JP2019047818A5 - - Google Patents
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- Publication number
- JP2019047818A5 JP2019047818A5 JP2018233311A JP2018233311A JP2019047818A5 JP 2019047818 A5 JP2019047818 A5 JP 2019047818A5 JP 2018233311 A JP2018233311 A JP 2018233311A JP 2018233311 A JP2018233311 A JP 2018233311A JP 2019047818 A5 JP2019047818 A5 JP 2019047818A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- sirpα
- gene
- human
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims 62
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 56
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 25
- 108700024394 Exon Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 229940000406 drug candidate Drugs 0.000 claims 3
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881261P | 2013-09-23 | 2013-09-23 | |
| US61/881,261 | 2013-09-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Division JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020026122A Division JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019047818A JP2019047818A (ja) | 2019-03-28 |
| JP2019047818A5 true JP2019047818A5 (enExample) | 2020-02-27 |
| JP6665269B2 JP6665269B2 (ja) | 2020-03-13 |
Family
ID=51663510
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Active JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2018233311A Active JP6665269B2 (ja) | 2013-09-23 | 2018-12-13 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2020026122A Active JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2021072857A Active JP7149370B2 (ja) | 2013-09-23 | 2021-04-22 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544055A Active JP6453893B2 (ja) | 2013-09-23 | 2014-09-23 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020026122A Active JP6875573B2 (ja) | 2013-09-23 | 2020-02-19 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
| JP2021072857A Active JP7149370B2 (ja) | 2013-09-23 | 2021-04-22 | ヒト化シグナル調節タンパク質遺伝子を有する非ヒト動物 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US9193977B2 (enExample) |
| EP (5) | EP4635977A3 (enExample) |
| JP (4) | JP6453893B2 (enExample) |
| KR (2) | KR102407354B1 (enExample) |
| CN (2) | CN108441497B (enExample) |
| AU (3) | AU2014321187B2 (enExample) |
| CA (1) | CA2925564C (enExample) |
| CY (1) | CY1121410T1 (enExample) |
| DK (4) | DK2922394T3 (enExample) |
| ES (4) | ES3037239T3 (enExample) |
| FI (2) | FI4269430T3 (enExample) |
| HR (3) | HRP20251062T1 (enExample) |
| HU (3) | HUE063376T2 (enExample) |
| IL (4) | IL297607B2 (enExample) |
| LT (3) | LT3434101T (enExample) |
| MX (1) | MX368931B (enExample) |
| NZ (1) | NZ717817A (enExample) |
| PH (1) | PH12016500342A1 (enExample) |
| PL (3) | PL3434101T3 (enExample) |
| PT (4) | PT2922394T (enExample) |
| RS (3) | RS64573B1 (enExample) |
| RU (2) | RU2018136614A (enExample) |
| SG (3) | SG10201801326PA (enExample) |
| SI (3) | SI3175706T1 (enExample) |
| SM (3) | SMT201900067T1 (enExample) |
| TR (1) | TR201901782T4 (enExample) |
| WO (1) | WO2015042557A1 (enExample) |
| ZA (1) | ZA201601138B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4049535B1 (en) | 2009-10-06 | 2024-11-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2730643C2 (ru) | 2011-02-15 | 2020-08-24 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| JP6283031B2 (ja) | 2012-09-07 | 2018-02-21 | イエール ユニバーシティ | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| EP3308641B1 (en) | 2012-11-05 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Immunodeficient, genetically modified rodent and methods of use thereof |
| SMT201900067T1 (it) | 2013-09-23 | 2019-02-28 | Regeneron Pharma | Animali non umani aventi un gene di proteina regolatoria del segnale umanizzato |
| HRP20170380T1 (hr) | 2013-10-15 | 2017-05-19 | Regeneron Pharmaceuticals, Inc. | Životinje s humaniziranim il-5 |
| ES2700972T3 (es) | 2013-11-19 | 2019-02-20 | Regeneron Pharma | Animales no humanos que tienen un gen de factor activador de células B humanizado |
| SG10201908800YA (en) | 2014-04-08 | 2019-11-28 | Regeneron Pharma | Non-human animals having humanized fc-gamma receptors |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| CA2947309A1 (en) | 2014-05-19 | 2015-11-26 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals expressing human epo |
| RS60097B1 (sr) | 2014-06-19 | 2020-05-29 | Regeneron Pharma | Ne-humane životinje koje imaju humanizovani gen za programiranu ćelijsku smrt 1 |
| RU2020122439A (ru) | 2014-11-24 | 2020-09-24 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| CN107205368B (zh) | 2014-12-05 | 2020-11-17 | 瑞泽恩制药公司 | 具有人源化分化簇47基因的非人动物 |
| SMT202400313T1 (it) | 2014-12-09 | 2024-09-16 | Regeneron Pharma | Animali non umani aventi un cluster umanizzato di un gene di differenziazione 274 |
| ES2950399T3 (es) | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| CN104904661B (zh) * | 2015-06-05 | 2018-07-24 | 杭州正因生物技术有限公司 | 一种人源化小鼠 |
| SG10202101909RA (en) | 2015-08-07 | 2021-04-29 | Alx Oncology Inc | Constructs having a sirp-alpha domain or variant thereof |
| RS61866B1 (sr) | 2015-11-20 | 2021-06-30 | Regeneron Pharma | Ne-humane životinje koje imaju humanizovani gen za aktivaciju limfocita 3 |
| JP6843872B2 (ja) | 2016-02-04 | 2021-03-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
| RU2749715C2 (ru) | 2016-02-29 | 2021-06-16 | Регенерон Фармасьютикалз, Инк. | Грызуны, характеризующиеся гуманизированным геном tmprss |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| WO2018233608A1 (en) * | 2017-06-19 | 2018-12-27 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric cd28 |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| KR102780441B1 (ko) | 2017-07-31 | 2025-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | Cas-형질전환 마우스 배아 줄기 세포 및 마우스 및 이것의 용도 |
| BR112020001996A2 (pt) | 2017-07-31 | 2020-08-18 | Regeneron Pharmaceuticals, Inc. | animal não humano, e, métodos para testar e para otimizar a capacidade de uma crispr/cas nuclease de excisar um ácido nucleico genômico in vivo, para testar a recombinação induzida por crispr/cas de um ácido nucleico genômico com um ácido nucleico de doador exógeno in vivo e para otimizar a capacidade de crispr/cas de induzir a recombinação de um ácido nucleico genômico com um ácido nucleico de doador exógeno in vivo. |
| WO2019067875A1 (en) * | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| CN111655031B (zh) | 2017-11-30 | 2022-11-18 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| CN116349651A (zh) | 2018-03-19 | 2023-06-30 | 瑞泽恩制药公司 | 使用crispr/cas系统对动物进行转录调制 |
| WO2019190990A1 (en) | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| US12024566B2 (en) | 2018-07-10 | 2024-07-02 | National University Corporation Kobe University | Anti-SIRPalpha antibody |
| PT3823443T (pt) | 2018-07-16 | 2024-07-29 | Regeneron Pharma | Modelos de roedores da-doença ditra e as suas utilizações |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20220120731A1 (en) * | 2019-02-01 | 2022-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | SIRPa EXPRESSION ON T CELLS IS A BIOMARKER FOR FUNCTIONAL T CELLS DURING EXHAUSTION |
| EP3772929B1 (en) | 2019-04-04 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized coagulation factor 12 locus |
| BR112021024003A2 (pt) | 2019-05-31 | 2022-04-19 | Alx Oncology Inc | Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico |
| JP7610339B2 (ja) | 2019-06-04 | 2025-01-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法 |
| TW202112229A (zh) | 2019-06-07 | 2021-04-01 | 美商雷傑納榮製藥公司 | 包含人化白蛋白基因座之非人的動物 |
| WO2021108693A1 (en) | 2019-11-27 | 2021-06-03 | ALX Oncology Inc. | Combination therapies for treating cancer |
| WO2021136537A1 (en) * | 2019-12-31 | 2021-07-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα/CD47 |
| KR20220133248A (ko) | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| AU2021261267A1 (en) | 2020-04-21 | 2022-09-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized Cxcl13 gene |
| WO2022140221A1 (en) | 2020-12-21 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene |
| US12098214B2 (en) | 2021-05-13 | 2024-09-24 | ALX Oncology Inc. | Combination therapies for treating cancer |
| US20250143272A1 (en) * | 2022-01-25 | 2025-05-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric nkp46 |
| WO2024020057A1 (en) | 2022-07-19 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified animal model and its use to model the human immune system |
| US20240224964A9 (en) | 2022-09-29 | 2024-07-11 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| CN121335619A (zh) | 2023-06-16 | 2026-01-13 | 瑞泽恩制药公司 | 载体、经基因修饰的细胞和包含其的经基因修饰的非人动物 |
| WO2025171307A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
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| ES2587344T3 (es) * | 2003-12-24 | 2016-10-24 | Novo Nordisk A/S | Ratón transgénico que comprende un polinucleótido que codifica C5aR humano o humanizado |
| PT1802193E (pt) | 2004-10-19 | 2014-06-23 | Regeneron Pharma | Método para gerar um murganho homozigótico para uma modificação genética |
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| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
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| US9402377B2 (en) * | 2010-09-20 | 2016-08-02 | Yale University | Human SIRPAalpha transgenic animals and their methods of use |
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| EP3308641B1 (en) | 2012-11-05 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Immunodeficient, genetically modified rodent and methods of use thereof |
| CN111484999B (zh) | 2013-02-20 | 2024-10-25 | 瑞泽恩制药公司 | 人源化的t细胞共受体的小鼠 |
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| SMT201900067T1 (it) | 2013-09-23 | 2019-02-28 | Regeneron Pharma | Animali non umani aventi un gene di proteina regolatoria del segnale umanizzato |
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2014
- 2014-09-23 SM SM20190067T patent/SMT201900067T1/it unknown
- 2014-09-23 LT LTEP18192264.2T patent/LT3434101T/lt unknown
- 2014-09-23 DK DK14781783.7T patent/DK2922394T3/en active
- 2014-09-23 WO PCT/US2014/056910 patent/WO2015042557A1/en not_active Ceased
- 2014-09-23 SI SI201431078T patent/SI3175706T1/sl unknown
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- 2014-09-23 EP EP25183430.5A patent/EP4635977A3/en active Pending
- 2014-09-23 PL PL18192264.2T patent/PL3434101T3/pl unknown
- 2014-09-23 LT LTEP23185050.4T patent/LT4269430T/lt unknown
- 2014-09-23 JP JP2016544055A patent/JP6453893B2/ja active Active
- 2014-09-23 SM SM20230287T patent/SMT202300287T1/it unknown
- 2014-09-23 IL IL297607A patent/IL297607B2/en unknown
- 2014-09-23 AU AU2014321187A patent/AU2014321187B2/en active Active
- 2014-09-23 RS RS20230816A patent/RS64573B1/sr unknown
- 2014-09-23 SM SM20250280T patent/SMT202500280T1/it unknown
- 2014-09-23 LT LTEP16206491.9T patent/LT3175706T/lt unknown
- 2014-09-23 CN CN201810267662.3A patent/CN108441497B/zh active Active
- 2014-09-23 FI FIEP23185050.4T patent/FI4269430T3/fi active
- 2014-09-23 DK DK18192264.2T patent/DK3434101T5/da active
- 2014-09-23 EP EP23185050.4A patent/EP4269430B1/en active Active
- 2014-09-23 ES ES23185050T patent/ES3037239T3/es active Active
- 2014-09-23 MX MX2016003636A patent/MX368931B/es active IP Right Grant
- 2014-09-23 PL PL16206491T patent/PL3175706T3/pl unknown
- 2014-09-23 US US14/493,745 patent/US9193977B2/en active Active
- 2014-09-23 DK DK16206491.9T patent/DK3175706T3/en active
- 2014-09-23 HU HUE18192264A patent/HUE063376T2/hu unknown
- 2014-09-23 RS RS20250788A patent/RS67091B1/sr unknown
- 2014-09-23 KR KR1020227006825A patent/KR102407354B1/ko active Active
- 2014-09-23 EP EP14781783.7A patent/EP2922394B1/en active Active
- 2014-09-23 PT PT147817837T patent/PT2922394T/pt unknown
- 2014-09-23 HU HUE16206491A patent/HUE042412T2/hu unknown
- 2014-09-23 ES ES18192264T patent/ES2959333T3/es active Active
- 2014-09-23 RU RU2018136614A patent/RU2018136614A/ru not_active Application Discontinuation
- 2014-09-23 RS RS20190162A patent/RS58365B1/sr unknown
- 2014-09-23 FI FIEP18192264.2T patent/FI3434101T3/fi active
- 2014-09-23 EP EP18192264.2A patent/EP3434101B1/en active Active
- 2014-09-23 TR TR2019/01782T patent/TR201901782T4/tr unknown
- 2014-09-23 CA CA2925564A patent/CA2925564C/en active Active
- 2014-09-23 SI SI201432112T patent/SI4269430T1/sl unknown
- 2014-09-23 HR HRP20251062TT patent/HRP20251062T1/hr unknown
- 2014-09-23 CN CN201480051997.1A patent/CN105592695B/zh active Active
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