KR102517112B1 - 인간화 IL-4 및 IL-4Rα 동물 - Google Patents
인간화 IL-4 및 IL-4Rα 동물 Download PDFInfo
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| JP7048051B2 (ja) | 2018-07-11 | 2022-04-05 | 正徳 染井 | 痒みを軽減するアトピー性皮膚炎治療剤 |
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| CN111057721B (zh) * | 2018-10-12 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用 |
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| CN117178959A (zh) | 2019-04-04 | 2023-12-08 | 瑞泽恩制药公司 | 包括人源化凝血因子12基因座的非人动物 |
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| CN112779285B (zh) * | 2019-11-11 | 2023-01-06 | 百奥赛图(北京)医药科技股份有限公司 | 人源化il-10和il-10ra基因改造动物的构建方法和应用 |
| US20220354097A1 (en) * | 2019-12-25 | 2022-11-10 | Gempharmatech Co., Ltd. | Il-15 humanized mouse model and use thereof |
| KR20220133248A (ko) * | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| CN111149767B (zh) * | 2020-02-24 | 2021-07-20 | 中南大学湘雅二医院 | 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用 |
| CN113527485B (zh) * | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN111808882B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | Il7r基因人源化改造的动物模型的构建方法及其应用 |
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| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
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| WO2022247936A1 (en) * | 2021-05-28 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd36 |
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| WO2013192030A1 (en) | 2012-06-18 | 2013-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized il-7 rodents |
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