DK3129400T3 - Ikke-humane dyr med humaniserede Fc-gamma-receptorer - Google Patents

Ikke-humane dyr med humaniserede Fc-gamma-receptorer Download PDF

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Publication number
DK3129400T3
DK3129400T3 DK15718060.5T DK15718060T DK3129400T3 DK 3129400 T3 DK3129400 T3 DK 3129400T3 DK 15718060 T DK15718060 T DK 15718060T DK 3129400 T3 DK3129400 T3 DK 3129400T3
Authority
DK
Denmark
Prior art keywords
humanized
human animals
gamma receptors
receptors
gamma
Prior art date
Application number
DK15718060.5T
Other languages
English (en)
Inventor
Andrew J Murphy
Lynn Macdonald
Karolina A Meagher
Naxin Tu
Cagan Gurer
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3129400T3 publication Critical patent/DK3129400T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0337Animal models for infectious diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15718060.5T 2014-04-08 2015-04-08 Ikke-humane dyr med humaniserede Fc-gamma-receptorer DK3129400T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08
PCT/US2015/024920 WO2015157415A1 (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Publications (1)

Publication Number Publication Date
DK3129400T3 true DK3129400T3 (da) 2020-06-08

Family

ID=52997579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15718060.5T DK3129400T3 (da) 2014-04-08 2015-04-08 Ikke-humane dyr med humaniserede Fc-gamma-receptorer

Country Status (23)

Country Link
US (4) US9474255B2 (da)
EP (2) EP3129400B1 (da)
JP (2) JP6652931B2 (da)
KR (2) KR102223264B1 (da)
CN (2) CN106163273B (da)
AU (2) AU2015243865C1 (da)
CA (1) CA2935472C (da)
CY (1) CY1123046T1 (da)
DK (1) DK3129400T3 (da)
ES (1) ES2794942T3 (da)
HR (1) HRP20200899T1 (da)
HU (1) HUE051088T2 (da)
IL (2) IL246497B (da)
LT (1) LT3129400T (da)
MX (1) MX2016013241A (da)
PH (1) PH12016501341A1 (da)
PL (1) PL3129400T3 (da)
PT (1) PT3129400T (da)
RS (1) RS60398B1 (da)
RU (2) RU2019128394A (da)
SG (2) SG10201908800YA (da)
SI (1) SI3129400T1 (da)
WO (1) WO2015157415A1 (da)

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NO2785538T3 (da) 2014-05-07 2018-08-04
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HUE059417T2 (hu) 2014-11-24 2022-11-28 Regeneron Pharma Humanizált CD3-komplexet expresszáló nem humán állatok
EP4296278A3 (en) 2014-12-05 2024-03-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
KR102457921B1 (ko) 2014-12-09 2022-10-25 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 274 유전자를 갖는 비인간 동물
KR102454546B1 (ko) 2015-11-20 2022-10-14 리제너론 파마슈티칼스 인코포레이티드 인간화 림프구 활성화 유전자 3을 갖는 비인간 동물
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
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AU2019308205A1 (en) 2018-07-16 2020-11-19 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
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Also Published As

Publication number Publication date
JP2017510285A (ja) 2017-04-13
AU2015243865B2 (en) 2020-05-14
RS60398B1 (sr) 2020-07-31
JP2020062051A (ja) 2020-04-23
HUE051088T2 (hu) 2021-03-01
SG11201604886WA (en) 2016-07-28
IL246497B (en) 2019-06-30
CA2935472C (en) 2024-02-20
IL264364A (en) 2019-02-28
US20230232795A1 (en) 2023-07-27
US9474255B2 (en) 2016-10-25
ES2794942T3 (es) 2020-11-19
CN106163273B (zh) 2020-07-24
CY1123046T1 (el) 2021-10-29
MX2016013241A (es) 2017-05-03
KR102439412B1 (ko) 2022-09-02
RU2016143036A (ru) 2018-05-08
AU2020217312A1 (en) 2020-08-27
AU2015243865A1 (en) 2016-08-18
IL246497A0 (en) 2016-08-31
CN111690052A (zh) 2020-09-22
HRP20200899T1 (hr) 2020-09-04
EP3693383A1 (en) 2020-08-12
SG10201908800YA (en) 2019-11-28
RU2016143036A3 (da) 2018-10-24
US20170086432A1 (en) 2017-03-30
AU2020217312C1 (en) 2023-10-26
PL3129400T3 (pl) 2020-09-07
WO2015157415A1 (en) 2015-10-15
KR20210024249A (ko) 2021-03-04
LT3129400T (lt) 2020-06-25
IL264364B (en) 2021-03-25
RU2019128394A (ru) 2019-10-07
US10555507B2 (en) 2020-02-11
EP3129400B1 (en) 2020-03-25
RU2700484C2 (ru) 2019-09-17
US20200288684A1 (en) 2020-09-17
CN106163273A (zh) 2016-11-23
US11503812B2 (en) 2022-11-22
KR102223264B1 (ko) 2021-03-09
KR20160142309A (ko) 2016-12-12
CN111690052B (zh) 2024-06-04
JP6652931B2 (ja) 2020-02-26
PT3129400T (pt) 2020-05-27
JP6858283B2 (ja) 2021-04-14
AU2015243865C1 (en) 2020-11-26
AU2020217312B2 (en) 2023-04-13
CA2935472A1 (en) 2015-10-15
SI3129400T1 (sl) 2020-07-31
EP3129400A1 (en) 2017-02-15
PH12016501341A1 (en) 2016-08-15
US20150282463A1 (en) 2015-10-08

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