SG10201908800YA - Non-human animals having humanized fc-gamma receptors - Google Patents

Non-human animals having humanized fc-gamma receptors

Info

Publication number
SG10201908800YA
SG10201908800YA SG10201908800YA SG10201908800YA SG 10201908800Y A SG10201908800Y A SG 10201908800YA SG 10201908800Y A SG10201908800Y A SG 10201908800YA SG 10201908800Y A SG10201908800Y A SG 10201908800YA
Authority
SG
Singapore
Prior art keywords
humanized
human animals
gamma receptors
gamma
protein
Prior art date
Application number
Inventor
Andrew Murphy
Lynn Macdonald
Cagan Gurer
Karolina Meagher
Naxin Tu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201908800YA publication Critical patent/SG10201908800YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

NON-HUMAN ANIMALS HAVING HUMANIZED FC-GAMMA RECEPTORS Genetically modified mice and methods and compositions for making and using the same are provided, wherein the genetic modification comprises humanization of an Fc RI protein. [No Figure]
SG10201908800Y 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors SG10201908800YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08

Publications (1)

Publication Number Publication Date
SG10201908800YA true SG10201908800YA (en) 2019-11-28

Family

ID=52997579

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201604886WA SG11201604886WA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors
SG10201908800Y SG10201908800YA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201604886WA SG11201604886WA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Country Status (23)

Country Link
US (4) US9474255B2 (en)
EP (2) EP3693383A1 (en)
JP (2) JP6652931B2 (en)
KR (2) KR102223264B1 (en)
CN (2) CN111690052A (en)
AU (2) AU2015243865C1 (en)
CA (1) CA2935472C (en)
CY (1) CY1123046T1 (en)
DK (1) DK3129400T3 (en)
ES (1) ES2794942T3 (en)
HR (1) HRP20200899T1 (en)
HU (1) HUE051088T2 (en)
IL (2) IL246497B (en)
LT (1) LT3129400T (en)
MX (1) MX2016013241A (en)
PH (1) PH12016501341A1 (en)
PL (1) PL3129400T3 (en)
PT (1) PT3129400T (en)
RS (1) RS60398B1 (en)
RU (2) RU2700484C2 (en)
SG (2) SG11201604886WA (en)
SI (1) SI3129400T1 (en)
WO (1) WO2015157415A1 (en)

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DK3129400T3 (en) 2014-04-08 2020-06-08 Regeneron Pharma Non-human animals with humanized Fc-gamma receptors
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BR112016029650A2 (en) 2014-06-19 2017-10-24 Regeneron Pharma rodent, pd-1 polypeptide, isolated cell or rodent tissue, rodent embryonic stem cell, methods of producing a rodent, reducing tumor growth in a rodent, killing tumor cells in a rodent, and evaluating pharmacokinetic properties of a drug that targets human pd-1, and, rodent tumor model?
AU2015353705C9 (en) 2014-11-24 2022-09-01 Regeneron Pharmaceuticals, Inc. Non-human animals expressing humanized CD3 complex
DK3466255T3 (en) 2014-12-05 2021-05-03 Regeneron Pharma NON-HUMAN ANIMALS WITH A HUMANIZED CLUSTER OF 47-GENE DIFFERENTIATION
AU2016358101B2 (en) 2015-11-20 2022-12-01 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized Lymphocyte-activation gene 3
PT3422845T (en) 2016-02-29 2021-08-26 Regeneron Pharma Rodents having a humanized tmprss gene
CN116064611A (en) 2017-11-30 2023-05-05 瑞泽恩制药公司 Non-human animals comprising a humanized TRKB locus
TWI829679B (en) 2018-03-26 2024-01-21 美商再生元醫藥公司 Humanized rodents for testing therapeutic agents
CN116200426A (en) 2018-07-16 2023-06-02 瑞泽恩制药公司 Non-human animal model of DITRA disease and uses thereof
WO2022132943A1 (en) 2020-12-16 2022-06-23 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors

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Also Published As

Publication number Publication date
JP2017510285A (en) 2017-04-13
PT3129400T (en) 2020-05-27
EP3129400B1 (en) 2020-03-25
PL3129400T3 (en) 2020-09-07
SI3129400T1 (en) 2020-07-31
IL264364B (en) 2021-03-25
JP2020062051A (en) 2020-04-23
AU2020217312A1 (en) 2020-08-27
CA2935472A1 (en) 2015-10-15
KR102439412B1 (en) 2022-09-02
CA2935472C (en) 2024-02-20
AU2015243865B2 (en) 2020-05-14
JP6652931B2 (en) 2020-02-26
RU2016143036A (en) 2018-05-08
US9474255B2 (en) 2016-10-25
AU2015243865A1 (en) 2016-08-18
RU2700484C2 (en) 2019-09-17
CN106163273B (en) 2020-07-24
CN111690052A (en) 2020-09-22
WO2015157415A1 (en) 2015-10-15
HUE051088T2 (en) 2021-03-01
RU2019128394A (en) 2019-10-07
MX2016013241A (en) 2017-05-03
AU2015243865C1 (en) 2020-11-26
SG11201604886WA (en) 2016-07-28
AU2020217312B2 (en) 2023-04-13
RS60398B1 (en) 2020-07-31
US20230232795A1 (en) 2023-07-27
US10555507B2 (en) 2020-02-11
IL246497B (en) 2019-06-30
US20170086432A1 (en) 2017-03-30
KR20160142309A (en) 2016-12-12
AU2020217312C1 (en) 2023-10-26
ES2794942T3 (en) 2020-11-19
IL264364A (en) 2019-02-28
HRP20200899T1 (en) 2020-09-04
KR102223264B1 (en) 2021-03-09
RU2016143036A3 (en) 2018-10-24
PH12016501341A1 (en) 2016-08-15
EP3129400A1 (en) 2017-02-15
LT3129400T (en) 2020-06-25
IL246497A0 (en) 2016-08-31
KR20210024249A (en) 2021-03-04
EP3693383A1 (en) 2020-08-12
DK3129400T3 (en) 2020-06-08
US11503812B2 (en) 2022-11-22
JP6858283B2 (en) 2021-04-14
US20150282463A1 (en) 2015-10-08
CN106163273A (en) 2016-11-23
CY1123046T1 (en) 2021-10-29
US20200288684A1 (en) 2020-09-17

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