JP2019047818A5 - - Google Patents
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- Publication number
- JP2019047818A5 JP2019047818A5 JP2018233311A JP2018233311A JP2019047818A5 JP 2019047818 A5 JP2019047818 A5 JP 2019047818A5 JP 2018233311 A JP2018233311 A JP 2018233311A JP 2018233311 A JP2018233311 A JP 2018233311A JP 2019047818 A5 JP2019047818 A5 JP 2019047818A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- sirpα
- gene
- human
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims 62
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 56
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 25
- 108700024394 Exon Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 229940000406 drug candidate Drugs 0.000 claims 3
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881261P | 2013-09-23 | 2013-09-23 | |
| US61/881,261 | 2013-09-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Division JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020026122A Division JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019047818A JP2019047818A (ja) | 2019-03-28 |
| JP2019047818A5 true JP2019047818A5 (enExample) | 2020-02-27 |
| JP6665269B2 JP6665269B2 (ja) | 2020-03-13 |
Family
ID=51663510
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Active JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2018233311A Active JP6665269B2 (ja) | 2013-09-23 | 2018-12-13 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2020026122A Active JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2021072857A Active JP7149370B2 (ja) | 2013-09-23 | 2021-04-22 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Active JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020026122A Active JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2021072857A Active JP7149370B2 (ja) | 2013-09-23 | 2021-04-22 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US9193977B2 (enExample) |
| EP (5) | EP2922394B1 (enExample) |
| JP (4) | JP6453893B2 (enExample) |
| KR (2) | KR102407354B1 (enExample) |
| CN (2) | CN108441497B (enExample) |
| AU (3) | AU2014321187B2 (enExample) |
| CA (1) | CA2925564C (enExample) |
| CY (1) | CY1121410T1 (enExample) |
| DK (4) | DK3175706T3 (enExample) |
| ES (4) | ES2624614T3 (enExample) |
| FI (2) | FI3434101T3 (enExample) |
| HR (3) | HRP20231121T1 (enExample) |
| HU (3) | HUE042412T2 (enExample) |
| IL (4) | IL297607B2 (enExample) |
| LT (3) | LT4269430T (enExample) |
| MX (1) | MX368931B (enExample) |
| NZ (1) | NZ717817A (enExample) |
| PH (1) | PH12016500342A1 (enExample) |
| PL (3) | PL3175706T3 (enExample) |
| PT (4) | PT2922394T (enExample) |
| RS (3) | RS67091B1 (enExample) |
| RU (2) | RU2018136614A (enExample) |
| SG (3) | SG10201801326PA (enExample) |
| SI (3) | SI3434101T1 (enExample) |
| SM (3) | SMT202300287T1 (enExample) |
| TR (1) | TR201901782T4 (enExample) |
| WO (1) | WO2015042557A1 (enExample) |
| ZA (1) | ZA201601138B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3040377C (en) | 2009-10-06 | 2025-12-30 | Yale University | Genetically modified mice and engraftment comprising the knock-in of a human thrombopoietin (tpo) gene |
| ES3040596T3 (en) | 2011-02-15 | 2025-11-03 | Regeneron Pharma | Humanized m-csf mice and uses thereof |
| KR102287541B1 (ko) | 2012-09-07 | 2021-08-10 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| EP4389764B1 (en) | 2012-11-05 | 2026-03-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified rodents and methods of use thereof |
| DK3175706T3 (en) | 2013-09-23 | 2019-03-04 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| SMT201900177T1 (it) | 2013-10-15 | 2019-05-10 | Regeneron Pharma | Animali con il-15 umanizzata |
| CN105792646B (zh) | 2013-11-19 | 2018-03-02 | 瑞泽恩制药公司 | 具有人源化的b细胞活化因子基因的非人动物 |
| ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| KR20250096864A (ko) | 2014-05-19 | 2025-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| HUE048677T2 (hu) | 2014-06-19 | 2020-07-28 | Regeneron Pharma | Humanizált programozott sejthalál 1 génnel rendelkezõ nem-humán állatok |
| KR20240055876A (ko) | 2014-11-24 | 2024-04-29 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cd3 복합체를 발현하는 비인간 동물 |
| KR102617691B1 (ko) | 2014-12-05 | 2023-12-27 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 분화 클러스터 47 유전자를 가진 비인간 동물 |
| NZ731954A (en) | 2014-12-09 | 2024-11-29 | Regeneron Pharma | Non-human animals having a humanized cluster of differentiation 274 gene |
| JP6752221B2 (ja) * | 2015-04-13 | 2020-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｓｉｒｐａ−ｉｌ１５ノックインマウス及びその使用方法 |
| CN104904661B (zh) * | 2015-06-05 | 2018-07-24 | 杭州正因生物技术有限公司 | 一种人源化小鼠 |
| CN117964732A (zh) | 2015-08-07 | 2024-05-03 | Alx肿瘤生物技术公司 | 具有SIRP-α结构域或其变体的构建体 |
| AU2016358101B2 (en) | 2015-11-20 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized Lymphocyte-activation gene 3 |
| CN108779159B (zh) | 2016-02-04 | 2022-12-30 | 瑞泽恩制药公司 | 具有经改造的angptl8基因的非人动物 |
| JP6980674B2 (ja) | 2016-02-29 | 2021-12-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類 |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) * | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| WO2018233608A1 (en) * | 2017-06-19 | 2018-12-27 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric cd28 |
| EP3585160A2 (en) | 2017-07-31 | 2020-01-01 | Regeneron Pharmaceuticals, Inc. | Crispr reporter non-human animals and uses thereof |
| SG11201912235PA (en) | 2017-07-31 | 2020-01-30 | Regeneron Pharma | Cas-transgenic mouse embryonic stem cells and mice and uses thereof |
| ES2962277T3 (es) | 2017-09-29 | 2024-03-18 | Regeneron Pharma | Roedores que comprenden un locus Ttr humanizado y métodos de uso |
| IL274740B2 (en) | 2017-11-30 | 2024-06-01 | Regeneron Pharma | Non-human animals comprising a humanized trkb locus |
| KR20240038811A (ko) | 2018-03-19 | 2024-03-25 | 리제너론 파마슈티칼스 인코포레이티드 | CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절 |
| JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
| AU2019302152B2 (en) | 2018-07-10 | 2025-07-10 | Daiichi Sankyo Company, Limited | Anti-sirpalpha antibody |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020160285A1 (en) * | 2019-02-01 | 2020-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | SIRPα EXPRESSION ON T CELLS IS A BIOMARKER FOR FUNCTIONAL T CELLS DURING EXHAUSTION |
| WO2020206139A1 (en) | 2019-04-04 | 2020-10-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| AU2020282791A1 (en) | 2019-05-31 | 2021-12-09 | ALX Oncology Inc. | Methods of treating cancer with SIRP alpha Fc fusion in combination with an immune checkpoint inhibitor |
| EP3801011A1 (en) | 2019-06-04 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| AU2020289581B2 (en) | 2019-06-07 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| BR112022008817A2 (pt) | 2019-11-27 | 2022-07-26 | Alx Oncology Inc | Terapias combinadas para tratamento de câncer |
| WO2021136537A1 (en) * | 2019-12-31 | 2021-07-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα/CD47 |
| US12250931B2 (en) | 2020-01-28 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with a humanized PNPLA3 gene and methods of use |
| JP7765403B2 (ja) | 2020-04-21 | 2025-11-06 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃｘｃｌ１３遺伝子を有する非ヒト動物 |
| JP2024500153A (ja) * | 2020-12-21 | 2024-01-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物 |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| US20250143272A1 (en) * | 2022-01-25 | 2025-05-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric nkp46 |
| WO2024020057A1 (en) | 2022-07-19 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified animal model and its use to model the human immune system |
| WO2024073679A1 (en) | 2022-09-29 | 2024-04-04 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| CN121335619A (zh) | 2023-06-16 | 2026-01-13 | 瑞泽恩制药公司 | 载体、经基因修饰的细胞和包含其的经基因修饰的非人动物 |
| WO2025171307A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
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| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2587344T3 (es) * | 2003-12-24 | 2016-10-24 | Novo Nordisk A/S | Ratón transgénico que comprende un polinucleótido que codifica C5aR humano o humanizado |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| EP1907566A4 (en) | 2005-05-27 | 2008-12-10 | Memory Pharm Corp | VECTORS FOR TRANSGENIC MORBUS ALZHEIMER MOUSE MODEL AND USES THEREOF |
| US20070028316A1 (en) | 2005-06-02 | 2007-02-01 | Xiaoxia Li | Transgenic non-human Act1-deficient mammals and uses thereof |
| CA2702217A1 (en) * | 2007-10-11 | 2009-04-16 | Jayne Danska | Modulation of sirp.alpha. - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
| WO2009114400A1 (en) | 2008-03-07 | 2009-09-17 | Regeneron Pharmaceuticals, Inc. | Es cell-derived mice from diploid host embryo injection |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| CA3040377C (en) | 2009-10-06 | 2025-12-30 | Yale University | Genetically modified mice and engraftment comprising the knock-in of a human thrombopoietin (tpo) gene |
| WO2012040207A2 (en) * | 2010-09-20 | 2012-03-29 | Yale University | HUMAM SIRPAα TRANSGENIC ANIMALS AND THEIR METHODS OF USE |
| CN103492576A (zh) * | 2011-02-14 | 2014-01-01 | 雷维维科公司 | 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪 |
| ES3040596T3 (en) * | 2011-02-15 | 2025-11-03 | Regeneron Pharma | Humanized m-csf mice and uses thereof |
| RS56330B1 (sr) | 2011-10-28 | 2017-12-29 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| MY186903A (en) | 2011-10-28 | 2021-08-26 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
| RS56656B1 (sr) | 2011-10-28 | 2018-03-30 | Regeneron Pharma | Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| KR102287541B1 (ko) | 2012-09-07 | 2021-08-10 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| EP4389764B1 (en) | 2012-11-05 | 2026-03-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified rodents and methods of use thereof |
| KR20240147707A (ko) | 2013-02-20 | 2024-10-08 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| CN110192541B (zh) | 2013-02-22 | 2022-02-18 | 瑞泽恩制药公司 | 表达人源化主要组织相容性复合物的小鼠 |
| DK3175706T3 (en) | 2013-09-23 | 2019-03-04 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| EP3289869B1 (en) | 2015-04-30 | 2020-10-14 | Institute Of Immunology Co., Ltd. | Transgenic non-human animal expressing human-specific molecules and human fc gamma receptor family |
-
2014
- 2014-09-23 DK DK16206491.9T patent/DK3175706T3/en active
- 2014-09-23 HU HUE16206491A patent/HUE042412T2/hu unknown
- 2014-09-23 WO PCT/US2014/056910 patent/WO2015042557A1/en not_active Ceased
- 2014-09-23 LT LTEP23185050.4T patent/LT4269430T/lt unknown
- 2014-09-23 US US14/493,745 patent/US9193977B2/en active Active
- 2014-09-23 AU AU2014321187A patent/AU2014321187B2/en active Active
- 2014-09-23 LT LTEP18192264.2T patent/LT3434101T/lt unknown
- 2014-09-23 PT PT147817837T patent/PT2922394T/pt unknown
- 2014-09-23 ES ES14781783.7T patent/ES2624614T3/es active Active
- 2014-09-23 MX MX2016003636A patent/MX368931B/es active IP Right Grant
- 2014-09-23 IL IL297607A patent/IL297607B2/en unknown
- 2014-09-23 PL PL16206491T patent/PL3175706T3/pl unknown
- 2014-09-23 HU HUE18192264A patent/HUE063376T2/hu unknown
- 2014-09-23 SI SI201432041T patent/SI3434101T1/sl unknown
- 2014-09-23 EP EP14781783.7A patent/EP2922394B1/en active Active
- 2014-09-23 PT PT181922642T patent/PT3434101T/pt unknown
- 2014-09-23 HR HRP20231121TT patent/HRP20231121T1/hr unknown
- 2014-09-23 SI SI201431078T patent/SI3175706T1/sl unknown
- 2014-09-23 SM SM20230287T patent/SMT202300287T1/it unknown
- 2014-09-23 HU HUE23185050A patent/HUE072332T2/hu unknown
- 2014-09-23 CN CN201810267662.3A patent/CN108441497B/zh active Active
- 2014-09-23 RU RU2018136614A patent/RU2018136614A/ru not_active Application Discontinuation
- 2014-09-23 JP JP2016544055A patent/JP6453893B2/ja active Active
- 2014-09-23 DK DK23185050.4T patent/DK4269430T3/da active
- 2014-09-23 RS RS20250788A patent/RS67091B1/sr unknown
- 2014-09-23 TR TR2019/01782T patent/TR201901782T4/tr unknown
- 2014-09-23 FI FIEP18192264.2T patent/FI3434101T3/fi active
- 2014-09-23 KR KR1020227006825A patent/KR102407354B1/ko active Active
- 2014-09-23 SG SG10201801326PA patent/SG10201801326PA/en unknown
- 2014-09-23 KR KR1020167008334A patent/KR102370419B1/ko active Active
- 2014-09-23 NZ NZ717817A patent/NZ717817A/en unknown
- 2014-09-23 SG SG11201601184UA patent/SG11201601184UA/en unknown
- 2014-09-23 CN CN201480051997.1A patent/CN105592695B/zh active Active
- 2014-09-23 FI FIEP23185050.4T patent/FI4269430T3/fi active
- 2014-09-23 EP EP16206491.9A patent/EP3175706B1/en active Active
- 2014-09-23 PT PT16206491T patent/PT3175706T/pt unknown
- 2014-09-23 PT PT231850504T patent/PT4269430T/pt unknown
- 2014-09-23 EP EP18192264.2A patent/EP3434101B1/en active Active
- 2014-09-23 SM SM20190067T patent/SMT201900067T1/it unknown
- 2014-09-23 EP EP23185050.4A patent/EP4269430B1/en active Active
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