JP2016532693A5 - - Google Patents
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- JP2016532693A5 JP2016532693A5 JP2016532265A JP2016532265A JP2016532693A5 JP 2016532693 A5 JP2016532693 A5 JP 2016532693A5 JP 2016532265 A JP2016532265 A JP 2016532265A JP 2016532265 A JP2016532265 A JP 2016532265A JP 2016532693 A5 JP2016532693 A5 JP 2016532693A5
- Authority
- JP
- Japan
- Prior art keywords
- immunocytokine
- amino acid
- antibody
- acid sequence
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940127130 immunocytokine Drugs 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 9
- 230000002519 immonomodulatory effect Effects 0.000 claims 5
- 230000001506 immunosuppresive effect Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 102000003812 Interleukin-15 Human genes 0.000 claims 3
- 108090000172 Interleukin-15 Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 102000056003 human IL15 Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102100035990 Adenosine receptor A2a Human genes 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 229940122786 CD134 agonist Drugs 0.000 claims 1
- 229940116741 CD137 agonist Drugs 0.000 claims 1
- 229940123189 CD40 agonist Drugs 0.000 claims 1
- 102000007346 Hepatitis A Virus Cellular Receptor 2 Human genes 0.000 claims 1
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 claims 1
- 101000783751 Homo sapiens Adenosine receptor A2a Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229940124060 PD-1 antagonist Drugs 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 108091008034 costimulatory receptors Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020004814A JP6951479B2 (ja) | 2013-08-08 | 2020-01-16 | ＩＬ−１５及びＩＬ−１５Ｒαスシドメインに基づくモジュロカイン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003963 | 2013-08-08 | ||
| EP13003963.9 | 2013-08-08 | ||
| PCT/EP2014/002181 WO2015018528A1 (en) | 2013-08-08 | 2014-08-08 | Il-15 and il-15raplha sushi domain based modulokines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020004814A Division JP6951479B2 (ja) | 2013-08-08 | 2020-01-16 | ＩＬ−１５及びＩＬ−１５Ｒαスシドメインに基づくモジュロカイン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016532693A JP2016532693A (ja) | 2016-10-20 |
| JP2016532693A5 true JP2016532693A5 (enExample) | 2017-09-14 |
| JP6649254B2 JP6649254B2 (ja) | 2020-02-19 |
Family
ID=48953308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532265A Active JP6649254B2 (ja) | 2013-08-08 | 2014-08-08 | ＩＬ−１５及びＩＬ−１５Ｒαスシドメインに基づくモジュロカイン |
| JP2020004814A Active JP6951479B2 (ja) | 2013-08-08 | 2020-01-16 | ＩＬ−１５及びＩＬ−１５Ｒαスシドメインに基づくモジュロカイン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020004814A Active JP6951479B2 (ja) | 2013-08-08 | 2020-01-16 | ＩＬ−１５及びＩＬ−１５Ｒαスシドメインに基づくモジュロカイン |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11273204B2 (enExample) |
| EP (4) | EP3995507B1 (enExample) |
| JP (2) | JP6649254B2 (enExample) |
| KR (2) | KR102564207B1 (enExample) |
| CN (1) | CN105612175B (enExample) |
| AU (1) | AU2014304931B2 (enExample) |
| BR (1) | BR112016002614B8 (enExample) |
| CA (1) | CA2919725C (enExample) |
| DK (2) | DK3444271T3 (enExample) |
| EA (1) | EA031080B1 (enExample) |
| ES (3) | ES2690046T3 (enExample) |
| HR (3) | HRP20231437T1 (enExample) |
| HU (2) | HUE064280T2 (enExample) |
| MX (1) | MX374291B (enExample) |
| PL (3) | PL3444271T3 (enExample) |
| PT (2) | PT3444271T (enExample) |
| SI (2) | SI3030575T1 (enExample) |
| WO (1) | WO2015018528A1 (enExample) |
Families Citing this family (89)
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| EP2251034B1 (en) | 2005-12-02 | 2018-02-14 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses presenting non-native surface proteins and uses thereof |
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| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| CN105051069B (zh) | 2013-01-14 | 2019-12-10 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| AU2014241843B2 (en) | 2013-03-14 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
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| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
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| WO2014170032A1 (en) * | 2013-04-19 | 2014-10-23 | Cytune Pharma | Cytokine derived treatment with reduced vascular leak syndrome |
| CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
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| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| EP3237449A2 (en) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Trispecific antibodies |
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| US11186641B2 (en) * | 2016-03-17 | 2021-11-30 | Oslo Universitetssykehus Hf | Fusion proteins targeting tumour associated macrophages for treating cancer |
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