 (en) | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
| WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
| EP3587594B1 (en) | 2008-12-19 | 2022-04-13 | President and Fellows of Harvard College | Particle-assisted nucleic acid sequencing |
| EP2817318A4 (en) | 2012-02-22 | 2016-04-27 | Univ Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| EP3095879B1 (en) | 2012-04-19 | 2018-09-19 | Life Technologies Corporation | Nucleic acid amplification |
| US20150005199A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US20150005200A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| CN114891871A (en) | 2012-08-14 | 2022-08-12 | 10X基因组学有限公司 | Microcapsule compositions and methods |
| US20140378345A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| EP3091074B1 (en) | 2013-11-21 | 2019-08-07 | Repertoire Genesis Incorporation | T cell receptor and b cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US20150298091A1 (en) | 2014-04-21 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for barcoding nucleic acids |
| SG10201911069WA (en) | 2014-09-15 | 2020-01-30 | Abvitro Llc | High-throughput nucleotide library sequencing |
| US10392663B2 (en) * | 2014-10-29 | 2019-08-27 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples |
| KR20170073667A (en) | 2014-10-29 | 2017-06-28 | 10엑스 제노믹스, 인크. | Methods and compositions for targeted nucleic acid sequencing |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| MX2017013471A (en) | 2015-04-27 | 2018-08-01 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens. |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| CN106459178B (en) * | 2015-09-09 | 2018-06-12 | 广东香雪精准医疗技术有限公司 | For the high-affinity T cell receptor of RHAMM antigen small peptides |
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| WO2017053902A1 (en) | 2015-09-25 | 2017-03-30 | Abvitro Llc | High throughput process for t cell receptor target identification of natively-paired t cell receptor sequences |
| WO2017096239A1 (en) * | 2015-12-04 | 2017-06-08 | St. Jude Children's Research Hospital, Inc. | Cloning and expression system for t-cell receptors |
| CN109477073B (en) | 2016-03-31 | 2024-04-12 | 来恩生物医药私人有限公司 | Non-activated T cells expressing exogenous virus specific T Cell Receptors (TCRs) |
| WO2017177217A2 (en) | 2016-04-08 | 2017-10-12 | Unum Therapeutics | Chimeric receptors and uses thereof in immune therapy |
| CA3022129A1 (en) * | 2016-06-17 | 2017-12-21 | Medigene Immunotherapies Gmbh | T cell receptors and uses thereof |
| CN110520530A (en) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | Tumor infiltrating lymphocyte and treatment method |
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| BR112019014510A2 (en) * | 2017-01-13 | 2020-02-18 | Agenus Inc. | T-CELL RECEPTORS THAT CONNECT TO NY-ESO-1 AND METHODS OF USING THEM |
| JP7335224B2 (en) * | 2017-07-18 | 2023-08-29 | ジェノヴィー エービー | A Two-Component Vector Library System for Rapid Assembly and Diversification of Full-Length T-Cell Receptor Open Reading Frames |
| WO2019126466A1 (en) | 2017-12-22 | 2019-06-27 | Rootpath Genomics, Inc. | Compositions and methods for barcoding |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| TW202003580A (en) | 2018-05-21 | 2020-01-16 | 美商坎伯斯治療有限責任公司 | Compositions and methods for enhancing the killing of target cells by NK cells |
| KR20230088518A (en) | 2018-08-13 | 2023-06-19 | 루트패스 제노믹스, 인크. | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof |
| EP3947436A4 (en) | 2019-04-05 | 2022-12-28 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| CN114786779A (en) | 2019-11-19 | 2022-07-22 | 根路径基因组学公司 | Compositions and methods for T cell receptor identification |
-
2020
- 2020-04-03 EP EP20782656.1A patent/EP3947436A4/en active Pending
- 2020-04-03 AU AU2020253491A patent/AU2020253491A1/en active Pending
- 2020-04-03 CA CA3135850A patent/CA3135850A1/en active Pending
- 2020-04-03 CN CN202080040738.4A patent/CN113906047A/en active Pending
- 2020-04-03 WO PCT/US2020/026558 patent/WO2020206238A2/en unknown
- 2020-04-03 KR KR1020217035399A patent/KR20220004060A/en active Search and Examination
- 2020-04-03 MX MX2021012207A patent/MX2021012207A/en unknown
- 2020-04-03 SG SG11202110956RA patent/SG11202110956RA/en unknown
- 2020-04-03 JP JP2021559366A patent/JP2022527364A/en active Pending
-
2021
- 2021-10-04 IL IL286977A patent/IL286977A/en unknown
- 2021-10-04 US US17/493,469 patent/US20220089785A1/en active Pending
- 2021-12-17 US US17/554,013 patent/US11746162B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3947436A4 (en) | 2022-12-28 |
| CN113906047A (en) | 2022-01-07 |
| KR20220004060A (en) | 2022-01-11 |
| CA3135850A1 (en) | 2020-10-08 |
| US20220089785A1 (en) | 2022-03-24 |
| US20220106377A1 (en) | 2022-04-07 |
| AU2020253491A1 (en) | 2021-10-28 |
| WO2020206238A2 (en) | 2020-10-08 |
| MX2021012207A (en) | 2021-12-10 |
| US11746162B2 (en) | 2023-09-05 |
| EP3947436A2 (en) | 2022-02-09 |
| JP2022527364A (en) | 2022-06-01 |
| WO2020206238A3 (en) | 2020-11-12 |
| IL286977A (en) | 2021-12-01 |
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