PH12016502058A1 - Humanized il-4 and il-4r alpha animals - Google Patents

Humanized il-4 and il-4r alpha animals

Info

Publication number
PH12016502058A1
PH12016502058A1 PH12016502058A PH12016502058A PH12016502058A1 PH 12016502058 A1 PH12016502058 A1 PH 12016502058A1 PH 12016502058 A PH12016502058 A PH 12016502058A PH 12016502058 A PH12016502058 A PH 12016502058A PH 12016502058 A1 PH12016502058 A1 PH 12016502058A1
Authority
PH
Philippines
Prior art keywords
human
humanized
animals
gene
human animals
Prior art date
Application number
PH12016502058A
Other languages
English (en)
Inventor
Wang Li-Hsien
Xue Yingzi
Andrew J Murphy
Stevens Sean
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PH12016502058A1 publication Critical patent/PH12016502058A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PH12016502058A 2014-05-07 2016-10-17 Humanized il-4 and il-4r alpha animals PH12016502058A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (1)

Publication Number Publication Date
PH12016502058A1 true PH12016502058A1 (en) 2017-01-09

Family

ID=53284509

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12016502058A PH12016502058A1 (en) 2014-05-07 2016-10-17 Humanized il-4 and il-4r alpha animals

Country Status (26)

Country Link
US (7) US9565841B2 (enExample)
EP (3) EP3027015B1 (enExample)
JP (5) JP6640740B2 (enExample)
KR (2) KR102517112B1 (enExample)
CN (2) CN110269047B (enExample)
AU (3) AU2015255977B2 (enExample)
BR (1) BR112016025745A2 (enExample)
CA (2) CA3207834C (enExample)
CY (2) CY1119773T1 (enExample)
DK (2) DK3027015T3 (enExample)
ES (2) ES2887852T3 (enExample)
HR (2) HRP20180242T1 (enExample)
HU (2) HUE038028T2 (enExample)
IL (3) IL297105B2 (enExample)
LT (2) LT3281521T (enExample)
MX (1) MX370672B (enExample)
NO (1) NO2785538T3 (enExample)
PH (1) PH12016502058A1 (enExample)
PL (2) PL3027015T3 (enExample)
PT (2) PT3281521T (enExample)
RS (2) RS57073B1 (enExample)
RU (1) RU2703139C2 (enExample)
SG (2) SG11201608570YA (enExample)
SI (2) SI3027015T1 (enExample)
SM (2) SMT202100560T1 (enExample)
WO (1) WO2015171861A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (enExample) 2014-05-07 2018-08-04
SMT202000184T1 (it) 2014-06-19 2020-05-08 Regeneron Pharma Animali non umani aventi un gene 1 della morte cellulare programmata umanizzato
HUE061930T2 (hu) * 2014-09-17 2023-09-28 Oerlikon Surface Solutions Ag Pfaeffikon Eljárás javított kopásállóságú kétrétegû bevonatos vágószerszám elõállítására
EP3223605B9 (en) 2014-11-24 2021-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals expressing humanized cd3 complex
HUE064960T2 (hu) 2014-12-05 2024-04-28 Regeneron Pharma Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok
AU2015360667B2 (en) 2014-12-09 2021-09-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
EP3376857B1 (en) 2015-11-20 2021-02-24 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
ES2908669T3 (es) 2016-02-04 2022-05-03 Regeneron Pharma Animales no humanos que tienen un gen ANGPTL8 modificado genéticamente
PT3422845T (pt) * 2016-02-29 2021-08-26 Regeneron Pharma Roedores com um gene tmprss humanizado
TWI857389B (zh) * 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
EP3957752B1 (en) 2017-04-13 2025-08-20 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
CN118994394A (zh) 2017-06-12 2024-11-22 蓝鳍生物医药公司 抗-il1rap抗体和抗体药物缀合物
EP4276185A3 (en) 2017-09-29 2024-02-21 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
CN111655031B (zh) 2017-11-30 2022-11-18 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
IL314733A (en) 2018-03-26 2024-10-01 Regeneron Pharma Humanized rodents for testing therapeutic agents
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
US11589562B2 (en) * 2018-07-16 2023-02-28 Regeneran Pharmaceuticals, Inc. Mouse model of DITRA disease and uses thereof
CN111057721B (zh) * 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
IL286905B2 (en) 2019-04-04 2024-06-01 Regeneron Pharma Non-human animals containing the human coagulation factor 12 locus
KR20220016869A (ko) 2019-06-04 2022-02-10 리제너론 파마슈티칼스 인코포레이티드 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법
BR112021022722A2 (pt) 2019-06-07 2022-01-04 Regeneron Pharma Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente
CN112300265B (zh) * 2019-07-29 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il33基因人源化的非人动物的构建方法和应用
CN112430621B (zh) * 2019-08-09 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il2ra基因人源化的非人动物的构建方法及应用
WO2021093790A1 (en) * 2019-11-11 2021-05-20 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes
US20220354097A1 (en) * 2019-12-25 2022-11-10 Gempharmatech Co., Ltd. Il-15 humanized mouse model and use thereof
KR20220133248A (ko) * 2020-01-28 2022-10-04 리제너론 파마슈티칼스 인코포레이티드 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485B (zh) * 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
IL303724A (en) * 2020-12-21 2023-08-01 Regeneron Pharma Non-human animals with a humanized TSLP gene, a humanized TSLP receptor gene, and/or a humanized IL7RA gene
WO2022247936A1 (en) * 2021-05-28 2022-12-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric cd36
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物
IL322030A (en) * 2023-01-11 2025-09-01 Regeneron Pharma Methods and systems for automated regulatory compliance testing
WO2025175099A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. A rodent copd model

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643427B2 (en) * 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
DK1802193T3 (da) 2004-10-19 2014-06-10 Regeneron Pharma Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
EP2449094A4 (en) * 2009-06-29 2013-07-10 Qingfeng Chen METHOD FOR PRODUCING HUMANIZED NON-MAMMAL MAMMALS
JP2013500018A (ja) * 2009-07-24 2013-01-07 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー ゲノム編集のための方法
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
ES2908587T3 (es) 2009-10-06 2022-05-03 Regeneron Pharma Ratones modificados genéticamente e injerto
PT4233537T (pt) 2011-02-15 2025-09-08 Regeneron Pharma Ratinhos humanizados para m-csf e utilizações dos mesmos
EP2770822B9 (en) 2011-10-28 2019-12-11 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
BR112014008529A2 (pt) * 2011-10-28 2017-04-18 Regeneron Pharma il-6 humanizado e receptor de il-6
DK2770821T3 (da) 2011-10-28 2017-11-27 Regeneron Pharma Genetisk modificerede major histocompatibility-kompleks-mus
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
JP6306588B2 (ja) * 2012-08-21 2018-04-04 サノフィ・バイオテクノロジー Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法
RU2642319C2 (ru) 2012-09-07 2018-01-24 Йель Юниверсити Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования
PT3939423T (pt) 2012-11-05 2024-05-29 Regeneron Pharma Animais não humanos geneticamente modificados e métodos de utilização dos mesmos
EP3543253B1 (en) 2013-02-20 2024-03-27 Regeneron Pharmaceuticals, Inc. Mice expressing humanized t-cell co-receptors
HRP20181866T1 (hr) 2013-02-22 2019-01-25 Regeneron Pharmaceuticals, Inc. Miševi koji izražavaju humanizirane komplekse glavne histokompatibilnosti
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
KR102407354B1 (ko) 2013-09-23 2022-06-10 리제너론 파마슈티칼스 인코포레이티드 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물
SI3138397T1 (sl) 2013-10-15 2019-04-30 Regeneron Pharmaceuticals, Inc. Humanizirane živali IL-15
MX358206B (es) 2013-11-19 2018-08-09 Regeneron Pharma Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion.
US20150143558A1 (en) 2013-11-19 2015-05-21 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
DK3129400T3 (da) 2014-04-08 2020-06-08 Regeneron Pharma Ikke-humane dyr med humaniserede Fc-gamma-receptorer
US9795121B2 (en) 2014-05-05 2017-10-24 Regeneron Pharmaceuticals, Inc. Humanized C3 animals
NO2785538T3 (enExample) * 2014-05-07 2018-08-04

Also Published As

Publication number Publication date
JP2017514501A (ja) 2017-06-08
BR112016025745A2 (pt) 2018-01-16
RU2016143376A3 (enExample) 2018-11-22
RU2019131253A (ru) 2019-12-06
RU2016143376A (ru) 2018-06-09
WO2015171861A1 (en) 2015-11-12
CN106470545B (zh) 2019-08-20
IL297105A (en) 2022-12-01
DK3027015T3 (en) 2018-01-22
EP3027015A1 (en) 2016-06-08
EP3906781A1 (en) 2021-11-10
CY1124605T1 (el) 2022-07-22
IL297105B1 (en) 2023-09-01
AU2015255977A1 (en) 2016-11-17
LT3027015T (lt) 2018-01-25
JP2024159985A (ja) 2024-11-08
JP2022171841A (ja) 2022-11-11
JP6640740B2 (ja) 2020-02-05
HUE055860T2 (hu) 2021-12-28
US9565841B2 (en) 2017-02-14
PT3027015T (pt) 2018-02-09
US20230027494A1 (en) 2023-01-26
SG11201608570YA (en) 2016-11-29
US20200022344A1 (en) 2020-01-23
CA3207834A1 (en) 2015-11-12
JP7145250B2 (ja) 2022-09-30
US11963521B2 (en) 2024-04-23
JP6838131B2 (ja) 2021-03-03
SI3027015T1 (en) 2018-02-28
JP2021087434A (ja) 2021-06-10
US20150320022A1 (en) 2015-11-12
AU2015255977B2 (en) 2021-09-02
EP3027015B1 (en) 2017-11-08
PT3281521T (pt) 2021-09-16
US20180000056A1 (en) 2018-01-04
AU2024204694A1 (en) 2024-09-05
AU2021218060A1 (en) 2021-09-09
ES2887852T3 (es) 2021-12-28
PL3281521T3 (pl) 2022-01-03
IL304841B1 (en) 2025-09-01
SMT202100560T1 (it) 2021-11-12
RS62345B1 (sr) 2021-10-29
SI3281521T1 (sl) 2021-11-30
CA2947307C (en) 2023-09-26
US12310340B2 (en) 2025-05-27
MX2016014563A (es) 2017-02-23
IL248358B2 (en) 2023-03-01
NO2785538T3 (enExample) 2018-08-04
US20150320021A1 (en) 2015-11-12
HUE038028T2 (hu) 2018-09-28
IL304841A (en) 2023-09-01
CA2947307A1 (en) 2015-11-12
DK3281521T3 (da) 2021-09-20
US9743647B2 (en) 2017-08-29
IL297105B2 (en) 2024-01-01
CY1119773T1 (el) 2018-06-27
SG10201912354PA (en) 2020-02-27
CN110269047B (zh) 2021-11-02
HRP20211455T1 (hr) 2022-01-07
KR20160150637A (ko) 2016-12-30
US10588298B2 (en) 2020-03-17
US20210368753A1 (en) 2021-12-02
EP3281521B1 (en) 2021-06-30
NZ763861A (en) 2024-05-31
JP7755699B2 (ja) 2025-10-16
JP2020058379A (ja) 2020-04-16
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
KR102473565B1 (ko) 2022-12-02
LT3281521T (lt) 2021-09-27
IL248358B (en) 2022-11-01
IL248358A0 (en) 2016-11-30
RS57073B1 (sr) 2018-06-29
EP3281521A1 (en) 2018-02-14
CN110269047A (zh) 2019-09-24
ES2656529T3 (es) 2018-02-27
KR20220165814A (ko) 2022-12-15
AU2021218060B2 (en) 2024-04-11
NZ725615A (en) 2024-05-31
HRP20180242T1 (hr) 2018-03-09
US20170311580A1 (en) 2017-11-02
CN106470545A (zh) 2017-03-01
SMT201800018T1 (it) 2018-03-08
RU2703139C2 (ru) 2019-10-15
PL3027015T3 (pl) 2018-04-30
AU2021218060C1 (en) 2024-11-07
KR102517112B1 (ko) 2023-04-03
MX370672B (es) 2019-12-19
CA3207834C (en) 2025-10-14

Similar Documents

Publication Publication Date Title
PH12016502058A1 (en) Humanized il-4 and il-4r alpha animals
MX2016014504A (es) Animales c5 y c3 humanizados.
PH12016502170A1 (en) Humanized dipeptidyl peptidase iv (dpp4) animals
HK1203761A1 (en) Humanized il-7 rodents
PH12016500342A1 (en) Non-human animals having a humanized signal-regulatory protein gene
MY172726A (en) Humanized il-6 and il-6 receptor
MX2016016903A (es) Animales no humanos que tienen un gen de muerte celular programada 1 humanizado.
EP3392337A4 (en) GENETIC CHANGE OF NON-HUMAN ORGANISM, EGGS, BURIED EGGS AND METHOD OF MODIFYING TARGET GENES
MY183188A (en) Non-human animals having a humanized b-cell activating factor gene
MY183189A (en) Non-human animals having a humanized a proliferation-inducing ligand gene
EP3507373A4 (en) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERAL PD-L1
AR102888A1 (es) Animales no humanos que tienen un gen humanizado de agrupamiento de diferenciación 47
MX2016004781A (es) Il-15 humanizada en animales.
MX2017007636A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 274 humanizado.
MX2022001202A (es) Ratones con genes insertados de sirp¿-il15 humanizadas y métodos para usarlos.
AU2018338790A8 (en) Non-human animals comprising a humanized TTR locus and methods of use
MX2016013241A (es) Animales no humanos que tienen receptores fc gamma humanizados.
EP4249502A3 (en) Rodents expressing humanized c1q complex
HK1244511A1 (zh) 与嗜酸细胞食管炎相关的基因改变的诊断和治疗