JP2021508236A5 - - Google Patents
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- Publication number
- JP2021508236A5 JP2021508236A5 JP2020527921A JP2020527921A JP2021508236A5 JP 2021508236 A5 JP2021508236 A5 JP 2021508236A5 JP 2020527921 A JP2020527921 A JP 2020527921A JP 2020527921 A JP2020527921 A JP 2020527921A JP 2021508236 A5 JP2021508236 A5 JP 2021508236A5
- Authority
- JP
- Japan
- Prior art keywords
- human animal
- trkb
- endogenous
- seq
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 claims description 54
- 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 claims description 54
- 101100517383 Homo sapiens NTRK2 gene Proteins 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 39
- 230000001086 cytosolic effect Effects 0.000 claims description 29
- 108091026890 Coding region Proteins 0.000 claims description 24
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 20
- 230000008685 targeting Effects 0.000 claims description 19
- 101150056950 Ntrk2 gene Proteins 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 210000001161 mammalian embryo Anatomy 0.000 claims description 9
- 210000004102 animal cell Anatomy 0.000 claims description 7
- 230000000324 neuroprotective effect Effects 0.000 claims description 7
- 102000005937 Tropomyosin Human genes 0.000 claims description 6
- 108010030743 Tropomyosin Proteins 0.000 claims description 6
- 239000000556 agonist Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 230000003833 cell viability Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 210000003994 retinal ganglion cell Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 102000025171 antigen binding proteins Human genes 0.000 claims description 4
- 108091000831 antigen binding proteins Proteins 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000004060 metabolic process Effects 0.000 claims description 4
- 210000001328 optic nerve Anatomy 0.000 claims description 4
- 150000003384 small molecules Chemical group 0.000 claims description 4
- 208000030768 Optic nerve injury Diseases 0.000 claims description 3
- 238000002266 amputation Methods 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102000043136 MAP kinase family Human genes 0.000 claims description 2
- 108091054455 MAP kinase family Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 108091007960 PI3Ks Proteins 0.000 claims description 2
- 241000283984 Rodentia Species 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 claims description 2
- 102000006261 human tropomyosin-related kinase-B Human genes 0.000 claims description 2
- 108010058135 human tropomyosin-related kinase-B Proteins 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000033001 locomotion Effects 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 230000026731 phosphorylation Effects 0.000 claims description 2
- 238000006366 phosphorylation reaction Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 108091005682 Receptor kinases Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 102000038030 PI3Ks Human genes 0.000 claims 1
- 108020005004 Guide RNA Proteins 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 6
- 101710163270 Nuclease Proteins 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 108091033409 CRISPR Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 210000002257 embryonic structure Anatomy 0.000 description 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023171306A JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762592905P | 2017-11-30 | 2017-11-30 | |
| US62/592,905 | 2017-11-30 | ||
| US201862661373P | 2018-04-23 | 2018-04-23 | |
| US62/661,373 | 2018-04-23 | ||
| PCT/US2018/063390 WO2019108983A1 (en) | 2017-11-30 | 2018-11-30 | Non-human animals comprising a humanized trkb locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171306A Division JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021508236A JP2021508236A (ja) | 2021-03-04 |
| JP2021508236A5 true JP2021508236A5 (enExample) | 2021-12-16 |
| JP7361031B2 JP7361031B2 (ja) | 2023-10-13 |
Family
ID=64734209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527921A Active JP7361031B2 (ja) | 2017-11-30 | 2018-11-30 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| JP2023171306A Active JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171306A Active JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11419318B2 (enExample) |
| EP (2) | EP3585164B1 (enExample) |
| JP (2) | JP7361031B2 (enExample) |
| KR (1) | KR102709884B1 (enExample) |
| CN (2) | CN111655031B (enExample) |
| AU (2) | AU2018375796B2 (enExample) |
| CA (1) | CA3076377A1 (enExample) |
| ES (1) | ES2973937T3 (enExample) |
| IL (2) | IL310006A (enExample) |
| SG (1) | SG11202002456WA (enExample) |
| WO (1) | WO2019108983A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111655031B (zh) | 2017-11-30 | 2022-11-18 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| CN113557301B (zh) * | 2019-03-04 | 2025-03-07 | 公益财团法人东京都医学综合研究所 | 编码Trk片段的核酸构建体及其利用 |
| EP4099821A1 (en) * | 2020-02-07 | 2022-12-14 | Regeneron Pharmaceuticals, Inc. | <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| AU8587598A (en) | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| AU2001273245A1 (en) | 2000-07-05 | 2002-01-14 | Pangene Corporation | Modulators of trk protein activity, compositions and uses |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7060429B2 (en) * | 2001-02-22 | 2006-06-13 | University Of Maryland, Baltimore | Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms |
| AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| CN101117633B (zh) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | 一种细胞核移植方法 |
| CN101157730A (zh) | 2006-09-25 | 2008-04-09 | 南方医科大学珠江医院 | 一种携带神经营养因子穿过血脑屏障的融合蛋白及其编码基因与用途 |
| JP2011501760A (ja) | 2007-10-23 | 2011-01-13 | ノバルティス アーゲー | 呼吸器疾患の処置のためのｔｒｋｂ抗体の使用 |
| JP2011517838A (ja) | 2008-04-11 | 2011-06-16 | ユーティーシー パワー コーポレイション | マニホルド・サンプを備えたバイポーラプレートおよび燃料電池 |
| ES2865648T3 (es) | 2009-06-26 | 2021-10-15 | Regeneron Pharma | Anticuerpos biespecíficos fácilmente aislados con formato de inmunoglobulina nativa |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| TR201903376T4 (tr) | 2009-10-29 | 2019-04-22 | Regeneron Pharma | Çok fonksiyonlu alleller. |
| EP2770822B9 (en) | 2011-10-28 | 2019-12-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| DK2770821T3 (da) | 2011-10-28 | 2017-11-27 | Regeneron Pharma | Genetisk modificerede major histocompatibility-kompleks-mus |
| BR112014008529A2 (pt) | 2011-10-28 | 2017-04-18 | Regeneron Pharma | il-6 humanizado e receptor de il-6 |
| CN104364380B (zh) | 2012-04-25 | 2018-10-09 | 瑞泽恩制药公司 | 核酸酶介导的使用大靶向载体的靶向 |
| RS59199B1 (sr) | 2012-05-25 | 2019-10-31 | Univ California | Metode i jedinjenja za rnk-upravljanu ciljanu dnk modifikaciju i za rnk- upravljanu modulaciju transkripta |
| WO2014033644A2 (en) | 2012-08-28 | 2014-03-06 | Novartis Ag | Methods of nuclease-based genetic engineering |
| PT3939423T (pt) | 2012-11-05 | 2024-05-29 | Regeneron Pharma | Animais não humanos geneticamente modificados e métodos de utilização dos mesmos |
| KR102479178B1 (ko) | 2012-12-06 | 2022-12-19 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
| EP3561050B1 (en) | 2013-02-20 | 2021-12-08 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| EP3543253B1 (en) | 2013-02-20 | 2024-03-27 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| HRP20181866T1 (hr) | 2013-02-22 | 2019-01-25 | Regeneron Pharmaceuticals, Inc. | Miševi koji izražavaju humanizirane komplekse glavne histokompatibilnosti |
| MX369747B (es) | 2013-04-16 | 2019-11-20 | Regeneron Pharma | Modificación dirigida del genoma de rata. |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| US20150143558A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| MX358206B (es) | 2013-11-19 | 2018-08-09 | Regeneron Pharma | Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion. |
| RU2685914C1 (ru) * | 2013-12-11 | 2019-04-23 | Регенерон Фармасьютикалс, Инк. | Способы и композиции для направленной модификации генома |
| WO2015091144A1 (en) | 2013-12-20 | 2015-06-25 | F. Hoffmann-La Roche Ag | Improved recombinant polypeptide production methods |
| WO2015127158A1 (en) * | 2014-02-21 | 2015-08-27 | Regeneron Pharmaceuticals, Inc. | Methods, compositions and kits for cell specific modulation of target antigens |
| DK3129400T3 (da) | 2014-04-08 | 2020-06-08 | Regeneron Pharma | Ikke-humane dyr med humaniserede Fc-gamma-receptorer |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| ES2936810T3 (es) * | 2014-05-16 | 2023-03-22 | Pfizer | Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería |
| MX379268B (es) | 2014-05-19 | 2025-03-11 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| SMT202000184T1 (it) | 2014-06-19 | 2020-05-08 | Regeneron Pharma | Animali non umani aventi un gene 1 della morte cellulare programmata umanizzato |
| DK3354732T3 (da) | 2014-06-23 | 2020-04-06 | Regeneron Pharma | Nukleasemedieret dna-samling |
| WO2015200805A2 (en) | 2014-06-26 | 2015-12-30 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| AU2015317370A1 (en) * | 2014-09-19 | 2017-03-23 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| RU2734770C2 (ru) | 2014-11-21 | 2020-10-23 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для нацеленной генетической модификации с использованием парных гидовых рнк |
| EP3223605B9 (en) | 2014-11-24 | 2021-08-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing humanized cd3 complex |
| HUE064960T2 (hu) * | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| AU2015360667B2 (en) | 2014-12-09 | 2021-09-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| WO2016164492A2 (en) | 2015-04-06 | 2016-10-13 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| EP3376857B1 (en) | 2015-11-20 | 2021-02-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| CN111655031B (zh) | 2017-11-30 | 2022-11-18 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| MY203247A (en) * | 2017-11-30 | 2024-06-19 | Regeneron Pharma | Anti-trkb monoclonal antibodies and methods of use |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
-
2018
- 2018-11-30 CN CN201880087972.5A patent/CN111655031B/zh active Active
- 2018-11-30 CA CA3076377A patent/CA3076377A1/en active Pending
- 2018-11-30 CN CN202211340155.0A patent/CN116064611A/zh active Pending
- 2018-11-30 WO PCT/US2018/063390 patent/WO2019108983A1/en not_active Ceased
- 2018-11-30 KR KR1020207013978A patent/KR102709884B1/ko active Active
- 2018-11-30 ES ES18821882T patent/ES2973937T3/es active Active
- 2018-11-30 JP JP2020527921A patent/JP7361031B2/ja active Active
- 2018-11-30 EP EP18821882.0A patent/EP3585164B1/en active Active
- 2018-11-30 US US16/206,330 patent/US11419318B2/en active Active
- 2018-11-30 EP EP23207807.1A patent/EP4299732A3/en active Pending
- 2018-11-30 IL IL310006A patent/IL310006A/en unknown
- 2018-11-30 IL IL274740A patent/IL274740B2/en unknown
- 2018-11-30 SG SG11202002456WA patent/SG11202002456WA/en unknown
- 2018-11-30 AU AU2018375796A patent/AU2018375796B2/en active Active
-
2022
- 2022-06-30 US US17/810,029 patent/US12396444B2/en active Active
-
2023
- 2023-10-02 JP JP2023171306A patent/JP7610672B2/ja active Active
-
2025
- 2025-02-07 AU AU2025200858A patent/AU2025200858A1/en active Pending
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