|
GB8626412D0
(en)
|
1986-11-05 |
1986-12-03 |
Clark M R |
Antibodies
|
|
GB8626413D0
(en)
|
1986-11-05 |
1986-12-03 |
Gilliland L K |
Antibodies
|
|
DE68929167T2
(de)
|
1988-09-06 |
2000-11-16 |
Xoma Corp., Berkeley |
Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-Antikörpern
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
|
US5574205A
(en)
|
1989-07-25 |
1996-11-12 |
Cell Genesys |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
CA2351200A1
(en)
|
1989-12-01 |
1991-06-13 |
Gene Pharming Europe Bv |
Production of recombinant polypeptides by bovine species and transgenic methods
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US6657103B1
(en)
|
1990-01-12 |
2003-12-02 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US7084260B1
(en)
|
1996-10-10 |
2006-08-01 |
Genpharm International, Inc. |
High affinity human antibodies and human antibodies against human antigens
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US7041871B1
(en)
|
1995-10-10 |
2006-05-09 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US7067284B1
(en)
|
1992-01-27 |
2006-06-27 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
ES2301158T3
(es)
|
1992-07-24 |
2008-06-16 |
Amgen Fremont Inc. |
Produccion de anticuerpos xenogenicos.
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
CZ140195A3
(en)
|
1992-12-01 |
1996-06-12 |
Protein Desing Labs |
Humanized antibodies reacting with l-selectin
|
|
GB9308271D0
(en)
|
1993-04-21 |
1993-06-02 |
Univ Edinburgh |
Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
|
|
US5877396A
(en)
|
1993-04-23 |
1999-03-02 |
Sloan Kettering Institute For Cancer Research |
Mice mutant for functional Fc receptors and method of treating autoimmune diseases
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
US5693506A
(en)
|
1993-11-16 |
1997-12-02 |
The Regents Of The University Of California |
Process for protein production in plants
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
WO1995017500A1
(en)
|
1993-12-23 |
1995-06-29 |
Abs Global, Inc. |
Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
|
|
GB9401380D0
(en)
|
1994-01-25 |
1994-03-23 |
Pharmaceutical Proteins Ltd |
Embryonic cell isolation
|
|
DE69534347T2
(de)
|
1994-01-31 |
2006-05-24 |
Trustees Of Boston University, Boston |
Bibliotheken aus Polyklonalen Antikörpern
|
|
US7119248B1
(en)
|
1994-04-12 |
2006-10-10 |
Miltenyi Biotec Gmbh |
Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
|
|
US6080560A
(en)
|
1994-07-25 |
2000-06-27 |
Monsanto Company |
Method for producing antibodies in plant cells
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
CA2246333A1
(en)
|
1996-03-05 |
1997-09-12 |
The Scripps Research Institute |
Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
|
|
EP0826696B1
(de)
|
1996-09-03 |
2002-05-29 |
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH |
Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität
|
|
CA2722378C
(en)
|
1996-12-03 |
2015-02-03 |
Amgen Fremont Inc. |
Human antibodies that bind tnf.alpha.
|
|
AU745334B2
(en)
|
1997-03-06 |
2002-03-21 |
Advanced Cell Technology, Inc. |
Method of cloning animals
|
|
CN1203922A
(zh)
|
1997-03-21 |
1999-01-06 |
三共株式会社 |
人源化抗人fas抗体
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
US20020062010A1
(en)
*
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US6774279B2
(en)
|
1997-05-30 |
2004-08-10 |
Carnegie Institution Of Washington |
Use of FLP recombinase in mice
|
|
RU2221809C2
(ru)
|
1997-10-03 |
2004-01-20 |
Тугаи Сейяку Кабусики Кайся |
Способ получения природного гуманизированного антитела
|
|
WO1999025821A1
(en)
|
1997-11-18 |
1999-05-27 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for genetic modification of plants
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
RU10506U1
(ru)
|
1999-04-08 |
1999-08-16 |
Кривулин Виталий Николаевич |
Ручной культиватор
|
|
HK1048138B
(zh)
|
1999-04-15 |
2009-06-12 |
荷兰克鲁塞尔公司 |
用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白
|
|
AU5043200A
(en)
|
1999-05-27 |
2000-12-18 |
Human Genome Sciences, Inc. |
Adam polynucleotides and polypeptides
|
|
GB0001448D0
(en)
|
2000-01-21 |
2000-03-08 |
Novartis Ag |
Organic compounds
|
|
EP1268832A4
(en)
|
2000-02-29 |
2003-04-02 |
Univ Auburn |
PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTIDES
|
|
RU2262511C2
(ru)
|
2000-05-18 |
2005-10-20 |
Джапан Тобакко, Инк. |
Человеческое моноклональное антитело против ailim, костимулирующей молекулы передачи сигнала, и его фармацевтическое применение
|
|
CA2409991A1
(en)
|
2000-05-24 |
2001-11-29 |
Imclone Systems Incorporated |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
BR0112633A
(pt)
|
2000-07-21 |
2003-09-16 |
Us Agriculture |
Método para substituir, translocar e empilhar dna em genomas eucarióticos
|
|
EA013564B1
(ru)
|
2000-08-03 |
2010-06-30 |
Терапеутик Хьюман Поликлоналз Инк. |
Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
|
|
EP1184458A1
(en)
|
2000-08-28 |
2002-03-06 |
U-BISys B.V. |
Differentially expressed CD46 epitopes, proteinaceous molecules capable of binding thereto, and uses thereof
|
|
US20020119148A1
(en)
|
2000-09-01 |
2002-08-29 |
Gerritsen Mary E. |
ErbB4 antagonists
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7449179B2
(en)
|
2000-11-16 |
2008-11-11 |
Cornell Research Foundation, Inc. |
Vectors for conditional gene inactivation
|
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
DE10064750A1
(de)
|
2000-12-22 |
2002-06-27 |
Bayer Ag |
Verfahren zur Herstellung von 1,6-Hexandiolen
|
|
ME00502B
(me)
|
2001-01-05 |
2011-10-10 |
Amgen Fremont Inc |
Antitjela za insulinu sličan receptor faktora i rasta
|
|
US6961875B2
(en)
|
2001-03-22 |
2005-11-01 |
International Business Machines Corporation |
Method and apparatus for capturing event traces for debug and analysis
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
US7034134B2
(en)
|
2001-04-26 |
2006-04-25 |
Bristol-Myers Squibb Company |
Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
|
|
US7074611B2
(en)
|
2001-04-27 |
2006-07-11 |
Gie-Cerbn, Centre Europeen De Recherche En Biologie Et En Medecine (Gie) |
Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof
|
|
CN1789416B
(zh)
|
2001-05-11 |
2011-11-16 |
协和发酵麒麟株式会社 |
含人抗体λ轻链基因的人类人工染色体
|
|
DK1399484T3
(da)
|
2001-06-28 |
2010-11-08 |
Domantis Ltd |
Dobbelt-specifik ligand og anvendelse af denne
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
EP1578917A4
(en)
|
2001-07-19 |
2008-01-23 |
Perlan Therapeutics Inc |
MULTIMEDIA PROTEINS AND METHODS FOR THE PRODUCTION AND USE THEREOF
|
|
PT1652920E
(pt)
|
2001-10-01 |
2010-11-08 |
Deutsches Krebsforsch |
Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma
|
|
US20030108925A1
(en)
|
2001-10-05 |
2003-06-12 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
US20060199204A1
(en)
|
2001-10-05 |
2006-09-07 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
EP2319301B1
(en)
|
2001-11-30 |
2017-09-06 |
Amgen Fremont Inc. |
Transgenic animals bearing human Ig lambda light chain genes
|
|
GB0130267D0
(en)
|
2001-12-19 |
2002-02-06 |
Neutec Pharma Plc |
Focussed antibody technology
|
|
WO2003061363A2
(en)
|
2002-01-17 |
2003-07-31 |
Albert Einstein College Of Medicine Of Yeshiva University |
Mutations caused by activation-induced cytidine deaminase
|
|
EP1470161A1
(en)
|
2002-01-18 |
2004-10-27 |
Inovio AS |
Bispecific antibody dna constructs for intramuscular administration
|
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
|
WO2003092611A2
(en)
|
2002-05-03 |
2003-11-13 |
Regeneron Pharmaceuticals, Inc. |
Methods of inducing formation of functional and organized lymphatic vessels
|
|
ES2524767T3
(es)
|
2002-06-14 |
2014-12-12 |
Immunomedics, Inc. |
Anticuerpo monoclonal humanizado HPAM4
|
|
CN101962408A
(zh)
|
2002-07-12 |
2011-02-02 |
杰斐逊·富特 |
超人源化抗体
|
|
DK2314629T4
(da)
*
|
2002-07-18 |
2023-02-06 |
Merus Nv |
Rekombinant produktion af blandinger af antistoffer
|
|
CL2003002461A1
(es)
|
2002-11-27 |
2005-01-07 |
Dow Chemical Company Agroscien |
Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
GB0230201D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Retargeting
|
|
EP1439234A1
(en)
|
2003-01-08 |
2004-07-21 |
ARTEMIS Pharmaceuticals GmbH |
Targeted transgenesis using the rosa26 locus
|
|
US8337841B2
(en)
|
2003-01-21 |
2012-12-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening for antibody light chains
|
|
EP3202899B1
(en)
|
2003-01-28 |
2020-10-21 |
Cellectis |
Custom-made meganuclease and use thereof
|
|
EP1606387A4
(en)
|
2003-03-04 |
2008-04-23 |
Alexion Pharma Inc |
VECTORS USED TO PRODUCE CONSTANT HYBRID AREAS
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
US7205148B2
(en)
|
2003-06-11 |
2007-04-17 |
Regeneron Pharmaceuticals, Inc. |
Genome mutation by intron insertion into an embryonic stem cell genome
|
|
ES2473596T3
(es)
|
2003-07-15 |
2014-07-07 |
Therapeutic Human Polyclonals, Inc. |
Loci de inmunoglobulina humanizada
|
|
US20050153392A1
(en)
|
2003-08-11 |
2005-07-14 |
Roland Buelow |
Transgenesis with humanized immunoglobulin loci
|
|
RU2251699C1
(ru)
|
2003-09-25 |
2005-05-10 |
Киселев Всеволод Иванович |
Способ ранней и доклинической диагностики цервикального рака
|
|
WO2005038001A2
(en)
|
2003-10-14 |
2005-04-28 |
Therapeutic Human Polyclonals, Inc. |
Improved transgenesis by sperm-mediated gene transfer
|
|
DK1709081T3
(da)
|
2004-01-16 |
2011-06-06 |
Regeneron Pharma |
Fusionspolypeptider, der kan aktivere receptorer
|
|
WO2005078098A1
(en)
|
2004-02-12 |
2005-08-25 |
The Walter And Eliza Hall Institute Of Medical Research |
Modified cells that co-express blimp1 and a reporter molecule and methods of using the same
|
|
CN1560081A
(zh)
|
2004-02-17 |
2005-01-05 |
大连帝恩生物工程有限公司 |
用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用
|
|
US7625549B2
(en)
|
2004-03-19 |
2009-12-01 |
Amgen Fremont Inc. |
Determining the risk of human anti-human antibodies in transgenic mice
|
|
ES2463476T3
(es)
|
2004-10-19 |
2014-05-28 |
Regeneron Pharmaceuticals, Inc. |
Método para generar un ratón homocigótico para una modificación genética
|
|
US20080184380A1
(en)
|
2004-10-22 |
2008-07-31 |
Therapeutic Human Polyclonals Inc. |
Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals
|
|
WO2007001422A2
(en)
*
|
2004-10-22 |
2007-01-04 |
Medimmune, Inc. |
High affinity antibodies against hmgb1 and methods of use thereof
|
|
DK1815001T3
(da)
|
2004-11-26 |
2011-05-16 |
Helmholtz Zentrum Muenchen |
Genfældekassetter til tilfældig og målrettet konditioneret geninaktivering
|
|
EP1662005A1
(en)
|
2004-11-26 |
2006-05-31 |
FrankGen Biotechnologie AG |
Enhancer-containing gene trap vectors for random and targeted gene trapping
|
|
US20110041370A1
(en)
|
2005-04-21 |
2011-02-24 |
Saint Andre M |
Face sheet, identification band, and related methods
|
|
AU2006242854A1
(en)
|
2005-04-29 |
2006-11-09 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Transgenic animals and methods of making recombinant antibodies
|
|
AU2005331864A1
(en)
|
2005-05-14 |
2006-11-23 |
Fudan University |
Piggybac as a tool for genetic manipulation and analysis in vertebrates
|
|
CA2609142C
(en)
|
2005-05-27 |
2016-02-09 |
Fondazione Centro San Raffaele Del Monte Tabor |
Therapeutic gene vectors comprising mirna target sequences
|
|
DE602005011421D1
(de)
|
2005-06-30 |
2009-01-15 |
Borealis Tech Oy |
Überzug-Schicht für Energie- oder Kommunikationskabel
|
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
|
US7850965B2
(en)
|
2005-12-05 |
2010-12-14 |
Symphogen A/S |
Anti-orthopoxvirus recombinant polyclonal antibody
|
|
AU2007219159B8
(en)
|
2006-01-25 |
2012-06-28 |
Roger Kingdon Craig |
Generation of heavy-chain only antibodies in transgenic animals
|
|
GB2434578A
(en)
|
2006-01-26 |
2007-08-01 |
Univ Basel |
Transgenic animals
|
|
US7462759B2
(en)
|
2006-02-03 |
2008-12-09 |
Pioneer Hi-Bred International, Inc. |
Brittle stalk 2 gene family and related methods and uses
|
|
GB0615327D0
(en)
|
2006-03-30 |
2006-09-13 |
Univ Edinburgh |
Culture medium containing kinase inhibitors and uses thereof
|
|
AU2007235496B2
(en)
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
JP5307708B2
(ja)
|
2006-06-02 |
2013-10-02 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒトｉｌ−６受容体に対する高親和性抗体
|
|
US20090217397A1
(en)
|
2006-06-12 |
2009-08-27 |
Patrick Stern |
Cre-lox based gene knockdown constructs and methods of use thereof
|
|
JP2010501165A
(ja)
|
2006-08-22 |
2010-01-21 |
ジーツー インフラメイション プロプライエタリー リミテッド |
抗体の作製方法
|
|
PE20081216A1
(es)
|
2006-09-01 |
2008-09-04 |
Therapeutic Human Polyclonals Inc |
Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos
|
|
MY149079A
(en)
|
2006-10-02 |
2013-07-15 |
Regeneron Pharma |
High affinity human antibodies to human il-4 receptor
|
|
US7608693B2
(en)
|
2006-10-02 |
2009-10-27 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human IL-4 receptor
|
|
RU2448979C2
(ru)
|
2006-12-14 |
2012-04-27 |
Ридженерон Фармасьютикалз, Инк. |
Антитела человека к дельта-подобному лиганду-4 человека
|
|
GB0700194D0
(en)
|
2007-01-05 |
2007-02-14 |
Univ Edinburgh |
Humanisation of animals
|
|
WO2008112226A2
(en)
|
2007-03-13 |
2008-09-18 |
Massachusetts Institute Of Technology |
Cre-lox based gene knockdown constructs and methods of use thereof
|
|
EP2583551A1
(en)
|
2007-03-13 |
2013-04-24 |
National Jewish Health |
Methods for generation of antibodies
|
|
GB0706628D0
(en)
|
2007-04-04 |
2007-05-16 |
Univ Erasmus |
Germ-line manipulation 1
|
|
PL2602323T3
(pl)
|
2007-06-01 |
2018-06-29 |
Open Monoclonal Technology, Inc. |
Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego
|
|
WO2009013620A2
(en)
|
2007-06-11 |
2009-01-29 |
Erasmus University Medical Center Rotterdam |
Homologous recombination
|
|
ITMI20071522A1
(it)
|
2007-07-27 |
2009-01-28 |
Areta Internat S R L |
Vaccino idiotipico
|
|
JP5588866B2
(ja)
|
2007-08-10 |
2014-09-10 |
メダレックス エル．エル．シー． |
Ｈｃｏ３２およびｈｃｏ２７、ならびに関連実施例
|
|
JP2010536341A
(ja)
|
2007-08-15 |
2010-12-02 |
アムニクス， インコーポレイテッド |
生物学的に活性なポリペプチドの特性を改変するための組成物および方法
|
|
US8426565B2
(en)
|
2007-08-30 |
2013-04-23 |
Walter And Eliza Hall Institute Of Medical Research |
Dendritic cell marker and uses thereof
|
|
EP3124497B1
(en)
|
2007-09-14 |
2020-04-15 |
Adimab, LLC |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP2050764A1
(en)
|
2007-10-15 |
2009-04-22 |
sanofi-aventis |
Novel polyvalent bispecific antibody format and uses thereof
|
|
US8536310B2
(en)
|
2007-10-17 |
2013-09-17 |
Arca Biopharma, Inc. |
Antibodies to CLL-1
|
|
US7659842B2
(en)
|
2007-10-24 |
2010-02-09 |
Infineon Technologies Ag |
Quantization error reduction in PWM full-MASH converters
|
|
AU2008337517B2
(en)
|
2007-12-14 |
2014-06-26 |
Novo Nordisk A/S |
Antibodies against human NKG2D and uses thereof
|
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法
|
|
TWI476280B
(zh)
|
2008-03-07 |
2015-03-11 |
Regeneron Pharma |
來自二倍體宿主胚胎注射之ｅｓ－細胞衍生的老鼠
|
|
US8012714B2
(en)
|
2008-04-14 |
2011-09-06 |
Innovative Targeting Solutions, Inc. |
Sequence diversity generation in immunoglobulins
|
|
EP2669298A3
(en)
|
2008-05-23 |
2014-02-26 |
Ablexis, LLC |
Single variable immunoglobulin domain comprising VL-DH-JL
|
|
EP2147594B1
(en)
*
|
2008-06-27 |
2013-11-13 |
Merus B.V. |
Antibody producing non-human mammals
|
|
AU2009298458B2
(en)
|
2008-09-30 |
2015-10-08 |
Ablexis, Llc |
Non-human mammals for the production of chimeric antibodies
|
|
CA2742969A1
(en)
|
2008-11-07 |
2010-05-14 |
Fabrus Llc |
Anti-dll4 antibodies and uses thereof
|
|
US8497325B2
(en)
|
2008-12-15 |
2013-07-30 |
Exxonmobil Chemical Patents Inc. |
Thermoplastic polyolefin blends and films therefrom
|
|
JP5827127B2
(ja)
|
2008-12-18 |
2015-12-02 |
エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム |
ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
|
|
CA2753287A1
(en)
|
2009-02-24 |
2010-09-02 |
Glaxo Group Limited |
Antigen-binding constructs
|
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
|
CN102427978B
(zh)
|
2009-05-07 |
2016-01-20 |
沃尔沃建筑设备公司 |
工程机械和用于操作工程机械的方法
|
|
CA2758356C
(en)
|
2009-05-29 |
2016-07-26 |
Morphosys Ag |
A collection of vh and vl pairs having favourable biophysical properties and methods for its use
|
|
MY192182A
(en)
|
2009-06-26 |
2022-08-04 |
Regeneron Pharma |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
DK3622815T3
(da)
|
2009-07-08 |
2023-06-26 |
Kymab Ltd |
Gnavermodeller og terapeutiske molekyler
|
|
RU2425880C2
(ru)
*
|
2009-07-30 |
2011-08-10 |
Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН |
Способ получения трансгенных мышей
|
|
EP2502993B1
(en)
|
2009-11-17 |
2017-07-26 |
Sanford Applied Biosciences L.L.C. |
Human artificial chromosome vector
|
|
ES2724975T3
(es)
|
2009-12-10 |
2019-09-18 |
Regeneron Pharma |
Ratones que producen anticuerpos de cadena pesada
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US20130185821A1
(en)
|
2010-02-08 |
2013-07-18 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
SMT202600080T1
(it)
|
2010-02-08 |
2026-03-09 |
Regeneron Pharma |
Topo con catena leggera comune
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US9527926B2
(en)
|
2010-05-14 |
2016-12-27 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
CN103228130B
(zh)
|
2010-06-17 |
2016-03-16 |
科马布有限公司 |
动物模型及治疗分子
|
|
PT3034608T
(pt)
|
2010-06-22 |
2019-05-28 |
Regeneron Pharma |
Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana
|
|
SMT201700023T1
(it)
|
2010-08-02 |
2017-03-08 |
Regeneron Pharma |
Topi che producono proteine leganti vl
|
|
EP2638155A1
(en)
|
2010-11-08 |
2013-09-18 |
Kymab Limited |
Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
|
|
ME02106B
(me)
|
2011-02-25 |
2015-10-20 |
Regeneron Pharma |
Miševi sa adam6
|
|
HUE047278T2
(hu)
|
2011-08-05 |
2020-04-28 |
Regeneron Pharma |
Humanizált univerzális könnyûláncú egerek
|
|
US20130044257A1
(en)
|
2011-08-18 |
2013-02-21 |
Lattice Energy Technology Corporation |
Mobile device with side-mounted camera module
|
|
BR112014006394A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
|
|
EP2758534B1
(en)
|
2011-09-19 |
2020-04-29 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
CA2791109C
(en)
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|
|
SG11201401181YA
(en)
|
2011-10-17 |
2014-04-28 |
Regeneron Pharma |
Restricted immunoglobulin heavy chain mice
|
|
GB2496375A
(en)
|
2011-10-28 |
2013-05-15 |
Kymab Ltd |
A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
SG10201605675WA
(en)
|
2011-12-20 |
2016-09-29 |
Regeneron Pharma |
Humanized light chain mice
|
|
EP3597038B1
(en)
|
2012-02-01 |
2021-04-21 |
Regeneron Pharmaceuticals, Inc. |
Humanized rodents that express heavy chains containing vl domains
|
|
US9248181B2
(en)
|
2012-04-20 |
2016-02-02 |
Merus B.V. |
Methods and means for the production of Ig-like molecules
|
|
ME03551B
(me)
|
2012-06-12 |
2020-07-20 |
Regeneron Pharma |
Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca
|
|
HK1218550A1
(zh)
|
2013-03-13 |
2017-02-24 |
Regeneron Pharmaceuticals, Inc. |
常見輕鏈小鼠
|
|
EP4545567A3
(en)
|
2013-03-13 |
2025-08-13 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|