JP2015523863A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523863A5 JP2015523863A5 JP2015517447A JP2015517447A JP2015523863A5 JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5 JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- rodent
- humanized
- exon
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010002586 Interleukin-7 Proteins 0.000 claims description 47
- 241000283984 Rodentia Species 0.000 claims description 39
- 101001043807 Homo sapiens Interleukin-7 Proteins 0.000 claims description 34
- 102000052622 human IL7 Human genes 0.000 claims description 34
- 102000000704 Interleukin-7 Human genes 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 108700024394 Exon Proteins 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 241000700159 Rattus Species 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 101150101112 7 gene Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101001043808 Mus musculus Interleukin-7 Proteins 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 7
- 108091023045 Untranslated Region Proteins 0.000 description 3
- 241000699800 Cricetinae Species 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660976P | 2012-06-18 | 2012-06-18 | |
| US61/660,976 | 2012-06-18 | ||
| US201261740074P | 2012-12-20 | 2012-12-20 | |
| US61/740,074 | 2012-12-20 | ||
| US13/795,765 US8962913B2 (en) | 2012-06-18 | 2013-03-12 | Humanized IL-7 rodents |
| US13/795,765 | 2013-03-12 | ||
| PCT/US2013/045788 WO2013192030A1 (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523863A JP2015523863A (ja) | 2015-08-20 |
| JP2015523863A5 true JP2015523863A5 (enExample) | 2016-05-19 |
| JP6174134B2 JP6174134B2 (ja) | 2017-08-02 |
Family
ID=49757275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517447A Expired - Fee Related JP6174134B2 (ja) | 2012-06-18 | 2013-06-14 | ヒト化ｉｌ−７齧歯類 |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US8962913B2 (enExample) |
| EP (2) | EP2859793B1 (enExample) |
| JP (1) | JP6174134B2 (enExample) |
| KR (1) | KR20150027752A (enExample) |
| CN (2) | CN105779467A (enExample) |
| AU (1) | AU2013277457B2 (enExample) |
| BR (1) | BR112014029892A2 (enExample) |
| CA (1) | CA2873134A1 (enExample) |
| CY (1) | CY1119071T1 (enExample) |
| DK (1) | DK2859793T3 (enExample) |
| ES (1) | ES2626965T3 (enExample) |
| HK (1) | HK1203761A1 (enExample) |
| HR (1) | HRP20170974T1 (enExample) |
| HU (1) | HUE034592T2 (enExample) |
| IL (3) | IL235773B (enExample) |
| IN (1) | IN2014DN10189A (enExample) |
| LT (1) | LT2859793T (enExample) |
| MX (1) | MX363540B (enExample) |
| NZ (1) | NZ702943A (enExample) |
| PL (1) | PL2859793T3 (enExample) |
| PT (1) | PT2859793T (enExample) |
| RS (1) | RS56039B1 (enExample) |
| RU (1) | RU2654565C2 (enExample) |
| SG (3) | SG10201609569PA (enExample) |
| SI (1) | SI2859793T1 (enExample) |
| SM (1) | SMT201700313T1 (enExample) |
| WO (1) | WO2013192030A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| BR112014006390A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano |
| CN104272635B (zh) * | 2012-03-05 | 2021-07-13 | 三星电子株式会社 | 在多个控制信道类型的情况下响应于控制信道类型的检测的混合自动重传请求-应答信号的传输 |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| DK3175706T3 (en) | 2013-09-23 | 2019-03-04 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| SMT201900177T1 (it) | 2013-10-15 | 2019-05-10 | Regeneron Pharma | Animali con il-15 umanizzata |
| SG10201811701YA (en) | 2013-11-19 | 2019-01-30 | Regeneron Pharma | Non-human animals having a humanized a proliferation-inducing ligand gene |
| JP6598798B2 (ja) * | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| KR102617691B1 (ko) | 2014-12-05 | 2023-12-27 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 분화 클러스터 47 유전자를 가진 비인간 동물 |
| JP6752221B2 (ja) * | 2015-04-13 | 2020-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｓｉｒｐａ−ｉｌ１５ノックインマウス及びその使用方法 |
| CN108779159B (zh) | 2016-02-04 | 2022-12-30 | 瑞泽恩制药公司 | 具有经改造的angptl8基因的非人动物 |
| JP6980674B2 (ja) | 2016-02-29 | 2021-12-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類 |
| ES2962277T3 (es) | 2017-09-29 | 2024-03-18 | Regeneron Pharma | Roedores que comprenden un locus Ttr humanizado y métodos de uso |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| CN114164177A (zh) * | 2019-01-17 | 2022-03-11 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| WO2020206139A1 (en) | 2019-04-04 | 2020-10-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| EP3801011A1 (en) | 2019-06-04 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| AU2020289581B2 (en) | 2019-06-07 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| CN112430621B (zh) * | 2019-08-09 | 2022-09-27 | 百奥赛图(北京)医药科技股份有限公司 | Il2ra基因人源化的非人动物的构建方法及应用 |
| US12250931B2 (en) * | 2020-01-28 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with a humanized PNPLA3 gene and methods of use |
| KR102316506B1 (ko) | 2020-02-26 | 2021-10-22 | 차의과학대학교 산학협력단 | 동물 면역계의 인간화 활성을 촉진하는 방법 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| JP2024500153A (ja) * | 2020-12-21 | 2024-01-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物 |
| WO2022247936A1 (en) * | 2021-05-28 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd36 |
| KR20250067149A (ko) * | 2022-09-08 | 2025-05-14 | 더 잭슨 래보라토리 | 인간화 면역결핍 마우스 모델 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| JP2003508038A (ja) | 1999-08-31 | 2003-03-04 | ジェネンコア インターナショナル インコーポレーテッド | ドナー特異的機能性免疫の産生を容易にすることができるトランスジェニック哺乳類 |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101302517B (zh) * | 2008-02-03 | 2010-11-03 | 中国科学院广州生物医药与健康研究院 | 人白细胞介素7在真核宿主中表达的方法 |
| CA3040377C (en) * | 2009-10-06 | 2025-12-30 | Yale University | Genetically modified mice and engraftment comprising the knock-in of a human thrombopoietin (tpo) gene |
| ES3040596T3 (en) | 2011-02-15 | 2025-11-03 | Regeneron Pharma | Humanized m-csf mice and uses thereof |
| MY186903A (en) | 2011-10-28 | 2021-08-26 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
-
2013
- 2013-03-12 US US13/795,765 patent/US8962913B2/en not_active Expired - Fee Related
- 2013-06-14 SG SG10201609569PA patent/SG10201609569PA/en unknown
- 2013-06-14 NZ NZ702943A patent/NZ702943A/en not_active IP Right Cessation
- 2013-06-14 CA CA2873134A patent/CA2873134A1/en not_active Abandoned
- 2013-06-14 RS RS20170543A patent/RS56039B1/sr unknown
- 2013-06-14 CN CN201610168011.XA patent/CN105779467A/zh active Pending
- 2013-06-14 SI SI201330664A patent/SI2859793T1/sl unknown
- 2013-06-14 SG SG10201609576YA patent/SG10201609576YA/en unknown
- 2013-06-14 JP JP2015517447A patent/JP6174134B2/ja not_active Expired - Fee Related
- 2013-06-14 BR BR112014029892A patent/BR112014029892A2/pt not_active Application Discontinuation
- 2013-06-14 EP EP14195502.1A patent/EP2859793B1/en active Active
- 2013-06-14 SM SM20170313T patent/SMT201700313T1/it unknown
- 2013-06-14 ES ES14195502.1T patent/ES2626965T3/es active Active
- 2013-06-14 KR KR1020147035047A patent/KR20150027752A/ko not_active Ceased
- 2013-06-14 DK DK14195502.1T patent/DK2859793T3/en active
- 2013-06-14 EP EP13739875.6A patent/EP2861063A1/en not_active Withdrawn
- 2013-06-14 LT LTEP14195502.1T patent/LT2859793T/lt unknown
- 2013-06-14 RU RU2014148107A patent/RU2654565C2/ru not_active IP Right Cessation
- 2013-06-14 PT PT141955021T patent/PT2859793T/pt unknown
- 2013-06-14 SG SG11201407370QA patent/SG11201407370QA/en unknown
- 2013-06-14 MX MX2014015679A patent/MX363540B/es unknown
- 2013-06-14 HU HUE14195502A patent/HUE034592T2/en unknown
- 2013-06-14 WO PCT/US2013/045788 patent/WO2013192030A1/en not_active Ceased
- 2013-06-14 AU AU2013277457A patent/AU2013277457B2/en not_active Ceased
- 2013-06-14 PL PL14195502T patent/PL2859793T3/pl unknown
- 2013-06-14 HK HK15104315.3A patent/HK1203761A1/xx unknown
- 2013-06-14 CN CN201380031333.4A patent/CN104378976B/zh not_active Expired - Fee Related
-
2014
- 2014-11-18 IL IL235773A patent/IL235773B/en active IP Right Grant
- 2014-11-24 US US14/551,538 patent/US9232776B2/en not_active Expired - Fee Related
- 2014-11-28 IN IN10189DEN2014 patent/IN2014DN10189A/en unknown
-
2015
- 2015-11-10 US US14/937,270 patent/US20160052986A1/en not_active Abandoned
-
2016
- 2016-11-21 US US15/357,021 patent/US9737059B2/en not_active Expired - Fee Related
-
2017
- 2017-05-31 CY CY20171100577T patent/CY1119071T1/el unknown
- 2017-06-27 HR HRP20170974TT patent/HRP20170974T1/hr unknown
- 2017-07-14 US US15/649,797 patent/US9974291B2/en not_active Expired - Fee Related
-
2018
- 2018-04-24 US US15/960,642 patent/US10314298B2/en not_active Expired - Fee Related
- 2018-06-25 IL IL260250A patent/IL260250B/en not_active IP Right Cessation
-
2019
- 2019-05-01 US US16/400,074 patent/US20190343093A1/en not_active Abandoned
- 2019-08-13 IL IL26867419A patent/IL268674A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015523863A5 (enExample) | ||
| RU2014148107A (ru) | Грызуны с гуманизированным il-7 | |
| Ruehle et al. | Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions | |
| Ng et al. | The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis | |
| Liang et al. | PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes | |
| US11317611B2 (en) | Genetically modified non-human animal with human or chimeric PD-L1 | |
| Taniguchi et al. | Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection | |
| US10945418B2 (en) | Genetically modified non-human animal with human or chimeric PD-L1 | |
| Kamiya et al. | A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, Takifugu rubripes (fugu) | |
| JP2019022518A5 (enExample) | ||
| US11071290B2 (en) | Genetically modified non-human animal with human or chimeric CTLA-4 | |
| Donaldson et al. | The relative contribution of proximal 5′ flanking sequence and microsatellite variation on brain vasopressin 1a receptor (Avpr1a) gene expression and behavior | |
| HRP20231121T1 (hr) | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale | |
| Justice et al. | Technical approaches for mouse models of human disease | |
| JP2014532416A5 (enExample) | ||
| HRP20231707T1 (hr) | Životinje koje nisu ljudi, koje sadrže humanizirani gen iz diferencijacijske skupine 47 | |
| JP2016523561A5 (enExample) | ||
| RU2016123135A (ru) | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда | |
| RU2016123708A (ru) | Отличные от человека животные, содержащие гуманизированный ген фактора активации в-клеток | |
| Zhang et al. | Novel endothelial cell-specific AQP1 knockout mice confirm the crucial role of endothelial AQP1 in ultrafiltration during peritoneal dialysis | |
| Zhang et al. | Expression patterns and potential biological roles of Dip2a | |
| Crowley et al. | Disruption of the miR-137 primary transcript results in early embryonic lethality in mouse | |
| IL319209A (en) | Non-human animals containing a humanized ASGR1 locus | |
| Chang et al. | Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles | |
| Menten-Dedoyart et al. | Development and validation of a new mouse model to investigate the role of SV2A in epilepsy |