JP2018500012A5 - - Google Patents
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- Publication number
- JP2018500012A5 JP2018500012A5 JP2017526681A JP2017526681A JP2018500012A5 JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5 JP 2017526681 A JP2017526681 A JP 2017526681A JP 2017526681 A JP2017526681 A JP 2017526681A JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- gene
- human
- polypeptide
- humanized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087992P | 2014-12-05 | 2014-12-05 | |
| US62/087,992 | 2014-12-05 | ||
| PCT/US2015/062614 WO2016089692A1 (en) | 2014-12-05 | 2015-11-25 | Non-human animals having a humanized cluster of differentiation 47 gene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114628A Division JP7089554B2 (ja) | 2014-12-05 | 2020-07-02 | ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500012A JP2018500012A (ja) | 2018-01-11 |
| JP2018500012A5 true JP2018500012A5 (enExample) | 2018-12-13 |
| JP6730277B2 JP6730277B2 (ja) | 2020-07-29 |
Family
ID=54979926
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526681A Active JP6730277B2 (ja) | 2014-12-05 | 2015-11-25 | ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 |
| JP2020114628A Active JP7089554B2 (ja) | 2014-12-05 | 2020-07-02 | ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114628A Active JP7089554B2 (ja) | 2014-12-05 | 2020-07-02 | ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US20160345549A1 (enExample) |
| EP (4) | EP4296278B1 (enExample) |
| JP (2) | JP6730277B2 (enExample) |
| KR (3) | KR102313073B1 (enExample) |
| CN (2) | CN107205368B (enExample) |
| AR (1) | AR102888A1 (enExample) |
| AU (2) | AU2015355328B2 (enExample) |
| BR (1) | BR112017010490A2 (enExample) |
| CA (1) | CA2967834C (enExample) |
| CY (2) | CY1121547T1 (enExample) |
| DK (3) | DK3466255T3 (enExample) |
| ES (3) | ES2716735T3 (enExample) |
| FI (1) | FI3850946T3 (enExample) |
| HR (3) | HRP20190634T1 (enExample) |
| HU (3) | HUE054661T2 (enExample) |
| IL (2) | IL286403B2 (enExample) |
| LT (3) | LT3850946T (enExample) |
| MX (1) | MX2017007293A (enExample) |
| NZ (2) | NZ769992A (enExample) |
| PL (3) | PL3086637T3 (enExample) |
| PT (3) | PT3850946T (enExample) |
| RS (3) | RS58536B1 (enExample) |
| RU (1) | RU2728412C2 (enExample) |
| SG (2) | SG10202103050YA (enExample) |
| SI (3) | SI3466255T1 (enExample) |
| SM (3) | SMT202300482T1 (enExample) |
| TR (1) | TR201903891T4 (enExample) |
| TW (1) | TWI681053B (enExample) |
| WO (1) | WO2016089692A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| ES2841353T3 (es) | 2014-12-09 | 2021-07-08 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado |
| US11284607B2 (en) * | 2015-03-24 | 2022-03-29 | The Trustees Of Columbia University In The City Of New York | Genetic modification of pigs for xenotransplantation |
| AU2016270587B2 (en) | 2015-05-29 | 2020-12-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a disruption in a C9ORF72 locus |
| CN108366548B (zh) | 2015-11-20 | 2021-10-08 | 瑞泽恩制药公司 | 具有人源化淋巴细胞活化基因3的非人动物 |
| WO2017136712A1 (en) | 2016-02-04 | 2017-08-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| US20190183101A1 (en) * | 2016-08-11 | 2019-06-20 | The Jackson Laboratory | Methods and compositions relating to improved human red blood cell survival in genetically modified immunodeficient non-human animals |
| CN107815465B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041119A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ox40 |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041121A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ctla-4 |
| MX381216B (es) * | 2016-09-30 | 2025-03-12 | Regeneron Pharma | Animales no humanos que tienen una expansion de repeticiones de hexanucleotidos en un locus c9orf72. |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) * | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN110869494B (zh) * | 2017-06-12 | 2025-02-18 | 西奈卫生系统公司 | 无需全身性免疫遏制的同种异体移植物耐受 |
| MX2020001309A (es) | 2017-08-02 | 2020-08-20 | Phanes Therapeutics Inc | Anticuerpos anti-cd47 y sus usos. |
| JP7361031B2 (ja) * | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| IL277355B2 (en) * | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3123102A1 (en) | 2018-12-13 | 2020-06-18 | Sinai Health System | Immunomodulatory cells and uses thereof |
| WO2020131632A1 (en) | 2018-12-20 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated repeat expansion |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| US20220312749A1 (en) * | 2019-08-09 | 2022-10-06 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric il2ra |
| CN112553252B (zh) * | 2019-09-06 | 2022-04-29 | 百奥赛图(北京)医药科技股份有限公司 | Tnfr2基因人源化的非人动物的构建方法和应用 |
| CN113122574A (zh) * | 2019-12-31 | 2021-07-16 | 百奥赛图(北京)医药科技股份有限公司 | 一种免疫缺陷型人源化非人动物的构建方法 |
| CN112080522A (zh) * | 2020-09-15 | 2020-12-15 | 广东药康生物科技有限公司 | 一种cd47人源化小鼠模型的构建方法 |
| CN112725379B (zh) * | 2021-01-27 | 2024-08-13 | 上海南方模式生物科技股份有限公司 | 人源化cd40基因改造动物模型的构建方法及应用 |
| WO2023046061A1 (en) * | 2021-09-24 | 2023-03-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric trop2 |
| US20240102045A1 (en) | 2022-07-19 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025171307A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JP4637749B2 (ja) * | 2003-11-11 | 2011-02-23 | 中外製薬株式会社 | ヒト化抗ｃｄ４７抗体 |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| WO2007033221A2 (en) * | 2005-09-13 | 2007-03-22 | The General Hospital Corporation | Methods and compositions for inhibition of immune responses |
| EP2064325B1 (en) * | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| WO2009039244A2 (en) * | 2007-09-18 | 2009-03-26 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| CN101668387A (zh) | 2008-09-02 | 2010-03-10 | 鸿富锦精密工业（深圳）有限公司 | 印刷电路板 |
| CN102281758B (zh) * | 2009-01-16 | 2014-12-10 | 公益财团法人实验动物中央研究所 | 移植了人肝细胞的小鼠 |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| SI2477648T1 (sl) * | 2009-09-15 | 2022-09-30 | The Board Of Trustees Of The Leland Stanford Junior University | Sinergijska terapija proti CD47 za krvne rake |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| WO2013056352A1 (en) * | 2011-10-19 | 2013-04-25 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| SI2818478T1 (sl) | 2011-10-28 | 2017-07-31 | Regeneron Pharmaceuticals, Inc. | Humanizirani il-6 in receptor il-6 |
| EP2644027A1 (en) * | 2012-03-26 | 2013-10-02 | Institut Pasteur | Transgenic immunodefficient mouse expressing human SIRPalpha. |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| KR102241962B1 (ko) | 2012-09-07 | 2021-04-20 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| DK4389764T3 (da) * | 2012-11-05 | 2026-04-13 | Regeneron Pharma | Genetisk modificerede gnavere og fremgangsmåder til anvendelse heraf |
| MX2015007446A (es) * | 2012-12-12 | 2015-12-07 | Vasculox Inc | Anticuerpos terapeuticos para cd47. |
| US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| HRP20231121T1 (hr) | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| JP6492095B2 (ja) | 2013-10-15 | 2019-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｉｌ−１５動物 |
| US20150143559A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| RS60398B1 (sr) | 2014-04-08 | 2020-07-31 | Regeneron Pharma | Ne-humane životinje sa humanizovanim fc-gama receptorima |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| EP3482629B1 (en) | 2014-05-19 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals expressing human epo |
| WO2015196051A1 (en) | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
-
2015
- 2015-11-25 BR BR112017010490A patent/BR112017010490A2/pt not_active Application Discontinuation
- 2015-11-25 WO PCT/US2015/062614 patent/WO2016089692A1/en not_active Ceased
- 2015-11-25 PL PL15813960T patent/PL3086637T3/pl unknown
- 2015-11-25 EP EP23192469.7A patent/EP4296278B1/en active Active
- 2015-11-25 ES ES15813960T patent/ES2716735T3/es active Active
- 2015-11-25 TR TR2019/03891T patent/TR201903891T4/tr unknown
- 2015-11-25 NZ NZ769992A patent/NZ769992A/en unknown
- 2015-11-25 PT PT202150462T patent/PT3850946T/pt unknown
- 2015-11-25 DK DK18207075.5T patent/DK3466255T3/da active
- 2015-11-25 AU AU2015355328A patent/AU2015355328B2/en active Active
- 2015-11-25 EP EP15813960.0A patent/EP3086637B1/en active Active
- 2015-11-25 SI SI201531599T patent/SI3466255T1/sl unknown
- 2015-11-25 IL IL286403A patent/IL286403B2/en unknown
- 2015-11-25 KR KR1020177013948A patent/KR102313073B1/ko active Active
- 2015-11-25 DK DK15813960.0T patent/DK3086637T3/en active
- 2015-11-25 US US14/951,825 patent/US20160345549A1/en not_active Abandoned
- 2015-11-25 CA CA2967834A patent/CA2967834C/en active Active
- 2015-11-25 KR KR1020217032415A patent/KR102508175B1/ko active Active
- 2015-11-25 PL PL18207075T patent/PL3466255T3/pl unknown
- 2015-11-25 RS RS20190370A patent/RS58536B1/sr unknown
- 2015-11-25 SG SG10202103050YA patent/SG10202103050YA/en unknown
- 2015-11-25 HU HUE18207075A patent/HUE054661T2/hu unknown
- 2015-11-25 EP EP20215046.2A patent/EP3850946B1/en active Active
- 2015-11-25 FI FIEP20215046.2T patent/FI3850946T3/fi active
- 2015-11-25 DK DK20215046.2T patent/DK3850946T5/da active
- 2015-11-25 HU HUE20215046A patent/HUE064960T2/hu unknown
- 2015-11-25 CN CN201580066047.0A patent/CN107205368B/zh active Active
- 2015-11-25 RS RS20231251A patent/RS64989B1/sr unknown
- 2015-11-25 SI SI201531982T patent/SI3850946T1/sl unknown
- 2015-11-25 SM SM20230482T patent/SMT202300482T1/it unknown
- 2015-11-25 CN CN202011160730.XA patent/CN112342197B/zh active Active
- 2015-11-25 KR KR1020237007814A patent/KR102617691B1/ko active Active
- 2015-11-25 HR HRP20190634TT patent/HRP20190634T1/hr unknown
- 2015-11-25 JP JP2017526681A patent/JP6730277B2/ja active Active
- 2015-11-25 RS RS20210547A patent/RS61774B1/sr unknown
- 2015-11-25 PT PT182070755T patent/PT3466255T/pt unknown
- 2015-11-25 SM SM20190178T patent/SMT201900178T1/it unknown
- 2015-11-25 LT LTEP20215046.2T patent/LT3850946T/lt unknown
- 2015-11-25 PL PL20215046.2T patent/PL3850946T3/pl unknown
- 2015-11-25 ES ES18207075T patent/ES2870462T3/es active Active
- 2015-11-25 PT PT15813960T patent/PT3086637T/pt unknown
- 2015-11-25 LT LTEP18207075.5T patent/LT3466255T/lt unknown
- 2015-11-25 NZ NZ731471A patent/NZ731471A/en unknown
- 2015-11-25 SI SI201530659T patent/SI3086637T1/sl unknown
- 2015-11-25 SG SG11201703463WA patent/SG11201703463WA/en unknown
- 2015-11-25 ES ES20215046T patent/ES2969389T3/es active Active
- 2015-11-25 HR HRP20231707TT patent/HRP20231707T1/hr unknown
- 2015-11-25 RU RU2017123357A patent/RU2728412C2/ru active
- 2015-11-25 HU HUE15813960A patent/HUE043132T2/hu unknown
- 2015-11-25 SM SM20210281T patent/SMT202100281T1/it unknown
- 2015-11-25 LT LTEP15813960.0T patent/LT3086637T/lt unknown
- 2015-11-25 MX MX2017007293A patent/MX2017007293A/es unknown
- 2015-11-25 EP EP18207075.5A patent/EP3466255B1/en active Active
- 2015-12-03 TW TW104140456A patent/TWI681053B/zh active
- 2015-12-03 AR ARP150103952A patent/AR102888A1/es unknown
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2016
- 2016-01-19 US US15/000,751 patent/US10015953B2/en active Active
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2017
- 2017-04-30 IL IL252019A patent/IL252019B/en unknown
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2018
- 2018-05-17 US US15/982,174 patent/US10939673B2/en active Active
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2019
- 2019-03-21 CY CY20191100334T patent/CY1121547T1/el unknown
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2020
- 2020-07-02 JP JP2020114628A patent/JP7089554B2/ja active Active
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2021
- 2021-01-29 US US17/161,801 patent/US11910788B2/en active Active
- 2021-04-27 HR HRP20210662TT patent/HRP20210662T1/hr unknown
- 2021-05-06 CY CY20211100382T patent/CY1124089T1/el unknown
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2022
- 2022-06-02 AU AU2022203787A patent/AU2022203787B2/en active Active
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2024
- 2024-01-16 US US18/413,219 patent/US12389889B2/en active Active
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