JP2015505477A5 - - Google Patents
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- JP2015505477A5 JP2015505477A5 JP2014555736A JP2014555736A JP2015505477A5 JP 2015505477 A5 JP2015505477 A5 JP 2015505477A5 JP 2014555736 A JP2014555736 A JP 2014555736A JP 2014555736 A JP2014555736 A JP 2014555736A JP 2015505477 A5 JP2015505477 A5 JP 2015505477A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- gene
- light chain
- chain constant
- rodent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 103
- 241000283984 Rodentia Species 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 18
- 150000007523 nucleic acids Chemical group 0.000 claims description 16
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 15
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 12
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 10
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 9
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 108091008324 binding proteins Proteins 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 8
- 230000037431 insertion Effects 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 8
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 2
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 2
- 102000025171 antigen binding proteins Human genes 0.000 claims description 2
- 108091000831 antigen binding proteins Proteins 0.000 claims description 2
- 230000008030 elimination Effects 0.000 claims description 2
- 238000003379 elimination reaction Methods 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 102000023732 binding proteins Human genes 0.000 claims 4
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
- 102100022964 Immunoglobulin kappa variable 3-20 Human genes 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261593463P | 2012-02-01 | 2012-02-01 | |
| US61/593,463 | 2012-02-01 | ||
| US201261677538P | 2012-07-31 | 2012-07-31 | |
| US61/677,538 | 2012-07-31 | ||
| PCT/US2013/024295 WO2013116609A1 (en) | 2012-02-01 | 2013-02-01 | Humanized rodents that express heavy chains containing vl domains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018022012A Division JP6698718B2 (ja) | 2012-02-01 | 2018-02-09 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015505477A JP2015505477A (ja) | 2015-02-23 |
| JP2015505477A5 true JP2015505477A5 (enExample) | 2016-03-03 |
Family
ID=47714588
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555736A Withdrawn JP2015505477A (ja) | 2012-02-01 | 2013-02-01 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2018022012A Active JP6698718B2 (ja) | 2012-02-01 | 2018-02-09 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2019130027A Active JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2021099420A Active JP7187615B2 (ja) | 2012-02-01 | 2021-06-15 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2022191963A Active JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2023173593A Pending JP2023168590A (ja) | 2012-02-01 | 2023-10-05 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018022012A Active JP6698718B2 (ja) | 2012-02-01 | 2018-02-09 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2019130027A Active JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2021099420A Active JP7187615B2 (ja) | 2012-02-01 | 2021-06-15 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2022191963A Active JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2023173593A Pending JP2023168590A (ja) | 2012-02-01 | 2023-10-05 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20130212719A1 (enExample) |
| EP (3) | EP3597038B1 (enExample) |
| JP (6) | JP2015505477A (enExample) |
| KR (2) | KR20190006029A (enExample) |
| CN (2) | CN104202971B (enExample) |
| AU (3) | AU2013204758B2 (enExample) |
| BR (1) | BR112014018843B1 (enExample) |
| CA (1) | CA2863175A1 (enExample) |
| CY (2) | CY1122419T1 (enExample) |
| DK (2) | DK3597038T3 (enExample) |
| ES (2) | ES2753774T3 (enExample) |
| HR (2) | HRP20192218T1 (enExample) |
| HU (2) | HUE055610T2 (enExample) |
| IL (3) | IL233827A0 (enExample) |
| LT (2) | LT3597038T (enExample) |
| ME (1) | ME03611B (enExample) |
| MX (2) | MX2020003491A (enExample) |
| NZ (5) | NZ793447A (enExample) |
| PL (2) | PL3597038T3 (enExample) |
| PT (2) | PT2809150T (enExample) |
| RS (2) | RS62023B1 (enExample) |
| RU (2) | RU2770016C2 (enExample) |
| SG (3) | SG10201606256TA (enExample) |
| SI (2) | SI3597038T1 (enExample) |
| SM (2) | SMT202100401T1 (enExample) |
| WO (1) | WO2013116609A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2669298A3 (en) * | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| RS66089B1 (sr) | 2011-08-05 | 2024-11-29 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| EP3839049A3 (en) | 2011-09-19 | 2021-10-20 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SI2793567T1 (sl) | 2011-12-20 | 2019-05-31 | Regeneron Pharmaceuticals, Inc. | Humanizirane lahkoverižne miši |
| HRP20192218T1 (hr) * | 2012-02-01 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi koji izražavaju teške lance koji sadrže vl domene |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| JP2015519076A (ja) | 2012-06-12 | 2015-07-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| CN105734081A (zh) | 2013-02-20 | 2016-07-06 | 瑞泽恩制药公司 | 具有修饰的免疫球蛋白重链序列的非人类动物 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| EP3895528A1 (en) | 2014-03-21 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| JP2018508224A (ja) * | 2015-03-19 | 2018-03-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗原を結合する軽鎖可変領域を選択する非ヒト動物 |
| EP4335918A3 (en) * | 2015-04-03 | 2024-04-17 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| CN109072191B (zh) * | 2016-04-04 | 2024-03-22 | 苏黎世联邦理工学院 | 用于蛋白生产和文库产生的哺乳动物细胞系 |
| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| CN110719732B (zh) * | 2017-03-30 | 2022-11-18 | 犹他州立大学 | 表达蜘蛛丝的转基因蚕 |
| PL4140297T3 (pl) * | 2017-12-05 | 2025-08-25 | Regeneron Pharmaceuticals, Inc. | Myszy mające zmodyfikowany sposobami inżynierii łańcuch lekki lambda immunoglobuliny i ich zastosowania |
| US20210051929A1 (en) * | 2018-03-24 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| JP2023540808A (ja) | 2020-09-11 | 2023-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗原特異的抗体の同定及び産生 |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CN114645042A (zh) * | 2020-12-18 | 2022-06-21 | 中国食品药品检定研究院 | 一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法 |
| CN114196626A (zh) * | 2022-02-16 | 2022-03-18 | 北京国卫生物科技有限公司 | 脐带间充质干细胞及其分离培养扩增方法 |
| CN118339300A (zh) * | 2024-01-02 | 2024-07-12 | 江苏集萃药康生物科技股份有限公司 | 产生人源化抗体的动物模型及其构建方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| CA2422155A1 (en) * | 2000-08-03 | 2002-02-14 | Wim Van Schooten | Production of humanized antibodies in transgenic animals |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN101016543A (zh) * | 2000-11-17 | 2007-08-15 | 罗切斯特大学 | 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法 |
| US7473557B2 (en) | 2001-06-06 | 2009-01-06 | Regeneron Pharmaceuticals, Inc. | Method for targeting transcriptionally active loci |
| EP1458852B1 (en) | 2001-12-21 | 2011-03-09 | ThromboGenics N.V. | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability and for the culture of adult stem cells |
| WO2003081993A2 (en) * | 2002-03-22 | 2003-10-09 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
| EP1644417B1 (en) * | 2003-07-15 | 2014-04-30 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| DK2767161T3 (en) | 2004-10-19 | 2018-05-07 | Regeneron Pharma | Method of generating an animal homozygous for genetic modification |
| WO2006047367A2 (en) * | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglubolin expression in non-human transgenic animals |
| JP5514539B2 (ja) * | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| ATE536374T1 (de) * | 2006-09-01 | 2011-12-15 | Therapeutic Human Polyclonals Inc | Erhöhte expression von humanem oder humanisiertem immunglobulin bei nicht-humanen transgenen tieren |
| US8426565B2 (en) * | 2007-08-30 | 2013-04-23 | Walter And Eliza Hall Institute Of Medical Research | Dendritic cell marker and uses thereof |
| TWI464262B (zh) * | 2007-09-26 | 2014-12-11 | 中外製藥股份有限公司 | 抗體固定區的變異 |
| US7659842B2 (en) | 2007-10-24 | 2010-02-09 | Infineon Technologies Ag | Quantization error reduction in PWM full-MASH converters |
| EP2669298A3 (en) * | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| HUE057994T2 (hu) * | 2008-06-27 | 2022-06-28 | Merus Nv | Antitesttermelõ, transzgenikus, egérfélékhez tartozó állat |
| AU2009287165A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
| WO2010091182A2 (en) * | 2009-02-04 | 2010-08-12 | Molecular Innovations | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin, and antibodies used therein |
| PT2564695E (pt) * | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| CN103228130B (zh) * | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| RU2612903C2 (ru) * | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| PL4067496T3 (pl) * | 2011-02-25 | 2023-07-31 | Regeneron Pharmaceuticals, Inc. | Myszy adam6 |
| RS66089B1 (sr) * | 2011-08-05 | 2024-11-29 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| SI2793567T1 (sl) * | 2011-12-20 | 2019-05-31 | Regeneron Pharmaceuticals, Inc. | Humanizirane lahkoverižne miši |
| HRP20192218T1 (hr) * | 2012-02-01 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi koji izražavaju teške lance koji sadrže vl domene |
| JP2015519076A (ja) * | 2012-06-12 | 2015-07-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| SMT202000558T1 (it) * | 2016-11-04 | 2020-11-10 | Regeneron Pharma | Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata |
-
2013
- 2013-02-01 HR HRP20192218TT patent/HRP20192218T1/hr unknown
- 2013-02-01 US US13/756,889 patent/US20130212719A1/en not_active Abandoned
- 2013-02-01 SG SG10201606256TA patent/SG10201606256TA/en unknown
- 2013-02-01 SG SG10201913428QA patent/SG10201913428QA/en unknown
- 2013-02-01 KR KR1020187037872A patent/KR20190006029A/ko not_active Ceased
- 2013-02-01 NZ NZ793447A patent/NZ793447A/en unknown
- 2013-02-01 LT LTEP19191081.9T patent/LT3597038T/lt unknown
- 2013-02-01 EP EP19191081.9A patent/EP3597038B1/en active Active
- 2013-02-01 HU HUE19191081A patent/HUE055610T2/hu unknown
- 2013-02-01 RU RU2018122695A patent/RU2770016C2/ru active
- 2013-02-01 JP JP2014555736A patent/JP2015505477A/ja not_active Withdrawn
- 2013-02-01 WO PCT/US2013/024295 patent/WO2013116609A1/en not_active Ceased
- 2013-02-01 CN CN201380017544.2A patent/CN104202971B/zh active Active
- 2013-02-01 CN CN201610371631.3A patent/CN106117364B/zh active Active
- 2013-02-01 NZ NZ734504A patent/NZ734504A/en unknown
- 2013-02-01 DK DK19191081.9T patent/DK3597038T3/da active
- 2013-02-01 RU RU2014133653A patent/RU2664185C2/ru active
- 2013-02-01 ME MEP-2019-348A patent/ME03611B/me unknown
- 2013-02-01 SG SG11201404477YA patent/SG11201404477YA/en unknown
- 2013-02-01 DK DK13704329T patent/DK2809150T3/da active
- 2013-02-01 NZ NZ810648A patent/NZ810648A/en unknown
- 2013-02-01 NZ NZ719228A patent/NZ719228A/en unknown
- 2013-02-01 SM SM20210401T patent/SMT202100401T1/it unknown
- 2013-02-01 ES ES13704329T patent/ES2753774T3/es active Active
- 2013-02-01 EP EP21167681.2A patent/EP3912465A1/en active Pending
- 2013-02-01 MX MX2020003491A patent/MX2020003491A/es unknown
- 2013-02-01 SI SI201331882T patent/SI3597038T1/sl unknown
- 2013-02-01 SI SI201331592T patent/SI2809150T1/sl unknown
- 2013-02-01 ES ES19191081T patent/ES2870703T3/es active Active
- 2013-02-01 PT PT137043295T patent/PT2809150T/pt unknown
- 2013-02-01 SM SM20190685T patent/SMT201900685T1/it unknown
- 2013-02-01 RS RS20210791A patent/RS62023B1/sr unknown
- 2013-02-01 EP EP13704329.5A patent/EP2809150B1/en active Active
- 2013-02-01 CA CA2863175A patent/CA2863175A1/en active Pending
- 2013-02-01 AU AU2013204758A patent/AU2013204758B2/en active Active
- 2013-02-01 NZ NZ627977A patent/NZ627977A/en active IP Right Revival
- 2013-02-01 PT PT191910819T patent/PT3597038T/pt unknown
- 2013-02-01 LT LT13704329T patent/LT2809150T/lt unknown
- 2013-02-01 PL PL19191081T patent/PL3597038T3/pl unknown
- 2013-02-01 MX MX2019002517A patent/MX373286B/es active IP Right Grant
- 2013-02-01 BR BR112014018843-2A patent/BR112014018843B1/pt active IP Right Grant
- 2013-02-01 KR KR1020147024417A patent/KR20140123983A/ko not_active Ceased
- 2013-02-01 HU HUE13704329A patent/HUE046744T2/hu unknown
- 2013-02-01 PL PL13704329T patent/PL2809150T3/pl unknown
- 2013-02-01 RS RS20191615A patent/RS59699B1/sr unknown
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2014
- 2014-07-27 IL IL233827A patent/IL233827A0/en active IP Right Grant
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2015
- 2015-10-23 AU AU2015246154A patent/AU2015246154B2/en active Active
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2016
- 2016-10-14 US US15/294,488 patent/US20170094955A1/en not_active Abandoned
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2017
- 2017-10-27 AU AU2017251848A patent/AU2017251848B2/en active Active
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2018
- 2018-02-09 JP JP2018022012A patent/JP6698718B2/ja active Active
- 2018-08-21 IL IL261280A patent/IL261280B/en active IP Right Grant
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2019
- 2019-07-12 JP JP2019130027A patent/JP6942757B2/ja active Active
- 2019-08-13 IL IL268675A patent/IL268675B/en active IP Right Grant
- 2019-12-10 CY CY20191101302T patent/CY1122419T1/el unknown
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2021
- 2021-04-07 US US17/224,524 patent/US20210368751A1/en not_active Abandoned
- 2021-06-15 JP JP2021099420A patent/JP7187615B2/ja active Active
- 2021-06-23 HR HRP20210987TT patent/HRP20210987T1/hr unknown
- 2021-07-20 CY CY20211100659T patent/CY1124361T1/el unknown
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2022
- 2022-11-30 JP JP2022191963A patent/JP7525579B2/ja active Active
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2023
- 2023-10-05 JP JP2023173593A patent/JP2023168590A/ja active Pending
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