JP2015510767A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015510767A5 JP2015510767A5 JP2015500639A JP2015500639A JP2015510767A5 JP 2015510767 A5 JP2015510767 A5 JP 2015510767A5 JP 2015500639 A JP2015500639 A JP 2015500639A JP 2015500639 A JP2015500639 A JP 2015500639A JP 2015510767 A5 JP2015510767 A5 JP 2015510767A5
- Authority
- JP
- Japan
- Prior art keywords
- light chain
- antibody
- human
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611950P | 2012-03-16 | 2012-03-16 | |
| US61/611,950 | 2012-03-16 | ||
| US201261736930P | 2012-12-13 | 2012-12-13 | |
| US61/736,930 | 2012-12-13 | ||
| PCT/US2013/031823 WO2013138680A1 (en) | 2012-03-16 | 2013-03-15 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017052358A Division JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510767A JP2015510767A (ja) | 2015-04-13 |
| JP2015510767A5 true JP2015510767A5 (enExample) | 2016-05-12 |
| JP6185978B2 JP6185978B2 (ja) | 2017-08-23 |
Family
ID=48045078
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500639A Active JP6185978B2 (ja) | 2012-03-16 | 2013-03-15 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2017052358A Active JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2019029627A Active JP7304169B2 (ja) | 2012-03-16 | 2019-02-21 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2020066673A Active JP7199398B2 (ja) | 2012-03-16 | 2020-04-02 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2021183079A Withdrawn JP2022017547A (ja) | 2012-03-16 | 2021-11-10 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017052358A Active JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2019029627A Active JP7304169B2 (ja) | 2012-03-16 | 2019-02-21 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2020066673A Active JP7199398B2 (ja) | 2012-03-16 | 2020-04-02 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2021183079A Withdrawn JP2022017547A (ja) | 2012-03-16 | 2021-11-10 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US9334334B2 (enExample) |
| EP (4) | EP3808175A1 (enExample) |
| JP (5) | JP6185978B2 (enExample) |
| KR (1) | KR102228296B1 (enExample) |
| CN (3) | CN107827979A (enExample) |
| AU (3) | AU2013204579B2 (enExample) |
| BR (1) | BR112014022850A2 (enExample) |
| CA (1) | CA2865643A1 (enExample) |
| CY (2) | CY1120599T1 (enExample) |
| DK (2) | DK2825036T3 (enExample) |
| ES (3) | ES2665793T3 (enExample) |
| HR (2) | HRP20181228T1 (enExample) |
| HU (3) | HUE037659T2 (enExample) |
| IL (5) | IL234355B (enExample) |
| LT (3) | LT2825036T (enExample) |
| MX (2) | MX381210B (enExample) |
| MY (1) | MY172730A (enExample) |
| NZ (1) | NZ629639A (enExample) |
| PL (2) | PL2825036T3 (enExample) |
| PT (3) | PT3348140T (enExample) |
| RS (2) | RS57414B1 (enExample) |
| RU (2) | RU2017135754A (enExample) |
| SG (2) | SG10201607689PA (enExample) |
| SI (3) | SI2825036T1 (enExample) |
| SM (2) | SMT201800395T1 (enExample) |
| WO (1) | WO2013138680A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| EP3604330A1 (en) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| HRP20220253T1 (hr) | 2011-10-17 | 2022-04-29 | Regeneron Pharmaceuticals, Inc. | Miševi s ograničenim teškim lancem imunoglobulina |
| BR112014013081A2 (pt) | 2011-11-30 | 2020-10-20 | Chugai Seiyaku Kabushiki Kaisha | veículo contendo fármaco em célula para formação de um complexo imune |
| PT2825037T (pt) | 2012-03-16 | 2019-08-07 | Regeneron Pharma | Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| KR102484480B1 (ko) | 2012-06-12 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| LT2840892T (lt) | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| US20160068613A1 (en) | 2013-04-29 | 2016-03-10 | Hoffmann-La Roche Inc. | Fc-receptor binding modified asymmetric antibodies and methods of use |
| EP3628685A1 (en) | 2013-04-29 | 2020-04-01 | F. Hoffmann-La Roche AG | Human fcrn-binding modified antibodies and methods of use |
| CA2932364A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with improved protein a-binding |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| EP3160996B1 (en) * | 2014-06-30 | 2022-06-08 | Merck Patent GmbH | Anti-tnfa antibodies with ph-dependent antigen binding |
| KR101838645B1 (ko) * | 2014-12-19 | 2018-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| JP2018511557A (ja) * | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | ２種以上の抗ｃ５抗体の組み合わせおよび使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| HK1250038A1 (zh) | 2015-03-19 | 2018-11-23 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| EP3549606A1 (en) * | 2015-05-28 | 2019-10-09 | Bio-rad Laboratories, Inc. | Affinity ligands and methods relating thereto |
| AR107078A1 (es) * | 2015-12-18 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Anticuerpo antimiostatina, polipéptidos que contienen regiones fc variantes así como métodos de uso |
| KR102467124B1 (ko) * | 2015-12-18 | 2022-11-15 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 사용 방법 |
| MA44146B1 (fr) | 2015-12-22 | 2023-10-31 | Regeneron Pharma | Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| SI3462853T1 (sl) | 2016-06-03 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Glodavci, ki izražajo eksogeno terminalno deoksinukleotidiltransferazo |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| GB201707484D0 (en) * | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
| EP3710589A4 (en) | 2017-11-14 | 2021-11-10 | Chugai Seiyaku Kabushiki Kaisha | ANTI-C1S ANTIBODIES AND METHOD OF USING |
| WO2019175131A1 (en) * | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
| HUE070158T2 (hu) | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
| JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| KR102697702B1 (ko) | 2018-08-10 | 2024-08-22 | 추가이 세이야쿠 가부시키가이샤 | 항cd137 항원 결합 분자 및 그의 사용 |
| JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| EP3880186B1 (en) | 2018-11-14 | 2024-04-03 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
| CN113825614B (zh) | 2019-04-04 | 2023-12-01 | 日精Asb机械株式会社 | 树脂容器的制造方法、注塑芯模具、注塑模具及树脂容器的制造设备 |
| BR112021021689A2 (pt) | 2019-05-15 | 2022-03-22 | Chugai Pharmaceutical Co Ltd | Molécula de ligação a antígeno, composição farmacêutica, e método |
| MX2021014893A (es) | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos. |
| BR112022007923A2 (pt) * | 2019-10-28 | 2022-07-26 | Regeneron Pharma | Anticorpo recombinante isolado ou fragmento de ligação ao antígeno deste, composição farmacêutica, molécula de polinucleotídeo, vetor, célula, e, método para prevenir, tratar ou melhorar pelo menos um sintoma da infecção por influenza |
| US20230295330A1 (en) * | 2020-08-04 | 2023-09-21 | Seagen Inc. | Anti-cd228 antibodies and antibody-drug conjugates |
| JP2023542490A (ja) | 2020-09-03 | 2023-10-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｐｄ－１阻害剤を投与することによりがん疼痛を処置する方法 |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CA3199879A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| US20240317849A1 (en) | 2020-12-23 | 2024-09-26 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| JPWO2023149565A1 (enExample) | 2022-02-07 | 2023-08-10 | ||
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DE69130561T2 (de) | 1990-02-16 | 1999-06-24 | Boston Biomedical Research Institute, Inc., Boston, Mass. | Hybride Reagenzien mit der Fähigkeit, Moleküle selektiv in Zellen freizusetzen |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス，インク． | 異種抗体の生産 |
| US5999908A (en) | 1992-08-06 | 1999-12-07 | Abelow; Daniel H. | Customer-based product design module |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0773288A3 (en) | 1995-08-29 | 1997-07-09 | Kirin Brewery | Chimera animal and its method of manufacture |
| SI0970126T1 (en) | 1997-04-14 | 2001-08-31 | Micromet Ag | Novel method for the production of antihuman antigen receptors and uses thereof |
| DK0979281T3 (da) | 1997-05-02 | 2005-11-21 | Genentech Inc | Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| AU750453B2 (en) | 1997-10-03 | 2002-07-18 | Chugai Seiyaku Kabushiki Kaisha | Natural human antibody |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| WO2002020767A2 (en) | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20030108925A1 (en) | 2001-10-05 | 2003-06-12 | U.S. Epa | Genetic testing for male factor infertility |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| EP3269235B1 (en) | 2001-11-30 | 2022-01-26 | Amgen Fremont Inc. | Transgenic mice bearing human ig lambda light chain genes |
| WO2003107009A2 (en) | 2002-06-12 | 2003-12-24 | Genencor International, Inc. | Methods for improving a binding characteristic of a molecule |
| EP1511861A4 (en) | 2002-06-12 | 2007-12-05 | Genencor Int | METHODS AND BINDING COMPOSITIONS DEPENDENT FROM THE MEDIUM OF A TARGET AGENT TO A TARGET |
| PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
| EP1439234A1 (en) | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Targeted transgenesis using the rosa26 locus |
| JP4477579B2 (ja) | 2003-01-21 | 2010-06-09 | 中外製薬株式会社 | 抗体の軽鎖スクリーニング方法 |
| EP2395016A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| CN1852925A (zh) | 2003-07-15 | 2006-10-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| CN1560081A (zh) | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用 |
| US7276585B2 (en) | 2004-03-24 | 2007-10-02 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| CN101132811B (zh) | 2004-10-22 | 2012-05-30 | 米迪缪尼有限公司 | 抗hmgb1的高亲和力抗体及其用法 |
| WO2006117699A2 (en) | 2005-04-29 | 2006-11-09 | Innate Pharma | Transgenic animals and methods of making recombinant antibodies |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| AU2007235496B2 (en) | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| RS52176B (sr) | 2006-06-02 | 2012-08-31 | Regeneron Pharmaceuticals Inc. | Antitela visokog afiniteta prema humanom il-6 receptoru |
| WO2008054606A2 (en) | 2006-10-02 | 2008-05-08 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| US8551968B2 (en) | 2007-03-13 | 2013-10-08 | National Jewish Health | Methods for generation of antibodies |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| JP5933894B2 (ja) | 2007-09-14 | 2016-06-15 | アディマブ， エルエルシー | 合理的に設計された、合成抗体ライブラリおよびその使用 |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| JP5591712B2 (ja) | 2007-12-14 | 2014-09-17 | ノボ・ノルデイスク・エー／エス | ヒトｎｋｇ２ｄに対する抗体とその使用 |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| US9315577B2 (en) * | 2008-05-01 | 2016-04-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| PT3456190T (pt) | 2008-06-27 | 2022-02-15 | Merus Nv | Animal murino transgénico produtor de anticorpo |
| TWI516501B (zh) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Ｐｃｓｋ９拮抗劑類 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| KR101987351B1 (ko) | 2008-09-30 | 2019-06-10 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| RU2011129459A (ru) | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| RU2011149353A (ru) | 2009-05-07 | 2013-06-20 | Вольво Констракшн Эквипмент Аб | Рабочая машина и способ управления ее работой |
| NZ596603A (en) | 2009-05-29 | 2013-07-26 | Morphosys Ag | A collection of antibodies or fragments having properties relevant to developability |
| KR101747103B1 (ko) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| CA2767957C (en) | 2009-07-16 | 2020-08-25 | Wageningen Universiteit | Regulation of zinc deficiency and tolerance in plants |
| GB2472108B (en) * | 2009-08-27 | 2011-07-13 | Budha Singh Dhinjan | Wall bead |
| WO2011072204A1 (en) | 2009-12-10 | 2011-06-16 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| EP2545079A2 (en) | 2010-03-11 | 2013-01-16 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| TWI667257B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的ＦｃＲｎ親和力之抗體 |
| AU2011266843C9 (en) | 2010-06-17 | 2018-03-01 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201504568YA (en) | 2010-06-22 | 2015-07-30 | Regeneron Pharma | Hybrid light chain mice |
| ME03732B (me) | 2011-02-25 | 2021-01-20 | Regeneron Pharma | Miševi s ADAM6 |
| HRP20192255T1 (hr) | 2011-08-05 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi s univerzalnim lakim lancem |
| CN113061993A (zh) | 2011-09-30 | 2021-07-02 | 中外制药株式会社 | 离子浓度依赖性结合分子文库 |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| CA2865029A1 (en) | 2012-03-06 | 2013-09-12 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| PT2825037T (pt) | 2012-03-16 | 2019-08-07 | Regeneron Pharma | Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph |
| CN104582476B (zh) | 2012-06-05 | 2017-03-08 | 瑞泽恩制药公司 | 使用共同轻链制备完全人双特异性抗体的方法 |
| LT2840892T (lt) | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
-
2013
- 2013-03-15 SM SM20180395T patent/SMT201800395T1/it unknown
- 2013-03-15 CA CA2865643A patent/CA2865643A1/en active Pending
- 2013-03-15 MX MX2018005293A patent/MX381210B/es unknown
- 2013-03-15 ES ES15151655.6T patent/ES2665793T3/es active Active
- 2013-03-15 BR BR112014022850A patent/BR112014022850A2/pt not_active Application Discontinuation
- 2013-03-15 HU HUE15151655A patent/HUE037659T2/hu unknown
- 2013-03-15 MY MYPI2014002400A patent/MY172730A/en unknown
- 2013-03-15 DK DK13713652.9T patent/DK2825036T3/en active
- 2013-03-15 LT LTEP13713652.9T patent/LT2825036T/lt unknown
- 2013-03-15 RU RU2017135754A patent/RU2017135754A/ru not_active Application Discontinuation
- 2013-03-15 PT PT181589607T patent/PT3348140T/pt unknown
- 2013-03-15 RS RS20180718A patent/RS57414B1/sr unknown
- 2013-03-15 AU AU2013204579A patent/AU2013204579B2/en active Active
- 2013-03-15 HU HUE18158960A patent/HUE053310T2/hu unknown
- 2013-03-15 HU HUE13713652A patent/HUE039573T2/hu unknown
- 2013-03-15 SI SI201331088T patent/SI2825036T1/en unknown
- 2013-03-15 KR KR1020147025407A patent/KR102228296B1/ko active Active
- 2013-03-15 SI SI201331847T patent/SI3348140T1/sl unknown
- 2013-03-15 EP EP20208322.6A patent/EP3808175A1/en active Pending
- 2013-03-15 EP EP18158960.7A patent/EP3348140B1/en active Active
- 2013-03-15 DK DK15151655.6T patent/DK2883449T3/en active
- 2013-03-15 PT PT137136529T patent/PT2825036T/pt unknown
- 2013-03-15 SI SI201330992T patent/SI2883449T1/en unknown
- 2013-03-15 CN CN201710968763.9A patent/CN107827979A/zh active Pending
- 2013-03-15 PL PL13713652T patent/PL2825036T3/pl unknown
- 2013-03-15 ES ES13713652.9T patent/ES2679369T3/es active Active
- 2013-03-15 RS RS20180416A patent/RS57118B1/sr unknown
- 2013-03-15 SG SG10201607689PA patent/SG10201607689PA/en unknown
- 2013-03-15 MX MX2014011051A patent/MX355732B/es active IP Right Grant
- 2013-03-15 HR HRP20181228TT patent/HRP20181228T1/hr unknown
- 2013-03-15 ES ES18158960T patent/ES2849349T3/es active Active
- 2013-03-15 SG SG11201405165UA patent/SG11201405165UA/en unknown
- 2013-03-15 PT PT151516556T patent/PT2883449T/pt unknown
- 2013-03-15 EP EP15151655.6A patent/EP2883449B1/en active Active
- 2013-03-15 NZ NZ629639A patent/NZ629639A/en not_active IP Right Cessation
- 2013-03-15 US US13/832,247 patent/US9334334B2/en active Active
- 2013-03-15 SM SM20180229T patent/SMT201800229T1/it unknown
- 2013-03-15 CN CN201710968748.4A patent/CN107840890A/zh active Pending
- 2013-03-15 EP EP13713652.9A patent/EP2825036B1/en active Active
- 2013-03-15 LT LTEP15151655.6T patent/LT2883449T/lt unknown
- 2013-03-15 WO PCT/US2013/031823 patent/WO2013138680A1/en not_active Ceased
- 2013-03-15 CN CN201380025684.4A patent/CN104302169B/zh active Active
- 2013-03-15 PL PL15151655T patent/PL2883449T3/pl unknown
- 2013-03-15 RU RU2014141537A patent/RU2644684C2/ru not_active IP Right Cessation
- 2013-03-15 LT LTEP18158960.7T patent/LT3348140T/lt unknown
- 2013-03-15 JP JP2015500639A patent/JP6185978B2/ja active Active
-
2014
- 2014-07-23 US US14/339,376 patent/US9422370B2/en active Active
- 2014-08-28 IL IL234355A patent/IL234355B/en active IP Right Grant
-
2016
- 2016-02-10 IL IL244097A patent/IL244097A/en active IP Right Grant
- 2016-04-13 AU AU2016202323A patent/AU2016202323B2/en active Active
- 2016-07-14 US US15/210,506 patent/US11192947B2/en active Active
-
2017
- 2017-03-17 JP JP2017052358A patent/JP6574802B2/ja active Active
- 2017-08-01 IL IL253775A patent/IL253775B/en active IP Right Grant
-
2018
- 2018-04-30 HR HRP20180682TT patent/HRP20180682T1/hr unknown
- 2018-05-07 CY CY181100476T patent/CY1120599T1/el unknown
- 2018-05-25 AU AU2018203713A patent/AU2018203713B2/en active Active
- 2018-08-01 CY CY20181100797T patent/CY1120491T1/el unknown
-
2019
- 2019-02-21 JP JP2019029627A patent/JP7304169B2/ja active Active
-
2020
- 2020-01-30 IL IL272357A patent/IL272357B/en active IP Right Grant
- 2020-04-02 JP JP2020066673A patent/JP7199398B2/ja active Active
-
2021
- 2021-04-20 IL IL282452A patent/IL282452B/en unknown
- 2021-11-10 JP JP2021183079A patent/JP2022017547A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015510767A5 (enExample) | ||
| WO2013138680A4 (en) | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same | |
| WO2015042250A4 (en) | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same | |
| JP2015525071A5 (enExample) | ||
| JP2015505477A5 (enExample) | ||
| JP2018138047A5 (enExample) | ||
| WO2014160202A4 (en) | Mice expressing a limited immunoglobulin light chain repertoire | |
| JP2015519055A5 (enExample) | ||
| JP2015509380A5 (enExample) | ||
| HRP20191333T1 (hr) | Glodavci koji izražavaju sekvence imunoglobulina osjetljive na ph vrijednost | |
| JP2015502177A5 (enExample) | ||
| RU2014133653A (ru) | Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl | |
| JP2015510769A5 (enExample) | ||
| JP2015519076A5 (enExample) | ||
| HRP20201403T1 (hr) | Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca | |
| JP2016512034A5 (enExample) | ||
| JP2020530760A5 (enExample) | ||
| JP2016127840A5 (enExample) | ||
| JP2014524243A5 (enExample) | ||
| JP2017509355A5 (enExample) | ||
| SI2840892T1 (en) | Animals other than humans with modified immunoglobulin heavy chain sequences | |
| RU2018119366A (ru) | Мыши с гуманизированной легкой цепью | |
| FI3865581T3 (fi) | Humanisoituja universaaleja kevytketjun hiiriä | |
| JP2014110814A5 (enExample) | ||
| HRP20170322T1 (hr) | Miševi koji stvaraju vl vezne proteine |