JP2020510418A5 - - Google Patents

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Publication number
JP2020510418A5
JP2020510418A5 JP2019545322A JP2019545322A JP2020510418A5 JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5 JP 2019545322 A JP2019545322 A JP 2019545322A JP 2019545322 A JP2019545322 A JP 2019545322A JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5
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JP
Japan
Prior art keywords
seq
tfr
animal
polypeptide
apical domain
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JP2019545322A
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English (en)
Japanese (ja)
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JP2020510418A (ja
JP7669113B2 (ja
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Priority claimed from PCT/US2018/018302 external-priority patent/WO2018152285A1/en
Publication of JP2020510418A publication Critical patent/JP2020510418A/ja
Publication of JP2020510418A5 publication Critical patent/JP2020510418A5/ja
Priority to JP2023085382A priority Critical patent/JP2023116513A/ja
Priority to JP2025036281A priority patent/JP2025087857A/ja
Application granted granted Critical
Publication of JP7669113B2 publication Critical patent/JP7669113B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2019545322A 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル Active JP7669113B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023085382A JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543559P 2017-08-10 2017-08-10
US201762543658P 2017-08-10 2017-08-10
US62/543,559 2017-08-10
US62/543,658 2017-08-10
US201762583314P 2017-11-08 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018302 WO2018152285A1 (en) 2017-02-17 2018-02-15 Transferrin receptor transgenic models

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023085382A Division JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル

Publications (3)

Publication Number Publication Date
JP2020510418A JP2020510418A (ja) 2020-04-09
JP2020510418A5 true JP2020510418A5 (enExample) 2021-03-11
JP7669113B2 JP7669113B2 (ja) 2025-04-28

Family

ID=61628463

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019545322A Active JP7669113B2 (ja) 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Country Status (9)

Country Link
EP (2) EP4628586A2 (enExample)
JP (3) JP7669113B2 (enExample)
KR (1) KR102637590B1 (enExample)
CN (1) CN110382526B (enExample)
AU (1) AU2018221704B2 (enExample)
CA (1) CA3053370A1 (enExample)
IL (1) IL268659A (enExample)
SG (1) SG11201907419PA (enExample)
WO (1) WO2018152285A1 (enExample)

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BR112020005271A2 (pt) 2017-10-02 2020-09-15 Denali Therapeutics Inc. proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica
SG11202011743SA (en) 2018-06-18 2021-01-28 Denali Therapeutics Inc Fusion proteins comprising progranulin
WO2021133907A1 (en) 2019-12-23 2021-07-01 Denali Therapeutics Inc. Progranulin variants
CN112243953B (zh) * 2020-07-15 2022-02-11 吉林医药学院 TfR1肺组织特异性敲除小鼠模型及其构建方法和应用
PE20231931A1 (es) 2020-10-14 2023-12-01 Denali Therapeutics Inc Proteinas de fusion que comprenden enzimas sulfoglucosamina sulfohidrolasa y metodos de estas
CN112501124A (zh) * 2020-11-27 2021-03-16 领诺(上海)医药科技有限公司 稳定表达人转铁蛋白受体1细胞株的制备方法及其应用
EP4370539A4 (en) * 2021-07-16 2025-05-28 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric tfr1
US20250136963A1 (en) 2021-12-17 2025-05-01 Denali Therapeutics Inc. Fusion proteins comprising alpha-l-iduronidase enzymes and methods
CA3242959A1 (en) 2021-12-17 2025-02-26 Denali Therapeutics Inc POLYPEPTIDE ENGINEERING, LIBRARIES AND ENGINEERED POLYPEPTIDES FOR CD98 HEAVY CHAIN LINK AND TRANSFERRINE RECEIVER
US20250215077A1 (en) 2022-03-28 2025-07-03 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
KR20250048010A (ko) * 2022-07-29 2025-04-07 리제너론 파마슈티칼스 인코포레이티드 변형된 트랜스페린 수용체 좌위를 포함하는 비-인간 동물
EP4658684A1 (en) 2023-01-30 2025-12-10 ISAR Bioscience GmbH Human anti-trem2 antibody for treating neurodegenerative disorders
CN116784280B (zh) * 2023-08-10 2025-08-19 广东药康生物科技有限公司 一种tfrc人源化小鼠模型的构建方法及其应用
WO2025137213A1 (en) 2023-12-20 2025-06-26 Denali Therapeutics Inc. Fusion proteins comprising acid alpha-glucosidase enzymes and methods thereof

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US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
US6175057B1 (en) 1997-10-08 2001-01-16 The Regents Of The University Of California Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
EP1620564A4 (en) * 2003-04-18 2008-03-12 Cytovia Inc METHODS FOR TREATING DISEASES INDUCING APOPTOSIS INDUCTION AND SCREENING ASSAYS
WO2009131632A1 (en) 2008-04-14 2009-10-29 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
EP3028565B1 (en) 2009-07-08 2017-09-27 Kymab Limited Animal models and therapeutic molecules
WO2011100058A1 (en) 2010-02-09 2011-08-18 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
US8476485B2 (en) 2010-06-24 2013-07-02 Academia Sinica Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
US9232775B2 (en) 2012-08-03 2016-01-12 Industry-Academic Cooperation Foundation, Yonsei University Genetically engineered mouse model for autism spectrum disorder having deletion of Shank2 gene and use thereof
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
JP2016516399A (ja) 2013-03-13 2016-06-09 オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション 非機能性tspo遺伝子を有するトランスジェニック非ヒト生物
EP4324480A3 (en) * 2013-05-20 2024-05-08 F. Hoffmann-La Roche AG Anti-transferrin receptor antibodies and methods of use
EP3988649B1 (en) 2013-09-18 2024-11-27 Kymab Limited Methods, cells and organisms
CN103897033A (zh) * 2014-03-31 2014-07-02 中国药科大学 转铁蛋白受体TfR特异性结合肽及其应用
EP3221362B1 (en) * 2014-11-19 2019-07-24 F.Hoffmann-La Roche Ag Anti-transferrin receptor antibodies and methods of use
CN107531788B (zh) * 2015-06-24 2022-06-21 豪夫迈·罗氏有限公司 对her2和血脑屏障受体特异性的三特异性抗体及使用方法
CA3053381A1 (en) * 2017-02-17 2018-08-23 Denali Therapeutics Inc. Engineered polypeptides

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