JP2015534819A5 - - Google Patents
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- JP2015534819A5 JP2015534819A5 JP2015540872A JP2015540872A JP2015534819A5 JP 2015534819 A5 JP2015534819 A5 JP 2015534819A5 JP 2015540872 A JP2015540872 A JP 2015540872A JP 2015540872 A JP2015540872 A JP 2015540872A JP 2015534819 A5 JP2015534819 A5 JP 2015534819A5
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- Prior art keywords
- human
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- genetically modified
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- 238000000034 method Methods 0.000 claims description 56
- 108020004707 nucleic acids Proteins 0.000 claims description 49
- 102000039446 nucleic acids Human genes 0.000 claims description 49
- 150000007523 nucleic acids Chemical class 0.000 claims description 49
- 210000004027 cell Anatomy 0.000 claims description 24
- 108090001005 Interleukin-6 Proteins 0.000 claims description 22
- 102000004889 Interleukin-6 Human genes 0.000 claims description 22
- 201000005787 hematologic cancer Diseases 0.000 claims description 22
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 22
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 20
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 102000052611 human IL6 Human genes 0.000 claims description 13
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 12
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 12
- 101150036449 SIRPA gene Proteins 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- 230000004083 survival effect Effects 0.000 claims description 7
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 6
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 6
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims description 6
- 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 claims description 6
- 101000799461 Homo sapiens Thrombopoietin Proteins 0.000 claims description 6
- 101000694103 Homo sapiens Thyroid peroxidase Proteins 0.000 claims description 6
- 102000000646 Interleukin-3 Human genes 0.000 claims description 6
- 108010002386 Interleukin-3 Proteins 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 101710113649 Thyroid peroxidase Proteins 0.000 claims description 6
- 102000046157 human CSF2 Human genes 0.000 claims description 6
- 102000055276 human IL3 Human genes 0.000 claims description 6
- 102000053400 human TPO Human genes 0.000 claims description 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 5
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 5
- 230000012010 growth Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims description 4
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 101001061851 Homo sapiens V(D)J recombination-activating protein 2 Proteins 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 102100029591 V(D)J recombination-activating protein 2 Human genes 0.000 claims description 2
- 238000010171 animal model Methods 0.000 claims description 2
- 230000011712 cell development Effects 0.000 claims description 2
- 230000003915 cell function Effects 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 13
- 102000025171 antigen binding proteins Human genes 0.000 claims 7
- 108091000831 antigen binding proteins Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 210000005260 human cell Anatomy 0.000 claims 6
- 101001076414 Mus musculus Interleukin-6 Proteins 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 4
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 210000000952 spleen Anatomy 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000003209 gene knockout Methods 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 description 7
- 230000010261 cell growth Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722437P | 2012-11-05 | 2012-11-05 | |
| US61/722,437 | 2012-11-05 | ||
| PCT/US2013/068569 WO2014071397A2 (en) | 2012-11-05 | 2013-11-05 | Genetically modified non-human animals and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018194712A Division JP6772234B2 (ja) | 2012-11-05 | 2018-10-16 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534819A JP2015534819A (ja) | 2015-12-07 |
| JP2015534819A5 true JP2015534819A5 (enExample) | 2016-12-22 |
| JP6422441B2 JP6422441B2 (ja) | 2018-11-14 |
Family
ID=49876957
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540872A Active JP6422441B2 (ja) | 2012-11-05 | 2013-11-05 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2018194712A Active JP6772234B2 (ja) | 2012-11-05 | 2018-10-16 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020165884A Active JP7105844B2 (ja) | 2012-11-05 | 2020-09-30 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022111649A Active JP7579304B2 (ja) | 2012-11-05 | 2022-07-12 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2024187836A Pending JP2025010204A (ja) | 2012-11-05 | 2024-10-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018194712A Active JP6772234B2 (ja) | 2012-11-05 | 2018-10-16 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020165884A Active JP7105844B2 (ja) | 2012-11-05 | 2020-09-30 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022111649A Active JP7579304B2 (ja) | 2012-11-05 | 2022-07-12 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2024187836A Pending JP2025010204A (ja) | 2012-11-05 | 2024-10-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US9901082B2 (enExample) |
| EP (5) | EP3308641B1 (enExample) |
| JP (5) | JP6422441B2 (enExample) |
| KR (5) | KR102649893B1 (enExample) |
| CN (3) | CN104918483B (enExample) |
| AU (3) | AU2013337242B2 (enExample) |
| CA (1) | CA2887706C (enExample) |
| DK (4) | DK3556206T3 (enExample) |
| ES (4) | ES2748662T3 (enExample) |
| FI (1) | FI3939423T3 (enExample) |
| IL (5) | IL311744B2 (enExample) |
| MX (3) | MX377561B (enExample) |
| MY (1) | MY175400A (enExample) |
| NO (1) | NO2946162T3 (enExample) |
| NZ (3) | NZ749626A (enExample) |
| PT (4) | PT3308641T (enExample) |
| RU (1) | RU2673156C2 (enExample) |
| SG (2) | SG11201502685XA (enExample) |
| WO (1) | WO2014071397A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| EP3417701B1 (en) | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2577978C2 (ru) | 2011-02-15 | 2016-03-20 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| NZ746089A (en) * | 2012-09-07 | 2020-05-29 | Institute For Res In Biomedicine Irb | Genetically modified non-human animals and methods of use thereof |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| SMT202500280T1 (it) | 2013-09-23 | 2025-09-12 | Regeneron Pharma | Animali non umani aventi un gene umanizzato della proteina regolatrice del segnale |
| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| EP3430898A1 (en) | 2013-11-19 | 2019-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| EP3071024B1 (en) | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| SMT202000332T1 (it) | 2014-04-08 | 2020-07-08 | Regeneron Pharma | Animali non umani aventi recettori fc-gamma umanizzati |
| MX2016014066A (es) | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) * | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| ES2969389T3 (es) * | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| WO2016137841A1 (en) * | 2015-02-26 | 2016-09-01 | William Paterson University Of New Jersey | Transgenic mice |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| SG10202103445QA (en) * | 2015-04-13 | 2021-05-28 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| CA3014645C (en) | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| EP4056031A1 (en) * | 2016-08-11 | 2022-09-14 | The Jackson Laboratory | Methods and compositions relating to improved human red blood cell survival in genetically modified immunodeficient non-human animals |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| JP7458185B2 (ja) | 2016-11-30 | 2024-03-29 | ザ ジャクソン ラボラトリー | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
| US11064685B2 (en) * | 2017-02-27 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of retinoschisis |
| CN107115424B (zh) * | 2017-05-09 | 2018-05-29 | 江西樟树市正康医药生物科技有限公司 | 改变酸性体质保钙及清热解毒的中药组合物及制备方法 |
| SG10202112528QA (en) | 2017-05-12 | 2021-12-30 | Jackson Lab | Nsg mice lacking mhc class i and class ii |
| EP3585162B1 (en) | 2017-09-29 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| US11712026B2 (en) | 2017-10-18 | 2023-08-01 | The Jackson Laboratory | Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| PE20201265A1 (es) | 2018-03-21 | 2020-11-19 | Alx Oncology Inc | Anticuerpos contra proteina alfa reguladora de senal y metodos de uso |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020074005A1 (en) * | 2018-10-12 | 2020-04-16 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric genes |
| CN111172190B (zh) * | 2018-12-25 | 2021-07-30 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf2基因改造非人动物的构建方法及应用 |
| AU2020253532B2 (en) | 2019-04-04 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| WO2021011853A2 (en) * | 2019-07-17 | 2021-01-21 | Yale University | Genetically modified non-human animals and methods of use thereof |
| CN111304246B (zh) * | 2019-12-17 | 2021-05-04 | 百奥赛图江苏基因生物技术有限公司 | 一种人源化细胞因子动物模型、制备方法及应用 |
| CN113105555B (zh) * | 2020-01-10 | 2023-05-30 | 百奥赛图(北京)医药科技股份有限公司 | Mhc分子人源化的非人动物的构建方法及应用 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| JP2023542539A (ja) | 2020-09-24 | 2023-10-10 | ザ ジャクソン ラボラトリー | 免疫細胞療法を評価するためのヒト化マウスモデル |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| CN116918766A (zh) * | 2022-04-07 | 2023-10-24 | 上海立迪生物技术股份有限公司 | 一种人aml小鼠原位pdox模型的建立方法及应用 |
| CN116918767A (zh) * | 2022-04-07 | 2023-10-24 | 上海立迪生物技术股份有限公司 | 一种人all小鼠原位pdox模型的建立方法及应用 |
| WO2024020057A1 (en) | 2022-07-19 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified animal model and its use to model the human immune system |
| WO2024259354A1 (en) | 2023-06-16 | 2024-12-19 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| US20250255282A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
| WO2025250495A1 (en) * | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
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