SI3027015T1 - HUMANIZED IL-4 AND IL-4R ALPHA ANIMALS - Google Patents

HUMANIZED IL-4 AND IL-4R ALPHA ANIMALS Download PDF

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Publication number
SI3027015T1
SI3027015T1 SI201530162T SI201530162T SI3027015T1 SI 3027015 T1 SI3027015 T1 SI 3027015T1 SI 201530162 T SI201530162 T SI 201530162T SI 201530162 T SI201530162 T SI 201530162T SI 3027015 T1 SI3027015 T1 SI 3027015T1
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Slovenia
Prior art keywords
rodent
gene
human
humanized
exon
Prior art date
Application number
SI201530162T
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English (en)
Slovenian (sl)
Inventor
Li-Hsien Wang
Yingzi Xue
Andrew J. Murphy
Sean Stevens
Original Assignee
Regeneron Pharmaceuticals, Inc.
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Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of SI3027015T1 publication Critical patent/SI3027015T1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201530162T 2014-05-07 2015-05-07 HUMANIZED IL-4 AND IL-4R ALPHA ANIMALS SI3027015T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals
EP15727106.5A EP3027015B1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (1)

Publication Number Publication Date
SI3027015T1 true SI3027015T1 (en) 2018-02-28

Family

ID=53284509

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201530162T SI3027015T1 (en) 2014-05-07 2015-05-07 HUMANIZED IL-4 AND IL-4R ALPHA ANIMALS
SI201531703T SI3281521T1 (sl) 2014-05-07 2015-05-07 Humanizirane IL-4 in IL-4R alfa živali

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201531703T SI3281521T1 (sl) 2014-05-07 2015-05-07 Humanizirane IL-4 in IL-4R alfa živali

Country Status (26)

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US (7) US9565841B2 (enExample)
EP (3) EP3027015B1 (enExample)
JP (5) JP6640740B2 (enExample)
KR (2) KR102517112B1 (enExample)
CN (2) CN110269047B (enExample)
AU (3) AU2015255977B2 (enExample)
BR (1) BR112016025745A2 (enExample)
CA (2) CA2947307C (enExample)
CY (2) CY1119773T1 (enExample)
DK (2) DK3281521T3 (enExample)
ES (2) ES2887852T3 (enExample)
HR (2) HRP20180242T1 (enExample)
HU (2) HUE055860T2 (enExample)
IL (3) IL297105B2 (enExample)
LT (2) LT3281521T (enExample)
MX (1) MX370672B (enExample)
NO (1) NO2785538T3 (enExample)
PH (1) PH12016502058A1 (enExample)
PL (2) PL3027015T3 (enExample)
PT (2) PT3027015T (enExample)
RS (2) RS62345B1 (enExample)
RU (1) RU2703139C2 (enExample)
SG (2) SG11201608570YA (enExample)
SI (2) SI3027015T1 (enExample)
SM (2) SMT202100560T1 (enExample)
WO (1) WO2015171861A1 (enExample)

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Publication number Publication date
PL3281521T3 (pl) 2022-01-03
JP7755699B2 (ja) 2025-10-16
RU2016143376A (ru) 2018-06-09
PT3281521T (pt) 2021-09-16
MX370672B (es) 2019-12-19
CN110269047B (zh) 2021-11-02
HRP20180242T1 (hr) 2018-03-09
SG10201912354PA (en) 2020-02-27
JP2020058379A (ja) 2020-04-16
SI3281521T1 (sl) 2021-11-30
JP6838131B2 (ja) 2021-03-03
CN106470545A (zh) 2017-03-01
US20150320022A1 (en) 2015-11-12
JP2021087434A (ja) 2021-06-10
AU2015255977B2 (en) 2021-09-02
EP3027015A1 (en) 2016-06-08
AU2015255977A1 (en) 2016-11-17
RU2703139C2 (ru) 2019-10-15
CN106470545B (zh) 2019-08-20
US20180000056A1 (en) 2018-01-04
IL297105A (en) 2022-12-01
AU2021218060A1 (en) 2021-09-09
KR102517112B1 (ko) 2023-04-03
US20230027494A1 (en) 2023-01-26
CA3207834C (en) 2025-10-14
CN110269047A (zh) 2019-09-24
NO2785538T3 (enExample) 2018-08-04
US20150320021A1 (en) 2015-11-12
BR112016025745A2 (pt) 2018-01-16
NZ763861A (en) 2024-05-31
ES2656529T3 (es) 2018-02-27
CA3207834A1 (en) 2015-11-12
PL3027015T3 (pl) 2018-04-30
PH12016502058A1 (en) 2017-01-09
SG11201608570YA (en) 2016-11-29
KR20160150637A (ko) 2016-12-30
US11963521B2 (en) 2024-04-23
SMT202100560T1 (it) 2021-11-12
ES2887852T3 (es) 2021-12-28
IL297105B1 (en) 2023-09-01
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
AU2021218060C1 (en) 2024-11-07
LT3027015T (lt) 2018-01-25
US10588298B2 (en) 2020-03-17
IL248358A0 (en) 2016-11-30
KR20220165814A (ko) 2022-12-15
EP3281521B1 (en) 2021-06-30
US20200022344A1 (en) 2020-01-23
US9743647B2 (en) 2017-08-29
MX2016014563A (es) 2017-02-23
JP2022171841A (ja) 2022-11-11
JP2017514501A (ja) 2017-06-08
RS62345B1 (sr) 2021-10-29
KR102473565B1 (ko) 2022-12-02
AU2024204694A1 (en) 2024-09-05
IL248358B2 (en) 2023-03-01
CY1119773T1 (el) 2018-06-27
PT3027015T (pt) 2018-02-09
NZ725615A (en) 2024-05-31
CA2947307A1 (en) 2015-11-12
SMT201800018T1 (it) 2018-03-08
CY1124605T1 (el) 2022-07-22
RU2016143376A3 (enExample) 2018-11-22
EP3027015B1 (en) 2017-11-08
RU2019131253A (ru) 2019-12-06
IL297105B2 (en) 2024-01-01
IL248358B (en) 2022-11-01
EP3906781A1 (en) 2021-11-10
US20170311580A1 (en) 2017-11-02
IL304841B1 (en) 2025-09-01
AU2021218060B2 (en) 2024-04-11
US9565841B2 (en) 2017-02-14
HUE038028T2 (hu) 2018-09-28
US12310340B2 (en) 2025-05-27
LT3281521T (lt) 2021-09-27
IL304841A (en) 2023-09-01
JP7145250B2 (ja) 2022-09-30
DK3281521T3 (da) 2021-09-20
WO2015171861A1 (en) 2015-11-12
EP3281521A1 (en) 2018-02-14
CA2947307C (en) 2023-09-26
US20210368753A1 (en) 2021-12-02
HUE055860T2 (hu) 2021-12-28
DK3027015T3 (en) 2018-01-22
JP6640740B2 (ja) 2020-02-05
RS57073B1 (sr) 2018-06-29
JP2024159985A (ja) 2024-11-08
HRP20211455T1 (hr) 2022-01-07

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