JP2015510769A5 - - Google Patents
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- JP2015510769A5 JP2015510769A5 JP2015500651A JP2015500651A JP2015510769A5 JP 2015510769 A5 JP2015510769 A5 JP 2015510769A5 JP 2015500651 A JP2015500651 A JP 2015500651A JP 2015500651 A JP2015500651 A JP 2015500651A JP 2015510769 A5 JP2015510769 A5 JP 2015510769A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- locus
- segment
- histidine
- histidine codon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 132
- 108020004705 Codon Proteins 0.000 claims description 103
- 210000004602 germ cell Anatomy 0.000 claims description 47
- 108090000623 proteins and genes Proteins 0.000 claims description 47
- 238000003780 insertion Methods 0.000 claims description 36
- 230000037431 insertion Effects 0.000 claims description 36
- 150000007523 nucleic acids Chemical group 0.000 claims description 36
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 34
- 238000006467 substitution reaction Methods 0.000 claims description 30
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 29
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 28
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 25
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 24
- 108060003951 Immunoglobulin Proteins 0.000 claims description 20
- 102000018358 immunoglobulin Human genes 0.000 claims description 20
- 241000283984 Rodentia Species 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims description 14
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims description 14
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims description 12
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims description 12
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims description 12
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims description 12
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims description 12
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims description 12
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 11
- 241000699800 Cricetinae Species 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 101150097493 D gene Proteins 0.000 claims description 6
- 101150008942 J gene Proteins 0.000 claims description 6
- 101150117115 V gene Proteins 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000002411 histidines Chemical class 0.000 claims description 3
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 6
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
- 241000700159 Rattus Species 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108700026220 vif Genes Proteins 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 description 69
- 210000004027 cell Anatomy 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612126P | 2012-03-16 | 2012-03-16 | |
| US201261611950P | 2012-03-16 | 2012-03-16 | |
| US61/612,126 | 2012-03-16 | ||
| US61/611,950 | 2012-03-16 | ||
| US201261613352P | 2012-03-20 | 2012-03-20 | |
| US61/613,352 | 2012-03-20 | ||
| US201261736930P | 2012-12-13 | 2012-12-13 | |
| US61/736,930 | 2012-12-13 | ||
| PCT/US2013/032036 WO2013138712A1 (en) | 2012-03-16 | 2013-03-15 | Non-human animals expressing ph-sensitive immunoglobulin sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017093832A Division JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510769A JP2015510769A (ja) | 2015-04-13 |
| JP2015510769A5 true JP2015510769A5 (enExample) | 2016-05-12 |
| JP6228589B2 JP6228589B2 (ja) | 2017-11-08 |
Family
ID=48045752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500651A Active JP6228589B2 (ja) | 2012-03-16 | 2013-03-15 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2017093832A Active JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2018145734A Active JP7011549B2 (ja) | 2012-03-16 | 2018-08-02 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2020174432A Pending JP2021007409A (ja) | 2012-03-16 | 2020-10-16 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017093832A Active JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2018145734A Active JP7011549B2 (ja) | 2012-03-16 | 2018-08-02 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2020174432A Pending JP2021007409A (ja) | 2012-03-16 | 2020-10-16 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9801362B2 (enExample) |
| EP (2) | EP3539374A1 (enExample) |
| JP (4) | JP6228589B2 (enExample) |
| KR (3) | KR102213535B1 (enExample) |
| CN (2) | CN107361011B (enExample) |
| BR (1) | BR112014022855A2 (enExample) |
| CY (1) | CY1121864T1 (enExample) |
| DK (1) | DK2825037T3 (enExample) |
| ES (1) | ES2737990T3 (enExample) |
| HR (1) | HRP20191333T1 (enExample) |
| HU (1) | HUE045537T2 (enExample) |
| IL (4) | IL234237B (enExample) |
| LT (1) | LT2825037T (enExample) |
| MX (3) | MX355944B (enExample) |
| NZ (3) | NZ712508A (enExample) |
| PL (1) | PL2825037T4 (enExample) |
| PT (1) | PT2825037T (enExample) |
| RS (1) | RS59076B1 (enExample) |
| RU (2) | RU2664473C2 (enExample) |
| SG (3) | SG10202107388VA (enExample) |
| SI (1) | SI2825037T1 (enExample) |
| SM (1) | SMT201900535T1 (enExample) |
| WO (1) | WO2013138712A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| EP3604330A1 (en) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| BR112014013081A2 (pt) | 2011-11-30 | 2020-10-20 | Chugai Seiyaku Kabushiki Kaisha | veículo contendo fármaco em célula para formação de um complexo imune |
| PT2825037T (pt) | 2012-03-16 | 2019-08-07 | Regeneron Pharma | Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SMT201800395T1 (it) | 2012-03-16 | 2018-09-13 | Regeneron Pharma | Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi |
| RU2014141536A (ru) * | 2012-03-16 | 2016-05-10 | Регенерон Фармасьютикалз, Инк. | Мыши, которые продуцируют антигенсвязывающие белки с зависимыми от величины ph характеристиками связывания |
| TWI596115B (zh) * | 2012-08-13 | 2017-08-21 | 再生元醫藥公司 | 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| LT2840892T (lt) * | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| US9738702B2 (en) | 2014-03-14 | 2017-08-22 | Janssen Biotech, Inc. | Antibodies with improved half-life in ferrets |
| KR101838645B1 (ko) | 2014-12-19 | 2018-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| JP2018511557A (ja) * | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | ２種以上の抗ｃ５抗体の組み合わせおよび使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| HK1250038A1 (zh) * | 2015-03-19 | 2018-11-23 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| CA2985125A1 (en) | 2015-05-06 | 2016-11-10 | Janssen Biotech, Inc. | Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| EP3402326A1 (en) * | 2016-01-13 | 2018-11-21 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| SI3462853T1 (sl) | 2016-06-03 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Glodavci, ki izražajo eksogeno terminalno deoksinukleotidiltransferazo |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| EP3710589A4 (en) | 2017-11-14 | 2021-11-10 | Chugai Seiyaku Kabushiki Kaisha | ANTI-C1S ANTIBODIES AND METHOD OF USING |
| HUE070158T2 (hu) | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
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| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
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| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
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