HRP20231437T1 - Il-15 i il-15ralpha sushi domena na temelju modulokina - Google Patents
Il-15 i il-15ralpha sushi domena na temelju modulokina Download PDFInfo
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- HRP20231437T1 HRP20231437T1 HRP20231437TT HRP20231437T HRP20231437T1 HR P20231437 T1 HRP20231437 T1 HR P20231437T1 HR P20231437T T HRP20231437T T HR P20231437TT HR P20231437 T HRP20231437 T HR P20231437T HR P20231437 T1 HRP20231437 T1 HR P20231437T1
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- Prior art keywords
- amino acid
- acid sequence
- immunocytokine
- seq
- conjugate
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 229940127130 immunocytokine Drugs 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 230000002519 immonomodulatory effect Effects 0.000 claims 3
- 102000003812 Interleukin-15 Human genes 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 229940124060 PD-1 antagonist Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Image Processing (AREA)
Claims (7)
1. Imunocitokin za uporabu u terapiji, naznačen time što imunocitokin sadrži:
a) konjugat, i
b) imunomodulatorno antitijelo ili njegov fragment,
pri čemu navedeni konjugat sadrži:
(i) polipeptid koji sadrži aminokiselinsku sekvencu interleukina 15 prema SEQ ID NO: 3 ili njegov derivat koji ima najmanje 92.5% identičnosti sekvence sa aminokiselinskom sekvencom prema SEQ ID NO: 3, i
(ii) polipeptid koji sadrži aminokiselinsku sekvencu sushi domene IL-15Rα prema SEQ ID NO: 8 ili njegov derivat koji ima najmanje 92% identičnosti sekvence sa sekvencom aminokiselina prema SEQ ID NO: 8,
pri čemu su polipeptidi i) i ii) konjugata kovalentno povezani u fuzijski protein i odvojeni veznom aminokiselinskom sekvencom od 15-30 aminokiselina, pri čemu je navedeno imunomodulatorno antitijelo ili njegov fragment antagonist PD-1, pri čemu su naveden konjugat i antitijelo ili njegov fragment kovalentni
povezani u fuzijski protein,
pri čemu navedeni konjugat sadrži aminokiselinsku sekvencu interleukina 15 ili njegovih derivata na C-terminalnom položaju u odnosu na aminokiselinsku sekvencu sushi domene IL-15Rα ili njegovih derivata, i
pri čemu je aminokiselinska sekvenca konjugata na C-terminalnom položaju u odnosu na aminokiselinsku sekvencu antitijela ili njegovog fragmenta.
2. Imunocitokin za uporabu prema zahtjevu 1, naznačen time što je navedeno imunomodulatorno antitijelo odabrano između nivolumaba, Merck 3745 ili CT-01 1 (također poznatog kao hBAT).
3. Imunocitokin za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačen time što polipeptid (ii) koji sadrži aminokiselinsku sekvencu sushi domene IL-15Rα ili njegovih derivata ima aminokiselinsku sekvencu SEQ ID NO 9.
4. Imunocitokin za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačen time što polipeptid (ii) koji sadrži aminokiselinsku sekvencu sushi domene IL-15Rα ili njegovih derivata ima aminokiselinsku sekvencu SEQ ID NO 12.
5. Imunocitokin za uporabu prema bilo kojem od zahtjeva 1-4, naznačen time što se poveznica sastoji od 18-22 aminokiseline.
6. Imunocitokin za uporabu prema bilo kojem od zahtjeva 1-5, naznačen time što se imunocitokin primjenjuje u kombinaciji s daljnjim terapijskim sredstvom.
7. Imunocitokin za uporabu prema zahtjevu 6, naznačen time što daljnje terapeutsko sredstvo je sredstvo protiv raka.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13003963 | 2013-08-08 | ||
EP21200870.0A EP3995507B1 (en) | 2013-08-08 | 2014-08-08 | Il-15 and il-15ralpha sushi domain based on modulokines |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20231437T1 true HRP20231437T1 (hr) | 2024-02-16 |
Family
ID=48953308
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231437TT HRP20231437T1 (hr) | 2013-08-08 | 2014-08-08 | Il-15 i il-15ralpha sushi domena na temelju modulokina |
HRP20212023TT HRP20212023T1 (hr) | 2013-08-08 | 2014-08-08 | Modulokini temeljeni na il-15 i il-15ralpha sushi domeni |
HRP20181472TT HRP20181472T1 (hr) | 2013-08-08 | 2018-09-13 | Il-15 i il-15r-alpha "sushi domain" modulokini |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20212023TT HRP20212023T1 (hr) | 2013-08-08 | 2014-08-08 | Modulokini temeljeni na il-15 i il-15ralpha sushi domeni |
HRP20181472TT HRP20181472T1 (hr) | 2013-08-08 | 2018-09-13 | Il-15 i il-15r-alpha "sushi domain" modulokini |
Country Status (18)
Country | Link |
---|---|
US (2) | US11273204B2 (hr) |
EP (4) | EP3030575B1 (hr) |
JP (2) | JP6649254B2 (hr) |
KR (2) | KR102364523B1 (hr) |
CN (1) | CN105612175B (hr) |
AU (1) | AU2014304931B2 (hr) |
BR (1) | BR112016002614B8 (hr) |
CA (1) | CA2919725C (hr) |
DK (2) | DK3444271T3 (hr) |
EA (1) | EA031080B1 (hr) |
ES (3) | ES2963591T3 (hr) |
HR (3) | HRP20231437T1 (hr) |
HU (2) | HUE057598T2 (hr) |
MX (1) | MX2016001555A (hr) |
PL (3) | PL3444271T3 (hr) |
PT (2) | PT3444271T (hr) |
SI (2) | SI3030575T1 (hr) |
WO (1) | WO2015018528A1 (hr) |
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