JP2015510769A5 - - Google Patents
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- JP2015510769A5 JP2015510769A5 JP2015500651A JP2015500651A JP2015510769A5 JP 2015510769 A5 JP2015510769 A5 JP 2015510769A5 JP 2015500651 A JP2015500651 A JP 2015500651A JP 2015500651 A JP2015500651 A JP 2015500651A JP 2015510769 A5 JP2015510769 A5 JP 2015510769A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- locus
- segment
- histidine
- histidine codon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 132
- 108020004705 Codon Proteins 0.000 claims description 103
- 210000004602 germ cell Anatomy 0.000 claims description 47
- 108090000623 proteins and genes Proteins 0.000 claims description 47
- 238000003780 insertion Methods 0.000 claims description 36
- 230000037431 insertion Effects 0.000 claims description 36
- 150000007523 nucleic acids Chemical group 0.000 claims description 36
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 34
- 238000006467 substitution reaction Methods 0.000 claims description 30
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 29
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 28
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 25
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 24
- 108060003951 Immunoglobulin Proteins 0.000 claims description 20
- 102000018358 immunoglobulin Human genes 0.000 claims description 20
- 241000283984 Rodentia Species 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims description 14
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims description 14
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims description 12
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims description 12
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims description 12
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims description 12
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims description 12
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims description 12
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 11
- 241000699800 Cricetinae Species 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 101150097493 D gene Proteins 0.000 claims description 6
- 101150008942 J gene Proteins 0.000 claims description 6
- 101150117115 V gene Proteins 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000002411 histidines Chemical class 0.000 claims description 3
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 6
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
- 241000700159 Rattus Species 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108700026220 vif Genes Proteins 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 description 69
- 210000004027 cell Anatomy 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611950P | 2012-03-16 | 2012-03-16 | |
| US201261612126P | 2012-03-16 | 2012-03-16 | |
| US61/612,126 | 2012-03-16 | ||
| US61/611,950 | 2012-03-16 | ||
| US201261613352P | 2012-03-20 | 2012-03-20 | |
| US61/613,352 | 2012-03-20 | ||
| US201261736930P | 2012-12-13 | 2012-12-13 | |
| US61/736,930 | 2012-12-13 | ||
| PCT/US2013/032036 WO2013138712A1 (en) | 2012-03-16 | 2013-03-15 | Non-human animals expressing ph-sensitive immunoglobulin sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017093832A Division JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510769A JP2015510769A (ja) | 2015-04-13 |
| JP2015510769A5 true JP2015510769A5 (enExample) | 2016-05-12 |
| JP6228589B2 JP6228589B2 (ja) | 2017-11-08 |
Family
ID=48045752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500651A Active JP6228589B2 (ja) | 2012-03-16 | 2013-03-15 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2017093832A Active JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2018145734A Active JP7011549B2 (ja) | 2012-03-16 | 2018-08-02 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2020174432A Pending JP2021007409A (ja) | 2012-03-16 | 2020-10-16 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017093832A Active JP6574811B2 (ja) | 2012-03-16 | 2017-05-10 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2018145734A Active JP7011549B2 (ja) | 2012-03-16 | 2018-08-02 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
| JP2020174432A Pending JP2021007409A (ja) | 2012-03-16 | 2020-10-16 | ｐＨ感受性免疫グロブリン配列を発現する非ヒト動物 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9801362B2 (enExample) |
| EP (2) | EP3539374A1 (enExample) |
| JP (4) | JP6228589B2 (enExample) |
| KR (3) | KR102213535B1 (enExample) |
| CN (2) | CN104302171B (enExample) |
| BR (1) | BR112014022855A2 (enExample) |
| CY (1) | CY1121864T1 (enExample) |
| DK (1) | DK2825037T3 (enExample) |
| ES (1) | ES2737990T3 (enExample) |
| HR (1) | HRP20191333T1 (enExample) |
| HU (1) | HUE045537T2 (enExample) |
| IL (4) | IL234237B (enExample) |
| LT (1) | LT2825037T (enExample) |
| MX (3) | MX355944B (enExample) |
| NZ (3) | NZ712508A (enExample) |
| PL (1) | PL2825037T4 (enExample) |
| PT (1) | PT2825037T (enExample) |
| RS (1) | RS59076B1 (enExample) |
| RU (2) | RU2664473C2 (enExample) |
| SG (3) | SG11201405171WA (enExample) |
| SI (1) | SI2825037T1 (enExample) |
| SM (1) | SMT201900535T1 (enExample) |
| WO (1) | WO2013138712A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| CA2827923C (en) | 2011-02-25 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc antibody |
| JP5997151B2 (ja) | 2011-06-30 | 2016-09-28 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| CA3233142A1 (en) | 2011-11-30 | 2013-06-06 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
| WO2013125667A1 (ja) | 2012-02-24 | 2013-08-29 | 中外製薬株式会社 | FcγRIIBを介して抗原の消失を促進する抗原結合分子 |
| DK2825036T3 (en) | 2012-03-16 | 2018-07-16 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents to generate them |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
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| KR102213535B1 (ko) | 2012-03-16 | 2021-02-08 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
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| MY185881A (en) * | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
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| NZ730607A (en) | 2014-12-19 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
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| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| US11111314B2 (en) * | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| WO2016179518A2 (en) | 2015-05-06 | 2016-11-10 | Janssen Biotech, Inc. | Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| IL302725A (en) * | 2016-01-13 | 2023-07-01 | Regeneron Pharma | Rodents having an engineered heavy chain diversity region |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| BR112019001902A2 (pt) | 2016-08-05 | 2019-07-09 | Chugai Seiyaku Kabushiki Kaisha | composição para profilaxia ou tratamento de doenças relacionadas à il-8 |
| PT3687287T (pt) * | 2017-09-29 | 2023-11-03 | Regeneron Pharma | Roedores que expressam complexo c1q humanizado |
| EP3710589A4 (en) | 2017-11-14 | 2021-11-10 | Chugai Seiyaku Kabushiki Kaisha | ANTI-C1S ANTIBODIES AND METHOD OF USING |
| SG11202008799PA (en) | 2018-03-24 | 2020-10-29 | Regeneron Pharma | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
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| WO2019190931A1 (en) * | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Anti-pfrh5 antibodies and antigen-binding fragments thereof |
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| ES3060550T3 (en) * | 2018-06-13 | 2026-03-26 | Acraf | Peptides having inhibitory activity on muscarinic receptor m3 |
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