ES2150898T3 - Receptor humano fc(gamma)riii. - Google Patents
Receptor humano fc(gamma)riii.Info
- Publication number
- ES2150898T3 ES2150898T3 ES89305241T ES89305241T ES2150898T3 ES 2150898 T3 ES2150898 T3 ES 2150898T3 ES 89305241 T ES89305241 T ES 89305241T ES 89305241 T ES89305241 T ES 89305241T ES 2150898 T3 ES2150898 T3 ES 2150898T3
- Authority
- ES
- Spain
- Prior art keywords
- riii
- gamma
- human receiver
- variants
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
FORMAS SOLUBLES Y UNIDAS COM MEMBRANAS DE FC GAMMA RIII HUMANA, JUNTO CON ACIDOS NUCLEICOS CAPACES DE CODIFICAR LA MISMA. FC GAMMA RIII SOLUBLES SON UTILES PARA MEJORAR LA DEFICIENCIA DE PLAQUETAS EN SUERO ASOCIADA CON PURPURA TROMBOCITOPENICA INMUNE. CELULAS QUE EXPRESAN FC GAMMA RIII UNIDAS CON MEMBRANA ES ENSAYOS PARA COMPLEJOS INMUNE DE SUERO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19951388A | 1988-05-27 | 1988-05-27 | |
US30003989A | 1989-01-19 | 1989-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150898T3 true ES2150898T3 (es) | 2000-12-16 |
Family
ID=26894851
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89305241T Expired - Lifetime ES2150898T3 (es) | 1988-05-27 | 1989-05-24 | Receptor humano fc(gamma)riii. |
ES97106398T Expired - Lifetime ES2262163T3 (es) | 1988-05-27 | 1989-05-24 | Receptor iii de fc gamma humano. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97106398T Expired - Lifetime ES2262163T3 (es) | 1988-05-27 | 1989-05-24 | Receptor iii de fc gamma humano. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5976831A (es) |
EP (3) | EP0791653B9 (es) |
JP (1) | JP2657221B2 (es) |
KR (1) | KR0149012B1 (es) |
AT (2) | ATE197053T1 (es) |
AU (1) | AU3740089A (es) |
DE (3) | DE68929256T2 (es) |
ES (2) | ES2150898T3 (es) |
GR (1) | GR3034698T3 (es) |
HK (1) | HK1001403A1 (es) |
WO (1) | WO1989011490A1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2657221B2 (ja) * | 1988-05-27 | 1997-09-24 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | ヒトFcγレセプター▲III▼ |
US5767077A (en) * | 1988-05-27 | 1998-06-16 | Applied Research Systems Ars Holding N.V. | Human Fc-γ receptor III |
US7038031B1 (en) * | 1989-07-28 | 2006-05-02 | Sloan-Kettering Institute For Cancer Research | DNA encoding FcγR receptor protein on NK cells |
FR2655269B1 (fr) * | 1989-12-01 | 1994-02-11 | Curie Universite Pierre Marie | Proteines empechant l'interaction entre un fragment fc d'une immunoglobuline et son recepteur et utilisation en therapeutique, notamment dans le traitement des affections liees aux virus hiv. |
FR2702481B1 (fr) * | 1993-03-09 | 1995-04-28 | Roussel Uclaf | Nouveaux récepteurs Fc-gamma III humains solubles, leur procédé de préparation, les compositions pharmaceutiques les contenant, leur application comme médicaments et leur application diagnostique. |
US5641875A (en) * | 1993-09-30 | 1997-06-24 | University Of Pennsylvania | DNA encoding chimeric IgG Fc receptor |
EP0679716A4 (en) * | 1993-11-12 | 1999-06-09 | Kenichi Matsubara | GENE SIGNATURE. |
US6444789B1 (en) * | 1995-05-03 | 2002-09-03 | Applied Research Systems Ars Holding N.V. | CD16-II variants |
FR2739560B1 (fr) * | 1995-10-09 | 1997-11-21 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite du cd16 humain soluble dans le traitement de l'infection par le virus vih |
US7195339B2 (en) | 1997-07-15 | 2007-03-27 | Silverbrook Research Pty Ltd | Ink jet nozzle assembly with a thermal bend actuator |
US7287836B2 (en) * | 1997-07-15 | 2007-10-30 | Sil;Verbrook Research Pty Ltd | Ink jet printhead with circular cross section chamber |
US6855264B1 (en) | 1997-07-15 | 2005-02-15 | Kia Silverbrook | Method of manufacture of an ink jet printer having a thermal actuator comprising an external coil spring |
US7465030B2 (en) | 1997-07-15 | 2008-12-16 | Silverbrook Research Pty Ltd | Nozzle arrangement with a magnetic field generator |
US6648453B2 (en) | 1997-07-15 | 2003-11-18 | Silverbrook Research Pty Ltd | Ink jet printhead chip with predetermined micro-electromechanical systems height |
US6935724B2 (en) | 1997-07-15 | 2005-08-30 | Silverbrook Research Pty Ltd | Ink jet nozzle having actuator with anchor positioned between nozzle chamber and actuator connection point |
US7468139B2 (en) | 1997-07-15 | 2008-12-23 | Silverbrook Research Pty Ltd | Method of depositing heater material over a photoresist scaffold |
US6712453B2 (en) | 1997-07-15 | 2004-03-30 | Silverbrook Research Pty Ltd. | Ink jet nozzle rim |
US6682174B2 (en) | 1998-03-25 | 2004-01-27 | Silverbrook Research Pty Ltd | Ink jet nozzle arrangement configuration |
US7556356B1 (en) | 1997-07-15 | 2009-07-07 | Silverbrook Research Pty Ltd | Inkjet printhead integrated circuit with ink spread prevention |
EP1006183A1 (en) | 1998-12-03 | 2000-06-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Recombinant soluble Fc receptors |
CN1329524C (zh) * | 2001-10-19 | 2007-08-01 | 图尔地区及大学医疗中心 | 评估抗体治疗反应的方法和组合物 |
US7351803B2 (en) | 2002-05-30 | 2008-04-01 | Macrogenics, Inc. | CD16A binding proteins and use for the treatment of immune disorders |
JP4459810B2 (ja) | 2002-08-14 | 2010-04-28 | マクロジェニクス,インコーポレーテッド | FcγRIIB特異的抗体とその利用法 |
US8193318B2 (en) | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8187593B2 (en) | 2002-08-14 | 2012-05-29 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8946387B2 (en) | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8044180B2 (en) | 2002-08-14 | 2011-10-25 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8530627B2 (en) | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8968730B2 (en) | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | 変異型Fc領域を含む抗体の同定および作製ならびにその利用法 |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
WO2004062619A2 (en) * | 2003-01-13 | 2004-07-29 | Macrogenics, Inc. | SOLUBLE FcϜR FUSION PROTEINS AND METHODS OF USE THEREOF |
WO2005110474A2 (en) | 2004-05-10 | 2005-11-24 | Macrogenics, Inc. | HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
US20070231813A1 (en) * | 2004-06-01 | 2007-10-04 | Centre Hospitalier Regional Et Universitaire De Tours | Fcgr3a Gebotype and Methods for Evaluating Treatment Response to Non-Depleting Antibodies |
US20070190657A1 (en) * | 2004-06-15 | 2007-08-16 | Universite Francois Rabelais | Methods of assessing susceptibility to drug-induced thrombocytopenia |
CA3052445C (en) * | 2004-07-10 | 2023-08-22 | Kerry S. Campbell | Genetically modified human natural killer cell lines |
AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
KR20080030673A (ko) | 2005-07-21 | 2008-04-04 | 젠맵 에이/에스 | Fc 수용체와 결합하는 항체 약품 성분에 대한 효력 검정 |
PT2573114T (pt) | 2005-08-10 | 2016-07-13 | Macrogenics Inc | Identificação e manipulação de anticorpos com regiões fc variantes e métodos de utilização dos mesmos |
WO2008105886A2 (en) | 2006-05-26 | 2008-09-04 | Macrogenics, Inc. | HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
WO2008002933A2 (en) | 2006-06-26 | 2008-01-03 | Macrogenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
WO2008019199A2 (en) | 2006-06-26 | 2008-02-14 | Macrogenics, Inc. | FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
WO2008140603A2 (en) | 2006-12-08 | 2008-11-20 | Macrogenics, Inc. | METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING |
EP3045475B1 (en) | 2008-04-02 | 2017-10-04 | MacroGenics, Inc. | Bcr-complex-specific antibodies and methods of using same |
DK2247304T3 (en) | 2008-04-02 | 2016-09-26 | Macrogenics Inc | Her2 / neu-specific antibodies and methods of use thereof |
DK2486141T3 (en) | 2009-10-07 | 2018-04-23 | Macrogenics Inc | FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE |
EP3336102A3 (en) | 2009-12-21 | 2018-08-01 | Regeneron Pharmaceuticals, Inc. | Humanized fc gamma r mice |
US8883496B2 (en) | 2009-12-21 | 2014-11-11 | Regeneron Phamaceuticals, Inc. | Humanized FcgR mice |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
GEP20166442B (en) | 2010-03-04 | 2016-03-10 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
EP2492689B8 (en) * | 2011-02-22 | 2013-12-25 | Bernhard-Nocht-Institut für Tropenmedizin | Detection of antibodies using an improved immune complex (IC) ELISA |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
US10815289B2 (en) * | 2014-06-27 | 2020-10-27 | Tosoh Corporation | Fc-binding protein, method for producing said protein, antibody adsorbent using said protein, and method for separating antibody using said adsorbent |
US10961311B2 (en) | 2016-04-15 | 2021-03-30 | Macrogenics, Inc. | B7-H3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US199153A (en) * | 1878-01-15 | Improvement in sulky-plows | ||
JP2713410B2 (ja) * | 1986-05-29 | 1998-02-16 | イレクサス ピーティワイ リミテッド | 免疫グロブリンに対するFcレセプター |
FR2611913B1 (fr) * | 1987-02-24 | 1994-04-15 | Khayat David | Procede de dosage des recepteurs fc gamma solubles seriques, coffret de dosage correspondant et applications |
HUT53672A (en) * | 1988-02-25 | 1990-11-28 | Gen Hospital Corp | Quick immunoselective cloning process |
JP2657221B2 (ja) * | 1988-05-27 | 1997-09-24 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | ヒトFcγレセプター▲III▼ |
-
1989
- 1989-05-24 JP JP1506363A patent/JP2657221B2/ja not_active Expired - Lifetime
- 1989-05-24 DE DE68929256T patent/DE68929256T2/de not_active Expired - Lifetime
- 1989-05-24 AU AU37400/89A patent/AU3740089A/en not_active Abandoned
- 1989-05-24 EP EP97106398A patent/EP0791653B9/en not_active Expired - Lifetime
- 1989-05-24 WO PCT/US1989/002182 patent/WO1989011490A1/en not_active Application Discontinuation
- 1989-05-24 EP EP89305241A patent/EP0343950B1/en not_active Expired - Lifetime
- 1989-05-24 ES ES89305241T patent/ES2150898T3/es not_active Expired - Lifetime
- 1989-05-24 DE DE68929546A patent/DE68929546D1/de not_active Expired - Lifetime
- 1989-05-24 ES ES97106398T patent/ES2262163T3/es not_active Expired - Lifetime
- 1989-05-24 EP EP89906578A patent/EP0449828A1/en active Pending
- 1989-05-24 DE DE68929546T patent/DE68929546T4/de not_active Expired - Lifetime
- 1989-05-24 AT AT89305241T patent/ATE197053T1/de not_active IP Right Cessation
- 1989-05-24 AT AT97106398T patent/ATE321134T1/de not_active IP Right Cessation
- 1989-05-24 KR KR1019900700147A patent/KR0149012B1/ko not_active IP Right Cessation
-
1995
- 1995-04-05 US US08/417,488 patent/US5976831A/en not_active Expired - Lifetime
-
1998
- 1998-01-20 HK HK98100444A patent/HK1001403A1/xx not_active IP Right Cessation
-
1999
- 1999-01-19 US US09/232,218 patent/US6294347B1/en not_active Expired - Fee Related
-
2000
- 2000-10-27 GR GR20000402387T patent/GR3034698T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2657221B2 (ja) | 1997-09-24 |
EP0791653B9 (en) | 2006-08-30 |
DE68929546T4 (de) | 2007-03-08 |
US6294347B1 (en) | 2001-09-25 |
DE68929546T2 (de) | 2006-09-21 |
KR0149012B1 (ko) | 1998-08-17 |
ATE321134T1 (de) | 2006-04-15 |
DE68929256D1 (de) | 2000-11-23 |
DE68929256T2 (de) | 2001-05-17 |
EP0791653B1 (en) | 2006-03-22 |
EP0343950A2 (en) | 1989-11-29 |
EP0449828A1 (en) | 1991-10-09 |
AU3740089A (en) | 1989-12-12 |
HK1001403A1 (en) | 1998-06-19 |
EP0343950B1 (en) | 2000-10-18 |
EP0791653A1 (en) | 1997-08-27 |
JPH03501484A (ja) | 1991-04-04 |
KR900701843A (ko) | 1990-12-04 |
US5976831A (en) | 1999-11-02 |
EP0343950A3 (en) | 1991-07-10 |
DE68929546D1 (de) | 2006-05-11 |
ES2262163T3 (es) | 2006-11-16 |
WO1989011490A1 (en) | 1989-11-30 |
GR3034698T3 (en) | 2001-01-31 |
ATE197053T1 (de) | 2000-11-15 |
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FG2A | Definitive protection |
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