JP2019506897A5 - - Google Patents

Download PDF

Info

Publication number
JP2019506897A5
JP2019506897A5 JP2018555851A JP2018555851A JP2019506897A5 JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5 JP 2018555851 A JP2018555851 A JP 2018555851A JP 2018555851 A JP2018555851 A JP 2018555851A JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5
Authority
JP
Japan
Prior art keywords
transgenic mouse
mouse
human
crbn
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018555851A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019506897A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/013909 external-priority patent/WO2017127414A1/en
Publication of JP2019506897A publication Critical patent/JP2019506897A/ja
Publication of JP2019506897A5 publication Critical patent/JP2019506897A5/ja
Priority to JP2022020184A priority Critical patent/JP7350911B2/ja
Pending legal-status Critical Current

Links

JP2018555851A 2016-01-19 2017-01-18 ヒトのセレブロンを発現するトランスジェニックマウス Pending JP2019506897A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022020184A JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662280633P 2016-01-19 2016-01-19
US62/280,633 2016-01-19
PCT/US2017/013909 WO2017127414A1 (en) 2016-01-19 2017-01-18 Transgenic mouse expressing human cereblon

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022020184A Division JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

Publications (2)

Publication Number Publication Date
JP2019506897A JP2019506897A (ja) 2019-03-14
JP2019506897A5 true JP2019506897A5 (enExample) 2020-03-05

Family

ID=59362645

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018555851A Pending JP2019506897A (ja) 2016-01-19 2017-01-18 ヒトのセレブロンを発現するトランスジェニックマウス
JP2022020184A Active JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022020184A Active JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

Country Status (4)

Country Link
US (2) US11963520B2 (enExample)
EP (1) EP3405790B1 (enExample)
JP (2) JP2019506897A (enExample)
WO (1) WO2017127414A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
EP3577459A4 (en) 2017-02-03 2020-12-16 Celgene Corporation METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON
EP3861854B1 (en) * 2018-09-27 2025-01-22 Central Institute for Experimental Medicine and Life Science Immunodeficient mouse
JP6935383B2 (ja) * 2018-09-27 2021-09-15 公益財団法人実験動物中央研究所 免疫不全マウス
AU2020379680A1 (en) * 2019-11-05 2022-05-26 Celgene Corporation Combination therapy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide
CN112980882A (zh) * 2021-03-15 2021-06-18 上海科技大学 Crbn基因在构建GSPT1敏感模型中的用途
WO2025164957A1 (ko) * 2024-01-31 2025-08-07 남부대학교산학협력단 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
DE69841452D1 (de) * 1997-02-28 2010-03-04 Kyowa Hakko Kirin Co Ltd Humanes Chromosomfragment und ein Vektor, der dies enthält
US20020187931A1 (en) * 2000-04-13 2002-12-12 Michael Hayden Modulating cell survival by modulating huntingtin function
US6875904B2 (en) * 2000-09-20 2005-04-05 The Ohio State University Research Foundation Animal model for identifying agents that inhibit or enhance CTLA4 signaling
AUPR446701A0 (en) * 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
WO2004060053A2 (en) * 2002-12-16 2004-07-22 Genentech, Inc. Transgenic mice expressing human cd20
US8110720B2 (en) * 2006-12-22 2012-02-07 Genentech, Inc Transgenic mice expressing humanized VEGF
EP2436387B1 (en) 2009-05-25 2018-07-25 Celgene Corporation Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
MX353482B (es) 2011-04-29 2018-01-16 Celgene Corp Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor.
WO2014028445A2 (en) 2012-08-14 2014-02-20 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
US9587281B2 (en) * 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
KR20140100731A (ko) * 2013-02-07 2014-08-18 광주과학기술원 Ｃｒｂ ｎ ｋｏ 마우스의 제조방법 및 이의 용도
WO2015077058A2 (en) * 2013-11-08 2015-05-28 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias
WO2015127351A1 (en) 2014-02-24 2015-08-27 Celgene Corporation Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
WO2015200795A1 (en) 2014-06-27 2015-12-30 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases
EP3577459A4 (en) 2017-02-03 2020-12-16 Celgene Corporation METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON

Similar Documents

Publication Publication Date Title
JP2019506897A5 (enExample)
Larcher et al. Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy
Banerjee et al. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response
KR102313073B1 (ko) 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
Lou et al. The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development
Wang et al. Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection
Liang et al. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes
ES2978496T3 (es) Modelos animales y moléculas terapéuticas
HRP20200613T1 (hr) Neljudske životinje koje imaju humanizirani gen 1 za programiranu staničnu smrt
ES2738679T3 (es) Anticuerpos de cadena ligera diseñados genéticamente con histidina y animales no humanos modificados genéticamente para generar los mismos
HRP20251062T1 (hr) Neljudske životinje koje imaju gen humaniziranog proteina za reguliranje signala
JP2019068857A5 (enExample)
JP2017514501A5 (enExample)
RU2016123708A (ru) Отличные от человека животные, содержащие гуманизированный ген фактора активации в-клеток
JP2017505127A5 (enExample)
JP2014110814A5 (enExample)
JP2020510418A5 (enExample)
BR112019021252A2 (pt) Modelos animais e moléculas terapêuticas.
JP2015523863A5 (enExample)
JP2016526924A5 (enExample)
HRP20202034T1 (hr) Neljudske životinje s genom za humanizirani diferencijacijski biljeg cd274
RU2016107434A (ru) Не являющиеся человеком животные с дефицитом дпнрнк
RU2016123135A (ru) Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда
Togi et al. Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart
JP2021166551A (ja) 鳥類および卵