JP2019022518A5 - - Google Patents
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- Publication number
- JP2019022518A5 JP2019022518A5 JP2018194898A JP2018194898A JP2019022518A5 JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5 JP 2018194898 A JP2018194898 A JP 2018194898A JP 2018194898 A JP2018194898 A JP 2018194898A JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- exon
- human
- humanized
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims 57
- 108090000172 Interleukin-15 Proteins 0.000 claims 45
- 102000003812 Interleukin-15 Human genes 0.000 claims 27
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 16
- 102000056003 human IL15 Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 12
- 241000700159 Rattus Species 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 238000011144 upstream manufacturing Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108700024394 Exon Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891013P | 2013-10-15 | 2013-10-15 | |
| US61/891,013 | 2013-10-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Division JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Division JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019022518A JP2019022518A (ja) | 2019-02-14 |
| JP2019022518A5 true JP2019022518A5 (enExample) | 2019-04-18 |
| JP6600061B2 JP6600061B2 (ja) | 2019-10-30 |
Family
ID=51830649
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
| JP2018194898A Active JP6600061B2 (ja) | 2013-10-15 | 2018-10-16 | ヒト化ｉｌ−１５動物 |
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9155290B2 (enExample) |
| EP (3) | EP2908626B1 (enExample) |
| JP (3) | JP6492095B2 (enExample) |
| KR (1) | KR102376041B1 (enExample) |
| CN (2) | CN109090037B (enExample) |
| AU (2) | AU2014337526B2 (enExample) |
| BR (1) | BR112016008175A2 (enExample) |
| CA (1) | CA2926090C (enExample) |
| CY (2) | CY1118675T1 (enExample) |
| DK (2) | DK3138397T3 (enExample) |
| ES (2) | ES2613379T3 (enExample) |
| HR (2) | HRP20170380T1 (enExample) |
| HU (2) | HUE043969T2 (enExample) |
| IL (2) | IL244525B (enExample) |
| LT (2) | LT3138397T (enExample) |
| MX (1) | MX2016004781A (enExample) |
| NZ (1) | NZ718655A (enExample) |
| PL (2) | PL3138397T3 (enExample) |
| PT (2) | PT3138397T (enExample) |
| RS (2) | RS58465B1 (enExample) |
| RU (1) | RU2674910C2 (enExample) |
| SG (2) | SG11201601828XA (enExample) |
| SI (2) | SI2908626T1 (enExample) |
| SM (3) | SMT201900177T1 (enExample) |
| TR (1) | TR201904342T4 (enExample) |
| WO (1) | WO2015057758A1 (enExample) |
| ZA (1) | ZA201601676B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2700852T3 (es) | 2009-10-06 | 2019-02-19 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| CN105861553B (zh) | 2011-02-15 | 2020-08-14 | 再生元制药公司 | 人源化m-csf小鼠 |
| IL307969B1 (en) | 2012-09-07 | 2025-10-01 | Regeneron Pharma | Genetically modified non-human animals and methods of using them |
| CA2887706C (en) | 2012-11-05 | 2022-08-02 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| AU2014353347B2 (en) | 2013-11-19 | 2020-07-02 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| CA2946412C (en) | 2014-05-05 | 2024-02-27 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| DK3145307T3 (en) | 2014-05-19 | 2019-04-15 | Regeneron Pharma | RE-MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO |
| DK3466255T3 (da) | 2014-12-05 | 2021-05-03 | Regeneron Pharma | Ikke-humane dyr med en humaniseret klynge af differentiering af 47-gen |
| CN113424798B (zh) | 2015-04-13 | 2023-01-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| US10582702B2 (en) | 2016-02-04 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered ANGPTL8 gene |
| SG10202001578RA (en) | 2016-02-29 | 2020-04-29 | Regeneron Pharma | Rodents having a humanized tmprss gene |
| DK3476865T5 (da) | 2016-06-28 | 2024-09-09 | Biocytogen Pharmaceuticals Beijing Co Ltd | Fremgangsmåde til konstruktion af pd-1-gen-modificeret humaniseret dyremodel og anvendelse deraf |
| WO2018041121A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ctla-4 |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041119A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ox40 |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| DK3507373T5 (da) | 2016-08-31 | 2024-09-02 | Biocytogen Pharmaceuticals Beijing Co Ltd | Genetisk modificeret ikke-menneskeligt dyr med human eller kimær pd-l1 |
| WO2018086594A1 (en) | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tim-3 |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018102546A1 (en) | 2016-11-30 | 2018-06-07 | The Jackson Laboratory | Humanized mouse model with improved human innate immune cell development |
| CN108239659B (zh) | 2016-12-23 | 2020-03-03 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN108424928B (zh) | 2016-12-30 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| CN109136274B (zh) | 2017-06-19 | 2021-04-23 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd40基因改造动物模型的制备方法及应用 |
| CN109136275B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| SG11202001109PA (en) * | 2017-08-09 | 2020-03-30 | Jackson Lab | Immunodeficient mice expressing human interleukin 15 |
| CA3071712C (en) | 2017-09-29 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus and methods of use |
| WO2019072241A1 (en) | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
| CN109913493B (zh) | 2017-12-12 | 2021-03-16 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd3基因改造动物模型的制备方法及应用 |
| SG11202011284RA (en) | 2018-07-16 | 2020-12-30 | Regeneron Pharma | Non-human animal models of ditra disease and uses thereof |
| CN111057721B (zh) | 2018-10-12 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用 |
| WO2020125763A1 (en) | 2018-12-20 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric lag3 |
| WO2020135518A1 (en) | 2018-12-25 | 2020-07-02 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric il15 |
| CN114164177A (zh) * | 2019-01-17 | 2022-03-11 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| CN117178959A (zh) | 2019-04-04 | 2023-12-08 | 瑞泽恩制药公司 | 包括人源化凝血因子12基因座的非人动物 |
| JP7610339B2 (ja) | 2019-06-04 | 2025-01-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法 |
| BR112021022722A2 (pt) | 2019-06-07 | 2022-01-04 | Regeneron Pharma | Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente |
| US20220354097A1 (en) * | 2019-12-25 | 2022-11-10 | Gempharmatech Co., Ltd. | Il-15 humanized mouse model and use thereof |
| KR20220133248A (ko) * | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| CN112481303B (zh) * | 2021-02-09 | 2021-05-25 | 百奥赛图(北京)医药科技股份有限公司 | Il15ra基因人源化非人动物及其构建方法和应用 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001058914A2 (en) * | 2000-02-08 | 2001-08-16 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the interleukin 15 gene |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| WO2007001677A2 (en) * | 2005-05-17 | 2007-01-04 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| DK3456190T3 (da) * | 2008-06-27 | 2022-02-14 | Merus Nv | Antistofproducerende transgent murint dyr |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| ES2700852T3 (es) | 2009-10-06 | 2019-02-19 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| NO2516457T3 (enExample) * | 2009-12-21 | 2018-08-11 | ||
| CN105861553B (zh) * | 2011-02-15 | 2020-08-14 | 再生元制药公司 | 人源化m-csf小鼠 |
| DK2663575T3 (en) * | 2011-10-28 | 2014-12-15 | Regeneron Pharma | HUMANIZED IL-6 and IL-6 receptor |
| US9043996B2 (en) * | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| HUE035652T2 (en) | 2011-10-28 | 2018-05-28 | Regeneron Pharma | Genetically modified major histocompatibility complex mice |
| KR102113108B1 (ko) * | 2011-10-28 | 2020-05-20 | 리제너론 파아마슈티컬스, 인크. | 키메라 주요 조직적합성 복합체 （ｍｈｃ） 제ｉｉ부류 분자들을 발현하는 유전자전이 마우스 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| IL307969B1 (en) | 2012-09-07 | 2025-10-01 | Regeneron Pharma | Genetically modified non-human animals and methods of using them |
| CA2887706C (en) | 2012-11-05 | 2022-08-02 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
| KR102211267B1 (ko) | 2013-02-22 | 2021-02-04 | 리제너론 파아마슈티컬스, 인크. | 사람화된 주요 조직적합성 복합체를 발현하는 마우스 |
| RU2018136614A (ru) | 2013-09-23 | 2018-11-27 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные с гуманизированным геном сигнального регуляторного белка |
| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
-
2014
- 2014-10-15 TR TR2019/04342T patent/TR201904342T4/tr unknown
- 2014-10-15 MX MX2016004781A patent/MX2016004781A/es unknown
- 2014-10-15 RU RU2016116847A patent/RU2674910C2/ru active
- 2014-10-15 SM SM20190177T patent/SMT201900177T1/it unknown
- 2014-10-15 SM SM20170024T patent/SMT201700024T1/it unknown
- 2014-10-15 PT PT16192440T patent/PT3138397T/pt unknown
- 2014-10-15 CA CA2926090A patent/CA2926090C/en active Active
- 2014-10-15 HU HUE16192440A patent/HUE043969T2/hu unknown
- 2014-10-15 ES ES14790452.8T patent/ES2613379T3/es active Active
- 2014-10-15 HR HRP20170380TT patent/HRP20170380T1/hr unknown
- 2014-10-15 EP EP14790452.8A patent/EP2908626B1/en active Active
- 2014-10-15 DK DK16192440.2T patent/DK3138397T3/en active
- 2014-10-15 US US14/514,454 patent/US9155290B2/en active Active
- 2014-10-15 PL PL16192440T patent/PL3138397T3/pl unknown
- 2014-10-15 RS RS20190349A patent/RS58465B1/sr unknown
- 2014-10-15 DK DK14790452.8T patent/DK2908626T3/en active
- 2014-10-15 LT LTEP16192440.2T patent/LT3138397T/lt unknown
- 2014-10-15 HU HUE14790452A patent/HUE033272T2/en unknown
- 2014-10-15 SG SG11201601828XA patent/SG11201601828XA/en unknown
- 2014-10-15 ES ES16192440T patent/ES2715949T3/es active Active
- 2014-10-15 KR KR1020167009228A patent/KR102376041B1/ko active Active
- 2014-10-15 CN CN201810808707.3A patent/CN109090037B/zh active Active
- 2014-10-15 SI SI201430109T patent/SI2908626T1/sl unknown
- 2014-10-15 RS RS20161140A patent/RS55472B1/sr unknown
- 2014-10-15 JP JP2016549191A patent/JP6492095B2/ja active Active
- 2014-10-15 BR BR112016008175A patent/BR112016008175A2/pt not_active Application Discontinuation
- 2014-10-15 NZ NZ718655A patent/NZ718655A/en unknown
- 2014-10-15 WO PCT/US2014/060568 patent/WO2015057758A1/en not_active Ceased
- 2014-10-15 LT LTEP14790452.8T patent/LT2908626T/lt unknown
- 2014-10-15 SG SG10201607768YA patent/SG10201607768YA/en unknown
- 2014-10-15 CN CN201480056455.3A patent/CN105744829B/zh active Active
- 2014-10-15 EP EP18206034.3A patent/EP3461331A1/en not_active Withdrawn
- 2014-10-15 PL PL14790452T patent/PL2908626T3/pl unknown
- 2014-10-15 AU AU2014337526A patent/AU2014337526B2/en active Active
- 2014-10-15 SI SI201431130T patent/SI3138397T1/sl unknown
- 2014-10-15 EP EP16192440.2A patent/EP3138397B1/en active Active
- 2014-10-15 PT PT147904528T patent/PT2908626T/pt unknown
-
2015
- 2015-09-01 US US14/842,342 patent/US20150366175A1/en not_active Abandoned
-
2016
- 2016-03-10 IL IL24452516A patent/IL244525B/en active IP Right Grant
- 2016-03-10 ZA ZA2016/01676A patent/ZA201601676B/en unknown
-
2017
- 2017-01-04 CY CY20171100008T patent/CY1118675T1/el unknown
- 2017-01-16 SM SM201700024T patent/SMT201700024B/it unknown
- 2017-12-06 US US15/832,976 patent/US10561125B2/en active Active
-
2018
- 2018-10-16 JP JP2018194898A patent/JP6600061B2/ja active Active
-
2019
- 2019-03-18 CY CY20191100323T patent/CY1121405T1/el unknown
- 2019-03-20 HR HRP20190542TT patent/HRP20190542T1/hr unknown
- 2019-10-03 JP JP2019182817A patent/JP2019216750A/ja active Pending
- 2019-10-10 IL IL269907A patent/IL269907B/en active IP Right Grant
-
2020
- 2020-01-02 US US16/732,400 patent/US11503813B2/en active Active
- 2020-12-08 AU AU2020286186A patent/AU2020286186B2/en active Active
-
2022
- 2022-10-17 US US18/047,014 patent/US12369570B2/en active Active
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