|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5169939A
(en)
|
1985-05-21 |
1992-12-08 |
Massachusetts Institute Of Technology & Pres. & Fellows Of Harvard College |
Chimeric antibodies
|
|
US4720449A
(en)
|
1985-06-03 |
1988-01-19 |
Polaroid Corporation |
Thermal imaging method
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6657103B1
(en)
|
1990-01-12 |
2003-12-02 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US7084260B1
(en)
|
1996-10-10 |
2006-08-01 |
Genpharm International, Inc. |
High affinity human antibodies and human antibodies against human antigens
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US7041871B1
(en)
|
1995-10-10 |
2006-05-09 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
WO1993004169A1
(en)
|
1991-08-20 |
1993-03-04 |
Genpharm International, Inc. |
Gene targeting in animal cells using isogenic dna constructs
|
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
|
JPH07509137A
(ja)
|
1992-07-24 |
1995-10-12 |
セル ジェネシス，インク． |
異種抗体の生産
|
|
DE4228162C1
(de)
|
1992-08-25 |
1994-01-13 |
Rajewsky Klaus Dr |
Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
|
|
US5565321A
(en)
|
1993-01-22 |
1996-10-15 |
Immunex Corporation |
Detection of mutations in a CD40 ligand gene
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
DE4331162A1
(de)
|
1993-09-14 |
1995-03-16 |
Bayer Ag |
Verfahren zur Herstellung von Cyaninfarbstoffen
|
|
BE1007904A3
(nl)
|
1993-12-23 |
1995-11-14 |
Dsm Nv |
Werkwijze voor de bereiding van een alkanol en/of een alkanon.
|
|
US7119248B1
(en)
|
1994-04-12 |
2006-10-10 |
Miltenyi Biotec Gmbh |
Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
WO1997049804A1
(en)
|
1996-06-26 |
1997-12-31 |
Baylor College Of Medicine |
Chromosomal rearrangement by insertion of two recombination substrates
|
|
AU740043B2
(en)
|
1996-06-27 |
2001-10-25 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Recognition molecules interacting specifically with the active site or cleft of a target molecule
|
|
EP2305027B1
(en)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
US6319906B1
(en)
|
1996-12-31 |
2001-11-20 |
Isis Pharmaceuticals |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
PT1034262E
(pt)
|
1997-11-18 |
2005-10-31 |
Pioneer Hi Bred Int |
Composicoes e metodos para a modificacao genetica de plantas
|
|
EP0939120A1
(en)
|
1998-02-27 |
1999-09-01 |
Gesellschaft für biotechnologische Forschung mbH (GBF) |
Method for marker-free repetitive DNA expression cassette exchange in the genome of cells or parts of cells
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
IL127127A0
(en)
|
1998-11-18 |
1999-09-22 |
Peptor Ltd |
Small functional units of antibody heavy chain variable regions
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
JP2003503015A
(ja)
|
1999-05-03 |
2003-01-28 |
メダレツクス・インコーポレーテツド |
スタフィロコッカス・アウレウスに対するヒト抗体
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
CA2307503A1
(en)
|
2000-05-02 |
2001-11-02 |
Carlos F. Barbas Iii |
Peptides for use as a vaccine or treatment for hiv infection
|
|
CN101525384A
(zh)
|
2000-06-29 |
2009-09-09 |
艾博特公司 |
双特异性抗体及其制备方法和用途
|
|
AU2001270609A1
(en)
*
|
2000-06-30 |
2002-01-14 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Heterodimeric fusion proteins
|
|
WO2002008409A2
(en)
|
2000-07-21 |
2002-01-31 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Methods for the replacement, translocation and stacking of dna in eukaryotic genomes
|
|
CA2421447C
(en)
|
2000-09-08 |
2012-05-08 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
DE60144305D1
(de)
|
2000-11-17 |
2011-05-05 |
Kyowa Hakko Kirin Co Ltd |
Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren
|
|
JP3523245B1
(ja)
|
2000-11-30 |
2004-04-26 |
メダレックス，インコーポレーテッド |
ヒト抗体作製用トランスジェニック染色体導入齧歯動物
|
|
AU2002246733B2
(en)
|
2000-12-19 |
2007-09-20 |
Altor Bioscience Corporation |
Transgenic animals comprising a humanized immune system
|
|
EP2796468A2
(en)
|
2001-01-05 |
2014-10-29 |
Pfizer Inc |
Antibodies to insulin-like growth factor I receptor
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
GB0115256D0
(en)
|
2001-06-21 |
2001-08-15 |
Babraham Inst |
Mouse light chain locus
|
|
FR2827302B1
(fr)
|
2001-07-13 |
2003-10-10 |
Genoway |
Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
|
|
AU2002319544B2
(en)
|
2001-08-10 |
2008-07-10 |
Aberdeen University |
Antigen binding domains from fish
|
|
US20060199204A1
(en)
|
2001-10-05 |
2006-09-07 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
US20030108925A1
(en)
|
2001-10-05 |
2003-06-12 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
DE60127143T2
(de)
|
2001-11-14 |
2007-11-15 |
Affimed Therapeutics Ag |
Bispezifische Antikörper gegen CD19 und CD16 und deren Verwendung
|
|
EP3269235B1
(en)
|
2001-11-30 |
2022-01-26 |
Amgen Fremont Inc. |
Transgenic mice bearing human ig lambda light chain genes
|
|
AU2003214842A1
(en)
|
2002-01-17 |
2003-09-02 |
Albert Einstein College Of Medicine Of Yeshiva University |
Mutations caused by activation-induced cytidine deaminase
|
|
US8877901B2
(en)
|
2002-12-13 |
2014-11-04 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
PT2314629E
(pt)
|
2002-07-18 |
2014-01-22 |
Merus B V |
Produção recombinante de misturas de anticorpos
|
|
AU2003278790A1
(en)
|
2002-09-09 |
2004-03-29 |
California Institute Of Technology |
Methods and compositions for the generation of humanized mice
|
|
EP1400534B1
(en)
|
2002-09-10 |
2015-10-28 |
Affimed GmbH |
Human CD3-specific antibody with immunosuppressive properties
|
|
US7700356B2
(en)
|
2002-11-08 |
2010-04-20 |
The United States Of America As Represented By The Secretary Of Agriculture |
System for gene targeting and producing stable genomic transgene insertions
|
|
DE10251918A1
(de)
|
2002-11-08 |
2004-05-19 |
Horn, Carsten, Dipl.-Biochem. Dr. |
Systeme zur Erzeugung stabiler genomischer Transgen-Insertionen
|
|
CL2003002461A1
(es)
|
2002-11-27 |
2005-01-07 |
Dow Chemical Company Agroscien |
Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
|
|
MXPA05006724A
(es)
|
2003-01-07 |
2005-09-08 |
Symphogen As |
Metodo para producir proteinas policlonales recombinantes.
|
|
GB2398784B
(en)
|
2003-02-26 |
2005-07-27 |
Babraham Inst |
Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
JP2008501621A
(ja)
|
2003-05-31 |
2008-01-24 |
マイクロメット アクツィエン ゲゼルシャフト |
Ｂ細胞関連疾患を処置するための二重特異性抗ｃｄ３、抗ｃｄ１９抗体構築物を含む薬学的組成物
|
|
WO2005001087A2
(en)
|
2003-06-11 |
2005-01-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying genes in eukaryotic cells
|
|
GB2403475B
(en)
|
2003-07-01 |
2008-02-06 |
Oxitec Ltd |
Stable integrands
|
|
ATE416190T1
(de)
|
2003-07-04 |
2008-12-15 |
Affibody Ab |
Polypeptide mit bindungsaffinität für her2
|
|
US7663017B2
(en)
|
2003-07-30 |
2010-02-16 |
Institut Pasteur |
Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
|
|
WO2005019463A1
(en)
|
2003-08-11 |
2005-03-03 |
Therapeutic Human Polyclonals, Inc. |
Improved transgenesis with humanized immunoglobulin loci
|
|
AU2003275958A1
(en)
|
2003-08-25 |
2005-03-10 |
Pieris Proteolab Ag |
Muteins of tear lipocalin
|
|
US7604994B2
(en)
*
|
2003-09-03 |
2009-10-20 |
Morphotek, Inc. |
Genetically altered antibody-producing cell lines with improved antibody characteristics
|
|
CA2445602C
(en)
|
2003-10-20 |
2014-01-14 |
Campusgen Gmbh |
Nucleotide sequence for creatinine deiminase and method of use
|
|
JP5006651B2
(ja)
|
2003-12-05 |
2012-08-22 |
ブリストル−マイヤーズ スクウィブ カンパニー |
２型血管内皮増殖因子受容体の阻害剤
|
|
KR101333449B1
(ko)
|
2003-12-10 |
2013-11-26 |
메다렉스, 엘.엘.시. |
Ｉｐ―１０ 항체 및 그의 용도
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
US7625549B2
(en)
|
2004-03-19 |
2009-12-01 |
Amgen Fremont Inc. |
Determining the risk of human anti-human antibodies in transgenic mice
|
|
AU2005227313A1
(en)
|
2004-03-19 |
2005-10-06 |
Amgen Inc. |
Reducing the risk of human and anti-human antibodies through V gene manipulation
|
|
EP4353819A3
(en)
|
2004-07-22 |
2024-07-17 |
Erasmus University Medical Center Rotterdam |
Binding molecules
|
|
FR2875239B1
(fr)
|
2004-09-10 |
2007-07-20 |
Inst Necker Ass Loi De 1901 |
Procede pour l'acceleration des mutations somatiques et son application en proteomique
|
|
WO2006029459A1
(en)
|
2004-09-13 |
2006-03-23 |
Evogenix, Inc |
Antibodies specific for hepatocellular carcinoma and other carcinomas and uses thereof
|
|
WO2006044492A2
(en)
|
2004-10-14 |
2006-04-27 |
Ingenious Targeting Laboratory, Inc. |
Methods for generating rat embryo-derived cell lines and genetic modification of rat genome
|
|
AU2005295269B2
(en)
|
2004-10-19 |
2010-05-13 |
Regeneron Pharmaceuticals, Inc. |
Method for generating an animal homozygous for a genetic modification
|
|
WO2006055704A2
(en)
|
2004-11-17 |
2006-05-26 |
Curagen Corporation |
Antibodies directed to ten-m proteins and uses thereof
|
|
WO2006068953A2
(en)
|
2004-12-21 |
2006-06-29 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
WO2006117699A2
(en)
|
2005-04-29 |
2006-11-09 |
Innate Pharma |
Transgenic animals and methods of making recombinant antibodies
|
|
CN101297031B
(zh)
|
2005-05-14 |
2013-06-05 |
复旦大学 |
在脊椎动物中作为遗传操作和分析工具的piggyBac
|
|
GB0510790D0
(en)
|
2005-05-26 |
2005-06-29 |
Syngenta Crop Protection Ag |
Anti-CD16 binding molecules
|
|
EP2500352A1
(en)
*
|
2005-08-19 |
2012-09-19 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
EP1780272A1
(en)
*
|
2005-10-27 |
2007-05-02 |
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH |
Method for enhancing somatic hypermutation, gene conversion and class switch recombination
|
|
GB0601513D0
(en)
|
2006-01-25 |
2006-03-08 |
Univ Erasmus Medical Ct |
Binding molecules 3
|
|
GB0601511D0
(en)
*
|
2006-01-25 |
2006-03-08 |
Univ Erasmus Medical Ct |
Binding Molecules 2
|
|
TWI404727B
(zh)
|
2006-01-25 |
2013-08-11 |
荷蘭鹿特丹Ｅｒａｓｍｕｓ大學醫學中心 |
對偶基因排除
|
|
US7462759B2
(en)
|
2006-02-03 |
2008-12-09 |
Pioneer Hi-Bred International, Inc. |
Brittle stalk 2 gene family and related methods and uses
|
|
AU2007235496B2
(en)
*
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
RS52176B
(sr)
|
2006-06-02 |
2012-08-31 |
Regeneron Pharmaceuticals Inc. |
Antitela visokog afiniteta prema humanom il-6 receptoru
|
|
EP2409714A1
(en)
|
2006-06-27 |
2012-01-25 |
Sanofi Pasteur VaxDesign Corporation |
Models for vaccine assessment
|
|
EP1878342A1
(en)
|
2006-07-13 |
2008-01-16 |
Institut Pasteur |
Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
|
|
WO2008022391A1
(en)
|
2006-08-22 |
2008-02-28 |
G2 Inflammation Pty Ltd |
Method for producing antibodies
|
|
WO2008054606A2
(en)
|
2006-10-02 |
2008-05-08 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human il-4 receptor
|
|
WO2008070367A2
(en)
|
2006-11-01 |
2008-06-12 |
Facet Biotech Corporation |
Mammalian cell-based immunoglobulin display libraries
|
|
US7556337B2
(en)
*
|
2006-11-02 |
2009-07-07 |
Xerox Corporation |
System and method for evaluating line formation in an ink jet imaging device to normalize print head driving voltages
|
|
NO347649B1
(no)
|
2006-12-14 |
2024-02-12 |
Regeneron Pharma |
Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
|
|
GB0700194D0
(en)
|
2007-01-05 |
2007-02-14 |
Univ Edinburgh |
Humanisation of animals
|
|
EP1958957A1
(en)
|
2007-02-16 |
2008-08-20 |
NascaCell Technologies AG |
Polypeptide comprising a knottin protein moiety
|
|
BRPI0807952A2
(pt)
*
|
2007-02-20 |
2014-06-10 |
Anaptysbio Inc |
Sistemas de hipermutação somática
|
|
JP5642972B2
(ja)
|
2007-02-21 |
2014-12-17 |
ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ |
Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用
|
|
EP2132312B1
(en)
|
2007-03-27 |
2016-01-27 |
Sea Lane Biotechnologies,llc. |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
GB0706628D0
(en)
*
|
2007-04-04 |
2007-05-16 |
Univ Erasmus |
Germ-line manipulation 1
|
|
PL2152872T3
(pl)
|
2007-05-25 |
2011-03-31 |
Symphogen As |
Sposób wytwarzania rekombinowanego białka poliklonalnego
|
|
KR102096731B1
(ko)
|
2007-06-01 |
2020-04-02 |
오픈 모노클로날 테크놀로지, 인코포레이티드 |
내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
|
|
WO2009013620A2
(en)
|
2007-06-11 |
2009-01-29 |
Erasmus University Medical Center Rotterdam |
Homologous recombination
|
|
US20090104221A1
(en)
*
|
2007-07-06 |
2009-04-23 |
Vaxdesign Corporation |
Rapid generation of t cell-independent antibody responses to t cell-dependent antigens
|
|
US20090021474A1
(en)
|
2007-07-17 |
2009-01-22 |
Motorola, Inc. |
System and method for displaying status information of a multimedia broadcast receiver on an ambient device
|
|
US7879984B2
(en)
|
2007-07-31 |
2011-02-01 |
Regeneron Pharmaceuticals, Inc. |
Human antibodies to human CD20 and method of using thereof
|
|
AU2008284015B2
(en)
*
|
2007-08-03 |
2014-05-15 |
Musc Foundation For Research Development |
Human monoclonal antibodies and methods for producing the same
|
|
JP5588866B2
(ja)
|
2007-08-10 |
2014-09-10 |
メダレックス エル．エル．シー． |
Ｈｃｏ３２およびｈｃｏ２７、ならびに関連実施例
|
|
KR101709488B1
(ko)
|
2007-08-10 |
2017-02-24 |
리제너론 파아마슈티컬스, 인크. |
인간 신경성장인자에 대한 고친화성 인간 항체
|
|
EP2641919A3
(en)
*
|
2007-11-30 |
2014-05-07 |
Glaxo Group Limited |
Antigen-binding constructs
|
|
KR20100103810A
(ko)
|
2007-12-10 |
2010-09-28 |
알리바 바이오파마수티컬스, 아이엔씨. |
동종 재조합에 의한 표적화된 영역의 순차적인 치환 방법
|
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
CA2718517A1
(en)
|
2008-03-26 |
2009-10-01 |
Iti Scotland Limited |
Efficient insertion of dna into embryonic stem cells
|
|
EP2271758B1
(en)
|
2008-04-14 |
2018-09-12 |
Innovative Targeting Solutions Inc. |
Sequence diversity generation in immunoglobulins
|
|
EP2281845B1
(en)
*
|
2008-04-25 |
2020-09-02 |
Kyowa Kirin Co., Ltd. |
Stable polyvalent antibody
|
|
EP2669298A3
(en)
*
|
2008-05-23 |
2014-02-26 |
Ablexis, LLC |
Single variable immunoglobulin domain comprising VL-DH-JL
|
|
PT3456190T
(pt)
*
|
2008-06-27 |
2022-02-15 |
Merus Nv |
Animal murino transgénico produtor de anticorpo
|
|
KR101987351B1
(ko)
|
2008-09-30 |
2019-06-10 |
아블렉시스, 엘엘씨 |
키메라 항체의 제조를 위한 인간 이외의 포유동물
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
RU2011129459A
(ru)
|
2008-12-18 |
2013-01-27 |
Эрасмус Юниверсити Медикал Сентр Роттердам |
Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение
|
|
US9085795B2
(en)
|
2009-02-04 |
2015-07-21 |
Molecular Innovations, Inc. |
Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies
|
|
CA2753287A1
(en)
*
|
2009-02-24 |
2010-09-02 |
Glaxo Group Limited |
Antigen-binding constructs
|
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
|
WO2010113039A1
(en)
|
2009-04-03 |
2010-10-07 |
Medical Research Council |
Mutants of activation-induced cytidine deaminase (aid) and methods of use
|
|
WO2010132872A1
(en)
|
2009-05-15 |
2010-11-18 |
Novimmune S.A |
Combination therapies and methods using anti-cd3 modulating agents and anti-tnf antagonists
|
|
US20120064064A1
(en)
|
2009-05-28 |
2012-03-15 |
Thil Dinuk Batuwangala |
Antigen-binding proteins
|
|
JP5901517B2
(ja)
|
2009-05-28 |
2016-04-13 |
グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ |
抗原結合性タンパク質
|
|
US8969082B2
(en)
|
2009-06-26 |
2015-03-03 |
Sea Lane Biotechnologies, Llc |
Expression of surrogate light chains
|
|
KR101747103B1
(ko)
|
2009-06-26 |
2017-06-14 |
리제너론 파마슈티칼스 인코포레이티드 |
천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
CN102638971B
(zh)
|
2009-07-08 |
2015-10-07 |
科马布有限公司 |
动物模型及治疗分子
|
|
DK2454283T3
(en)
*
|
2009-07-15 |
2018-05-07 |
Aimm Therapeutics Bv |
METHODS AND PROCEDURES FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
AU2010282508B2
(en)
|
2009-08-13 |
2015-05-28 |
Crystal Bioscience Inc. |
Transgenic animal for production of antibodies having minimal CDRs
|
|
US20120251552A1
(en)
*
|
2009-11-05 |
2012-10-04 |
Anaptysbio, Inc. |
Methods of generating improved antigen-binding agents using chain shuffling and optionally somatic hypermutation
|
|
NZ600002A
(en)
|
2009-11-17 |
2014-08-29 |
Sanford Applied Biosciences L L C |
Human artificial chromosome vector
|
|
EP2509997B1
(en)
|
2009-12-07 |
2017-08-30 |
i2 Pharmaceuticals, Inc. |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
|
WO2011072204A1
(en)
|
2009-12-10 |
2011-06-16 |
Regeneron Pharmaceuticals, Inc. |
Mice that make heavy chain antibodies
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
US10143186B2
(en)
|
2010-02-08 |
2018-12-04 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
AU2011266843C9
(en)
*
|
2010-06-17 |
2018-03-01 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
SG10201504568YA
(en)
|
2010-06-22 |
2015-07-30 |
Regeneron Pharma |
Hybrid light chain mice
|
|
US8890233B2
(en)
*
|
2010-07-06 |
2014-11-18 |
Macronix International Co., Ltd. |
3D memory array with improved SSL and BL contact layout
|
|
EP2407487A1
(en)
*
|
2010-07-14 |
2012-01-18 |
F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. |
Multispecific modular antibody
|
|
EP3960865A1
(en)
|
2010-08-02 |
2022-03-02 |
Regeneron Pharmaceuticals, Inc. |
Mice that make binding proteins comprising vl domains
|
|
RU2608640C2
(ru)
*
|
2010-08-16 |
2017-01-23 |
Новиммун С.А. |
Способы получения мультиспецифичных и мультивалентных антител
|
|
WO2012063048A1
(en)
*
|
2010-11-08 |
2012-05-18 |
Kymab Limited |
Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
CA2820953A1
(en)
|
2010-12-22 |
2012-06-28 |
Genentech, Inc. |
Anti-pcsk9 antibodies and methods of use
|
|
ME03732B
(me)
|
2011-02-25 |
2021-01-20 |
Regeneron Pharma |
Miševi s ADAM6
|
|
HRP20192255T1
(hr)
|
2011-08-05 |
2020-03-06 |
Regeneron Pharmaceuticals, Inc. |
Humanizirani miševi s univerzalnim lakim lancem
|
|
JP2014531452A
(ja)
|
2011-09-19 |
2014-11-27 |
カイマブ・リミテッド |
動物、レパートリーおよび方法
|
|
BR112014006390A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
HRP20220253T1
(hr)
|
2011-10-17 |
2022-04-29 |
Regeneron Pharmaceuticals, Inc. |
Miševi s ograničenim teškim lancem imunoglobulina
|
|
US20130102031A1
(en)
|
2011-10-25 |
2013-04-25 |
Anaptysbio, Inc. |
Use of somatic hypermutation to create insertion and deletion mutations in vitro
|
|
GB2496375A
(en)
|
2011-10-28 |
2013-05-15 |
Kymab Ltd |
A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
ME03477B
(me)
|
2011-12-20 |
2020-01-20 |
Regeneron Pharma |
Miševi sa humanizovanim lakim lancem
|
|
SG10201913428QA
(en)
|
2012-02-01 |
2020-03-30 |
Regeneron Pharma |
Humanized rodents that express heavy chains containing vl domains
|
|
SG10201610123UA
(en)
|
2012-03-02 |
2017-01-27 |
Regeneron Pharma |
Human antibodies to clostridium difficile toxins
|
|
CA2865029A1
(en)
|
2012-03-06 |
2013-09-12 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
RU2014141536A
(ru)
|
2012-03-16 |
2016-05-10 |
Регенерон Фармасьютикалз, Инк. |
Мыши, которые продуцируют антигенсвязывающие белки с зависимыми от величины ph характеристиками связывания
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
EP2831245A1
(en)
|
2012-03-28 |
2015-02-04 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
JO3820B1
(ar)
|
2012-05-03 |
2021-01-31 |
Regeneron Pharma |
أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
|
|
PL4289948T3
(pl)
|
2012-05-25 |
2025-06-02 |
The Regents Of The University Of California |
Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji
|
|
KR102484480B1
(ko)
|
2012-06-12 |
2023-01-04 |
리제너론 파마슈티칼스 인코포레이티드 |
제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
|
|
WO2014093622A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
LT2840892T
(lt)
|
2013-02-20 |
2018-07-25 |
Regeneron Pharmaceuticals, Inc. |
Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US20150033372A1
(en)
|
2013-05-01 |
2015-01-29 |
Kymab Limited |
Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
US20140331344A1
(en)
|
2013-05-03 |
2014-11-06 |
Kymab Ltd. |
Transgenic Animals
|
|
US20140331339A1
(en)
|
2013-05-03 |
2014-11-06 |
Kymab Limited |
Transgenic Non-Human Assay Vertebrates, Assays and Kits
|
|
ES2993142T3
(en)
|
2013-10-01 |
2024-12-23 |
Kymab Ltd |
Animal models and therapeutic molecules
|
|
GB201710984D0
(en)
|
2017-07-07 |
2017-08-23 |
Kymab Ltd |
Cells, vertebrates, populations & methods
|