KR20180021135A - 인간화 심장 근육 - Google Patents

인간화 심장 근육 Download PDF

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KR20180021135A
KR20180021135A KR1020187002387A KR20187002387A KR20180021135A KR 20180021135 A KR20180021135 A KR 20180021135A KR 1020187002387 A KR1020187002387 A KR 1020187002387A KR 20187002387 A KR20187002387 A KR 20187002387A KR 20180021135 A KR20180021135 A KR 20180021135A
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handii
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KR1020187002387A
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Korean (ko)
Inventor
다니엘 제이. 게리
마리 지. 게리
나오코 고야노-나카가와
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리젠츠 오브 더 유니버시티 오브 미네소타
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/15Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/108Swine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • A01K2267/025Animal producing cells or organs for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
KR1020187002387A 2015-06-30 2016-06-30 인간화 심장 근육 Ceased KR20180021135A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187040P 2015-06-30 2015-06-30
US62/187,040 2015-06-30
PCT/US2016/040431 WO2017004388A1 (en) 2015-06-30 2016-06-30 Humanized heart muscle

Publications (1)

Publication Number Publication Date
KR20180021135A true KR20180021135A (ko) 2018-02-28

Family

ID=57609529

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187002387A Ceased KR20180021135A (ko) 2015-06-30 2016-06-30 인간화 심장 근육

Country Status (13)

Country Link
US (2) US10897880B2 (enExample)
EP (1) EP3316899A4 (enExample)
JP (1) JP2018523999A (enExample)
KR (1) KR20180021135A (enExample)
CN (1) CN108472318A (enExample)
AU (1) AU2016288671A1 (enExample)
BR (1) BR112017028608A2 (enExample)
CA (1) CA2991056A1 (enExample)
CO (1) CO2018000859A2 (enExample)
IL (1) IL256544A (enExample)
MX (1) MX2018000071A (enExample)
RU (1) RU2018103234A (enExample)
WO (1) WO2017004388A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016141234A1 (en) 2015-03-03 2016-09-09 Regents Of The University Of Minnesota Etv2 and uses thereof
BR112017028608A2 (pt) 2015-06-30 2018-09-04 Univ Minnesota músculo cardíaco humanizado
CN108135943A (zh) 2015-06-30 2018-06-08 明尼苏达大学校董会 人源化的骨骼肌

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997025412A1 (en) * 1996-01-09 1997-07-17 The Regents Of The University Of California Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
CN1241210A (zh) * 1996-10-11 2000-01-12 得克萨斯农业及机械体系综合大学 产生原生殖细胞和转基因动物物种的方法
WO2003034818A1 (en) 2001-10-24 2003-05-01 Chugai Seiyaku Kabushiki Kaisha Sgrf genetically modified nonhuman animal
US20040133931A1 (en) 2003-01-08 2004-07-08 Gavin William G. Method and system for fusion and activation following nuclear transfer in reconstructed embryos
WO2003081990A2 (en) 2002-03-22 2003-10-09 St. Jude Children's Research Hospital Improved method for generating genetically modified animals
WO2004004447A2 (en) * 2002-07-03 2004-01-15 Merck & Co., Inc. Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism
GB2398784B (en) * 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
WO2006014551A2 (en) 2004-07-06 2006-02-09 Michigan State University In vivo methods for effecting tissue specific differentiation of embryonic stem cells
WO2008086040A1 (en) 2007-01-11 2008-07-17 University Of Pittsburgh Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
CA2675100A1 (en) 2007-01-20 2008-07-24 Boehringer Ingelheim International Gmbh C-reactive protein (crp) knockout mouse
JPWO2008102602A1 (ja) 2007-02-22 2010-05-27 国立大学法人 東京大学 Blastocystcomplementationを利用した臓器再生法
JP5688788B2 (ja) 2008-02-22 2015-03-25 国立大学法人 東京大学 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法
GB2475656B (en) 2008-08-22 2013-04-24 Univ Tokyo Organ regeneration method utilizing ips cell and blastocyst complementation
WO2010108126A2 (en) * 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Reprogramming compositions and methods of using the same
NZ623454A (en) * 2009-05-20 2015-12-24 Cardio3 Biosciences Sa Pharmaceutical composition for the treatment of heart diseases
JP6158170B2 (ja) 2011-04-27 2017-07-12 アミリス, インコーポレイテッド ゲノム修飾のための方法
EP3354343B1 (en) * 2011-06-02 2023-09-06 President and Fellows of Harvard College Methods and uses for ex vivo tissue culture systems
US9862929B2 (en) 2011-11-18 2018-01-09 Kyoto University Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells
IL221187A (en) 2012-07-30 2017-01-31 Adom Advanced Optical Tech Ltd A system to perform optical tomography in two 2D beams
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
US11377639B2 (en) * 2013-11-15 2022-07-05 Wisconsin Alumni Research Foundation Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
BR112016024945A2 (pt) 2014-04-28 2017-10-24 Recombinetics Inc edição de gene multiplex em suínos
WO2016141234A1 (en) 2015-03-03 2016-09-09 Regents Of The University Of Minnesota Etv2 and uses thereof
CN108135943A (zh) 2015-06-30 2018-06-08 明尼苏达大学校董会 人源化的骨骼肌
BR112017028608A2 (pt) 2015-06-30 2018-09-04 Univ Minnesota músculo cardíaco humanizado
KR20180100303A (ko) 2015-10-27 2018-09-10 리젠츠 오브 더 유니버시티 오브 미네소타 키메라 배아-보조 기관 생성을 위한 조성물 및 방법
CN108125943A (zh) 2018-01-17 2018-06-08 云南省第二人民医院 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用

Also Published As

Publication number Publication date
EP3316899A1 (en) 2018-05-09
AU2016288671A1 (en) 2018-02-01
CO2018000859A2 (es) 2018-07-10
US20180177165A1 (en) 2018-06-28
CN108472318A (zh) 2018-08-31
US10897880B2 (en) 2021-01-26
CA2991056A1 (en) 2017-01-05
MX2018000071A (es) 2018-03-16
BR112017028608A2 (pt) 2018-09-04
WO2017004388A1 (en) 2017-01-05
JP2018523999A (ja) 2018-08-30
EP3316899A4 (en) 2019-04-03
US20210169054A1 (en) 2021-06-10
RU2018103234A (ru) 2019-07-31
IL256544A (en) 2018-02-28

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