EP2456877A4 - Method for genome editing - Google Patents
Method for genome editingInfo
- Publication number
- EP2456877A4 EP2456877A4 EP20100803004 EP10803004A EP2456877A4 EP 2456877 A4 EP2456877 A4 EP 2456877A4 EP 20100803004 EP20100803004 EP 20100803004 EP 10803004 A EP10803004 A EP 10803004A EP 2456877 A4 EP2456877 A4 EP 2456877A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- genome editing
- editing
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly
Applications Claiming Priority (41)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22841909P | 2009-07-24 | 2009-07-24 | |
US23262009P | 2009-08-10 | 2009-08-10 | |
US24587709P | 2009-09-25 | 2009-09-25 | |
US26369609P | 2009-11-23 | 2009-11-23 | |
US26390409P | 2009-11-24 | 2009-11-24 | |
US33600010P | 2010-01-14 | 2010-01-14 | |
US30808910P | 2010-02-25 | 2010-02-25 | |
US30972910P | 2010-03-02 | 2010-03-02 | |
US32370210P | 2010-04-13 | 2010-04-13 | |
US32369810P | 2010-04-13 | 2010-04-13 | |
US32371910P | 2010-04-13 | 2010-04-13 | |
US34328710P | 2010-04-26 | 2010-04-26 | |
US12/842,219 US20110023156A1 (en) | 2008-12-04 | 2010-07-23 | Feline genome editing with zinc finger nucleases |
PCT/US2010/043167 WO2011011767A1 (en) | 2009-07-24 | 2010-07-23 | Method for genome editing |
US12/842,839 US20110016542A1 (en) | 2008-12-04 | 2010-07-23 | Canine genome editing with zinc finger nucleases |
US12/842,999 US20110016543A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in inflammation |
US12/842,993 US20110023153A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in alzheimer's disease |
US12/842,620 US20110016539A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of neurotransmission-related genes in animals |
US12/843,000 US20120159654A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of genes involved in adme and toxicology in animals |
US12/842,886 US20110023157A1 (en) | 2008-12-04 | 2010-07-23 | Equine genome editing with zinc finger nucleases |
US12/842,994 US20110030072A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of immunodeficiency genes in animals |
US12/842,208 US20110023140A1 (en) | 2008-12-04 | 2010-07-23 | Rabbit genome editing with zinc finger nucleases |
US12/842,204 US20110023159A1 (en) | 2008-12-04 | 2010-07-23 | Ovine genome editing with zinc finger nucleases |
US12/842,708 US20110016540A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of genes associated with trinucleotide repeat expansion disorders in animals |
US12/842,893 US20110016546A1 (en) | 2008-12-04 | 2010-07-23 | Porcine genome editing with zinc finger nucleases |
US12/842,578 US20110023143A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of neurodevelopmental genes in animals |
US12/842,991 US20110023152A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of cognition related genes in animals |
US12/842,713 US20110023147A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of prion disorder-related genes in animals |
US12/842,269 US20110023154A1 (en) | 2008-12-04 | 2010-07-23 | Silkworm genome editing with zinc finger nucleases |
US12/842,978 US20110023149A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in tumor suppression in animals |
US12/842,976 US20120159653A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in macular degeneration |
US12/842,980 US20110023150A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of genes associated with schizophrenia in animals |
US12/842,666 US20110023144A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in amyotrophyic lateral sclerosis disease |
US12/842,188 US20110023158A1 (en) | 2008-12-04 | 2010-07-23 | Bovine genome editing with zinc finger nucleases |
US12/842,719 US20110016541A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of sensory-related genes in animals |
US12/842,694 US20110023146A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in secretase-associated disorders |
US12/842,897 US20110023148A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of addiction-related genes in animals |
US12/842,678 US20110023145A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in autism spectrum disorders |
US12/842,982 US20110023151A1 (en) | 2008-12-04 | 2010-07-23 | Genome editing of abc transporters |
US12/842,217 US20110023141A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved with parkinson's disease |
US12/842,198 US20110023139A1 (en) | 2008-12-04 | 2010-07-23 | Genomic editing of genes involved in cardiovascular disease |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2456877A4 true EP2456877A4 (en) | 2012-05-30 |
EP2456877A1 EP2456877A1 (en) | 2012-05-30 |
Family
ID=43499447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10803004A Withdrawn EP2456877A1 (en) | 2009-07-24 | 2010-07-23 | Method for genome editing |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2456877A1 (en) |
JP (1) | JP2013500018A (en) |
KR (1) | KR20120097483A (en) |
AU (1) | AU2010275432A1 (en) |
CA (1) | CA2767377A1 (en) |
IL (1) | IL217409A0 (en) |
SG (1) | SG177711A1 (en) |
WO (1) | WO2011011767A1 (en) |
Families Citing this family (74)
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AU2010281705B2 (en) | 2009-07-28 | 2015-02-05 | Sangamo Therapeutics, Inc. | Methods and compositions for treating trinucleotide repeat disorders |
EP2566972B1 (en) * | 2010-05-03 | 2020-01-15 | Sangamo Therapeutics, Inc. | Compositions for linking zinc finger modules |
SG187075A1 (en) | 2010-07-23 | 2013-03-28 | Sigma Aldrich Co Llc | Genome editing using targeting endonucleases and single-stranded nucleic acids |
US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
EP3461898A1 (en) * | 2011-02-25 | 2019-04-03 | The University Court Of The University of Edinburgh | Genetically modified animals and methods for making the same |
US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
CN102296073B (en) * | 2011-08-11 | 2014-04-23 | 中国农业科学院北京畜牧兽医研究所 | Specific target site for site-directed knockout of gene Myostatin by zinc finger nuclease |
IL277027B (en) * | 2011-09-21 | 2022-07-01 | Sangamo Therapeutics Inc | Methods and compositions for regulation of transgene expression |
AU2012328682B2 (en) * | 2011-10-27 | 2017-09-21 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of the HPRT locus |
RU2624139C2 (en) | 2011-12-05 | 2017-06-30 | Фэктор Байосайенс Инк. | Methods and formulations for cells transfection |
US8497124B2 (en) * | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
US20130216579A1 (en) * | 2012-01-23 | 2013-08-22 | The Trustees Of Columbia University In The City Of New York | Methods and compostitions for gene editing of a pathogen |
CN102660642A (en) * | 2012-04-24 | 2012-09-12 | 西北农林科技大学 | Screening system for screening zinc finger protein |
CA2871524C (en) | 2012-05-07 | 2021-07-27 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
PE20190844A1 (en) | 2012-05-25 | 2019-06-17 | Emmanuelle Charpentier | MODULATION OF TRANSCRIPTION WITH ADDRESSING RNA TO GENERIC DNA |
EP2858486A4 (en) * | 2012-06-12 | 2016-04-13 | Hoffmann La Roche | Methods and compositions for generating conditional knock-out alleles |
AR091482A1 (en) * | 2012-06-21 | 2015-02-04 | Recombinetics Inc | GENETICALLY MODIFIED CELLS AND METHODS FOR OBTAINING |
US10648001B2 (en) | 2012-07-11 | 2020-05-12 | Sangamo Therapeutics, Inc. | Method of treating mucopolysaccharidosis type I or II |
DK3444342T3 (en) | 2012-07-11 | 2020-08-24 | Sangamo Therapeutics Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF LYSOSOMAL DEPOSIT DISEASES |
EP2914714A4 (en) * | 2012-10-30 | 2016-09-21 | Recombinetics Inc | Control of sexual maturation in animals |
AU2013355327A1 (en) * | 2012-12-05 | 2015-06-11 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of metabolic disorders |
SG10202107423UA (en) | 2012-12-06 | 2021-08-30 | Sigma Aldrich Co Llc | Crispr-based genome modification and regulation |
ES2883590T3 (en) * | 2012-12-12 | 2021-12-09 | Broad Inst Inc | Supply, modification and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
ES2701749T3 (en) | 2012-12-12 | 2019-02-25 | Broad Inst Inc | Methods, models, systems and apparatus to identify target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and transmit results thereof |
NZ712727A (en) | 2013-03-14 | 2017-05-26 | Caribou Biosciences Inc | Compositions and methods of nucleic acid-targeting nucleic acids |
CA2906970C (en) * | 2013-03-21 | 2021-05-18 | Ospedale San Raffaele Srl | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
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AU2014262867B2 (en) * | 2013-05-10 | 2019-12-05 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
EP3730615A3 (en) * | 2013-05-15 | 2020-12-09 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
DK3011029T3 (en) | 2013-06-17 | 2020-03-16 | Broad Inst Inc | ADMINISTRATION, MODIFICATION AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
EP3011034B1 (en) | 2013-06-17 | 2019-08-07 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
BR112015031608A2 (en) | 2013-06-17 | 2017-08-22 | Massachusetts Inst Technology | APPLICATION AND USE OF CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR LIVER TARGETING AND THERAPY |
CA2915837A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute, Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
US20160264995A1 (en) * | 2013-11-06 | 2016-09-15 | Hiroshima University | Vector for Nucleic Acid Insertion |
WO2015073867A1 (en) * | 2013-11-15 | 2015-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Engineering neural stem cells using homologous recombination |
JP6300302B2 (en) * | 2013-11-27 | 2018-03-28 | 国立研究開発法人農業・食品産業技術総合研究機構 | Silkworm sericin 1 mutant strain |
WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
CA2932472A1 (en) | 2013-12-12 | 2015-06-18 | Massachusetts Institute Of Technology | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
EP3653229A1 (en) | 2013-12-12 | 2020-05-20 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing |
WO2015108180A1 (en) * | 2014-01-17 | 2015-07-23 | 洋孝 松尾 | Molecule associated with onset of gout, and method and kit for evaluating diathesis of uric acid-related diseases and inflammation-related diseases, and inspection object and drug |
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WO2016112961A1 (en) * | 2015-01-13 | 2016-07-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Caspase-2 conditional knockouts and methods |
WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
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US20190227067A1 (en) * | 2015-07-31 | 2019-07-25 | Sapporo Medical University | Method and kit for determining prognosis, remote recurrence risk and invasion of glioma, and pharmaceutical composition for treating glioma |
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CA3029141A1 (en) | 2016-07-06 | 2018-01-11 | Crispr Therapeutics Ag | Materials and methods for treatment of pain related disorders |
US11801313B2 (en) | 2016-07-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
JP7026304B2 (en) * | 2016-07-29 | 2022-02-28 | マックス-プランク-ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー.ファウ. | Targeted in-situ protein diversification through site-specific DNA cleavage and repair |
WO2018222667A1 (en) * | 2017-05-31 | 2018-12-06 | 22Nd Century Limited, Llc | Genome editing methods for producing low-nicotine tobacco products |
AU2018388850A1 (en) * | 2017-12-21 | 2020-07-23 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
US11179479B2 (en) * | 2018-01-05 | 2021-11-23 | Animatus Biosciences, Llc | Enhanced cardiomyocyte regeneration |
CN111684078B (en) * | 2018-02-12 | 2024-04-19 | 豪夫迈·罗氏有限公司 | Methods for predicting response to treatment by assessing tumor genetic heterogeneity |
CN108441577B (en) * | 2018-05-25 | 2021-05-14 | 兰州大学 | Primer pair, kit and application thereof, and method for detecting whether alfalfa product contains soybeans |
BR112020025824A2 (en) | 2018-06-28 | 2021-03-23 | Crispr Therapeutics Ag | compositions and methods for genome editing by inserting donor polynucleotides |
WO2022240649A1 (en) * | 2021-05-12 | 2022-11-17 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators |
CN111073900B (en) * | 2019-12-09 | 2023-05-02 | 温氏食品集团股份有限公司 | Method for improving development efficiency of pig cloned embryo |
CN111172274B (en) * | 2020-01-22 | 2021-10-15 | 清华大学 | Application of Synaptotagmin-7 in diagnosis and treatment of bidirectional affective disorder |
WO2021168412A1 (en) * | 2020-02-21 | 2021-08-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Non-human animal models for aging and/or neurodegeneration |
CN111235153B (en) * | 2020-04-01 | 2023-05-26 | 陕西慧康生物科技有限责任公司 | sgRNA for targeted knockout of human MC1R gene and cell strain constructed by same |
CN111235154A (en) * | 2020-04-01 | 2020-06-05 | 陕西慧康生物科技有限责任公司 | sgRNA for targeted knockout of human MC1R gene and cell strain constructed by sgRNA |
WO2022145495A1 (en) * | 2021-01-04 | 2022-07-07 | Modalis Therapeutics Corporation | Method for treating spinocerebellar ataxias (sca) by targeting atxn7 gene |
IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
CN113355356A (en) * | 2021-07-05 | 2021-09-07 | 西北农林科技大学 | CSN1S1 gene knockout vector and preparation method of CSN1S1 gene knockout mammary epithelial cell |
CN113881646B (en) * | 2021-09-28 | 2023-08-04 | 北京市农林科学院 | Related protein TaFAH1 involved in plant disease resistance, gene and application thereof |
CN113916754B (en) * | 2021-10-12 | 2023-11-10 | 四川大学华西医院 | Cell surface marker for detecting circulating tumor cells of breast cancer patient and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003087341A2 (en) * | 2002-01-23 | 2003-10-23 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2700170A1 (en) * | 2007-09-27 | 2009-04-02 | Sangamo Biosciences, Inc. | Genomic editing in zebrafish using zinc finger nucleases |
-
2010
- 2010-07-23 WO PCT/US2010/043167 patent/WO2011011767A1/en active Application Filing
- 2010-07-23 EP EP10803004A patent/EP2456877A1/en not_active Withdrawn
- 2010-07-23 SG SG2012004131A patent/SG177711A1/en unknown
- 2010-07-23 JP JP2012521867A patent/JP2013500018A/en active Pending
- 2010-07-23 CA CA2767377A patent/CA2767377A1/en not_active Abandoned
- 2010-07-23 AU AU2010275432A patent/AU2010275432A1/en not_active Abandoned
- 2010-07-23 KR KR1020127004819A patent/KR20120097483A/en not_active Application Discontinuation
-
2012
- 2012-01-05 IL IL217409A patent/IL217409A0/en unknown
Patent Citations (1)
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JP2013500018A (en) | 2013-01-07 |
IL217409A0 (en) | 2012-02-29 |
AU2010275432A1 (en) | 2012-02-02 |
CA2767377A1 (en) | 2011-01-27 |
WO2011011767A1 (en) | 2011-01-27 |
SG177711A1 (en) | 2012-02-28 |
KR20120097483A (en) | 2012-09-04 |
EP2456877A1 (en) | 2012-05-30 |
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