JP2018500012A5 - - Google Patents

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JP2018500012A5
JP2018500012A5 JP2017526681A JP2017526681A JP2018500012A5 JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5 JP 2017526681 A JP2017526681 A JP 2017526681A JP 2017526681 A JP2017526681 A JP 2017526681A JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5
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rodent
gene
human
polypeptide
humanized
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JP2017526681A
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JP6730277B2 (ja
JP2018500012A (ja
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Priority claimed from PCT/US2015/062614 external-priority patent/WO2016089692A1/en
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JP2017526681A 2014-12-05 2015-11-25 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 Active JP6730277B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087992P 2014-12-05 2014-12-05
US62/087,992 2014-12-05
PCT/US2015/062614 WO2016089692A1 (en) 2014-12-05 2015-11-25 Non-human animals having a humanized cluster of differentiation 47 gene

Related Child Applications (1)

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JP2020114628A Division JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

Publications (3)

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JP2018500012A JP2018500012A (ja) 2018-01-11
JP2018500012A5 true JP2018500012A5 (enExample) 2018-12-13
JP6730277B2 JP6730277B2 (ja) 2020-07-29

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JP2017526681A Active JP6730277B2 (ja) 2014-12-05 2015-11-25 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物
JP2020114628A Active JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

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JP2020114628A Active JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

Country Status (29)

Country Link
US (5) US20160345549A1 (enExample)
EP (4) EP4296278A3 (enExample)
JP (2) JP6730277B2 (enExample)
KR (3) KR102313073B1 (enExample)
CN (2) CN107205368B (enExample)
AR (1) AR102888A1 (enExample)
AU (2) AU2015355328B2 (enExample)
BR (1) BR112017010490A2 (enExample)
CA (1) CA2967834C (enExample)
CY (2) CY1121547T1 (enExample)
DK (3) DK3086637T3 (enExample)
ES (3) ES2716735T3 (enExample)
FI (1) FI3850946T3 (enExample)
HR (3) HRP20190634T1 (enExample)
HU (3) HUE043132T2 (enExample)
IL (2) IL286403B2 (enExample)
LT (3) LT3466255T (enExample)
MX (1) MX2017007293A (enExample)
NZ (2) NZ731471A (enExample)
PL (3) PL3466255T3 (enExample)
PT (3) PT3466255T (enExample)
RS (3) RS58536B1 (enExample)
RU (1) RU2728412C2 (enExample)
SG (2) SG11201703463WA (enExample)
SI (3) SI3850946T1 (enExample)
SM (3) SMT201900178T1 (enExample)
TR (1) TR201903891T4 (enExample)
TW (1) TWI681053B (enExample)
WO (1) WO2016089692A1 (enExample)

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US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US12622932B2 (en) 2018-12-13 2026-05-12 Sinai Health System Immunomodulatory cells and uses thereof
US11690362B2 (en) 2018-12-20 2023-07-04 Regeneran Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
CN112553252B (zh) * 2019-09-06 2022-04-29 百奥赛图(北京)医药科技股份有限公司 Tnfr2基因人源化的非人动物的构建方法和应用
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CN112080522A (zh) * 2020-09-15 2020-12-15 广东药康生物科技有限公司 一种cd47人源化小鼠模型的构建方法
CN112725379B (zh) * 2021-01-27 2024-08-13 上海南方模式生物科技股份有限公司 人源化cd40基因改造动物模型的构建方法及应用
WO2023046061A1 (en) * 2021-09-24 2023-03-30 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric trop2
AU2023310163A1 (en) 2022-07-19 2025-01-16 Regeneron Pharmaceuticals, Inc. Genetically modified animal model and its use to model the human immune system
WO2025171307A1 (en) 2024-02-08 2025-08-14 Regeneron Pharmaceuticals, Inc. Vectors, genetically modified cells, and genetically modified non-human animals comprising the same
WO2026096736A1 (en) 2024-10-31 2026-05-07 Regeneron Pharmaceuticals, Inc. Rodents expressing humanized polymeric immunoglobulin receptor

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