JP2019022518A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019022518A5 JP2019022518A5 JP2018194898A JP2018194898A JP2019022518A5 JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5 JP 2018194898 A JP2018194898 A JP 2018194898A JP 2018194898 A JP2018194898 A JP 2018194898A JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- exon
- human
- humanized
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims 57
- 108090000172 Interleukin-15 Proteins 0.000 claims 45
- 102000003812 Interleukin-15 Human genes 0.000 claims 27
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 16
- 102000056003 human IL15 Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 12
- 241000700159 Rattus Species 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 238000011144 upstream manufacturing Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108700024394 Exon Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891013P | 2013-10-15 | 2013-10-15 | |
| US61/891,013 | 2013-10-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Division JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Division JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019022518A JP2019022518A (ja) | 2019-02-14 |
| JP2019022518A5 true JP2019022518A5 (enExample) | 2019-04-18 |
| JP6600061B2 JP6600061B2 (ja) | 2019-10-30 |
Family
ID=51830649
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
| JP2018194898A Active JP6600061B2 (ja) | 2013-10-15 | 2018-10-16 | ヒト化ｉｌ−１５動物 |
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9155290B2 (enExample) |
| EP (3) | EP2908626B1 (enExample) |
| JP (3) | JP6492095B2 (enExample) |
| KR (1) | KR102376041B1 (enExample) |
| CN (2) | CN105744829B (enExample) |
| AU (2) | AU2014337526B2 (enExample) |
| BR (1) | BR112016008175A2 (enExample) |
| CA (1) | CA2926090C (enExample) |
| CY (2) | CY1118675T1 (enExample) |
| DK (2) | DK2908626T3 (enExample) |
| ES (2) | ES2715949T3 (enExample) |
| HR (2) | HRP20170380T1 (enExample) |
| HU (2) | HUE043969T2 (enExample) |
| IL (2) | IL244525B (enExample) |
| LT (2) | LT2908626T (enExample) |
| MX (1) | MX2016004781A (enExample) |
| NZ (1) | NZ718655A (enExample) |
| PL (2) | PL2908626T3 (enExample) |
| PT (2) | PT2908626T (enExample) |
| RS (2) | RS58465B1 (enExample) |
| RU (1) | RU2674910C2 (enExample) |
| SG (2) | SG10201607768YA (enExample) |
| SI (2) | SI2908626T1 (enExample) |
| SM (3) | SMT201700024T1 (enExample) |
| TR (1) | TR201904342T4 (enExample) |
| WO (1) | WO2015057758A1 (enExample) |
| ZA (1) | ZA201601676B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541646B2 (en) | 2009-10-06 | 2013-09-24 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| IN2015DN02032A (enExample) | 2012-09-07 | 2015-08-14 | Univ Yale | |
| ES2884598T3 (es) | 2012-11-05 | 2021-12-10 | Regeneron Pharma | Animales no humanos modificados genéticamente y métodos de uso de los mismos |
| AU2014337526B2 (en) | 2013-10-15 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
| BR112016011004A2 (pt) | 2013-11-19 | 2017-12-05 | Regeneron Pharma | animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo |
| CN106659146B (zh) | 2014-05-05 | 2020-06-23 | 再生元制药公司 | 人源化c5和c3动物 |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| PT3482629T (pt) | 2014-05-19 | 2021-02-18 | Univ Yale | Animais não humanos geneticamente modificados que expressam epo humana |
| FI3850946T3 (fi) | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni |
| PT3282835T (pt) | 2015-04-13 | 2023-07-25 | Univ Yale | Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos |
| EP3411392B1 (en) | 2016-02-04 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| EP3895529B1 (en) | 2016-02-29 | 2026-04-29 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| EP3476865B1 (en) | 2016-06-28 | 2023-09-13 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Method for constructing pd-1 gene-modified humanized animal model and use thereof |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041121A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ctla-4 |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041118A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric pd-l1 |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| WO2018041119A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ox40 |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018086594A1 (en) | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tim-3 |
| US20190320633A1 (en) | 2016-11-30 | 2019-10-24 | The Jackson Laboratory | Humanized mouse model with improved human innate immune cell development |
| CN108239659B (zh) | 2016-12-23 | 2020-03-03 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN108424928B (zh) | 2016-12-30 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN109136274B (zh) | 2017-06-19 | 2021-04-23 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd40基因改造动物模型的制备方法及应用 |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| CN109136275B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| CN116998459A (zh) * | 2017-08-09 | 2023-11-07 | 杰克逊实验室 | 表达人白介素15的免疫缺陷小鼠 |
| JP7139419B2 (ja) | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法 |
| WO2019072241A1 (en) | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
| CN109913493B (zh) | 2017-12-12 | 2021-03-16 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd3基因改造动物模型的制备方法及应用 |
| IL315703A (en) | 2018-07-16 | 2024-11-01 | Regeneron Pharma | Non-human animal models of DITRA disease and their uses |
| WO2020074005A1 (en) | 2018-10-12 | 2020-04-16 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric genes |
| WO2020125763A1 (en) | 2018-12-20 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric lag3 |
| WO2020135518A1 (en) * | 2018-12-25 | 2020-07-02 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric il15 |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| CA3137764A1 (en) | 2019-06-07 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| WO2021129766A1 (zh) * | 2019-12-25 | 2021-07-01 | 江苏集萃药康生物科技股份有限公司 | 一种il-15人源化小鼠模型及其用途 |
| CN115175559A (zh) * | 2020-01-28 | 2022-10-11 | 瑞泽恩制药公司 | 包含人源化pnpla3基因座的非人动物及其使用方法 |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| CN112481303B (zh) * | 2021-02-09 | 2021-05-25 | 百奥赛图(北京)医药科技股份有限公司 | Il15ra基因人源化非人动物及其构建方法和应用 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001058914A2 (en) * | 2000-02-08 | 2001-08-16 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the interleukin 15 gene |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| PL1899364T5 (pl) * | 2005-05-17 | 2024-12-09 | University Of Connecticut | Kompozycje i sposoby immunomodulacji w organizmie |
| RU2731084C2 (ru) * | 2008-06-27 | 2020-08-28 | Мерюс Н.В. | Продуцирующие антитела млекопитающие, не являющиеся человеком |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8541646B2 (en) | 2009-10-06 | 2013-09-24 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| NO2516457T3 (enExample) * | 2009-12-21 | 2018-08-11 | ||
| PT4233537T (pt) * | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| ES2741649T3 (es) | 2011-10-28 | 2020-02-11 | Regeneron Pharma | Ratones con complejo mayor de histocompatibilidad modificado genéticamente |
| RS63220B1 (sr) * | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| US9043996B2 (en) * | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| PL2818478T3 (pl) | 2011-10-28 | 2017-09-29 | Regeneron Pharmaceuticals, Inc. | Humanizowane il-6 i receptor il-6 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| IN2015DN02032A (enExample) | 2012-09-07 | 2015-08-14 | Univ Yale | |
| ES2884598T3 (es) | 2012-11-05 | 2021-12-10 | Regeneron Pharma | Animales no humanos modificados genéticamente y métodos de uso de los mismos |
| CA2900824A1 (en) | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| MX368931B (es) | 2013-09-23 | 2019-10-22 | Regeneron Pharma | Animales no humanos que tienen un gen de proteina reguladora de señal humanizado. |
| AU2014337526B2 (en) | 2013-10-15 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
-
2014
- 2014-10-15 AU AU2014337526A patent/AU2014337526B2/en active Active
- 2014-10-15 JP JP2016549191A patent/JP6492095B2/ja active Active
- 2014-10-15 ES ES16192440T patent/ES2715949T3/es active Active
- 2014-10-15 HU HUE16192440A patent/HUE043969T2/hu unknown
- 2014-10-15 RU RU2016116847A patent/RU2674910C2/ru active
- 2014-10-15 LT LTEP14790452.8T patent/LT2908626T/lt unknown
- 2014-10-15 CN CN201480056455.3A patent/CN105744829B/zh active Active
- 2014-10-15 WO PCT/US2014/060568 patent/WO2015057758A1/en not_active Ceased
- 2014-10-15 US US14/514,454 patent/US9155290B2/en active Active
- 2014-10-15 KR KR1020167009228A patent/KR102376041B1/ko active Active
- 2014-10-15 TR TR2019/04342T patent/TR201904342T4/tr unknown
- 2014-10-15 ES ES14790452.8T patent/ES2613379T3/es active Active
- 2014-10-15 RS RS20190349A patent/RS58465B1/sr unknown
- 2014-10-15 PT PT147904528T patent/PT2908626T/pt unknown
- 2014-10-15 HU HUE14790452A patent/HUE033272T2/en unknown
- 2014-10-15 EP EP14790452.8A patent/EP2908626B1/en active Active
- 2014-10-15 BR BR112016008175A patent/BR112016008175A2/pt not_active Application Discontinuation
- 2014-10-15 CA CA2926090A patent/CA2926090C/en active Active
- 2014-10-15 DK DK14790452.8T patent/DK2908626T3/en active
- 2014-10-15 PT PT16192440T patent/PT3138397T/pt unknown
- 2014-10-15 LT LTEP16192440.2T patent/LT3138397T/lt unknown
- 2014-10-15 RS RS20161140A patent/RS55472B1/sr unknown
- 2014-10-15 MX MX2016004781A patent/MX2016004781A/es unknown
- 2014-10-15 DK DK16192440.2T patent/DK3138397T3/en active
- 2014-10-15 CN CN201810808707.3A patent/CN109090037B/zh active Active
- 2014-10-15 PL PL14790452T patent/PL2908626T3/pl unknown
- 2014-10-15 EP EP16192440.2A patent/EP3138397B1/en active Active
- 2014-10-15 SG SG10201607768YA patent/SG10201607768YA/en unknown
- 2014-10-15 SM SM20170024T patent/SMT201700024T1/it unknown
- 2014-10-15 PL PL16192440T patent/PL3138397T3/pl unknown
- 2014-10-15 SI SI201430109T patent/SI2908626T1/sl unknown
- 2014-10-15 SG SG11201601828XA patent/SG11201601828XA/en unknown
- 2014-10-15 SI SI201431130T patent/SI3138397T1/sl unknown
- 2014-10-15 SM SM20190177T patent/SMT201900177T1/it unknown
- 2014-10-15 HR HRP20170380TT patent/HRP20170380T1/hr unknown
- 2014-10-15 NZ NZ718655A patent/NZ718655A/en unknown
- 2014-10-15 EP EP18206034.3A patent/EP3461331A1/en not_active Withdrawn
-
2015
- 2015-09-01 US US14/842,342 patent/US20150366175A1/en not_active Abandoned
-
2016
- 2016-03-10 ZA ZA2016/01676A patent/ZA201601676B/en unknown
- 2016-03-10 IL IL24452516A patent/IL244525B/en active IP Right Grant
-
2017
- 2017-01-04 CY CY20171100008T patent/CY1118675T1/el unknown
- 2017-01-16 SM SM201700024T patent/SMT201700024B/it unknown
- 2017-12-06 US US15/832,976 patent/US10561125B2/en active Active
-
2018
- 2018-10-16 JP JP2018194898A patent/JP6600061B2/ja active Active
-
2019
- 2019-03-18 CY CY20191100323T patent/CY1121405T1/el unknown
- 2019-03-20 HR HRP20190542TT patent/HRP20190542T1/hr unknown
- 2019-10-03 JP JP2019182817A patent/JP2019216750A/ja active Pending
- 2019-10-10 IL IL269907A patent/IL269907B/en active IP Right Grant
-
2020
- 2020-01-02 US US16/732,400 patent/US11503813B2/en active Active
- 2020-12-08 AU AU2020286186A patent/AU2020286186B2/en active Active
-
2022
- 2022-10-17 US US18/047,014 patent/US12369570B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2016123708A (ru) | Отличные от человека животные, содержащие гуманизированный ген фактора активации в-клеток | |
| HRP20170380T1 (hr) | Životinje s humaniziranim il-5 | |
| FI3434101T3 (fi) | Ei-ihmiseläimiä, joissa on humanisoitu signaalinsäätelyproteiinigeeni | |
| JP2017505127A5 (enExample) | ||
| RU2014148107A (ru) | Грызуны с гуманизированным il-7 | |
| RU2016123135A (ru) | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда | |
| CN104450602B (zh) | 非人哺乳动物神经精神疾病动物模型及其制备方法和用途 | |
| HRP20202034T1 (hr) | Neljudske životinje s genom za humanizirani diferencijacijski biljeg cd274 | |
| JP2014532416A5 (enExample) | ||
| JP2017521060A5 (enExample) | ||
| CN110269047A (zh) | 人源化IL-4和IL-4Rα动物 | |
| JP2017213006A5 (enExample) | ||
| RU2016143036A (ru) | Не относящиеся к человеку животные, имеющие гуманизированные fc-гамма-рецепторы | |
| IL319209A (en) | Non-human animals containing a humanized ASGR1 locus | |
| Liu et al. | Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function | |
| JP2016526924A5 (enExample) | ||
| JP2019506897A5 (enExample) | ||
| JP2019511918A5 (enExample) | ||
| RU2018131152A (ru) | Грызуны, характеризующиеся гуманизированным геном tmprss | |
| CN106282122A (zh) | 一种非人哺乳动物恐惧症或其相关疾病动物模型的建立方法及其用途 | |
| JP2024500153A5 (enExample) | ||
| Zhou et al. | Potential but limited redundant roles of MtPIN4, MtPIN5 and MtPIN10/SLM1 in the development of Medicago truncatula | |
| CN119752892B (zh) | 靶向敲除猪txlnb基因座的方法和应用 | |
| CN110904114A (zh) | 一种Gnb2基因的编码序列和Gnb2基因的编码序列在构建小鼠模型中的应用 | |
| RU2018140914A (ru) | Животные с гуманизированным геном il-15 |