JP2018523999A5 - - Google Patents
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- Publication number
- JP2018523999A5 JP2018523999A5 JP2017568252A JP2017568252A JP2018523999A5 JP 2018523999 A5 JP2018523999 A5 JP 2018523999A5 JP 2017568252 A JP2017568252 A JP 2017568252A JP 2017568252 A JP2017568252 A JP 2017568252A JP 2018523999 A5 JP2018523999 A5 JP 2018523999A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- handii
- tbx5
- nkx2
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims description 70
- 108010014480 T-box transcription factor 5 Proteins 0.000 claims description 52
- 210000002459 blastocyst Anatomy 0.000 claims description 52
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims description 44
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 claims description 42
- -1 HANDII Proteins 0.000 claims description 41
- 210000000472 morula Anatomy 0.000 claims description 38
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 210000004102 animal cell Anatomy 0.000 claims description 22
- 101150115978 tbx5 gene Proteins 0.000 claims description 22
- 230000035772 mutation Effects 0.000 claims description 18
- 241000282898 Sus scrofa Species 0.000 claims description 15
- 210000000130 stem cell Anatomy 0.000 claims description 15
- 210000000287 oocyte Anatomy 0.000 claims description 14
- 108700028369 Alleles Proteins 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 108700026220 vif Genes Proteins 0.000 claims description 12
- 102000043416 human NKX2-5 Human genes 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 9
- 210000002064 heart cell Anatomy 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 6
- 241000283073 Equus caballus Species 0.000 claims description 6
- 210000005260 human cell Anatomy 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 6
- 210000005003 heart tissue Anatomy 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 241000282887 Suidae Species 0.000 claims description 2
- 210000004504 adult stem cell Anatomy 0.000 claims description 2
- 210000004700 fetal blood Anatomy 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 235000015277 pork Nutrition 0.000 claims description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 3
- 101000958865 Homo sapiens Myogenic factor 5 Proteins 0.000 description 2
- 102100038379 Myogenic factor 6 Human genes 0.000 description 2
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 description 2
- 108010084677 myogenic factor 6 Proteins 0.000 description 2
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 description 1
- 101150047028 MRF4 gene Proteins 0.000 description 1
- 101150097771 MYF5 gene Proteins 0.000 description 1
- 102100035077 Myoblast determination protein 1 Human genes 0.000 description 1
- 102100038380 Myogenic factor 5 Human genes 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 101150042523 myod gene Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187040P | 2015-06-30 | 2015-06-30 | |
| US62/187,040 | 2015-06-30 | ||
| PCT/US2016/040431 WO2017004388A1 (en) | 2015-06-30 | 2016-06-30 | Humanized heart muscle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018523999A JP2018523999A (ja) | 2018-08-30 |
| JP2018523999A5 true JP2018523999A5 (enExample) | 2019-08-08 |
Family
ID=57609529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568252A Pending JP2018523999A (ja) | 2015-06-30 | 2016-06-30 | ヒト化心筋 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10897880B2 (enExample) |
| EP (1) | EP3316899A4 (enExample) |
| JP (1) | JP2018523999A (enExample) |
| KR (1) | KR20180021135A (enExample) |
| CN (1) | CN108472318A (enExample) |
| AU (1) | AU2016288671A1 (enExample) |
| BR (1) | BR112017028608A2 (enExample) |
| CA (1) | CA2991056A1 (enExample) |
| CO (1) | CO2018000859A2 (enExample) |
| IL (1) | IL256544A (enExample) |
| MX (1) | MX2018000071A (enExample) |
| RU (1) | RU2018103234A (enExample) |
| WO (1) | WO2017004388A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| JP2018522553A (ja) | 2015-06-30 | 2018-08-16 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化骨格筋 |
| US10897880B2 (en) | 2015-06-30 | 2021-01-26 | Regents Of The University Of Minnesota | Humanized heart muscle |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU721375B2 (en) * | 1996-01-09 | 2000-06-29 | Regents Of The University Of California, The | Porcine embryonic stem-like cells, methods of making and using the cells to produce transgenic pigs |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) * | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| WO2003034818A1 (en) | 2001-10-24 | 2003-05-01 | Chugai Seiyaku Kabushiki Kaisha | Sgrf genetically modified nonhuman animal |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| US20050125853A1 (en) | 2002-03-22 | 2005-06-09 | St. Jude Children's Resarch Hospital | Method for generating genetically modified animals |
| CA2488725A1 (en) | 2002-07-03 | 2004-01-15 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| AU2008205278B2 (en) | 2007-01-11 | 2014-06-12 | University Of Pittsburgh | Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same |
| US20100107263A1 (en) | 2007-01-20 | 2010-04-29 | Boehringer Ingelheim International Gmbh & Co., Kg | C-reactive protein (crp) knockout mouse |
| JPWO2008102602A1 (ja) | 2007-02-22 | 2010-05-27 | 国立大学法人 東京大学 | Ｂｌａｓｔｏｃｙｓｔｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法 |
| US20110067125A1 (en) | 2008-02-22 | 2011-03-17 | The University Of Tokyo | Method for producing founder animal for reproducing animal having lethal phenotype caused by gene modification |
| WO2010021390A1 (ja) | 2008-08-22 | 2010-02-25 | 国立大学法人 東京大学 | ｉＰＳ細胞とＢＬＡＳＴＯＣＹＳＴ ＣＯＭＰＬＥＭＥＮＴＡＴＩＯＮを利用した臓器再生法 |
| WO2010108126A2 (en) * | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| MX2011012183A (es) * | 2009-05-20 | 2012-03-06 | Cardio3 Biosciences Sa | Composicion farmaceutica para el tratamiento de enfermedades cardiacas. |
| PT2702160T (pt) | 2011-04-27 | 2020-07-30 | Amyris Inc | Métodos para modificação genómica |
| US9951313B2 (en) | 2011-06-02 | 2018-04-24 | President And Fellows Of Harvard College | Methods and uses for ex vivo tissue culture systems |
| JP6083877B2 (ja) | 2011-11-18 | 2017-02-22 | 国立大学法人京都大学 | 多能性幹細胞から骨格筋細胞への分化誘導方法 |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| CA2946881A1 (en) | 2014-04-28 | 2015-11-05 | Recombinetics, Inc. | Multiplex gene editing in swine |
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| JP2018522553A (ja) | 2015-06-30 | 2018-08-16 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化骨格筋 |
| US10897880B2 (en) | 2015-06-30 | 2021-01-26 | Regents Of The University Of Minnesota | Humanized heart muscle |
| AU2016344152A1 (en) | 2015-10-27 | 2018-05-24 | Recombinetics, Inc. | Compositions and methods for chimeric embryo-assisted organ production |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 US US15/739,066 patent/US10897880B2/en active Active
- 2016-06-30 CA CA2991056A patent/CA2991056A1/en not_active Abandoned
- 2016-06-30 WO PCT/US2016/040431 patent/WO2017004388A1/en not_active Ceased
- 2016-06-30 EP EP16818799.5A patent/EP3316899A4/en not_active Withdrawn
- 2016-06-30 CN CN201680050242.9A patent/CN108472318A/zh active Pending
- 2016-06-30 AU AU2016288671A patent/AU2016288671A1/en not_active Abandoned
- 2016-06-30 MX MX2018000071A patent/MX2018000071A/es unknown
- 2016-06-30 JP JP2017568252A patent/JP2018523999A/ja active Pending
- 2016-06-30 RU RU2018103234A patent/RU2018103234A/ru not_active Application Discontinuation
- 2016-06-30 BR BR112017028608A patent/BR112017028608A2/pt not_active Application Discontinuation
- 2016-06-30 KR KR1020187002387A patent/KR20180021135A/ko not_active Ceased
-
2017
- 2017-12-25 IL IL256544A patent/IL256544A/en unknown
-
2018
- 2018-01-29 CO CONC2018/0000859A patent/CO2018000859A2/es unknown
-
2020
- 2020-12-11 US US17/118,981 patent/US20210169054A1/en not_active Abandoned
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