JP2008512987A5 - - Google Patents
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- JP2008512987A5 JP2008512987A5 JP2007522034A JP2007522034A JP2008512987A5 JP 2008512987 A5 JP2008512987 A5 JP 2008512987A5 JP 2007522034 A JP2007522034 A JP 2007522034A JP 2007522034 A JP2007522034 A JP 2007522034A JP 2008512987 A5 JP2008512987 A5 JP 2008512987A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- domain
- heavy chain
- binding
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 11
- 230000027455 binding Effects 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 7
- 230000009261 transgenic effect Effects 0.000 claims 7
- 101150097493 D gene Proteins 0.000 claims 4
- 101150008942 J gene Proteins 0.000 claims 4
- 101150117115 V gene Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 241000282836 Camelus dromedarius Species 0.000 claims 2
- 230000009824 affinity maturation Effects 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 206010069754 Acquired gene mutation Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 230000037439 somatic mutation Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0416392A GB2416768A (en) | 2004-07-22 | 2004-07-22 | Heavy chain immunoglobulin complexes |
| GB0511881A GB0511881D0 (en) | 2005-06-10 | 2005-06-10 | Binding molecules |
| PCT/GB2005/002892 WO2006008548A2 (en) | 2004-07-22 | 2005-07-22 | Binding molecules |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011166562A Division JP5888893B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
| JP2011166561A Division JP5855381B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512987A JP2008512987A (ja) | 2008-05-01 |
| JP2008512987A5 true JP2008512987A5 (enExample) | 2008-11-13 |
Family
ID=35431831
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522034A Pending JP2008512987A (ja) | 2004-07-22 | 2005-07-22 | 結合分子 |
| JP2011166562A Expired - Fee Related JP5888893B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
| JP2011166561A Expired - Lifetime JP5855381B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011166562A Expired - Fee Related JP5888893B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
| JP2011166561A Expired - Lifetime JP5855381B2 (ja) | 2004-07-22 | 2011-07-29 | 結合分子 |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US20090285805A1 (enExample) |
| EP (6) | EP4353819A3 (enExample) |
| JP (3) | JP2008512987A (enExample) |
| KR (4) | KR101457753B1 (enExample) |
| CN (2) | CN102659941B (enExample) |
| AU (2) | AU2005263994B2 (enExample) |
| BR (1) | BRPI0513577A (enExample) |
| CA (1) | CA2580336C (enExample) |
| CY (2) | CY1115762T1 (enExample) |
| DK (3) | DK1776383T3 (enExample) |
| ES (3) | ES2523661T3 (enExample) |
| HU (1) | HUE034335T2 (enExample) |
| LT (1) | LT2311874T (enExample) |
| MX (2) | MX2007000921A (enExample) |
| PL (2) | PL2311874T3 (enExample) |
| PT (2) | PT1776383E (enExample) |
| RU (1) | RU2398882C2 (enExample) |
| SG (1) | SG188080A1 (enExample) |
| SI (2) | SI2311874T1 (enExample) |
| WO (1) | WO2006008548A2 (enExample) |
| ZA (3) | ZA200701186B (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP4353819A3 (en) * | 2004-07-22 | 2024-07-17 | Erasmus University Medical Center Rotterdam | Binding molecules |
| ES2460517T3 (es) | 2005-07-25 | 2014-05-13 | Emergent Product Development Seattle, Llc | Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20 |
| GB0601513D0 (en) * | 2006-01-25 | 2006-03-08 | Univ Erasmus Medical Ct | Binding molecules 3 |
| GB0618345D0 (en) * | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| TWI404727B (zh) | 2006-01-25 | 2013-08-11 | 荷蘭鹿特丹Ｅｒａｓｍｕｓ大學醫學中心 | 對偶基因排除 |
| EP2418223A3 (en) * | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
| AU2007336242B2 (en) | 2006-12-19 | 2012-08-30 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| AU2007336243B2 (en) | 2006-12-19 | 2012-07-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| GB0706628D0 (en) * | 2007-04-04 | 2007-05-16 | Univ Erasmus | Germ-line manipulation 1 |
| KR102096731B1 (ko) | 2007-06-01 | 2020-04-02 | 오픈 모노클로날 테크놀로지, 인코포레이티드 | 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 |
| WO2009013620A2 (en) * | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| US10214588B2 (en) | 2007-07-03 | 2019-02-26 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
| CN101970490A (zh) * | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| CN101945892B (zh) | 2007-12-26 | 2017-11-24 | 生物测试股份公司 | 用于改进对表达cd138的肿瘤细胞的靶向的方法和试剂 |
| DK2242772T3 (en) | 2007-12-26 | 2015-01-05 | Biotest Ag | Immunoconjugates that targets CD138, and uses thereof |
| BRPI0821447A2 (pt) | 2007-12-26 | 2015-06-16 | Biotest Ag | Anticorpo de alvejamento engenheirado, composição farmacêutica, hibridoma, ensaio com base em anticorpo, polipeptídeo isolado, e, método para ligação homogênea |
| WO2009124931A2 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
| PT2132228E (pt) | 2008-04-11 | 2011-10-11 | Emergent Product Dev Seattle | Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional |
| AU2009248049B2 (en) | 2008-05-16 | 2015-07-23 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
| EP2669298A3 (en) | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| ES2713864T3 (es) | 2008-06-05 | 2019-05-24 | Ablynx Nv | Secuencias de aminoácidos dirigidas contra proteínas de la envuelta de un virus y polipéptidos que comprenden las mismas para el tratamiento de enfermedades virales |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| RU2011129459A (ru) | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| DK2370465T3 (da) | 2008-12-19 | 2019-05-06 | Ablynx Nv | Genetisk immunisering til fremstilling af immunoglobuliner mod celleassocierede antigener, såsom p2x7, cxcr7 eller cxcr4 |
| WO2010079149A1 (de) | 2009-01-09 | 2010-07-15 | Ipk Gatersleben | Fusionsantikörper |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| WO2011072204A1 (en) * | 2009-12-10 | 2011-06-16 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| RS67588B1 (sr) | 2009-12-14 | 2026-01-30 | Ablynx Nv | Antitela sa pojedinačnim varijabilnim domenom imunoglobulina protiv ox40l, konstrukti i njihova terapijska upotreba |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| US9637557B2 (en) * | 2010-04-23 | 2017-05-02 | Genentech, Inc. | Production of heteromultimeric proteins |
| EP3960865A1 (en) | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| JP5933573B2 (ja) | 2010-11-08 | 2016-06-15 | ノバルティス アーゲー | Ｃｘｃｒ２結合ポリペプチド |
| WO2012122512A1 (en) * | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| WO2012156981A1 (en) | 2011-05-13 | 2012-11-22 | Cadila Healthcare Limited | Pharmaceutical compositions of lurasidone |
| BR112014006390A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US9409899B2 (en) | 2012-02-13 | 2016-08-09 | Cadila Healthcare Limited | Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its intermediates |
| EP2825559B1 (en) * | 2012-03-13 | 2019-02-27 | Novimmune SA | Readily isolated bispecific antibodies with native immunoglobulin format |
| GB2502127A (en) * | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| EA201990959A1 (ru) | 2012-04-11 | 2020-02-10 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| EP4269602A3 (en) | 2012-12-14 | 2023-12-27 | OmniAB, Inc. | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
| PL2967012T3 (pl) | 2013-03-14 | 2021-04-19 | Erasmus University Medical Center Rotterdam | Transgeniczne ssaki inne niż człowiek do wytwarzania przeciwciał |
| WO2014141192A1 (en) | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| CA2922830A1 (en) * | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| AU2015213593B2 (en) * | 2014-02-10 | 2020-09-03 | Igm Biosciences, Inc. | IgA multi-specific binding molecules |
| RU2723940C2 (ru) * | 2014-03-21 | 2020-06-18 | Экс-Боди, Инк. | Биспецифические антигенсвязывающие полипептиды |
| SG10201808225TA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
| BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| HUE063273T2 (hu) | 2014-05-06 | 2024-01-28 | Hoffmann La Roche | Heteromultimer fehérjék elõállítása emlõssejtek felhasználásával |
| US11547099B2 (en) | 2014-10-22 | 2023-01-10 | Crescendo Biologies Limited | Transgenic mice |
| HK1250038A1 (zh) | 2015-03-19 | 2018-11-23 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| RU2749674C2 (ru) | 2015-07-29 | 2021-06-16 | Аллерган, Инк. | Антитела против ang-2, содержащие только тяжелую цепь |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| WO2017030909A1 (en) | 2015-08-14 | 2017-02-23 | Allergan, Inc. | Heavy chain only antibodies to pdgf |
| MX2018003292A (es) | 2015-09-21 | 2018-08-01 | Aptevo Res & Development Llc | Polipéptidos de unión a cd3. |
| US10358497B2 (en) | 2015-09-29 | 2019-07-23 | Amgen Inc. | Methods of treating cardiovascular disease with an ASGR inhibitor |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| AU2017316604C1 (en) * | 2016-08-24 | 2025-01-30 | Teneobio, Inc. | Transgenic non-human animals producing modified heavy chain-only antibodies |
| HRP20240767T1 (hr) | 2016-09-14 | 2024-09-13 | Teneoone, Inc. | Cd3 vezujuća antitijela |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| EP3332637A1 (en) * | 2016-12-09 | 2018-06-13 | Universitätsklinikum Hamburg-Eppendorf | Vhh-containing heavy chain antibody and production thereof |
| BR112019012354A2 (pt) | 2016-12-21 | 2019-11-26 | Teneobio, Inc. | anticorpos apenas de cadeia pesada anti-bcma |
| SG10202109874VA (en) | 2017-01-19 | 2021-10-28 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| CA3059634A1 (en) | 2017-04-13 | 2018-10-18 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN110891971B (zh) | 2017-06-20 | 2024-01-12 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| MX2019015563A (es) | 2017-06-20 | 2020-07-28 | Teneoone Inc | Anticuerpos anti-bcma unicamente de cadena pesada. |
| CA3075399A1 (en) | 2017-09-13 | 2019-03-21 | Teneobio, Inc. | Heavy chain antibodies binding to ectoenzymes |
| DK3710484T5 (da) | 2017-12-20 | 2024-08-26 | Harbour Biomed Shanghai Co Ltd | Ctla-4-bindende antistoffer og anvendelser deraf |
| CA3086665A1 (en) | 2017-12-22 | 2019-06-27 | Teneobio, Inc. | Heavy chain antibodies binding to cd22 |
| AU2018396970B2 (en) | 2017-12-28 | 2025-09-25 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
| CN111699200B (zh) | 2018-01-15 | 2023-05-26 | 南京传奇生物科技有限公司 | 针对pd-1的单域抗体和其变体 |
| AU2019241350B2 (en) | 2018-03-30 | 2025-10-02 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against LAG-3 and uses thereof |
| KR102115300B1 (ko) * | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법 |
| EP3801772A1 (en) * | 2018-06-11 | 2021-04-14 | Aarhus Universitet | Single domain antibodies for complement regulation |
| KR20210021024A (ko) * | 2018-06-13 | 2021-02-24 | 크리스탈 바이오사이언스 주식회사 | 유전자 변환에 의한 자율 중쇄 가변 도메인의 수정에 의한 항체 생산 |
| SG11202011597RA (en) | 2018-07-20 | 2020-12-30 | Teneobio Inc | Heavy chain antibodies binding to cd19 |
| GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
| CN112673022B (zh) | 2018-09-10 | 2024-07-09 | 南京传奇生物科技有限公司 | 针对cd33的单结构域抗体及其构建体 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| MX2021004732A (es) | 2018-10-26 | 2021-06-04 | Teneobio Inc | Anticuerpos de cadena pesada que se unen a cd38. |
| EP3927432B1 (en) | 2019-02-20 | 2026-01-28 | Harbour Antibodies BV | Antibodies |
| AU2020252556B2 (en) | 2019-04-05 | 2026-02-05 | Teneobio, Inc. | Heavy chain antibodies binding to PSMA |
| US20220259329A1 (en) | 2019-06-07 | 2022-08-18 | Amgen Inc. | Bispecific binding constructs |
| CR20210622A (es) | 2019-06-14 | 2022-06-27 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
| EP4022067A4 (en) * | 2019-08-28 | 2023-12-20 | Senti Biosciences, Inc. | COMBINATORIAL CANCER IMMUNOTHERAPY |
| WO2021127489A1 (en) | 2019-12-18 | 2021-06-24 | Teneobio, Inc. | Heavy chain antibodies binding to cd38 |
| GB202003632D0 (en) | 2020-03-12 | 2020-04-29 | Harbour Antibodies Bv | SARS-Cov-2 (SARS2, COVID-19) antibodies |
| UY40898A (es) | 2020-04-29 | 2024-10-15 | Teneobio Inc | Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas |
| AU2021263926A1 (en) | 2020-04-29 | 2023-01-19 | Teneoone, Inc. | Methods of treating multiple myeloma |
| MX2022013453A (es) | 2020-04-29 | 2022-11-16 | Teneobio Inc | Anticuerpos de cadena pesada multiespecificos con regiones constantes de cadena pesada modificadas. |
| WO2021247812A1 (en) | 2020-06-04 | 2021-12-09 | Amgen Inc. | Bispecific binding constructs |
| IL299027A (en) | 2020-06-30 | 2023-02-01 | Teneobio Inc | Multispecific antibodies that bind BCMA |
| JP2023531042A (ja) * | 2020-06-30 | 2023-07-20 | 諾納生物（蘇州）有限公司 | ４－１ｂｂ結合タンパク質及びその用途 |
| WO2022011457A1 (en) * | 2020-07-13 | 2022-01-20 | Kisoji Biotechnology Inc. | Transgenic animals expressing heavy chain antibodies |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| GB202017555D0 (en) | 2020-11-06 | 2020-12-23 | Harbour Antibodies Bv | Antibody-conjugated nanoparticles |
| TW202233684A (zh) | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
| MX2023006573A (es) | 2020-12-03 | 2023-06-19 | Amgen Inc | Constructos de inmunoglobulina con multiples dominios de union. |
| WO2022126113A1 (en) | 2020-12-09 | 2022-06-16 | Trianni, Inc. | Heavy chain-only antibodies |
| CA3199879A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| AU2022224636A1 (en) | 2021-02-19 | 2023-09-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
| MX2023009874A (es) | 2021-02-25 | 2023-08-30 | Teneobio Inc | Anticuerpos anti-psma y estructuras car-t. |
| KR20230150825A (ko) | 2021-02-26 | 2023-10-31 | 테네오바이오, 인코포레이티드 | 항-muc1-c 항체 및 car-t 구조 |
| TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗ｉｌ－２ｒ抗體及使用方法 |
| AU2022255709A1 (en) | 2021-04-06 | 2023-09-28 | Teneobio, Inc. | Anti-cd19 antibodies and car-t structures |
| CN117337303A (zh) | 2021-04-16 | 2024-01-02 | 特尼奥生物股份有限公司 | 抗cd20抗体及car-t结构 |
| CN117651486A (zh) * | 2021-05-05 | 2024-03-05 | 利威瑞健股份有限公司 | 用于生产抗体的工程改造的非人动物 |
| US20240251767A1 (en) * | 2021-05-05 | 2024-08-01 | Leveragen, Inc. | Engineered non-human animals for producing antibodies |
| WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
| WO2023004197A1 (en) | 2021-07-23 | 2023-01-26 | Teneoten, Inc. | Heavy chain antibodies binding to hepatitis b surface antigen |
| GB202112935D0 (en) | 2021-09-10 | 2021-10-27 | Harbour Antibodies Bv | Sars-cov-2 (sars2, covid-19) heavy chain only antibodies |
| WO2023036982A1 (en) | 2021-09-10 | 2023-03-16 | Harbour Antibodies Bv | Anti-sars2-s antibodies |
| EP4598958A1 (en) | 2022-10-05 | 2025-08-13 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| EP4512243A1 (en) | 2023-08-21 | 2025-02-26 | Kymab Limited | Binding molecules |
| WO2025217101A2 (en) | 2024-04-09 | 2025-10-16 | Amgen Inc. | Agonistic anti-il-2rbg heavy‑chain antibodies |
| GB202406483D0 (en) | 2024-05-09 | 2024-06-26 | Harbour Antibodies Bv | Crossing the blood brain barrier to treat diseases of the brain |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0143151A3 (en) | 1980-08-11 | 1985-07-10 | BAUSCH & LOMB INCORPORATED | Apparatus for use in an ophthalmic instrument |
| AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
| AU8869291A (en) | 1990-10-04 | 1992-04-28 | University Of Virginia Alumni Patents Foundation, The | Primate erythrocyte bound monoclonal antibody heteropolymers |
| EP1498427B1 (en) * | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| WO1998021355A1 (en) * | 1996-11-15 | 1998-05-22 | Life Technologies, Inc. | Mutants of green fluorescent protein |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| EP0954978B1 (en) * | 1998-03-12 | 2011-11-30 | VHsquared Limited | New products comprising inactivated yeasts or moulds provided with active antibodies |
| US7083950B2 (en) † | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| WO2002012437A2 (en) * | 2000-08-03 | 2002-02-14 | Schooten Wim Van | Production of humanized antibodies in transgenic animals |
| CA2417769A1 (en) | 2000-08-04 | 2002-02-14 | Incyte Genomics, Inc. | Drug metabolizing enzymes |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US20030022240A1 (en) | 2001-04-17 | 2003-01-30 | Peizhi Luo | Generation and affinity maturation of antibody library in silico |
| GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| JP4298498B2 (ja) | 2001-06-13 | 2009-07-22 | ゲンマブ エー／エス | 上皮成長因子受容体（ｅｇｆｒ）に対するヒトモノクローナル抗体 |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| CA2447851C (en) † | 2001-06-28 | 2012-08-28 | Domantis Limited | Dual-specific ligand and its use |
| US6880232B2 (en) | 2001-09-26 | 2005-04-19 | Intel Corporation | Method of making an electrical inductor using a sacrificial electrode |
| JP2005289809A (ja) * | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US6755339B2 (en) † | 2002-06-21 | 2004-06-29 | Delphi Technologies, Inc. | Fluxing apparatus for applying powdered flux |
| EP1517921B1 (en) * | 2002-06-28 | 2006-06-07 | Domantis Limited | Dual specific ligands with increased serum half-life |
| GB0218030D0 (en) | 2002-08-02 | 2002-09-11 | Minos Biosystems | Multi-submit protein production system |
| GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| EP1597280B2 (en) | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
| CA2550551C (en) † | 2004-01-16 | 2013-10-29 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| EP4353819A3 (en) | 2004-07-22 | 2024-07-17 | Erasmus University Medical Center Rotterdam | Binding molecules |
| CA2584814A1 (en) | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglobulin expression in non-human transgenic animals |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| DK2444424T3 (en) | 2005-05-20 | 2018-12-03 | Ablynx Nv | IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS |
| TWI404727B (zh) * | 2006-01-25 | 2013-08-11 | 荷蘭鹿特丹Ｅｒａｓｍｕｓ大學醫學中心 | 對偶基因排除 |
| GB0618345D0 (en) * | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| WO2007134050A2 (en) | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
| US7731969B1 (en) | 2006-12-06 | 2010-06-08 | Neoclone Biotechnology International, Llc | Methods for developing and producing antigen-specific antibody-producing cells |
| KR102096731B1 (ko) | 2007-06-01 | 2020-04-02 | 오픈 모노클로날 테크놀로지, 인코포레이티드 | 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 |
| WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| WO2011072204A1 (en) | 2009-12-10 | 2011-06-16 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| ME03732B (me) | 2011-02-25 | 2021-01-20 | Regeneron Pharma | Miševi s ADAM6 |
| WO2012122512A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP4269602A3 (en) | 2012-12-14 | 2023-12-27 | OmniAB, Inc. | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
| WO2014141192A1 (en) | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
-
2005
- 2005-07-22 EP EP23218163.6A patent/EP4353819A3/en not_active Withdrawn
- 2005-07-22 EP EP07075586.3A patent/EP1864998B2/en not_active Expired - Lifetime
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- 2005-07-22 EP EP17173113.6A patent/EP3272770B1/en not_active Expired - Lifetime
- 2005-07-22 MX MX2007000921A patent/MX2007000921A/es active IP Right Grant
- 2005-07-22 KR KR1020117019563A patent/KR101457753B1/ko not_active Ceased
- 2005-07-22 SI SI200532162T patent/SI2311874T1/sl unknown
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- 2005-07-22 PL PL10179784T patent/PL2311874T3/pl unknown
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- 2005-07-22 US US11/658,361 patent/US20090285805A1/en not_active Abandoned
- 2005-07-22 CN CN201210057684.XA patent/CN102659941B/zh not_active Expired - Lifetime
- 2005-07-22 HU HUE10179784A patent/HUE034335T2/en unknown
- 2005-07-22 ES ES07075586T patent/ES2440990T5/es not_active Expired - Lifetime
- 2005-07-22 KR KR1020127016031A patent/KR101443473B1/ko not_active Expired - Lifetime
- 2005-07-22 SI SI200531906T patent/SI1776383T1/sl unknown
- 2005-07-22 KR KR1020077004055A patent/KR101422286B1/ko not_active Expired - Lifetime
- 2005-07-22 EP EP05766644.8A patent/EP1776383B1/en not_active Revoked
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- 2005-07-22 DK DK10179784.3T patent/DK2311874T3/en active
- 2005-07-22 PL PL05766644T patent/PL1776383T3/pl unknown
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- 2005-07-22 EP EP10179784.3A patent/EP2311874B1/en not_active Expired - Lifetime
- 2005-07-22 SG SG2013004643A patent/SG188080A1/en unknown
- 2005-07-22 BR BRPI0513577-0A patent/BRPI0513577A/pt active Search and Examination
- 2005-07-22 DK DK07075586.3T patent/DK1864998T4/da active
- 2005-07-22 PT PT101797843T patent/PT2311874T/pt unknown
- 2005-07-22 EP EP08075481A patent/EP1978032A3/en not_active Withdrawn
- 2005-07-22 KR KR1020107026625A patent/KR101151957B1/ko not_active Expired - Lifetime
- 2005-07-22 ES ES10179784.3T patent/ES2635497T3/es not_active Expired - Lifetime
- 2005-07-22 CA CA2580336A patent/CA2580336C/en not_active Expired - Lifetime
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- 2007-01-22 MX MX2012000436A patent/MX338603B/es unknown
- 2007-02-09 ZA ZA2007/01186A patent/ZA200701186B/en unknown
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