CN105779467A - 人源化il-7 啮齿动物 - Google Patents
人源化il-7 啮齿动物 Download PDFInfo
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- CN105779467A CN105779467A CN201610168011.XA CN201610168011A CN105779467A CN 105779467 A CN105779467 A CN 105779467A CN 201610168011 A CN201610168011 A CN 201610168011A CN 105779467 A CN105779467 A CN 105779467A
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- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
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- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
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| EP2564695B1 (en) | 2009-07-08 | 2015-04-15 | Kymab Limited | Animal models and therapeutic molecules |
| CN103945689B (zh) | 2011-09-19 | 2016-10-19 | 科马布有限公司 | 免疫球蛋白基因多样性的操纵及多抗体治疗剂 |
| US9072086B2 (en) * | 2012-03-05 | 2015-06-30 | Samsung Electronics Co., Ltd. | HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| SI3138397T1 (sl) | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MX358206B (es) | 2013-11-19 | 2018-08-09 | Regeneron Pharma | Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion. |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN107896479B (zh) * | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| ES2908669T3 (es) | 2016-02-04 | 2022-05-03 | Regeneron Pharma | Animales no humanos que tienen un gen ANGPTL8 modificado genéticamente |
| PT3422845T (pt) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Roedores com um gene tmprss humanizado |
| EP4276185A3 (en) | 2017-09-29 | 2024-02-21 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| BR112021022722A2 (pt) | 2019-06-07 | 2022-01-04 | Regeneron Pharma | Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente |
| CN112430621B (zh) * | 2019-08-09 | 2022-09-27 | 百奥赛图(北京)医药科技股份有限公司 | Il2ra基因人源化的非人动物的构建方法及应用 |
| KR20220133248A (ko) * | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| KR102316506B1 (ko) | 2020-02-26 | 2021-10-22 | 차의과학대학교 산학협력단 | 동물 면역계의 인간화 활성을 촉진하는 방법 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| IL303724A (en) * | 2020-12-21 | 2023-08-01 | Regeneron Pharma | Non-human animals with a humanized TSLP gene, a humanized TSLP receptor gene, and/or a humanized IL7RA gene |
| WO2022247936A1 (en) * | 2021-05-28 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd36 |
| KR20250067149A (ko) * | 2022-09-08 | 2025-05-14 | 더 잭슨 래보라토리 | 인간화 면역결핍 마우스 모델 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
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| GB2434578A (en) * | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101302517A (zh) * | 2008-02-03 | 2008-11-12 | 中国科学院广州生物医药与健康研究院 | 人白细胞介素7在真核宿主中表达的方法 |
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| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| WO2001015521A1 (en) | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| ES2908587T3 (es) * | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| BR112014008529A2 (pt) | 2011-10-28 | 2017-04-18 | Regeneron Pharma | il-6 humanizado e receptor de il-6 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
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- 2013-06-14 WO PCT/US2013/045788 patent/WO2013192030A1/en not_active Ceased
- 2013-06-14 PT PT141955021T patent/PT2859793T/pt unknown
- 2013-06-14 SG SG10201609569PA patent/SG10201609569PA/en unknown
- 2013-06-14 ES ES14195502.1T patent/ES2626965T3/es active Active
- 2013-06-14 EP EP14195502.1A patent/EP2859793B1/en active Active
- 2013-06-14 CA CA2873134A patent/CA2873134A1/en not_active Abandoned
- 2013-06-14 HU HUE14195502A patent/HUE034592T2/en unknown
- 2013-06-14 JP JP2015517447A patent/JP6174134B2/ja not_active Expired - Fee Related
- 2013-06-14 SM SM20170313T patent/SMT201700313T1/it unknown
- 2013-06-14 LT LTEP14195502.1T patent/LT2859793T/lt unknown
- 2013-06-14 RU RU2014148107A patent/RU2654565C2/ru not_active IP Right Cessation
- 2013-06-14 NZ NZ702943A patent/NZ702943A/en not_active IP Right Cessation
- 2013-06-14 CN CN201610168011.XA patent/CN105779467A/zh active Pending
- 2013-06-14 PL PL14195502T patent/PL2859793T3/pl unknown
- 2013-06-14 SI SI201330664A patent/SI2859793T1/sl unknown
- 2013-06-14 MX MX2014015679A patent/MX363540B/es unknown
- 2013-06-14 HK HK15104315.3A patent/HK1203761A1/xx unknown
- 2013-06-14 SG SG11201407370QA patent/SG11201407370QA/en unknown
- 2013-06-14 SG SG10201609576YA patent/SG10201609576YA/en unknown
- 2013-06-14 AU AU2013277457A patent/AU2013277457B2/en not_active Ceased
- 2013-06-14 CN CN201380031333.4A patent/CN104378976B/zh not_active Expired - Fee Related
- 2013-06-14 DK DK14195502.1T patent/DK2859793T3/en active
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2014
- 2014-11-18 IL IL235773A patent/IL235773B/en active IP Right Grant
- 2014-11-24 US US14/551,538 patent/US9232776B2/en not_active Expired - Fee Related
- 2014-11-28 IN IN10189DEN2014 patent/IN2014DN10189A/en unknown
-
2015
- 2015-11-10 US US14/937,270 patent/US20160052986A1/en not_active Abandoned
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2016
- 2016-11-21 US US15/357,021 patent/US9737059B2/en not_active Expired - Fee Related
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2017
- 2017-05-31 CY CY20171100577T patent/CY1119071T1/el unknown
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- 2017-07-14 US US15/649,797 patent/US9974291B2/en not_active Expired - Fee Related
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2018
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- 2018-06-25 IL IL260250A patent/IL260250B/en not_active IP Right Cessation
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2019
- 2019-05-01 US US16/400,074 patent/US20190343093A1/en not_active Abandoned
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