JP2017514501A5 - - Google Patents
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- JP2017514501A5 JP2017514501A5 JP2016566656A JP2016566656A JP2017514501A5 JP 2017514501 A5 JP2017514501 A5 JP 2017514501A5 JP 2016566656 A JP2016566656 A JP 2016566656A JP 2016566656 A JP2016566656 A JP 2016566656A JP 2017514501 A5 JP2017514501 A5 JP 2017514501A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- gene
- exon
- human
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims description 218
- 108090000978 Interleukin-4 Proteins 0.000 claims description 103
- 108090000623 proteins and genes Proteins 0.000 claims description 75
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 60
- 102000004388 Interleukin-4 Human genes 0.000 claims description 57
- 239000012634 fragment Substances 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 41
- 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 claims description 39
- 230000001105 regulatory effect Effects 0.000 claims description 38
- 108091081024 Start codon Proteins 0.000 claims description 35
- 101100232919 Homo sapiens IL4 gene Proteins 0.000 claims description 27
- 230000014509 gene expression Effects 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 238000006467 substitution reaction Methods 0.000 claims description 15
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 claims description 12
- 108700024394 Exon Proteins 0.000 claims description 11
- 102000055229 human IL4 Human genes 0.000 claims description 11
- 101100232925 Mus musculus Il4 gene Proteins 0.000 claims description 10
- 239000005557 antagonist Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 201000004624 Dermatitis Diseases 0.000 claims description 6
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 claims description 6
- 206010035664 Pneumonia Diseases 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- 241000699670 Mus sp. Species 0.000 claims description 3
- 230000001086 cytosolic effect Effects 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims 8
- 238000001467 acupuncture Methods 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 description 20
- 101001033311 Mus musculus Interleukin-4 receptor subunit alpha Proteins 0.000 description 18
- 101001002703 Mus musculus Interleukin-4 Proteins 0.000 description 7
- 210000001744 T-lymphocyte Anatomy 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 241001529936 Murinae Species 0.000 description 3
- 101100460719 Mus musculus Noto gene Proteins 0.000 description 3
- 210000002865 immune cell Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011577 humanized mouse model Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461989757P | 2014-05-07 | 2014-05-07 | |
| US61/989,757 | 2014-05-07 | ||
| PCT/US2015/029638 WO2015171861A1 (en) | 2014-05-07 | 2015-05-07 | Humanized il-4 and il-4r alpha animals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019235722A Division JP6838131B2 (ja) | 2014-05-07 | 2019-12-26 | ヒト化ＩＬ−４およびＩＬ−４Ｒα動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514501A JP2017514501A (ja) | 2017-06-08 |
| JP2017514501A5 true JP2017514501A5 (enExample) | 2018-05-24 |
| JP6640740B2 JP6640740B2 (ja) | 2020-02-05 |
Family
ID=53284509
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016566656A Active JP6640740B2 (ja) | 2014-05-07 | 2015-05-07 | ヒト化ＩＬ−４およびＩＬ−４Ｒα動物 |
| JP2019235722A Active JP6838131B2 (ja) | 2014-05-07 | 2019-12-26 | ヒト化ＩＬ−４およびＩＬ−４Ｒα動物 |
| JP2021019538A Active JP7145250B2 (ja) | 2014-05-07 | 2021-02-10 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
| JP2022147925A Pending JP2022171841A (ja) | 2014-05-07 | 2022-09-16 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
| JP2024150803A Active JP7755699B2 (ja) | 2014-05-07 | 2024-09-02 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019235722A Active JP6838131B2 (ja) | 2014-05-07 | 2019-12-26 | ヒト化ＩＬ−４およびＩＬ−４Ｒα動物 |
| JP2021019538A Active JP7145250B2 (ja) | 2014-05-07 | 2021-02-10 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
| JP2022147925A Pending JP2022171841A (ja) | 2014-05-07 | 2022-09-16 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
| JP2024150803A Active JP7755699B2 (ja) | 2014-05-07 | 2024-09-02 | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US9565841B2 (enExample) |
| EP (3) | EP3906781A1 (enExample) |
| JP (5) | JP6640740B2 (enExample) |
| KR (2) | KR102473565B1 (enExample) |
| CN (2) | CN106470545B (enExample) |
| AU (3) | AU2015255977B2 (enExample) |
| BR (1) | BR112016025745A2 (enExample) |
| CA (2) | CA2947307C (enExample) |
| CY (2) | CY1119773T1 (enExample) |
| DK (2) | DK3281521T3 (enExample) |
| ES (2) | ES2656529T3 (enExample) |
| HR (2) | HRP20180242T1 (enExample) |
| HU (2) | HUE055860T2 (enExample) |
| IL (3) | IL297105B2 (enExample) |
| LT (2) | LT3281521T (enExample) |
| MX (1) | MX370672B (enExample) |
| NO (1) | NO2785538T3 (enExample) |
| PH (1) | PH12016502058A1 (enExample) |
| PL (2) | PL3281521T3 (enExample) |
| PT (2) | PT3027015T (enExample) |
| RS (2) | RS62345B1 (enExample) |
| RU (1) | RU2703139C2 (enExample) |
| SG (2) | SG10201912354PA (enExample) |
| SI (2) | SI3027015T1 (enExample) |
| SM (2) | SMT201800018T1 (enExample) |
| WO (1) | WO2015171861A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| US10390522B2 (en) | 2014-06-19 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| HUE061930T2 (hu) * | 2014-09-17 | 2023-09-28 | Oerlikon Surface Solutions Ag Pfaeffikon | Eljárás javított kopásállóságú kétrétegû bevonatos vágószerszám elõállítására |
| MX2017006802A (es) | 2014-11-24 | 2018-01-30 | Regeneron Pharma | Animales no humanos que expresan el complejo cd3 humanizado. |
| TR201903891T4 (tr) | 2014-12-05 | 2019-04-22 | Regeneron Pharma | Bir insanlaştırılmış farklılaşma kümesi 47 genine sahip olan insan dışı hayvanlar. |
| HRP20202034T1 (hr) | 2014-12-09 | 2021-02-19 | Regeneron Pharmaceuticals, Inc. | Neljudske životinje s genom za humanizirani diferencijacijski biljeg cd274 |
| JP6997708B2 (ja) | 2015-11-20 | 2022-02-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化されたｌｙｍｐｈｏｃｙｔｅ－ａｃｔｉｖａｔｉｏｎ ｇｅｎｅ ３遺伝子を有する非ヒト動物 |
| JP6843872B2 (ja) | 2016-02-04 | 2021-03-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
| RU2749715C2 (ru) | 2016-02-29 | 2021-06-16 | Регенерон Фармасьютикалз, Инк. | Грызуны, характеризующиеся гуманизированным геном tmprss |
| TWI784988B (zh) * | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2018190990A1 (en) | 2017-04-13 | 2018-10-18 | Regeneron Pharmaceuticals, Inc. | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| KR102544051B1 (ko) | 2017-09-29 | 2023-06-16 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 ttr 유전자좌를 포함하는 비인간 동물 및 사용 방법 |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| CN112105260B (zh) | 2018-03-26 | 2023-04-28 | 瑞泽恩制药公司 | 用于测试治疗剂的人源化啮齿动物 |
| IL277890B2 (en) | 2018-04-11 | 2024-03-01 | Regeneron Pharma | Methods for quantifying il-33 |
| JP7048051B2 (ja) | 2018-07-11 | 2022-04-05 | 正徳 染井 | 痒みを軽減するアトピー性皮膚炎治療剤 |
| SMT202400300T1 (it) * | 2018-07-16 | 2024-09-16 | Regeneron Pharma | Modelli di roditori della sindrome ditra e loro utilizzo |
| WO2020074005A1 (en) * | 2018-10-12 | 2020-04-16 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric genes |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| AU2020286382A1 (en) | 2019-06-04 | 2021-11-04 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| TW202112229A (zh) | 2019-06-07 | 2021-04-01 | 美商雷傑納榮製藥公司 | 包含人化白蛋白基因座之非人的動物 |
| WO2021018198A1 (en) * | 2019-07-29 | 2021-02-04 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric il33 |
| WO2021027737A1 (en) * | 2019-08-09 | 2021-02-18 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric il2ra |
| EP4057807A4 (en) * | 2019-11-11 | 2023-12-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMAL CONTAINING HUMAN OR CHIMERIC GENES |
| US20220354097A1 (en) * | 2019-12-25 | 2022-11-10 | Gempharmatech Co., Ltd. | Il-15 humanized mouse model and use thereof |
| AU2021212668A1 (en) * | 2020-01-28 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized PNPLA3 locus and methods of use |
| CN111149767B (zh) * | 2020-02-24 | 2021-07-20 | 中南大学湘雅二医院 | 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用 |
| CN113527485B (zh) | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN111808882B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | Il7r基因人源化改造的动物模型的构建方法及其应用 |
| CN111793646B (zh) * | 2020-09-08 | 2021-01-15 | 北京百奥赛图基因生物技术有限公司 | Il1r1基因人源化改造的非人动物的构建方法及其应用 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| AU2021409632A1 (en) * | 2020-12-21 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene |
| CN114835798B (zh) * | 2021-05-28 | 2024-02-23 | 百奥赛图(北京)医药科技股份有限公司 | Cd36基因人源化非人动物的构建方法及应用 |
| CN120035675A (zh) * | 2022-09-28 | 2025-05-23 | 百奥赛图(北京)医药科技股份有限公司 | 一种il5和/或il5ra基因人源化修饰的非人动物 |
| EP4649500A1 (en) * | 2023-01-11 | 2025-11-19 | Regeneron Pharmaceuticals, Inc. | Systems and methods for a regulatory-compliant automated assay |
| WO2025175099A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | A rodent copd model |
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| AU643427B2 (en) * | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| JP2007252370A (ja) * | 2006-02-22 | 2007-10-04 | Institute Of Physical & Chemical Research | Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用 |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US20110016543A1 (en) * | 2008-12-04 | 2011-01-20 | Sigma-Aldrich Co. | Genomic editing of genes involved in inflammation |
| SG10201403703XA (en) * | 2009-06-29 | 2014-10-30 | Qingfeng Chen | Methods of producing humanized non-human mammals |
| WO2011011767A1 (en) * | 2009-07-24 | 2011-01-27 | Sigma-Aldrich Co. | Method for genome editing |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
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| EP2675271B1 (en) | 2011-02-15 | 2018-06-13 | Regeneron Pharmaceuticals, Inc. | Humanized m-csf mice |
| PT2770821T (pt) | 2011-10-28 | 2017-12-18 | Regeneron Pharma | Ratinhos de complexo principal de histocompatibilidade principal modificados geneticamente |
| PL2663575T3 (pl) * | 2011-10-28 | 2015-03-31 | Regeneron Pharma | Humanizowane IL-6 i receptor IL-6 |
| HRP20220616T1 (hr) | 2011-10-28 | 2022-06-24 | Regeneron Pharmaceuticals, Inc. | Genetski modificirani miš koji eksprimira kimerne molekule glavnog kompleksa histokompatibilnosti (mhc) ii |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| WO2014031610A1 (en) * | 2012-08-21 | 2014-02-27 | Sanofi | Methods for treating or preventing asthma by administering an il-4r antagonist |
| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| US9901082B2 (en) | 2012-11-05 | 2018-02-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
| KR102369454B1 (ko) | 2013-02-20 | 2022-03-04 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| CN110192541B (zh) | 2013-02-22 | 2022-02-18 | 瑞泽恩制药公司 | 表达人源化主要组织相容性复合物的小鼠 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| SG11201601184UA (en) | 2013-09-23 | 2016-03-30 | Regeneron Pharma | Non-human animals having a humanized signal-regulatory protein gene |
| US9155290B2 (en) | 2013-10-15 | 2015-10-13 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
| WO2015077071A1 (en) | 2013-11-19 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| CN105792647B (zh) | 2013-11-19 | 2018-10-02 | 瑞泽恩制药公司 | 具有人源化的增殖诱导配体基因的非人动物 |
| CN106163273B (zh) | 2014-04-08 | 2020-07-24 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 |
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2012
- 2012-11-22 NO NO12794266A patent/NO2785538T3/no unknown
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2015
- 2015-05-07 CN CN201580036907.6A patent/CN106470545B/zh active Active
- 2015-05-07 HU HUE17193855A patent/HUE055860T2/hu unknown
- 2015-05-07 SI SI201530162T patent/SI3027015T1/en unknown
- 2015-05-07 CN CN201910691834.4A patent/CN110269047B/zh active Active
- 2015-05-07 EP EP21166663.1A patent/EP3906781A1/en active Pending
- 2015-05-07 CA CA2947307A patent/CA2947307C/en active Active
- 2015-05-07 CA CA3207834A patent/CA3207834C/en active Active
- 2015-05-07 MX MX2016014563A patent/MX370672B/es active IP Right Grant
- 2015-05-07 HU HUE15727106A patent/HUE038028T2/hu unknown
- 2015-05-07 KR KR1020167034170A patent/KR102473565B1/ko active Active
- 2015-05-07 IL IL297105A patent/IL297105B2/en unknown
- 2015-05-07 IL IL304841A patent/IL304841B1/en unknown
- 2015-05-07 SM SM20180018T patent/SMT201800018T1/it unknown
- 2015-05-07 AU AU2015255977A patent/AU2015255977B2/en active Active
- 2015-05-07 DK DK17193855.8T patent/DK3281521T3/da active
- 2015-05-07 PL PL17193855T patent/PL3281521T3/pl unknown
- 2015-05-07 SI SI201531703T patent/SI3281521T1/sl unknown
- 2015-05-07 IL IL248358A patent/IL248358B2/en unknown
- 2015-05-07 RS RS20211141A patent/RS62345B1/sr unknown
- 2015-05-07 RS RS20180131A patent/RS57073B1/sr unknown
- 2015-05-07 JP JP2016566656A patent/JP6640740B2/ja active Active
- 2015-05-07 SG SG10201912354PA patent/SG10201912354PA/en unknown
- 2015-05-07 ES ES15727106.5T patent/ES2656529T3/es active Active
- 2015-05-07 ES ES17193855T patent/ES2887852T3/es active Active
- 2015-05-07 HR HRP20180242TT patent/HRP20180242T1/hr unknown
- 2015-05-07 LT LTEP17193855.8T patent/LT3281521T/lt unknown
- 2015-05-07 EP EP17193855.8A patent/EP3281521B1/en active Active
- 2015-05-07 SM SM20210560T patent/SMT202100560T1/it unknown
- 2015-05-07 RU RU2016143376A patent/RU2703139C2/ru active
- 2015-05-07 PT PT157271065T patent/PT3027015T/pt unknown
- 2015-05-07 LT LTEP15727106.5T patent/LT3027015T/lt unknown
- 2015-05-07 PT PT171938558T patent/PT3281521T/pt unknown
- 2015-05-07 BR BR112016025745-6A patent/BR112016025745A2/pt not_active Application Discontinuation
- 2015-05-07 EP EP15727106.5A patent/EP3027015B1/en active Active
- 2015-05-07 KR KR1020227041893A patent/KR102517112B1/ko active Active
- 2015-05-07 PL PL15727106T patent/PL3027015T3/pl unknown
- 2015-05-07 US US14/706,319 patent/US9565841B2/en active Active
- 2015-05-07 DK DK15727106.5T patent/DK3027015T3/en active
- 2015-05-07 WO PCT/US2015/029638 patent/WO2015171861A1/en not_active Ceased
- 2015-05-07 SG SG11201608570YA patent/SG11201608570YA/en unknown
- 2015-05-07 HR HRP20211455TT patent/HRP20211455T1/hr unknown
- 2015-07-06 US US14/791,978 patent/US9743647B2/en active Active
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2017
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