JP2018522553A5 - - Google Patents
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- JP2018522553A5 JP2018522553A5 JP2017568279A JP2017568279A JP2018522553A5 JP 2018522553 A5 JP2018522553 A5 JP 2018522553A5 JP 2017568279 A JP2017568279 A JP 2017568279A JP 2017568279 A JP2017568279 A JP 2017568279A JP 2018522553 A5 JP2018522553 A5 JP 2018522553A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- mrf4
- myod
- myf5
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100038379 Myogenic factor 6 Human genes 0.000 claims description 53
- 210000002459 blastocyst Anatomy 0.000 claims description 50
- 108010084677 myogenic factor 6 Proteins 0.000 claims description 50
- 101000958865 Homo sapiens Myogenic factor 5 Proteins 0.000 claims description 48
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims description 45
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims description 41
- 102100038380 Myogenic factor 5 Human genes 0.000 claims description 35
- 210000000472 morula Anatomy 0.000 claims description 28
- 210000004102 animal cell Anatomy 0.000 claims description 26
- 101150047028 MRF4 gene Proteins 0.000 claims description 24
- 101150042523 myod gene Proteins 0.000 claims description 24
- 101150097771 MYF5 gene Proteins 0.000 claims description 22
- 241000282898 Sus scrofa Species 0.000 claims description 17
- 230000035772 mutation Effects 0.000 claims description 17
- 210000000130 stem cell Anatomy 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 14
- 210000000287 oocyte Anatomy 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 108700028369 Alleles Proteins 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 210000001519 tissue Anatomy 0.000 claims description 9
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 6
- 241000283073 Equus caballus Species 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 210000002363 skeletal muscle cell Anatomy 0.000 claims description 6
- 101100025378 Homo sapiens MYF6 gene Proteins 0.000 claims description 4
- 108010054849 MyoD1 myogenic differentiation protein Proteins 0.000 claims description 4
- 102000049132 human MYF5 Human genes 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 101100025371 Homo sapiens MYF5 gene Proteins 0.000 claims description 2
- 235000008708 Morus alba Nutrition 0.000 claims description 2
- 240000000249 Morus alba Species 0.000 claims description 2
- 210000004504 adult stem cell Anatomy 0.000 claims description 2
- 210000004700 fetal blood Anatomy 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 210000002027 skeletal muscle Anatomy 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 3
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187027P | 2015-06-30 | 2015-06-30 | |
| US62/187,027 | 2015-06-30 | ||
| PCT/US2016/040378 WO2017004367A1 (en) | 2015-06-30 | 2016-06-30 | Humanized skeletal muscle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522553A JP2018522553A (ja) | 2018-08-16 |
| JP2018522553A5 true JP2018522553A5 (enExample) | 2019-08-08 |
Family
ID=57609173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568279A Pending JP2018522553A (ja) | 2015-06-30 | 2016-06-30 | ヒト化骨格筋 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10874092B2 (enExample) |
| EP (1) | EP3316898A4 (enExample) |
| JP (1) | JP2018522553A (enExample) |
| CN (1) | CN108135943A (enExample) |
| AU (1) | AU2016288196A1 (enExample) |
| BR (1) | BR112017028619A2 (enExample) |
| CA (1) | CA2991053A1 (enExample) |
| MX (1) | MX2018000273A (enExample) |
| RU (1) | RU2018103093A (enExample) |
| WO (1) | WO2017004367A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016141234A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| CN108472318A (zh) | 2015-06-30 | 2018-08-31 | 明尼苏达大学校董会 | 人源化心脏肌肉 |
| US10874092B2 (en) | 2015-06-30 | 2020-12-29 | Regents Of The University Of Minnesota | Humanized skeletal muscle |
| CN111808820A (zh) * | 2020-06-01 | 2020-10-23 | 贵州省种畜禽种质测定中心 | 基于CRISPRCAS9技术构建MyoD1基因敲除的MDBK细胞系的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ326996A (en) | 1996-01-09 | 1998-11-25 | Univ California | Sustained culture of pluripotent ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| JPWO2003034818A1 (ja) | 2001-10-24 | 2005-02-10 | 中外製薬株式会社 | Ｓｇｒｆ遺伝子改変非ヒト動物 |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| AU2003213813A1 (en) | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| JP2006506968A (ja) | 2002-07-03 | 2006-03-02 | メルク エンド カムパニー インコーポレーテッド | アグーチ関連蛋白質欠損細胞、非ヒトトランスジェニック動物及びエネルギー代謝を調節する化合物の選択方法 |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US20060008451A1 (en) | 2004-07-06 | 2006-01-12 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| ES2678416T3 (es) | 2007-01-11 | 2018-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Células derivadas de músculo para el tratamiento de patologías de las vías urinarias y métodos de fabricación y uso de las mismas |
| EP2106210A4 (en) | 2007-01-20 | 2010-11-24 | Boehringer Ingelheim Int | KNOCKOUT MOUSE OF REACTIVE PROTEIN C |
| CN101679950A (zh) | 2007-02-22 | 2010-03-24 | 国立大学法人东京大学 | 利用胚泡互补的器官再生法 |
| JP5688788B2 (ja) | 2008-02-22 | 2015-03-25 | 国立大学法人 東京大学 | 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法 |
| WO2010021390A1 (ja) | 2008-08-22 | 2010-02-25 | 国立大学法人 東京大学 | ｉＰＳ細胞とＢＬＡＳＴＯＣＹＳＴ ＣＯＭＰＬＥＭＥＮＴＡＴＩＯＮを利用した臓器再生法 |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| US9446076B2 (en) | 2009-05-20 | 2016-09-20 | Cardio3 Biosciences S.A. | Pharmaceutical composition for the treatment of heart diseases |
| MX363013B (es) * | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| CA2834375C (en) | 2011-04-27 | 2020-07-14 | Amyris, Inc. | Methods for genomic modification |
| AU2012262139B2 (en) | 2011-06-02 | 2017-02-23 | Children's Medical Center Corporation | Methods and uses for ex vivo tissue culture systems |
| US9862929B2 (en) | 2011-11-18 | 2018-01-09 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) * | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| BR122023023211A2 (pt) * | 2014-04-28 | 2024-01-23 | Recombinetics, Inc. | Método de fazer edições de genes multiplex em uma célula de vertebrado ou de embrião primário não-humano |
| WO2016141234A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| US10874092B2 (en) | 2015-06-30 | 2020-12-29 | Regents Of The University Of Minnesota | Humanized skeletal muscle |
| CN108472318A (zh) | 2015-06-30 | 2018-08-31 | 明尼苏达大学校董会 | 人源化心脏肌肉 |
| EP3367785A4 (en) | 2015-10-27 | 2019-08-14 | Regents of the University of Minnesota | COMPOSITIONS AND METHODS FOR CHIMERIC EMBRYO-ASSISTED ORGAN PRODUCTION |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 US US15/739,042 patent/US10874092B2/en active Active
- 2016-06-30 RU RU2018103093A patent/RU2018103093A/ru not_active Application Discontinuation
- 2016-06-30 BR BR112017028619A patent/BR112017028619A2/pt not_active Application Discontinuation
- 2016-06-30 MX MX2018000273A patent/MX2018000273A/es unknown
- 2016-06-30 CN CN201680049673.3A patent/CN108135943A/zh active Pending
- 2016-06-30 EP EP16818785.4A patent/EP3316898A4/en active Pending
- 2016-06-30 JP JP2017568279A patent/JP2018522553A/ja active Pending
- 2016-06-30 CA CA2991053A patent/CA2991053A1/en not_active Abandoned
- 2016-06-30 AU AU2016288196A patent/AU2016288196A1/en not_active Abandoned
- 2016-06-30 WO PCT/US2016/040378 patent/WO2017004367A1/en not_active Ceased
-
2020
- 2020-11-19 US US16/952,807 patent/US12089574B2/en active Active
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