RU2654565C2 - Грызуны с гуманизированным il-7 - Google Patents

Грызуны с гуманизированным il-7 Download PDF

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RU2654565C2
RU2654565C2 RU2014148107A RU2014148107A RU2654565C2 RU 2654565 C2 RU2654565 C2 RU 2654565C2 RU 2014148107 A RU2014148107 A RU 2014148107A RU 2014148107 A RU2014148107 A RU 2014148107A RU 2654565 C2 RU2654565 C2 RU 2654565C2
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human
rodent
humanized
gene
mouse
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RU2014148107A
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Russian (ru)
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RU2014148107A (ru
Inventor
Эндрю Дж. МЕРФИ
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Регенерон Фармасьютикалс, Инк.
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
RU2014148107A 2012-06-18 2013-06-14 Грызуны с гуманизированным il-7 RU2654565C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US61/660,976 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US61/740,074 2012-12-20
US13/795,765 2013-03-12
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Publications (2)

Publication Number Publication Date
RU2014148107A RU2014148107A (ru) 2016-08-10
RU2654565C2 true RU2654565C2 (ru) 2018-05-21

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EP (2) EP2861063A1 (enExample)
JP (1) JP6174134B2 (enExample)
KR (1) KR20150027752A (enExample)
CN (2) CN104378976B (enExample)
AU (1) AU2013277457B2 (enExample)
BR (1) BR112014029892A2 (enExample)
CA (1) CA2873134A1 (enExample)
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IL (3) IL235773B (enExample)
IN (1) IN2014DN10189A (enExample)
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RU (1) RU2654565C2 (enExample)
SG (3) SG10201609576YA (enExample)
SI (1) SI2859793T1 (enExample)
SM (1) SMT201700313T1 (enExample)
WO (1) WO2013192030A1 (enExample)

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JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子12遺伝子座を含む非ヒト動物
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HK1203761A1 (en) 2015-11-06
US9232776B2 (en) 2016-01-12
US20190343093A1 (en) 2019-11-14
BR112014029892A2 (pt) 2017-07-25
IL260250B (en) 2019-08-29
SG10201609576YA (en) 2016-12-29
SI2859793T1 (sl) 2017-07-31
MX2014015679A (es) 2015-04-08
EP2859793B1 (en) 2017-04-05
RU2014148107A (ru) 2016-08-10
IN2014DN10189A (enExample) 2015-08-21
IL235773B (en) 2018-07-31
IL268674A (en) 2019-10-31
WO2013192030A1 (en) 2013-12-27
EP2861063A1 (en) 2015-04-22
US20170064932A1 (en) 2017-03-09
SG11201407370QA (en) 2014-12-30
US20180360007A1 (en) 2018-12-20
US9737059B2 (en) 2017-08-22
HUE034592T2 (en) 2018-02-28
US20150082469A1 (en) 2015-03-19
RS56039B1 (sr) 2017-09-29
CY1119071T1 (el) 2018-01-10
US9974291B2 (en) 2018-05-22
AU2013277457B2 (en) 2018-03-15
NZ702943A (en) 2017-07-28
EP2859793A1 (en) 2015-04-15
CA2873134A1 (en) 2013-12-27
LT2859793T (lt) 2017-07-10
US8962913B2 (en) 2015-02-24
MX363540B (es) 2019-03-27
PL2859793T3 (pl) 2017-09-29
HRP20170974T1 (hr) 2017-09-22
PT2859793T (pt) 2017-07-06
JP6174134B2 (ja) 2017-08-02
CN104378976A (zh) 2015-02-25
CN104378976B (zh) 2016-03-23
AU2013277457A1 (en) 2015-01-22
SG10201609569PA (en) 2016-12-29
CN105779467A (zh) 2016-07-20
SMT201700313T1 (it) 2017-07-18
KR20150027752A (ko) 2015-03-12
HK1203302A1 (en) 2015-10-30
ES2626965T3 (es) 2017-07-26
US10314298B2 (en) 2019-06-11
IL235773A0 (en) 2015-01-29
JP2015523863A (ja) 2015-08-20
US20160052986A1 (en) 2016-02-25
US20130340104A1 (en) 2013-12-19
US20170311581A1 (en) 2017-11-02
DK2859793T3 (en) 2017-06-19

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