AU2013277457B2 - Humanized IL-7 rodents - Google Patents

Humanized IL-7 rodents Download PDF

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Publication number
AU2013277457B2
AU2013277457B2 AU2013277457A AU2013277457A AU2013277457B2 AU 2013277457 B2 AU2013277457 B2 AU 2013277457B2 AU 2013277457 A AU2013277457 A AU 2013277457A AU 2013277457 A AU2013277457 A AU 2013277457A AU 2013277457 B2 AU2013277457 B2 AU 2013277457B2
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AU
Australia
Prior art keywords
human
rodent
humanized
mouse
synthetic
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Ceased
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AU2013277457A
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AU2013277457A1 (en
Inventor
Andrew J. Murphy
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of AU2013277457A1 publication Critical patent/AU2013277457A1/en
Application granted granted Critical
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Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
AU2013277457A 2012-06-18 2013-06-14 Humanized IL-7 rodents Ceased AU2013277457B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US61/660,976 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US61/740,074 2012-12-20
US13/795,765 2013-03-12
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Publications (2)

Publication Number Publication Date
AU2013277457A1 AU2013277457A1 (en) 2015-01-22
AU2013277457B2 true AU2013277457B2 (en) 2018-03-15

Family

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Application Number Title Priority Date Filing Date
AU2013277457A Ceased AU2013277457B2 (en) 2012-06-18 2013-06-14 Humanized IL-7 rodents

Country Status (27)

Country Link
US (7) US8962913B2 (enExample)
EP (2) EP2861063A1 (enExample)
JP (1) JP6174134B2 (enExample)
KR (1) KR20150027752A (enExample)
CN (2) CN104378976B (enExample)
AU (1) AU2013277457B2 (enExample)
BR (1) BR112014029892A2 (enExample)
CA (1) CA2873134A1 (enExample)
CY (1) CY1119071T1 (enExample)
DK (1) DK2859793T3 (enExample)
ES (1) ES2626965T3 (enExample)
HK (1) HK1203761A1 (enExample)
HR (1) HRP20170974T1 (enExample)
HU (1) HUE034592T2 (enExample)
IL (3) IL235773B (enExample)
IN (1) IN2014DN10189A (enExample)
LT (1) LT2859793T (enExample)
MX (1) MX363540B (enExample)
NZ (1) NZ702943A (enExample)
PL (1) PL2859793T3 (enExample)
PT (1) PT2859793T (enExample)
RS (1) RS56039B1 (enExample)
RU (1) RU2654565C2 (enExample)
SG (3) SG10201609576YA (enExample)
SI (1) SI2859793T1 (enExample)
SM (1) SMT201700313T1 (enExample)
WO (1) WO2013192030A1 (enExample)

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US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
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US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
HRP20231121T1 (hr) 2013-09-23 2023-12-22 Regeneron Pharmaceuticals, Inc. Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale
WO2015049517A2 (en) 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
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CA3098040A1 (en) 2018-07-16 2020-01-23 Regeneron Pharmaceuticals, Inc. Non-human animal models of ditra disease and uses thereof
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子１２遺伝子座を含む非ヒト動物
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN113939595A (zh) 2019-06-07 2022-01-14 瑞泽恩制药公司 包括人源化白蛋白基因座的非人动物
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
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Publication number Publication date
HK1203761A1 (en) 2015-11-06
US9232776B2 (en) 2016-01-12
US20190343093A1 (en) 2019-11-14
BR112014029892A2 (pt) 2017-07-25
IL260250B (en) 2019-08-29
SG10201609576YA (en) 2016-12-29
SI2859793T1 (sl) 2017-07-31
MX2014015679A (es) 2015-04-08
EP2859793B1 (en) 2017-04-05
RU2014148107A (ru) 2016-08-10
IN2014DN10189A (enExample) 2015-08-21
IL235773B (en) 2018-07-31
IL268674A (en) 2019-10-31
WO2013192030A1 (en) 2013-12-27
RU2654565C2 (ru) 2018-05-21
EP2861063A1 (en) 2015-04-22
US20170064932A1 (en) 2017-03-09
SG11201407370QA (en) 2014-12-30
US20180360007A1 (en) 2018-12-20
US9737059B2 (en) 2017-08-22
HUE034592T2 (en) 2018-02-28
US20150082469A1 (en) 2015-03-19
RS56039B1 (sr) 2017-09-29
CY1119071T1 (el) 2018-01-10
US9974291B2 (en) 2018-05-22
NZ702943A (en) 2017-07-28
EP2859793A1 (en) 2015-04-15
CA2873134A1 (en) 2013-12-27
LT2859793T (lt) 2017-07-10
US8962913B2 (en) 2015-02-24
MX363540B (es) 2019-03-27
PL2859793T3 (pl) 2017-09-29
HRP20170974T1 (hr) 2017-09-22
PT2859793T (pt) 2017-07-06
JP6174134B2 (ja) 2017-08-02
CN104378976A (zh) 2015-02-25
CN104378976B (zh) 2016-03-23
AU2013277457A1 (en) 2015-01-22
SG10201609569PA (en) 2016-12-29
CN105779467A (zh) 2016-07-20
SMT201700313T1 (it) 2017-07-18
KR20150027752A (ko) 2015-03-12
HK1203302A1 (en) 2015-10-30
ES2626965T3 (es) 2017-07-26
US10314298B2 (en) 2019-06-11
IL235773A0 (en) 2015-01-29
JP2015523863A (ja) 2015-08-20
US20160052986A1 (en) 2016-02-25
US20130340104A1 (en) 2013-12-19
US20170311581A1 (en) 2017-11-02
DK2859793T3 (en) 2017-06-19

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