RU2018103234A - Гуманизированная мышца сердца - Google Patents
Гуманизированная мышца сердца Download PDFInfo
- Publication number
- RU2018103234A RU2018103234A RU2018103234A RU2018103234A RU2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A
- Authority
- RU
- Russia
- Prior art keywords
- nkx2
- handii
- tbx5
- human animal
- combination
- Prior art date
Links
- 210000004165 myocardium Anatomy 0.000 title 1
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims 38
- 108010014480 T-box transcription factor 5 Proteins 0.000 claims 28
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims 27
- 210000002459 blastocyst Anatomy 0.000 claims 25
- -1 HANDII Proteins 0.000 claims 21
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 241000282898 Sus scrofa Species 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 210000000472 morula Anatomy 0.000 claims 16
- 101150115978 tbx5 gene Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 210000000287 oocyte Anatomy 0.000 claims 8
- 210000004940 nucleus Anatomy 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 7
- 210000002064 heart cell Anatomy 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 210000005003 heart tissue Anatomy 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000283073 Equus caballus Species 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 101100206168 Homo sapiens TBX5 gene Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000004504 adult stem cell Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 102000043416 human NKX2-5 Human genes 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 235000015277 pork Nutrition 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187040P | 2015-06-30 | 2015-06-30 | |
| US62/187,040 | 2015-06-30 | ||
| PCT/US2016/040431 WO2017004388A1 (en) | 2015-06-30 | 2016-06-30 | Humanized heart muscle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018103234A true RU2018103234A (ru) | 2019-07-31 |
Family
ID=57609529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018103234A RU2018103234A (ru) | 2015-06-30 | 2016-06-30 | Гуманизированная мышца сердца |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10897880B2 (enExample) |
| EP (1) | EP3316899A4 (enExample) |
| JP (1) | JP2018523999A (enExample) |
| KR (1) | KR20180021135A (enExample) |
| CN (1) | CN108472318A (enExample) |
| AU (1) | AU2016288671A1 (enExample) |
| BR (1) | BR112017028608A2 (enExample) |
| CA (1) | CA2991056A1 (enExample) |
| CO (1) | CO2018000859A2 (enExample) |
| IL (1) | IL256544A (enExample) |
| MX (1) | MX2018000071A (enExample) |
| RU (1) | RU2018103234A (enExample) |
| WO (1) | WO2017004388A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| CN108135943A (zh) | 2015-06-30 | 2018-06-08 | 明尼苏达大学校董会 | 人源化的骨骼肌 |
| EP3316899A4 (en) | 2015-06-30 | 2019-04-03 | Regents of the University of Minnesota | HUMANIZED CARDIAC MUSCLE |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2242666A1 (en) * | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) * | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| WO2003034818A1 (en) | 2001-10-24 | 2003-05-01 | Chugai Seiyaku Kabushiki Kaisha | Sgrf genetically modified nonhuman animal |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| AU2003213813A1 (en) | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| US20050257279A1 (en) * | 2002-07-03 | 2005-11-17 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) * | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US20060008451A1 (en) | 2004-07-06 | 2006-01-12 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| WO2008086040A1 (en) | 2007-01-11 | 2008-07-17 | University Of Pittsburgh | Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same |
| WO2008089482A1 (en) | 2007-01-20 | 2008-07-24 | Boehringer Ingelheim International Gmbh | C-reactive protein (crp) knockout mouse |
| CN101679950A (zh) | 2007-02-22 | 2010-03-24 | 国立大学法人东京大学 | 利用胚泡互补的器官再生法 |
| US20110067125A1 (en) | 2008-02-22 | 2011-03-17 | The University Of Tokyo | Method for producing founder animal for reproducing animal having lethal phenotype caused by gene modification |
| GB2475656B (en) | 2008-08-22 | 2013-04-24 | Univ Tokyo | Organ regeneration method utilizing ips cell and blastocyst complementation |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| NZ623454A (en) * | 2009-05-20 | 2015-12-24 | Cardio3 Biosciences Sa | Pharmaceutical composition for the treatment of heart diseases |
| SG194089A1 (en) | 2011-04-27 | 2013-11-29 | Amyris Inc | Methods for genomic modification |
| EP3354343B1 (en) | 2011-06-02 | 2023-09-06 | President and Fellows of Harvard College | Methods and uses for ex vivo tissue culture systems |
| US9862929B2 (en) | 2011-11-18 | 2018-01-09 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| EP3136850A1 (en) | 2014-04-28 | 2017-03-08 | Recombinetics, Inc. | Multiplex gene editing in swine |
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| EP3316899A4 (en) | 2015-06-30 | 2019-04-03 | Regents of the University of Minnesota | HUMANIZED CARDIAC MUSCLE |
| CN108135943A (zh) | 2015-06-30 | 2018-06-08 | 明尼苏达大学校董会 | 人源化的骨骼肌 |
| CA3003652A1 (en) | 2015-10-27 | 2017-05-04 | Regents Of The University Of Minnesota | Compositions and methods for chimeric embryo-assisted organ production |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 EP EP16818799.5A patent/EP3316899A4/en not_active Withdrawn
- 2016-06-30 US US15/739,066 patent/US10897880B2/en active Active
- 2016-06-30 AU AU2016288671A patent/AU2016288671A1/en not_active Abandoned
- 2016-06-30 WO PCT/US2016/040431 patent/WO2017004388A1/en not_active Ceased
- 2016-06-30 CN CN201680050242.9A patent/CN108472318A/zh active Pending
- 2016-06-30 BR BR112017028608A patent/BR112017028608A2/pt not_active Application Discontinuation
- 2016-06-30 MX MX2018000071A patent/MX2018000071A/es unknown
- 2016-06-30 JP JP2017568252A patent/JP2018523999A/ja active Pending
- 2016-06-30 CA CA2991056A patent/CA2991056A1/en not_active Abandoned
- 2016-06-30 KR KR1020187002387A patent/KR20180021135A/ko not_active Ceased
- 2016-06-30 RU RU2018103234A patent/RU2018103234A/ru not_active Application Discontinuation
-
2017
- 2017-12-25 IL IL256544A patent/IL256544A/en unknown
-
2018
- 2018-01-29 CO CONC2018/0000859A patent/CO2018000859A2/es unknown
-
2020
- 2020-12-11 US US17/118,981 patent/US20210169054A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018000071A (es) | 2018-03-16 |
| IL256544A (en) | 2018-02-28 |
| BR112017028608A2 (pt) | 2018-09-04 |
| EP3316899A1 (en) | 2018-05-09 |
| US20210169054A1 (en) | 2021-06-10 |
| CN108472318A (zh) | 2018-08-31 |
| JP2018523999A (ja) | 2018-08-30 |
| CO2018000859A2 (es) | 2018-07-10 |
| US20180177165A1 (en) | 2018-06-28 |
| EP3316899A4 (en) | 2019-04-03 |
| CA2991056A1 (en) | 2017-01-05 |
| KR20180021135A (ko) | 2018-02-28 |
| AU2016288671A1 (en) | 2018-02-01 |
| WO2017004388A1 (en) | 2017-01-05 |
| US10897880B2 (en) | 2021-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Nagashima et al. | Growing human organs in pigs—A dream or reality? | |
| Hall et al. | Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals | |
| JP2015533284A5 (enExample) | ||
| CA3003652A1 (en) | Compositions and methods for chimeric embryo-assisted organ production | |
| US20230365638A1 (en) | Etv2 and uses thereof | |
| RU2018103093A (ru) | Гуманизированная скелетная мышца | |
| Hong et al. | Dogs cloned from fetal fibroblasts by nuclear transfer | |
| IL274740B2 (en) | Non-human animals comprising a humanized trkb locus | |
| RU2018103234A (ru) | Гуманизированная мышца сердца | |
| RU2015122802A (ru) | Клонированное животное, отличное от человека, которое не содержит селективный маркер | |
| JP2016502407A5 (enExample) | ||
| JP2018506984A5 (enExample) | ||
| JP2018522553A5 (enExample) | ||
| JP2018523999A5 (enExample) | ||
| Ibtisham et al. | Animal cloning applications and issues | |
| CN105039402A (zh) | 一种改良猪肌肉品质的方法 | |
| Anton | On recent advances in human engineering: Provocative trends in embryology, genetics, and regenerative medicine | |
| Reardon | Hybrid zoo: introducing pig–human embryos and a rat–mouse | |
| JP2018520682A5 (enExample) | ||
| Hussain et al. | CRISPR/Cas System and Stem Cell Editing: Prospects and Possibilities in Veterinary Sciences | |
| Selokar et al. | 10 years after the birth of India’s first cloned farm animal, where is buffalo cloning heading | |
| JP6366944B2 (ja) | プライム型多能性幹細胞からキメラ形成能を向上させた多能性幹細胞を製造する方法並びにそのための組成物および組合せ | |
| CN103923215B (zh) | 使ACC-α基因启动子PⅢ失活的物质及其应用 | |
| Song et al. | Developmental analysis of reconstructed embryos of second‐generation cloned transgenic goats | |
| Reardon | Scientists stumble across unknown stem-cell type |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20190701 |