JP2018500012A5 - - Google Patents

Download PDF

Info

Publication number
JP2018500012A5
JP2018500012A5 JP2017526681A JP2017526681A JP2018500012A5 JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5 JP 2017526681 A JP2017526681 A JP 2017526681A JP 2017526681 A JP2017526681 A JP 2017526681A JP 2018500012 A5 JP2018500012 A5 JP 2018500012A5
Authority
JP
Japan
Prior art keywords
rodent
gene
human
polypeptide
humanized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017526681A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018500012A (ja
JP6730277B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/062614 external-priority patent/WO2016089692A1/en
Publication of JP2018500012A publication Critical patent/JP2018500012A/ja
Publication of JP2018500012A5 publication Critical patent/JP2018500012A5/ja
Application granted granted Critical
Publication of JP6730277B2 publication Critical patent/JP6730277B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017526681A 2014-12-05 2015-11-25 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物 Active JP6730277B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087992P 2014-12-05 2014-12-05
US62/087,992 2014-12-05
PCT/US2015/062614 WO2016089692A1 (en) 2014-12-05 2015-11-25 Non-human animals having a humanized cluster of differentiation 47 gene

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020114628A Division JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

Publications (3)

Publication Number Publication Date
JP2018500012A JP2018500012A (ja) 2018-01-11
JP2018500012A5 true JP2018500012A5 (enExample) 2018-12-13
JP6730277B2 JP6730277B2 (ja) 2020-07-29

Family

ID=54979926

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017526681A Active JP6730277B2 (ja) 2014-12-05 2015-11-25 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物
JP2020114628A Active JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020114628A Active JP7089554B2 (ja) 2014-12-05 2020-07-02 ヒト化されたｃｌｕｓｔｅｒ ｏｆ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ４７遺伝子を有する非ヒト動物

Country Status (29)

Country Link
US (5) US20160345549A1 (enExample)
EP (4) EP4296278A3 (enExample)
JP (2) JP6730277B2 (enExample)
KR (3) KR102313073B1 (enExample)
CN (2) CN107205368B (enExample)
AR (1) AR102888A1 (enExample)
AU (2) AU2015355328B2 (enExample)
BR (1) BR112017010490A2 (enExample)
CA (1) CA2967834C (enExample)
CY (2) CY1121547T1 (enExample)
DK (3) DK3086637T3 (enExample)
ES (3) ES2969389T3 (enExample)
FI (1) FI3850946T3 (enExample)
HR (3) HRP20190634T1 (enExample)
HU (3) HUE043132T2 (enExample)
IL (2) IL286403B2 (enExample)
LT (3) LT3466255T (enExample)
MX (1) MX2017007293A (enExample)
NZ (2) NZ769992A (enExample)
PL (3) PL3850946T3 (enExample)
PT (3) PT3850946T (enExample)
RS (3) RS58536B1 (enExample)
RU (1) RU2728412C2 (enExample)
SG (2) SG10202103050YA (enExample)
SI (3) SI3086637T1 (enExample)
SM (3) SMT201900178T1 (enExample)
TR (1) TR201903891T4 (enExample)
TW (1) TWI681053B (enExample)
WO (1) WO2016089692A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107205368B (zh) 2014-12-05 2020-11-17 瑞泽恩制药公司 具有人源化分化簇47基因的非人动物
SMT202400313T1 (it) 2014-12-09 2024-09-16 Regeneron Pharma Animali non umani aventi un cluster umanizzato di un gene di differenziazione 274
WO2016154299A1 (en) * 2015-03-24 2016-09-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
BR112017025507A2 (pt) 2015-05-29 2018-08-07 Regeneron Pharmaceuticals, Inc. roedor, célula isolada de roedor ou tecido isolado de roedor, célula-tronco embrionária de roedor, embrião de roedor, e, métodos para preparação de um roedor e para identificação de um candidato terapêutico.
RS61866B1 (sr) 2015-11-20 2021-06-30 Regeneron Pharma Ne-humane životinje koje imaju humanizovani gen za aktivaciju limfocita 3
JP6843872B2 (ja) 2016-02-04 2021-03-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物
RU2749715C2 (ru) 2016-02-29 2021-06-16 Регенерон Фармасьютикалз, Инк. Грызуны, характеризующиеся гуманизированным геном tmprss
SG10202101133SA (en) * 2016-08-11 2021-03-30 Jackson Lab Methods and compositions relating to improved human red blood cell survival in genetically modified immunodeficient non-human animals
CN107815465B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
CN107815468B (zh) * 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018041119A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ox40
WO2018064600A1 (en) * 2016-09-30 2018-04-05 Regeneron Pharmaceuticals, Inc. Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
CN108467873B (zh) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN108588126B (zh) * 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
IL270835B2 (en) * 2017-06-12 2025-01-01 Sinai Health Sys Allograft tolerance without the need for systemic immunosuppression
US11401329B2 (en) 2017-08-02 2022-08-02 Phanes Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
CN111655031B (zh) * 2017-11-30 2022-11-18 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
WO2019190990A1 (en) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
PT3823443T (pt) 2018-07-16 2024-07-29 Regeneron Pharma Modelos de roedores da-doença ditra e as suas utilizações
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
IL301193A (en) 2018-12-20 2023-05-01 Regeneron Pharma Nuclease-mediated repeat expansion
CN111218425B (zh) * 2019-01-17 2022-02-08 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
WO2021027737A1 (en) * 2019-08-09 2021-02-18 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
WO2021043290A1 (en) * 2019-09-06 2021-03-11 Biocytogen Pharmaceuticals (Beijing) Co., Ltd Genetically modified non-human animal with human or chimeric tnfr2
WO2021136537A1 (en) * 2019-12-31 2021-07-08 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα/CD47
CN112080522A (zh) * 2020-09-15 2020-12-15 广东药康生物科技有限公司 一种cd47人源化小鼠模型的构建方法
CN112725379B (zh) * 2021-01-27 2024-08-13 上海南方模式生物科技股份有限公司 人源化cd40基因改造动物模型的构建方法及应用
CN116064558A (zh) * 2021-09-24 2023-05-05 百奥赛图(北京)医药科技股份有限公司 Trop2基因人源化非人动物的构建方法及应用
WO2024020057A1 (en) 2022-07-19 2024-01-25 Regeneron Pharmaceuticals, Inc. Genetically modified animal model and its use to model the human immune system
WO2025171307A1 (en) 2024-02-08 2025-08-14 Regeneron Pharmaceuticals, Inc. Vectors, genetically modified cells, and genetically modified non-human animals comprising the same

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2004287722A1 (en) * 2003-11-11 2005-05-19 Chugai Seiyaku Kabushiki Kaisha Humanized anti-CD47 antibody
PT1802193E (pt) 2004-10-19 2014-06-23 Regeneron Pharma Método para gerar um murganho homozigótico para uma modificação genética
US20070113297A1 (en) * 2005-09-13 2007-05-17 Yongguang Yang Methods and compositions for inhibition of immune responses
EP2064325B1 (en) * 2006-09-01 2011-12-07 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
WO2009039244A2 (en) * 2007-09-18 2009-03-26 Genizon Biosciences Inc. Genemap of the human genes associated with crohn's disease
CN101668387A (zh) 2008-09-02 2010-03-10 鸿富锦精密工业（深圳）有限公司 印刷电路板
CN102281758B (zh) * 2009-01-16 2014-12-10 公益财团法人实验动物中央研究所 移植了人肝细胞的小鼠
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
WO2011020014A1 (en) 2009-08-14 2011-02-17 Regeneron Pharmaceuticals, Inc. Promoter-regulated differentiation-dependent self-deleting cassette
SI2477648T1 (sl) * 2009-09-15 2022-09-30 The Board Of Trustees Of The Leland Stanford Junior University Sinergijska terapija proti CD47 za krvne rake
EP4049535B1 (en) 2009-10-06 2024-11-27 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
RU2730643C2 (ru) 2011-02-15 2020-08-24 Ридженерон Фармасьютикалз, Инк. Гуманизированные m-csf мыши
WO2013056352A1 (en) * 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
SG10201909638UA (en) 2011-10-28 2019-11-28 Regeneron Pharma Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
DK3262932T3 (da) 2011-10-28 2019-08-05 Regeneron Pharma Genmodificerede mus med major histokompatibilitetskompleks
ES2624605T3 (es) 2011-10-28 2017-07-17 Regeneron Pharmaceuticals, Inc. IL-6 y receptor de IL-6 humanizados
EP2644027A1 (en) * 2012-03-26 2013-10-02 Institut Pasteur Transgenic immunodefficient mouse expressing human SIRPalpha.
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
JP6283031B2 (ja) 2012-09-07 2018-02-21 イエール ユニバーシティ 遺伝学的に修飾された非ヒト動物およびその使用法
EP3308641B1 (en) * 2012-11-05 2019-07-03 Regeneron Pharmaceuticals, Inc. Immunodeficient, genetically modified rodent and methods of use thereof
CN105102479B (zh) * 2012-12-12 2019-06-28 瓦斯库劳克斯有限公司 治疗性cd47抗体
CN111484999B (zh) 2013-02-20 2024-10-25 瑞泽恩制药公司 人源化的t细胞共受体的小鼠
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
US10154658B2 (en) 2013-02-22 2018-12-18 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
SMT201900067T1 (it) 2013-09-23 2019-02-28 Regeneron Pharma Animali non umani aventi un gene di proteina regolatoria del segnale umanizzato
HRP20170380T1 (hr) 2013-10-15 2017-05-19 Regeneron Pharmaceuticals, Inc. Životinje s humaniziranim il-5
CA2929774C (en) 2013-11-19 2020-09-15 Regeneron Pharmaceuticals, Inc. Non-human animal cells having a humanized proliferation-inducing ligand gene
ES2700972T3 (es) 2013-11-19 2019-02-20 Regeneron Pharma Animales no humanos que tienen un gen de factor activador de células B humanizado
SG10201908800YA (en) 2014-04-08 2019-11-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
NO2785538T3 (enExample) 2014-05-07 2018-08-04
CA2947309A1 (en) 2014-05-19 2015-11-26 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals expressing human epo
RS60097B1 (sr) 2014-06-19 2020-05-29 Regeneron Pharma Ne-humane životinje koje imaju humanizovani gen za programiranu ćelijsku smrt 1
RU2020122439A (ru) 2014-11-24 2020-09-24 Регенерон Фармасьютикалз, Инк. Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3
CN107205368B (zh) 2014-12-05 2020-11-17 瑞泽恩制药公司 具有人源化分化簇47基因的非人动物

Similar Documents

Publication Publication Date Title
JP2018500012A5 (enExample)
JP7649370B2 (ja) 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
Ma et al. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth
JP7168641B2 (ja) 刺激性骨髄系細胞及び非刺激性骨髄系細胞の調節
JP6945444B2 (ja) 高親和性ｐｄ−１薬剤とその使用方法
AU2017355218B2 (en) Immunologically discernible cell surface variants for use in cell therapy
JP6665269B2 (ja) ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物
Antonioli et al. Anti-CD73 in cancer immunotherapy: awakening new opportunities
JP2019047818A5 (enExample)
EP3209769B1 (en) Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
JP7611836B2 (ja) 抗原特異的ｔ細胞の同定のための組成物と方法
US12187801B2 (en) Chimeric antigen receptors against AXL or ROR2 and methods of use thereof
JP2021166522A (ja) キメラ抗原受容体組成物
RU2017123357A (ru) Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47
JP2019536480A (ja) Ｔ細胞悪性腫瘍の免疫療法のためのｃｄ７発現およびキメラ抗原受容体の遮断
CN112867503A (zh) 掩蔽的细胞因子缀合物
US20170267755A1 (en) Isolated anti-mesothelin antibodies, conjugates and uses thereof
JP2016514099A5 (enExample)
CN109152837A (zh) 用于确定和实现抗cd47药剂治疗癌症的治疗有效剂量的方法
US20210213055A1 (en) Compositions and methods for inducing phagocytosis
KR20190027832A (ko) 향상된 효능을 갖는 치료를 위한 질병-특이적 표적으로서 네오에피토프의 선택
Chao et al. Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
CN111629715A (zh) 通过调节细胞活化状态改变体内免疫细胞的炎症状态
Bandara et al. Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
EP3678673A1 (en) Compositions and processes for targeted delivery, expression and modulation of coding ribonucleic acids in tissue