JP2019511918A5 - - Google Patents
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- Publication number
- JP2019511918A5 JP2019511918A5 JP2018545182A JP2018545182A JP2019511918A5 JP 2019511918 A5 JP2019511918 A5 JP 2019511918A5 JP 2018545182 A JP2018545182 A JP 2018545182A JP 2018545182 A JP2018545182 A JP 2018545182A JP 2019511918 A5 JP2019511918 A5 JP 2019511918A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- rodent
- tmprss
- humanized
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301023P | 2016-02-29 | 2016-02-29 | |
| US62/301,023 | 2016-02-29 | ||
| PCT/US2017/019574 WO2017151453A1 (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511918A JP2019511918A (ja) | 2019-05-09 |
| JP2019511918A5 true JP2019511918A5 (enExample) | 2020-04-09 |
| JP6980674B2 JP6980674B2 (ja) | 2021-12-15 |
Family
ID=58264641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545182A Active JP6980674B2 (ja) | 2016-02-29 | 2017-02-27 | ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10070632B2 (enExample) |
| EP (2) | EP3895529B1 (enExample) |
| JP (1) | JP6980674B2 (enExample) |
| KR (2) | KR102493894B1 (enExample) |
| CN (1) | CN109068621B (enExample) |
| AU (1) | AU2017228293B2 (enExample) |
| CA (1) | CA3014645C (enExample) |
| DK (1) | DK3422845T3 (enExample) |
| ES (1) | ES2886958T3 (enExample) |
| IL (1) | IL261139B (enExample) |
| PT (1) | PT3422845T (enExample) |
| RU (1) | RU2749715C2 (enExample) |
| SG (2) | SG10202001578RA (enExample) |
| WO (1) | WO2017151453A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3895529B1 (en) * | 2016-02-29 | 2026-04-29 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| JP7139419B2 (ja) * | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法 |
| BR112020015112A2 (pt) | 2018-01-26 | 2021-04-06 | Regeneron Pharmaceuticals, Inc. | Anticorpos anti-tmprss2 e fragmentos que ligam antígenos |
| IL315703A (en) | 2018-07-16 | 2024-11-01 | Regeneron Pharma | Non-human animal models of DITRA disease and their uses |
| KR20210116480A (ko) * | 2019-01-17 | 2021-09-27 | 리제너론 파마슈티칼스 인코포레이티드 | 기분 장애의 설치류 모델 |
| EP4103619A1 (en) | 2020-02-10 | 2022-12-21 | Regeneron Pharmaceuticals, Inc. | Anti-tmprss2 antibodies and antigen-binding fragments |
| CN115161326B (zh) * | 2021-06-21 | 2024-09-24 | 百奥赛图(北京)医药科技股份有限公司 | Sost基因人源化非人动物及其构建方法和应用 |
| EP4451863A1 (en) | 2021-12-20 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
| KR20250169390A (ko) * | 2024-05-23 | 2025-12-03 | 한국화학연구원 | 인간 ace2 및 tmprss2 유전자를 발현하는 형질전환마우스와 이의 용도 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002065266A (ja) * | 2000-08-28 | 2002-03-05 | Teijin Ltd | 気道特異的トリプシン様酵素およびその利用法 |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7479579B2 (en) * | 2001-12-20 | 2009-01-20 | The Regents Of The University Of California | Triple transgenic mouse model of Alzheimer's disease |
| US20050026255A1 (en) * | 2002-06-25 | 2005-02-03 | Morser John Michael | Corin, a serine protease |
| US20040132156A1 (en) * | 2002-10-04 | 2004-07-08 | Schering Aktiengesellschaft | Modified hepsin molecules having a substitute activation sequence and uses thereof |
| US7176013B2 (en) * | 2003-06-11 | 2007-02-13 | Schering Aktiengesellschaft | Modified corin molecules having substitute activation sequences and uses thereof |
| US7491865B2 (en) * | 2004-08-19 | 2009-02-17 | Fred Hutchinson Cancer Research Center | Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene |
| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| RU2419625C2 (ru) * | 2006-05-23 | 2011-05-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| GB0821624D0 (en) * | 2008-11-26 | 2008-12-31 | Eisai London Res Lab Ltd | Assay |
| WO2010081173A2 (en) * | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8541646B2 (en) | 2009-10-06 | 2013-09-24 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| ES2741649T3 (es) | 2011-10-28 | 2020-02-11 | Regeneron Pharma | Ratones con complejo mayor de histocompatibilidad modificado genéticamente |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| PL2818478T3 (pl) | 2011-10-28 | 2017-09-29 | Regeneron Pharmaceuticals, Inc. | Humanizowane il-6 i receptor il-6 |
| BR112014025339A8 (pt) * | 2012-04-16 | 2018-01-16 | Regeneron Pharma | método para tratamento ou prevenção ou redução de infecção do virus influenza e composição farmacêutica para o mesmo. |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| SG11201408554QA (en) * | 2012-06-22 | 2015-02-27 | Cytomx Therapeutics Inc | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| IN2015DN02032A (enExample) | 2012-09-07 | 2015-08-14 | Univ Yale | |
| ES2884598T3 (es) | 2012-11-05 | 2021-12-10 | Regeneron Pharma | Animales no humanos modificados genéticamente y métodos de uso de los mismos |
| US20140235933A1 (en) | 2013-02-20 | 2014-08-21 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| CA2900824A1 (en) | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| BR112015030514A2 (pt) * | 2013-06-04 | 2017-08-29 | Cytomx Therapeutics Inc | Composições e métodos para conjugação de anticorpos ativáveis |
| MX368931B (es) | 2013-09-23 | 2019-10-22 | Regeneron Pharma | Animales no humanos que tienen un gen de proteina reguladora de señal humanizado. |
| AU2014337526B2 (en) | 2013-10-15 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
| US20150143558A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| BR112016011004A2 (pt) | 2013-11-19 | 2017-12-05 | Regeneron Pharma | animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo |
| RU2700484C2 (ru) | 2014-04-08 | 2019-09-17 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, имеющие гуманизированные fc-гамма-рецепторы |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| PT3482629T (pt) | 2014-05-19 | 2021-02-18 | Univ Yale | Animais não humanos geneticamente modificados que expressam epo humana |
| EP3683238A1 (en) | 2014-06-19 | 2020-07-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| KR102659123B1 (ko) | 2014-11-24 | 2024-04-22 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cd3 복합체를 발현하는 비인간 동물 |
| FI3850946T3 (fi) | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni |
| EP3808775B1 (en) | 2014-12-09 | 2024-04-17 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| RU2732628C2 (ru) | 2015-04-06 | 2020-09-21 | Регенерон Фармасьютикалз, Инк. | Опосредованные гуманизированными т-клетками иммунные ответы у не относящихся к человеку животных |
| KR102454546B1 (ko) | 2015-11-20 | 2022-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 림프구 활성화 유전자 3을 갖는 비인간 동물 |
| EP3895529B1 (en) * | 2016-02-29 | 2026-04-29 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| KR101693243B1 (ko) | 2016-06-15 | 2017-01-05 | 재단법인 한국파스퇴르연구소 | 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도 |
-
2017
- 2017-02-27 EP EP21170433.3A patent/EP3895529B1/en active Active
- 2017-02-27 WO PCT/US2017/019574 patent/WO2017151453A1/en not_active Ceased
- 2017-02-27 SG SG10202001578RA patent/SG10202001578RA/en unknown
- 2017-02-27 PT PT177098886T patent/PT3422845T/pt unknown
- 2017-02-27 US US15/442,857 patent/US10070632B2/en active Active
- 2017-02-27 SG SG11201807038UA patent/SG11201807038UA/en unknown
- 2017-02-27 DK DK17709888.6T patent/DK3422845T3/da active
- 2017-02-27 KR KR1020187026552A patent/KR102493894B1/ko active Active
- 2017-02-27 RU RU2018131152A patent/RU2749715C2/ru active
- 2017-02-27 EP EP17709888.6A patent/EP3422845B1/en active Active
- 2017-02-27 CA CA3014645A patent/CA3014645C/en active Active
- 2017-02-27 AU AU2017228293A patent/AU2017228293B2/en active Active
- 2017-02-27 CN CN201780010404.0A patent/CN109068621B/zh active Active
- 2017-02-27 ES ES17709888T patent/ES2886958T3/es active Active
- 2017-02-27 KR KR1020237003004A patent/KR102775366B1/ko active Active
- 2017-02-27 JP JP2018545182A patent/JP6980674B2/ja active Active
- 2017-06-16 US US15/624,774 patent/US10070631B2/en active Active
-
2018
- 2018-08-02 US US16/052,700 patent/US10863729B2/en active Active
- 2018-08-13 IL IL261139A patent/IL261139B/en unknown
-
2020
- 2020-11-17 US US17/099,942 patent/US11910787B2/en active Active
-
2024
- 2024-01-16 US US18/413,096 patent/US20240147971A1/en active Pending
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