IL244525B - Animal il–15 of human origin - Google Patents

Animal il–15 of human origin

Info

Publication number
IL244525B
IL244525B IL24452516A IL24452516A IL244525B IL 244525 B IL244525 B IL 244525B IL 24452516 A IL24452516 A IL 24452516A IL 24452516 A IL24452516 A IL 24452516A IL 244525 B IL244525 B IL 244525B
Authority
IL
Israel
Prior art keywords
humanized
animals
Prior art date
Application number
IL24452516A
Other languages
English (en)
Hebrew (he)
Other versions
IL244525A0 (en
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL244525A0 publication Critical patent/IL244525A0/en
Publication of IL244525B publication Critical patent/IL244525B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL24452516A 2013-10-15 2016-03-10 Animal il–15 of human origin IL244525B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Publications (2)

Publication Number Publication Date
IL244525A0 IL244525A0 (en) 2016-04-21
IL244525B true IL244525B (en) 2019-10-31

Family

ID=51830649

Family Applications (2)

Application Number Title Priority Date Filing Date
IL24452516A IL244525B (en) 2013-10-15 2016-03-10 Animal il–15 of human origin
IL269907A IL269907B (en) 2013-10-15 2019-10-10 Humanized animals for – il–15

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL269907A IL269907B (en) 2013-10-15 2019-10-10 Humanized animals for – il–15

Country Status (27)

Country Link
US (5) US9155290B2 (enExample)
EP (3) EP2908626B1 (enExample)
JP (3) JP6492095B2 (enExample)
KR (1) KR102376041B1 (enExample)
CN (2) CN109090037B (enExample)
AU (2) AU2014337526B2 (enExample)
BR (1) BR112016008175A2 (enExample)
CA (1) CA2926090C (enExample)
CY (2) CY1118675T1 (enExample)
DK (2) DK3138397T3 (enExample)
ES (2) ES2613379T3 (enExample)
HR (2) HRP20170380T1 (enExample)
HU (2) HUE043969T2 (enExample)
IL (2) IL244525B (enExample)
LT (2) LT3138397T (enExample)
MX (1) MX2016004781A (enExample)
NZ (1) NZ718655A (enExample)
PL (2) PL3138397T3 (enExample)
PT (2) PT3138397T (enExample)
RS (2) RS58465B1 (enExample)
RU (1) RU2674910C2 (enExample)
SG (2) SG11201601828XA (enExample)
SI (2) SI2908626T1 (enExample)
SM (3) SMT201900177T1 (enExample)
TR (1) TR201904342T4 (enExample)
WO (1) WO2015057758A1 (enExample)
ZA (1) ZA201601676B (enExample)

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ES2700852T3 (es) 2009-10-06 2019-02-19 Regeneron Pharma Ratones modificados genéticamente e injerto
CN105861553B (zh) 2011-02-15 2020-08-14 再生元制药公司 人源化m-csf小鼠
IL307969B1 (en) 2012-09-07 2025-10-01 Regeneron Pharma Genetically modified non-human animals and methods of using them
CA2887706C (en) 2012-11-05 2022-08-02 Regeneron Pharmaceuticals Genetically modified non-human animals and methods of use thereof
TR201904342T4 (tr) 2013-10-15 2019-05-21 Regeneron Pharma Hümani̇ze il-15 hayvanlar
AU2014353347B2 (en) 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
CA2946412C (en) 2014-05-05 2024-02-27 Regeneron Pharmaceuticals, Inc. Humanized c5 and c3 animals
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DK3145307T3 (en) 2014-05-19 2019-04-15 Regeneron Pharma RE-MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO
DK3466255T3 (da) 2014-12-05 2021-05-03 Regeneron Pharma Ikke-humane dyr med en humaniseret klynge af differentiering af 47-gen
CN113424798B (zh) 2015-04-13 2023-01-13 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
US10582702B2 (en) 2016-02-04 2020-03-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered ANGPTL8 gene
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WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
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CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
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CN114164177A (zh) * 2019-01-17 2022-03-11 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
CN117178959A (zh) 2019-04-04 2023-12-08 瑞泽恩制药公司 包括人源化凝血因子12基因座的非人动物
JP7610339B2 (ja) 2019-06-04 2025-01-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
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Also Published As

Publication number Publication date
EP3138397B1 (en) 2018-12-26
EP2908626A1 (en) 2015-08-26
US11503813B2 (en) 2022-11-22
RU2674910C2 (ru) 2018-12-13
JP2019216750A (ja) 2019-12-26
DK2908626T3 (en) 2017-03-20
KR102376041B1 (ko) 2022-03-18
PL3138397T3 (pl) 2019-06-28
CA2926090C (en) 2022-07-05
US9155290B2 (en) 2015-10-13
US20200178508A1 (en) 2020-06-11
SI3138397T1 (sl) 2019-04-30
HUE033272T2 (en) 2017-11-28
CA2926090A1 (en) 2015-04-23
JP2019022518A (ja) 2019-02-14
HRP20170380T1 (hr) 2017-05-19
RU2016116847A (ru) 2017-11-21
NZ718655A (en) 2022-08-26
US12369570B2 (en) 2025-07-29
EP3461331A1 (en) 2019-04-03
DK3138397T3 (en) 2019-04-15
JP6600061B2 (ja) 2019-10-30
KR20160068774A (ko) 2016-06-15
CN109090037A (zh) 2018-12-28
PT2908626T (pt) 2017-01-09
CN109090037B (zh) 2021-05-28
PL2908626T3 (pl) 2017-05-31
ES2613379T3 (es) 2017-05-24
EP3138397A1 (en) 2017-03-08
US20180116192A1 (en) 2018-05-03
AU2014337526B2 (en) 2020-09-10
ES2715949T3 (es) 2019-06-07
ZA201601676B (en) 2019-12-18
SG10201607768YA (en) 2016-11-29
CY1118675T1 (el) 2018-03-07
HRP20190542T1 (hr) 2019-07-26
PT3138397T (pt) 2019-03-26
LT2908626T (lt) 2017-01-25
US20230189772A1 (en) 2023-06-22
CN105744829B (zh) 2018-08-07
SMT201700024T1 (it) 2017-03-08
EP2908626B1 (en) 2016-12-07
TR201904342T4 (tr) 2019-05-21
US10561125B2 (en) 2020-02-18
WO2015057758A1 (en) 2015-04-23
US20150366175A1 (en) 2015-12-24
BR112016008175A2 (pt) 2017-10-03
HUE043969T2 (hu) 2019-09-30
SMT201900177T1 (it) 2019-05-10
IL244525A0 (en) 2016-04-21
MX2016004781A (es) 2016-07-26
SI2908626T1 (sl) 2017-02-28
RS55472B1 (sr) 2017-04-28
RS58465B1 (sr) 2019-04-30
LT3138397T (lt) 2019-04-10
US20150106961A1 (en) 2015-04-16
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
AU2014337526A1 (en) 2016-04-28
AU2020286186A1 (en) 2021-01-07
AU2020286186B2 (en) 2024-05-23
CY1121405T1 (el) 2020-05-29
RU2016116847A3 (enExample) 2018-06-07
JP6492095B2 (ja) 2019-03-27
JP2016533192A (ja) 2016-10-27
SG11201601828XA (en) 2016-04-28
CN105744829A (zh) 2016-07-06
SMT201700024B (it) 2017-03-08

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