AU2014337526B2 - Humanized IL-15 animals - Google Patents

Humanized IL-15 animals Download PDF

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Publication number
AU2014337526B2
AU2014337526B2 AU2014337526A AU2014337526A AU2014337526B2 AU 2014337526 B2 AU2014337526 B2 AU 2014337526B2 AU 2014337526 A AU2014337526 A AU 2014337526A AU 2014337526 A AU2014337526 A AU 2014337526A AU 2014337526 B2 AU2014337526 B2 AU 2014337526B2
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AU
Australia
Prior art keywords
human
mouse
humanized
gene
rodent
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AU2014337526A
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AU2014337526A1 (en
Inventor
Ka-Man Venus Lai
Andrew J. Murphy
Jose F. Rojas
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2014337526A 2013-10-15 2014-10-15 Humanized IL-15 animals Active AU2014337526B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020286186A AU2020286186B2 (en) 2013-10-15 2020-12-08 Humanized il-15 animals

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
US61/891,013 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020286186A Division AU2020286186B2 (en) 2013-10-15 2020-12-08 Humanized il-15 animals

Publications (2)

Publication Number Publication Date
AU2014337526A1 AU2014337526A1 (en) 2016-04-28
AU2014337526B2 true AU2014337526B2 (en) 2020-09-10

Family

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AU2014337526A Active AU2014337526B2 (en) 2013-10-15 2014-10-15 Humanized IL-15 animals
AU2020286186A Active AU2020286186B2 (en) 2013-10-15 2020-12-08 Humanized il-15 animals

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Country Status (27)

Country Link
US (5) US9155290B2 (enExample)
EP (3) EP2908626B1 (enExample)
JP (3) JP6492095B2 (enExample)
KR (1) KR102376041B1 (enExample)
CN (2) CN105744829B (enExample)
AU (2) AU2014337526B2 (enExample)
BR (1) BR112016008175A2 (enExample)
CA (1) CA2926090C (enExample)
CY (2) CY1118675T1 (enExample)
DK (2) DK2908626T3 (enExample)
ES (2) ES2715949T3 (enExample)
HR (2) HRP20170380T1 (enExample)
HU (2) HUE043969T2 (enExample)
IL (2) IL244525B (enExample)
LT (2) LT2908626T (enExample)
MX (1) MX2016004781A (enExample)
NZ (1) NZ718655A (enExample)
PL (2) PL2908626T3 (enExample)
PT (2) PT2908626T (enExample)
RS (2) RS58465B1 (enExample)
RU (1) RU2674910C2 (enExample)
SG (2) SG10201607768YA (enExample)
SI (2) SI2908626T1 (enExample)
SM (3) SMT201700024T1 (enExample)
TR (1) TR201904342T4 (enExample)
WO (1) WO2015057758A1 (enExample)
ZA (1) ZA201601676B (enExample)

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ES2884598T3 (es) 2012-11-05 2021-12-10 Regeneron Pharma Animales no humanos modificados genéticamente y métodos de uso de los mismos
AU2014337526B2 (en) 2013-10-15 2020-09-10 Regeneron Pharmaceuticals, Inc. Humanized IL-15 animals
BR112016011004A2 (pt) 2013-11-19 2017-12-05 Regeneron Pharma animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
CN106659146B (zh) 2014-05-05 2020-06-23 再生元制药公司 人源化c5和c3动物
NO2785538T3 (enExample) 2014-05-07 2018-08-04
PT3482629T (pt) 2014-05-19 2021-02-18 Univ Yale Animais não humanos geneticamente modificados que expressam epo humana
FI3850946T3 (fi) 2014-12-05 2023-12-28 Regeneron Pharma Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
PT3282835T (pt) 2015-04-13 2023-07-25 Univ Yale Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos
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CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
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WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
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CN115175559A (zh) * 2020-01-28 2022-10-11 瑞泽恩制药公司 包含人源化pnpla3基因座的非人动物及其使用方法
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JP2019022518A (ja) 2019-02-14
IL244525A0 (en) 2016-04-21
PL3138397T3 (pl) 2019-06-28
RU2016116847A (ru) 2017-11-21
SI3138397T1 (sl) 2019-04-30
US11503813B2 (en) 2022-11-22
US20200178508A1 (en) 2020-06-11
SMT201700024B (it) 2017-03-08
RU2016116847A3 (enExample) 2018-06-07
NZ718655A (en) 2022-08-26
US20230189772A1 (en) 2023-06-22
DK2908626T3 (en) 2017-03-20
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EP3461331A1 (en) 2019-04-03
RS58465B1 (sr) 2019-04-30
JP6600061B2 (ja) 2019-10-30
AU2020286186B2 (en) 2024-05-23
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EP2908626A1 (en) 2015-08-26
KR20160068774A (ko) 2016-06-15
EP3138397B1 (en) 2018-12-26
PL2908626T3 (pl) 2017-05-31
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
SMT201900177T1 (it) 2019-05-10
ES2613379T3 (es) 2017-05-24
CN109090037B (zh) 2021-05-28
WO2015057758A1 (en) 2015-04-23
CN105744829A (zh) 2016-07-06
RU2674910C2 (ru) 2018-12-13
ZA201601676B (en) 2019-12-18
PT3138397T (pt) 2019-03-26
SG10201607768YA (en) 2016-11-29
PT2908626T (pt) 2017-01-09
JP6492095B2 (ja) 2019-03-27
EP3138397A1 (en) 2017-03-08
US9155290B2 (en) 2015-10-13
LT2908626T (lt) 2017-01-25
US12369570B2 (en) 2025-07-29
AU2014337526A1 (en) 2016-04-28
EP2908626B1 (en) 2016-12-07
HUE043969T2 (hu) 2019-09-30
LT3138397T (lt) 2019-04-10
BR112016008175A2 (pt) 2017-10-03
AU2020286186A1 (en) 2021-01-07
CN105744829B (zh) 2018-08-07
ES2715949T3 (es) 2019-06-07
US20180116192A1 (en) 2018-05-03
CN109090037A (zh) 2018-12-28
CA2926090C (en) 2022-07-05
CY1121405T1 (el) 2020-05-29
IL244525B (en) 2019-10-31
CA2926090A1 (en) 2015-04-23
TR201904342T4 (tr) 2019-05-21
RS55472B1 (sr) 2017-04-28
SG11201601828XA (en) 2016-04-28
SMT201700024T1 (it) 2017-03-08
HUE033272T2 (en) 2017-11-28
HRP20170380T1 (hr) 2017-05-19
US20150366175A1 (en) 2015-12-24
KR102376041B1 (ko) 2022-03-18
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US20150106961A1 (en) 2015-04-16
DK3138397T3 (en) 2019-04-15
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