JP2017514501A5 - - Google Patents

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JP2017514501A5
JP2017514501A5 JP2016566656A JP2016566656A JP2017514501A5 JP 2017514501 A5 JP2017514501 A5 JP 2017514501A5 JP 2016566656 A JP2016566656 A JP 2016566656A JP 2016566656 A JP2016566656 A JP 2016566656A JP 2017514501 A5 JP2017514501 A5 JP 2017514501A5
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rodent
gene
exon
human
modified
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JP2016566656A
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JP6640740B2 (ja
JP2017514501A (ja
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JP2016566656A 2014-05-07 2015-05-07 ヒト化ＩＬ−４およびＩＬ−４Ｒα動物 Active JP6640740B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
US61/989,757 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Related Child Applications (1)

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JP2019235722A Division JP6838131B2 (ja) 2014-05-07 2019-12-26 ヒト化ＩＬ−４およびＩＬ−４Ｒα動物

Publications (3)

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JP2017514501A JP2017514501A (ja) 2017-06-08
JP2017514501A5 true JP2017514501A5 (enExample) 2018-05-24
JP6640740B2 JP6640740B2 (ja) 2020-02-05

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JP2016566656A Active JP6640740B2 (ja) 2014-05-07 2015-05-07 ヒト化ＩＬ−４およびＩＬ−４Ｒα動物
JP2019235722A Active JP6838131B2 (ja) 2014-05-07 2019-12-26 ヒト化ＩＬ−４およびＩＬ−４Ｒα動物
JP2021019538A Active JP7145250B2 (ja) 2014-05-07 2021-02-10 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物
JP2022147925A Pending JP2022171841A (ja) 2014-05-07 2022-09-16 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物
JP2024150803A Active JP7755699B2 (ja) 2014-05-07 2024-09-02 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物

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JP2019235722A Active JP6838131B2 (ja) 2014-05-07 2019-12-26 ヒト化ＩＬ−４およびＩＬ−４Ｒα動物
JP2021019538A Active JP7145250B2 (ja) 2014-05-07 2021-02-10 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物
JP2022147925A Pending JP2022171841A (ja) 2014-05-07 2022-09-16 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物
JP2024150803A Active JP7755699B2 (ja) 2014-05-07 2024-09-02 ヒト化ＩＬ－４およびＩＬ－４Ｒα動物

Country Status (26)

Country Link
US (7) US9565841B2 (enExample)
EP (3) EP3281521B1 (enExample)
JP (5) JP6640740B2 (enExample)
KR (2) KR102473565B1 (enExample)
CN (2) CN106470545B (enExample)
AU (3) AU2015255977B2 (enExample)
BR (1) BR112016025745A2 (enExample)
CA (2) CA3207834C (enExample)
CY (2) CY1119773T1 (enExample)
DK (2) DK3027015T3 (enExample)
ES (2) ES2656529T3 (enExample)
HR (2) HRP20211455T1 (enExample)
HU (2) HUE055860T2 (enExample)
IL (3) IL297105B2 (enExample)
LT (2) LT3281521T (enExample)
MX (1) MX370672B (enExample)
NO (1) NO2785538T3 (enExample)
PH (1) PH12016502058A1 (enExample)
PL (2) PL3027015T3 (enExample)
PT (2) PT3027015T (enExample)
RS (2) RS57073B1 (enExample)
RU (1) RU2703139C2 (enExample)
SG (2) SG10201912354PA (enExample)
SI (2) SI3281521T1 (enExample)
SM (2) SMT201800018T1 (enExample)
WO (1) WO2015171861A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (enExample) 2014-05-07 2018-08-04
WO2015196051A1 (en) 2014-06-19 2015-12-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
EP3212819B1 (en) * 2014-09-17 2023-03-29 Oerlikon Surface Solutions AG, Pfäffikon Method for producing a double-layer coated cutting tool with improved wear resistance
BR112017010793A2 (pt) 2014-11-24 2017-12-26 Regeneron Pharma animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo.
BR112017010490A2 (pt) 2014-12-05 2018-04-03 Regeneron Pharma roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano.
ES2841353T3 (es) 2014-12-09 2021-07-08 Regeneron Pharma Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado
CN108366548B (zh) 2015-11-20 2021-10-08 瑞泽恩制药公司 具有人源化淋巴细胞活化基因3的非人动物
WO2017136712A1 (en) 2016-02-04 2017-08-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
TWI784988B (zh) * 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
MX2019012171A (es) 2017-04-13 2019-11-25 Regeneron Pharma Tratamiento e inhibicion de enfermedades pulmonares inflamatorias en pacientes que tienen alelos de riesgo en los genes que codifican la il33 e il1rl1.
WO2018231827A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
WO2019067875A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
JP7361031B2 (ja) 2017-11-30 2023-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物
IL277355B2 (en) 2018-03-26 2025-01-01 Regeneron Pharma Humanized rodents for testing therapeutic agents
IL307286B2 (en) 2018-04-11 2026-03-01 Regeneron Pharma Methods and compositions for quantifying il-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
CA3098040A1 (en) 2018-07-16 2020-01-23 Regeneron Pharmaceuticals, Inc. Non-human animal models of ditra disease and uses thereof
CN111057721B (zh) * 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子１２遺伝子座を含む非ヒト動物
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN113939595A (zh) 2019-06-07 2022-01-14 瑞泽恩制药公司 包括人源化白蛋白基因座的非人动物
US20220272953A1 (en) * 2019-07-29 2022-09-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il33
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
CN112779285B (zh) * 2019-11-11 2023-01-06 百奥赛图(北京)医药科技股份有限公司 人源化il-10和il-10ra基因改造动物的构建方法和应用
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
WO2021154791A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485B (zh) 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
JP2024500153A (ja) * 2020-12-21 2024-01-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物
CN114835798B (zh) * 2021-05-28 2024-02-23 百奥赛图(北京)医药科技股份有限公司 Cd36基因人源化非人动物的构建方法及应用
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物
EP4649500A1 (en) * 2023-01-11 2025-11-19 Regeneron Pharmaceuticals, Inc. Systems and methods for a regulatory-compliant automated assay
WO2025175099A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. A rodent copd model

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (en) * 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20110016543A1 (en) 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
SG10201403703XA (en) * 2009-06-29 2014-10-30 Qingfeng Chen Methods of producing humanized non-human mammals
KR20120097483A (ko) * 2009-07-24 2012-09-04 시그마-알드리치 컴퍼니., 엘엘씨 게놈 편집을 위한 방법
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
EP4502152A3 (en) 2009-10-06 2025-04-30 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
PT4233537T (pt) 2011-02-15 2025-09-08 Regeneron Pharma Ratinhos humanizados para m-csf e utilizações dos mesmos
SI2818478T1 (sl) * 2011-10-28 2017-07-31 Regeneron Pharmaceuticals, Inc. Humanizirani il-6 in receptor il-6
RS63220B1 (sr) 2011-10-28 2022-06-30 Regeneron Pharma Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
KR102295746B1 (ko) 2011-10-28 2021-09-01 리제너론 파아마슈티컬스, 인크. 유전자 변형된 주요 조직적합성 복합체 마우스
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
KR102502640B1 (ko) 2012-08-21 2023-02-23 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR102241962B1 (ko) 2012-09-07 2021-04-20 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
DK4389764T3 (da) 2012-11-05 2026-04-13 Regeneron Pharma Genetisk modificerede gnavere og fremgangsmåder til anvendelse heraf
US9848587B2 (en) 2013-02-20 2017-12-26 Regeneron Pharmaceuticals, Inc. Humanized T cell co-receptor mice
SI2958937T1 (sl) 2013-02-22 2018-12-31 Regeneron Pharmaceuticals, Inc. Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
HRP20231121T1 (hr) 2013-09-23 2023-12-22 Regeneron Pharmaceuticals, Inc. Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale
JP6492095B2 (ja) 2013-10-15 2019-03-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｉｌ−１５動物
MY183188A (en) 2013-11-19 2021-02-18 Regeneron Pharma Non-human animals having a humanized b-cell activating factor gene
US20150143559A1 (en) 2013-11-19 2015-05-21 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
RS60398B1 (sr) 2014-04-08 2020-07-31 Regeneron Pharma Ne-humane životinje sa humanizovanim fc-gama receptorima
MX2016014504A (es) 2014-05-05 2017-05-23 Regeneron Pharma Animales c5 y c3 humanizados.
NO2785538T3 (enExample) * 2014-05-07 2018-08-04

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