JP2015523863A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523863A5 JP2015523863A5 JP2015517447A JP2015517447A JP2015523863A5 JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5 JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- rodent
- humanized
- exon
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010002586 Interleukin-7 Proteins 0.000 claims description 47
- 241000283984 Rodentia Species 0.000 claims description 39
- 101001043807 Homo sapiens Interleukin-7 Proteins 0.000 claims description 34
- 102000052622 human IL7 Human genes 0.000 claims description 34
- 102000000704 Interleukin-7 Human genes 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 108700024394 Exon Proteins 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 241000700159 Rattus Species 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 101150101112 7 gene Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101001043808 Mus musculus Interleukin-7 Proteins 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 7
- 108091023045 Untranslated Region Proteins 0.000 description 3
- 241000699800 Cricetinae Species 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660976P | 2012-06-18 | 2012-06-18 | |
| US61/660,976 | 2012-06-18 | ||
| US201261740074P | 2012-12-20 | 2012-12-20 | |
| US61/740,074 | 2012-12-20 | ||
| US13/795,765 | 2013-03-12 | ||
| US13/795,765 US8962913B2 (en) | 2012-06-18 | 2013-03-12 | Humanized IL-7 rodents |
| PCT/US2013/045788 WO2013192030A1 (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523863A JP2015523863A (ja) | 2015-08-20 |
| JP2015523863A5 true JP2015523863A5 (enExample) | 2016-05-19 |
| JP6174134B2 JP6174134B2 (ja) | 2017-08-02 |
Family
ID=49757275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517447A Expired - Fee Related JP6174134B2 (ja) | 2012-06-18 | 2013-06-14 | ヒト化ｉｌ−７齧歯類 |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US8962913B2 (enExample) |
| EP (2) | EP2861063A1 (enExample) |
| JP (1) | JP6174134B2 (enExample) |
| KR (1) | KR20150027752A (enExample) |
| CN (2) | CN104378976B (enExample) |
| AU (1) | AU2013277457B2 (enExample) |
| BR (1) | BR112014029892A2 (enExample) |
| CA (1) | CA2873134A1 (enExample) |
| CY (1) | CY1119071T1 (enExample) |
| DK (1) | DK2859793T3 (enExample) |
| ES (1) | ES2626965T3 (enExample) |
| HK (1) | HK1203761A1 (enExample) |
| HR (1) | HRP20170974T1 (enExample) |
| HU (1) | HUE034592T2 (enExample) |
| IL (3) | IL235773B (enExample) |
| IN (1) | IN2014DN10189A (enExample) |
| LT (1) | LT2859793T (enExample) |
| MX (1) | MX363540B (enExample) |
| NZ (1) | NZ702943A (enExample) |
| PL (1) | PL2859793T3 (enExample) |
| PT (1) | PT2859793T (enExample) |
| RS (1) | RS56039B1 (enExample) |
| RU (1) | RU2654565C2 (enExample) |
| SG (3) | SG10201609576YA (enExample) |
| SI (1) | SI2859793T1 (enExample) |
| SM (1) | SMT201700313T1 (enExample) |
| WO (1) | WO2013192030A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3241435T3 (da) * | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| CA2866363C (en) * | 2012-03-05 | 2019-08-27 | Samsung Electronics Co., Ltd. | Harq-ack signal transmission in response to detection of control channel type in case of multiple control channel types |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| HRP20231121T1 (hr) | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| WO2015049517A2 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| JP6492095B2 (ja) | 2013-10-15 | 2019-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｉｌ−１５動物 |
| US20150143559A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| MX2016014504A (es) | 2014-05-05 | 2017-05-23 | Regeneron Pharma | Animales c5 y c3 humanizados. |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| ES2950399T3 (es) * | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| WO2017136712A1 (en) | 2016-02-04 | 2017-08-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| GB201710984D0 (en) | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| US20220312749A1 (en) * | 2019-08-09 | 2022-10-06 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric il2ra |
| WO2021154791A1 (en) * | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| KR102316506B1 (ko) | 2020-02-26 | 2021-10-22 | 차의과학대학교 산학협력단 | 동물 면역계의 인간화 활성을 촉진하는 방법 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| JP2024500153A (ja) * | 2020-12-21 | 2024-01-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物 |
| CN114835798B (zh) * | 2021-05-28 | 2024-02-23 | 百奥赛图(北京)医药科技股份有限公司 | Cd36基因人源化非人动物的构建方法及应用 |
| US20230417899A1 (en) * | 2022-06-27 | 2023-12-28 | Oshkosh Corporation | Position tracking for a lift device |
| AU2023338373A1 (en) * | 2022-09-08 | 2025-04-03 | The Jackson Laboratory | Humanized immunodeficient mouse models |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| EP1209968A1 (en) | 1999-08-31 | 2002-06-05 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101302517B (zh) * | 2008-02-03 | 2010-11-03 | 中国科学院广州生物医药与健康研究院 | 人白细胞介素7在真核宿主中表达的方法 |
| EP4502152A3 (en) * | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| SI2818478T1 (sl) | 2011-10-28 | 2017-07-31 | Regeneron Pharmaceuticals, Inc. | Humanizirani il-6 in receptor il-6 |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
-
2013
- 2013-03-12 US US13/795,765 patent/US8962913B2/en not_active Expired - Fee Related
- 2013-06-14 AU AU2013277457A patent/AU2013277457B2/en not_active Ceased
- 2013-06-14 CN CN201380031333.4A patent/CN104378976B/zh not_active Expired - Fee Related
- 2013-06-14 RS RS20170543A patent/RS56039B1/sr unknown
- 2013-06-14 SI SI201330664A patent/SI2859793T1/sl unknown
- 2013-06-14 HK HK15104315.3A patent/HK1203761A1/xx unknown
- 2013-06-14 LT LTEP14195502.1T patent/LT2859793T/lt unknown
- 2013-06-14 PT PT141955021T patent/PT2859793T/pt unknown
- 2013-06-14 SG SG10201609576YA patent/SG10201609576YA/en unknown
- 2013-06-14 ES ES14195502.1T patent/ES2626965T3/es active Active
- 2013-06-14 KR KR1020147035047A patent/KR20150027752A/ko not_active Ceased
- 2013-06-14 PL PL14195502T patent/PL2859793T3/pl unknown
- 2013-06-14 JP JP2015517447A patent/JP6174134B2/ja not_active Expired - Fee Related
- 2013-06-14 SG SG11201407370QA patent/SG11201407370QA/en unknown
- 2013-06-14 CN CN201610168011.XA patent/CN105779467A/zh active Pending
- 2013-06-14 DK DK14195502.1T patent/DK2859793T3/en active
- 2013-06-14 MX MX2014015679A patent/MX363540B/es unknown
- 2013-06-14 NZ NZ702943A patent/NZ702943A/en not_active IP Right Cessation
- 2013-06-14 WO PCT/US2013/045788 patent/WO2013192030A1/en not_active Ceased
- 2013-06-14 SG SG10201609569PA patent/SG10201609569PA/en unknown
- 2013-06-14 BR BR112014029892A patent/BR112014029892A2/pt not_active Application Discontinuation
- 2013-06-14 HU HUE14195502A patent/HUE034592T2/en unknown
- 2013-06-14 EP EP13739875.6A patent/EP2861063A1/en not_active Withdrawn
- 2013-06-14 RU RU2014148107A patent/RU2654565C2/ru not_active IP Right Cessation
- 2013-06-14 CA CA2873134A patent/CA2873134A1/en not_active Abandoned
- 2013-06-14 EP EP14195502.1A patent/EP2859793B1/en active Active
- 2013-06-14 SM SM20170313T patent/SMT201700313T1/it unknown
-
2014
- 2014-11-18 IL IL235773A patent/IL235773B/en active IP Right Grant
- 2014-11-24 US US14/551,538 patent/US9232776B2/en not_active Expired - Fee Related
- 2014-11-28 IN IN10189DEN2014 patent/IN2014DN10189A/en unknown
-
2015
- 2015-11-10 US US14/937,270 patent/US20160052986A1/en not_active Abandoned
-
2016
- 2016-11-21 US US15/357,021 patent/US9737059B2/en not_active Expired - Fee Related
-
2017
- 2017-05-31 CY CY20171100577T patent/CY1119071T1/el unknown
- 2017-06-27 HR HRP20170974TT patent/HRP20170974T1/hr unknown
- 2017-07-14 US US15/649,797 patent/US9974291B2/en not_active Expired - Fee Related
-
2018
- 2018-04-24 US US15/960,642 patent/US10314298B2/en not_active Expired - Fee Related
- 2018-06-25 IL IL260250A patent/IL260250B/en not_active IP Right Cessation
-
2019
- 2019-05-01 US US16/400,074 patent/US20190343093A1/en not_active Abandoned
- 2019-08-13 IL IL26867419A patent/IL268674A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014148107A (ru) | Грызуны с гуманизированным il-7 | |
| Ng et al. | The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis | |
| Ruehle et al. | Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions | |
| Liang et al. | PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes | |
| US11317611B2 (en) | Genetically modified non-human animal with human or chimeric PD-L1 | |
| Taniguchi et al. | Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection | |
| Kamiya et al. | A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, Takifugu rubripes (fugu) | |
| US10945418B2 (en) | Genetically modified non-human animal with human or chimeric PD-L1 | |
| JP2019022518A5 (enExample) | ||
| Donaldson et al. | The relative contribution of proximal 5′ flanking sequence and microsatellite variation on brain vasopressin 1a receptor (Avpr1a) gene expression and behavior | |
| US11071290B2 (en) | Genetically modified non-human animal with human or chimeric CTLA-4 | |
| HRP20231121T1 (hr) | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale | |
| Justice et al. | Technical approaches for mouse models of human disease | |
| JP2014532416A5 (enExample) | ||
| HRP20231707T1 (hr) | Životinje koje nisu ljudi, koje sadrže humanizirani gen iz diferencijacijske skupine 47 | |
| JP2016523561A5 (enExample) | ||
| RU2016123135A (ru) | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда | |
| RU2016123708A (ru) | Отличные от человека животные, содержащие гуманизированный ген фактора активации в-клеток | |
| Zhang et al. | Novel endothelial cell-specific AQP1 knockout mice confirm the crucial role of endothelial AQP1 in ultrafiltration during peritoneal dialysis | |
| Zhang et al. | Expression patterns and potential biological roles of Dip2a | |
| Crowley et al. | Disruption of the miR-137 primary transcript results in early embryonic lethality in mouse | |
| IL319209A (en) | Non-human animals containing a humanized ASGR1 locus | |
| Chang et al. | Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles | |
| Menten-Dedoyart et al. | Development and validation of a new mouse model to investigate the role of SV2A in epilepsy | |
| Kuramoto et al. | Identification of Candidate Genes for Generalized Tonic–Clonic Seizures in Noda Epileptic Rat |